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Öğe Anesthesia in a patient with Stiff Person Syndrome(Elsevier Science Inc, 2016) Yagan, Ozgur; Ozyilmaz, Kadir; Ozmaden, Ahmet; Sayin, Ozgur; Hanci, VolkanStiff Person Syndrome (SPS), typified by rigidity in muscles of the torso and extremities and painful episodic spasms, is a rare autoimmune-based neurological disease. Here we present the successful endotracheal intubation and application of TIVA without muscle relaxants on an SPS patient. A 46 years old male patient was operated with ASA-II physical status because of lumber vertebral compression fracture. After induction of anesthesia using lidocaine, propofol and remifentanil tracheal intubation was completed easily without neuromuscular blockage. Anesthesia was maintained with propofol, remifentanil and O-2/air mixture. After a problem-free intraoperative period the patient was extubated and seven days later was discharged walking with aid. Though the mechanism is not clear neuromuscular blockers and volatile anesthetics may cause prolonged hypotonia in patients with SPS. We think the TIVA technique, a general anesthetic practice which does not require neuromuscular blockage, is suitable for these patients. (C) 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. This is an open access article under the CC BY-NC-ND license.Öğe Atrial conduction time, and left atrial mechanical and electromechanical functions in patients with polycystic ovary syndrome: interatrial conduction delay(Clinics Cardive Publ Pty Ltd, 2015) Gazi, Emine; Gencer, Meryem; Hanci, Volkan; Temiz, Ahmet; Altun, Burak; Barutcu, Ahmet; Gungor, Ayse NurBackground: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders of women during the reproductive period. Cardiovascular risk factors are more frequent in patients with PCOS. We aimed to investigate the P-wave dispersion (Pd), inter-and intra-atrial conduction time and mechanical functions of the left atrium (LA) in patients with PCOS. Methods: Forty-eight patients with PCOS and 38 normal healthy women were enrolled in this study. A 12-lead surface electrocardiogram was used to evaluate Pd. Left ventricular (LV) functions were measured using conventional and tissue Doppler imaging (TDI) methods. Inter-and intra-atrial conduction times were measured by TDI. LA volumes were measured echocardiographically with the biplane area-length method from the apical four-chamber view. Results: Heart rate (82.02 +/- 13.15 vs 74.24 +/- 11.02 bpm, p = 0.014) and Pd were significantly increased in the PCOS patients [ 27 +/- 5 vs 24 +/- 6 ms, p = 0.035]. Transmitral E/A ratio was significantly lower in the PCOS patients than in the controls (1.5 +/- 0.3 vs 1.7 +/- 0.4 m/s, p = 0.023). Passive emptying volume (12.54 +/- 4.39 vs 15.28 +/- 3.85 ml/m(2), p = 0.004) and passive emptying fraction [54.4 (21-69) vs 59.1% (28-74), p = 0.008] were significantly decreased in PCOS patients. Total emptying volume was significantly decreased (17.9 +/- 5.49 vs 20.67 +/- 4.29 ml/m(2), p = 0.018) in PCOS patients. Interatrial (19 +/- 7.4 vs 15 +/- 6.4 ms, p = 0.035) and intra-atrial [8.5 (1-19) vs 5 ms (1-20), p = 0.026] electromechanical delays were found to be significantly higher in PCOS patients. Conclusion: This study showed that patients with PCOS had increased inter-and intra-atrial conduction delays, and decreased LA passive emptying volumes and fractions.Öğe Effects of esmolol, lidocaine and fentanyl on P wave dispersion, QT, QTc intervals and hemodynamic responses to endotracheal intubation during propofol induction: a comparative study(Elsevier Science Inc, 2013) Hanci, Volkan; Yurtlu, Serhan; Karabag, Turgut; Okyay, Dilek; Hakimoglu, Sedat; Kayhan, Gulay; Buyukuysal, CagatayBackground and objectives: In our study we aimed to investigate the effect of esmolol, lidocaine and fentanyl on P-wave dispersion (Pwd), QT and corrected QT (QTc) durations and hemodynamic responses to endotracheal intubation during propofol induction. Methods: A total of eighty adult patients, American Society of Anesthesiologists (ASA) Physical Status I or II aged 18 to 60 years were included in this prospective, randomised, double-blind study. All patients had control