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The Effects of Sugammadex on Vitamin D Levels in Rabbits Under General Anesthesia
(Galenos Yayincilik, 2019) Hunerel, Tugba; Altinisik, Hatice Betul
Objective: Sugammadex is a widely used anesthetic agent for reversing of the non-depolarizing block. It reduces blood levels of steroid compounds by encapsulation. The aim of this study was to investigate the effect of sugammadex on the blood levels of vitamin D levels, which has a steroid structure. Materials and Methods: A total of 15 adult male New Zealand white rabbits weighing 2-2.5 kg were randomized into three groups according to decurarization: Group S [sugammadex (16 mg/kg), n=5], group N [neostigmine (0.05 mg/kg), n=5], group C (control group, n=5). Vitamin D levels from venous blood were measured at baseline, 20 minutes and 24 hours after general anesthesia. Results: Mean +/- SD vitamin D levels before anesthesia, 20 minutes and 24 hours after anesthesia were 4.42 +/- 0.60 ng/mL, 4.93 +/- 0.72 ng/mL, and 4.66 +/- 0.94 ng/mL for group S, 4.92 +/- 0.45 ng/mL, 5.02 +/- 0.41 ng/mL, and 5.41 +/- 0.56 ng/mL for group N, and 5.15 +/- 0.82 ng/ mL, 4.57 +/- 1.10 ng/mL, and 5.21 +/- 1.05 ng/mL for group C, respectively. There were no significant differences in the mean vitamin D levels between the groups at baseline, 20 minutes, and 24 hours. Conclusion: Contrary to expectations, it was found that sugammadex did not have a statistically significant effect on blood levels of vitamin D.