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    Circulating Salusin-beta Levels in Various Open-Angle Glaucoma Types
    (2021) Turgut, Burak; Mercan, Kadir; Ilhan, Nevin; Demır, Nesrin; Catak, Onur
    Purpose: To evaluate the levels of salusin-beta (?-Sal) in the serum in patients with open-angle glaucoma.\rMaterials and Methods: This pilot work was designed as an institutional controlled comparative clinical study. The serum ?-Sal levels of age\rand sex-matched 20 healthy volunteers as controls (Group 1), 15 patients with normal-tension glaucoma (NTG) (Group 2), 18 patients with\rpseudoexfoliative glaucoma (PXG) (Group 3) and 26 patients with primary open-angle glaucoma (POAG) (Group 4) were measured with the\renzyme-linked immunosorbent assay (ELISA) method.\rResults: There was no statistically signifi cant difference concerning age and gender among the groups (p>0. 05). The mean serum ?-Sal levels\rin Group 1, Group 2, Group 3 and Group 4 were 4977.02±3741.44 pg/mL; 1086.57±253.41 pg/mL; 1044.98±268.80 pg/mL and 868.32±181.78\rpg/mL, respectively. Although the mean ?-Sal levels in all glaucoma groups seem numerically lower than the control group, there was no\rstatistically signifi cant difference between the serum ?-Sal concentrations of the study groups (p>0.05).\rConclusion: These fi ndings suggest that serum salusin-? levels are not different among various open-angle glaucoma types. However,\rtheoretically, ?-Sal may contribute to the pathogenesis of glaucoma and may play a neuroprotective hormone in glaucoma. Further studies with\rlarge patient population are required to say whether ?-Sal plays a role in the pathogenesis of glaucomatous optic neuropathy.
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    Serum cystatin c concentrations in patients with graves' ophthalmopathy
    (Korean Ophthalmological Society (KOS), 2020) Can, Nagehan; Ozsoy, Ercan; Kobat, Sabiha Gungor; Yusufoglu, Elif; Ilhan, Nevin; Demir, Tamer
    Purpose: To evaluate the concentration of serum cystatin C (CysC) in patients with Graves' ophthalmopathy (GO) and the usability of the serum CysC concentrations in the follow-up of the disease. Methods: Thirty patients with GO and 30 healthy age-matched volunteers were included in this cross-sectional study. GO was diagnosed based on the European Group on Graves' Orbitopathy consensus. Serum thyroid-stimulating hormone, free triiodothyronine, free thyroxine, and CysC concentrations were measured in the participants. The serum CysC concentrations were compared between patients with GO and controls. Patients with GO were subdivided into hyperthyroid and euthyroid patients, and their serum CysC concentrations were compared. In addition, the CysC concentrations in hyperthyroid and euthyroid patients with GO were compared separately with those of healthy subjects. Kruskal-Wallis test and Student's t-test were used for statistical evaluation. Results: The mean serum CysC concentrations in GO patients and controls were 1.04 ± 0.36 and 0.74 ± 0.09 mg/L, respectively. There was a statistically significant difference in the serum CysC concentrations between patients with GO and control subjects (p < 0.001). Fifteen patients had hyperthyroid status, and 15 patients had euthyroid status. The mean serum CysC concentrations in hyperthyroid and euthyroid patients with GO were 1.35 ± 0.22 and 0.72 ± 0.13 mg/L, respectively. Serum CysC concentrations were significantly higher in hyperthyroid patients than in euthyroid patients (p = 0.001). In addition, hyperthyroid patients had significantly higher serum CysC concentrations than healthy subjects. Among patients with GO, 21 and nine had mild and moderate- to-severe GO, respectively. Active and inactive GO were observed in eight and 22 patients, respectively. Conclusions: The serum CysC concentrations in hyperthyroid patients were higher than those in healthy subjects. Moreover, hyperthyroid patients had higher serum CysC concentrations than euthyroid patients. Further studies with a larger sample size are needed to confirm these results. © 2020 The Korean Ophthalmological Society.