electrocardiograms (ECGs) done before anesthesia induction. The patients were randomised into four equal groups. The control group (Group C) received saline 5 mL, the esmolol group (Group E) received esmolol 0.5 mg.kg(-1), the fentanyl group (Group F) received fentanyl 2 mu g.kg(-1) and the lidocaine group (Group L) received lidocaine 1.5 mg.kg(-1) before anesthesia induction. Anesthesia was induced with intravenous propofol. ECGs for all patients were performed during the 1st and 3rd minutes of induction, 3 minutes after administration of muscle relaxant, and at 5 minutes and 10 minutes after intubation. Pwd and QT intervals were measured on all ECGs. QTc intervals were determined using the Bazett formula. Heart rate (HR) and mean arterial pressure (MAP) were recorded before and after induction of anesthesia, immediately after intubation, and 1, 3, 5, 7 and 10 minutes after intubation. Results: Compared with control, HR significantly increased in Group C, Group Land Group F after intubation. However, in Group E, there was no significant difference in HR values between control and after intubation. Compared with control, MAP significantly increased in Group C and Group L after the intubation. However, in Group E and Group F, there was no significant difference in MAP values between control and after the intubation. Compared with control, Pwd significantly increased in Group C after intubation. In Group L, Group F and Group E, there was no significant difference in Pwd values between control and after the intubation. Compared with control, QTc duration significantly increased in Group C and L after the intubation. In Group F and Group E, there was no significant difference in QTc durations between control and after the intubation. Conclusion: We concluded that administration of esmolol before intubation prevents tachycardia and an increase in MAP, Pwd and QTc duration caused by laryngoscopy and tracheal intubation. (C) 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.Öğe Effects of smoking on venous cannulation pain: a randomized prospective trial(Elsevier Science Inc, 2015) Hanci, Volkan; Kiraz, Hasan Ali; Omur, Dilek; Ekin, Serpil; Uyan, Berna; Yurtlu, Derya Arslan; Yurtlu, SerhanBackground and objectives: It has been demonstrated that smoking increases pain perception; however the effect of smoking on perception of pain during venous cannulation is not known. The purpose of this study is to determine whether or not smoking has an effect on pain perception due to peripheral venous cannulation. Methods: 220 patients scheduled to have elective surgery were enrolled in the study and were divided into two groups (Group S and C, n=110 for each) according to their smoking habits. Numerical rating scale was introduced to the patients and then peripheral venous cannulation at the dorsum of the hand was made with a 20 G intracath. Pain perception of the patients was scored by subsequent numerical rating scale questioning. Results: The demographic characteristics of the groups were identical. Numerical rating scale scores in Group S and C were 3.31 +/- 1.56 and 1.65 +/- 1.23, respectively (p < 0.001). Conclusion: Pain perception due to peripheral venous cannulation is higher in smokers. Future studies on pain treatment should consider the smoking habits of patients. (C) 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.Öğe Evaluation of precipitation characteristics of commonly used non-steroidal anti-inflammatory analgesic drugs(Colegio de Farmaceuticos de la Provincia de Buenos Aires, 2015) Kiraz, Hasan Ali; Ömür, Dilek; Ekin, Serpil; Toman, Hüseyin; Uyan, Berna; Yurtlu, Bülent Serhan; Hanci, VolkanPostoperative pain is a major problem in clinical practice. Non-steroidal anti-inflammatory drugs have traditionally been used to relieve postoperative pain. Administration of intravenous products together can result incompatibility problems and this is clinically hazardous. Reference texts, published reports can provide information about drugs’ incompatibility characteristics but there have been limited data for new drugs such as lornoxicam, tenoxicam and dexketoprofen, commonly used non-steroidal antiinflammatory drugs. In this study, it was aimed to investigate whether there is precipitation between lornoxicam, tenoxicam and dexketoprofen with other commonly used drugs in anesthesiology practice © 2015, Latin American Journal of Pharmacy. All rights reserved.Öğe Evaluation of Precipitation Characteristics of Commonly Used Non-Steroidal Anti-Inflammatory Analgesic Drugs(Colegio Farmaceuticos Provincia De Buenos Aires, 2015) Kiraz, Hasan Ali; Omur, Dilek; Ekin, Serpil; Toman, Huseyin; Uyan, Berna; Yurtlu, Bulent Serhan; Hanci, VolkanPostoperative pain is a major problem in clinical practice. Non-steroidal anti-inflammatory drugs have traditionally been used to relieve postoperative pain. Administration of intravenous products together can result incompatibility problems and this is clinically hazardous. Reference texts, published reports can provide information about drugs' incompatibility characteristics but there have been limited data for new drugs such as lornoxicam, tenoxicam and dexketoprofen, commonly used non-steroidal anti-inflammatory drugs. In this study, it was aimed to investigate whether there is precipitation between lornoxicam, tenoxicam and dexketoprofen with other commonly used drugs in anesthesiology practice.Öğe In vitro evaluation of antimicrobial features of sugammadex(Elsevier Science Inc, 2014) Hanci, Volkan; Vural, Ahmet; Hanci, Sevgi Yilmaz; Kiraz, Hasan Ali; Omur, Dilek; Unver, AhmetBackground: Drugs administered by intravenous routes may be contaminated during several stages of production or preparation. Sugammadex is a modified gamma cyclodextrin. While research into the antibacterial effects of varieties of cyclodextrin is available, there are no studies focusing on the antibacterial effects of sugammadex. This study investigates the in vitro antimicrobial activity of sugammadex. Materials and methods: The in vitro antimicrobial activity of sugammadex was investigated using the broth microdilution method. The pH of the test solution was determined using a pH meter. The test microorganisms included Staphylococcus aureus ATCC 29213, Enterococcus fecalis ATCC 29212, Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853. In the second phase of the study 100 mg/mL sugammadex (54 mu g) was contaminated with test microorganisms (50 mu g), including S. aureus ATCC 29213, E. fecalis ATCC 29212, E. cob ATCC 25922 and P aeruginosa ATCC 27853, Left to incubate for 24 h and then the bacterial production in sugammadex was evaluated. Results: The pH of the test solutions ranged between 7.25 and 6.97. Using the microdilution method, sugammadex had no antibacterial effect on S. aureus, E. fecalis, E. coli and P aeruginosa at any concentration. In the second phase of the study bacterial production was observed after 24h in 100 mg/mL sugammadex contaminated with the test microorganisms S. aureus, E. fecalis, E. coli and P. aeruginosa. Conclusions: Sugammadex had no antimicrobial effect on the test microorganisms, S. aureus, E. fecal's, E. coli and P aeruginosa. Care should be taken that sterile conditions are maintained in the preparation of sugammadex; that the same sugammadex preparation not be used for more than one patient; and that storage conditions are adhered to after sugammadex is put into the injector. (C) 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rightsÖğe In vitro evaluation of antimicrobial features of vasopressors(Elsevier Science Inc, 2014) Bostan, Habib; Tomak, Yakup; Karaoglu, Sengul Alpay; Erdivanli, Basar; Hanci, VolkanBackground: Drugs administered as intravenous infusion may be contaminated during several stages of production or preparation. However studies focusing on antibacterial effects of vasopressor drugs are very rare. This study investigates the in vitro antimicrobial activity of the clinically used forms of vasopressors. Materials and Methods: In vitro antimicrobial activities of vasopressor drugs of different concentrations were investigated by using the micro dilution technique. Microorganisms used in the test were Escherichia coli ATCC 25922, Yersinia pseudotuberculosis ATCC 911, Pseudomonas aeruginosa ATCC 10145, Listeria monocytogenes ATCC 43251, Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, Bacillus cereus 702 Roma, Mycobacterium smegmatis ATCC607, Candida albicans ATCC 60193, and Saccharomyces cerevisiae RSKK 251. Antibacterial assays were performed in Mueller-Hinton broth at pH 7.3 and antifungal assays were performed in buffered Yeast Nitrogen Base at pH 7.0. Results: Two different dopamine preparations showed antimicrobial activity. No other study drug showed any antimicrobial activity. Conclusions : In our opinion, dopamine's antibacterial effects may be advantageous for inhibiting the spread of bacterial contamination during the preparation of the infusion solutions. However, it is important that strict guidelines regarding the need for sterile equipment and deliverables be adhered to during all procedures performed in the intensive care units. (C) 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.Öğe Passive smoking increases pain perception in children undergoing venous catheterization(Wiley, 2013) Topaloglu, Naci; Tekin, Mustafa; Yildirim, Sule; Kucuk, Adem; Gonullu, Burcin; Hanci, VolkanAimTo establish whether there is any association between passive smoking and pain perception in children, in the absence of existing studies into possible links. MethodsThis single-centre study focused on 100 children - 50 who had been exposed to passive smoking and 50 who had not - who were admitted to general polyclinics from September 2012 to December 2012 and needed venous catheterization. Patients with chronic diseases, neurologic and psychiatric illnesses, communication problems and analgesic use in the last 24h were excluded. The passive smoking group had a mean age of 7.3years (56% male) and the nonpassive smoking group had a mean age of 7.7years (44% male). The main study parameter was the Wong-Baker faces pain rating scale (WBFPS) score during catheterization. ResultsThere was a statistically significant difference between the pain perceptions of the 100 children studied and smoke exposure. The WBFPS scores of the 50 children who were passive smokers were significantly higher than the scores of the 50 who were not passive smokers (p=0.00). ConclusionPassive smoking increases pain perception in children during invasive medical procedures.Öğe Post operative effects: Anesthesia(2013) Haliloglu, Murat; Omur, Dilek; Yuksel, Tuba Can; Alan, Cabir; Hanci, VolkanAnesthesia result in a variety of metabolic and endocrine responses, but conventional wisdom maintains that anesthetic technique has little long-term effect on patient outcomes. There is accumulating evidence that, on contrary, anesthetic management may in fact exert a number of longer-term effects in postoperative outcome. Here, we review the most topical aspects of anaesthetic management which may potentially influence later postoperative outcomes. Overall, there is insufficient evidence to confirm the ability of postoperative outcomes. This is primarily due to typically insufficient subject numbers to detect differences in currently low incidences of postoperative complications. © 2012 Haliloglu M, et al.Öğe Precipitation in Gallipoli: Sugammadex / Amiodarone & Sugammadex / Dobutamine & Sugammadex / Protamine(2013) Hanci, Volkan; Ali Kiraz, Hasan; ömür, Dilek; Ekin, Serpil; Uyan, Berna; Yurtlu, Bulent Serhan[No abstract available]Öğe Precipitation in Gallipoli: Sugammadex/Amiodarone & Sugammadex/Dobutamine & Sugammadex/Protamine(Elsevier Science Inc, 2013) Hanci, Volkan; Kiraz, Hasan Ali; Omur, Dilek; Ekin, Serpil; Uyan, Berna; Yurtlu, Bulent Serhan[Anstract Not Available]Öğe Protective effect of dexmedetomidine in a rat model of ?-naphthylthioureae-induced acute lung injury(Academic Press Inc Elsevier Science, 2012) Hanci, Volkan; Yurdakan, Gamze; Yurtlu, Serhan; Turan, Isil Ozkocak; Sipahi, Emine YilmazBackground: We assessed the effects of dexmedetomidine in a rat model of alpha-naphthylthiourea (ANTU)-induced acute lung injury. Methods: Forty Wistar Albino male rats weighing 200-240 g were divided into 5 groups (n = 8 each), including a control group. Thus, there were one ANTU group and three dexmedetomidine groups (10-, 50-, and 100- mu g/kg treatment groups), plus a control group. The control group provided the normal base values. The rats in the ANTU group were given 10 mg/kg of ANTU intraperitoneally and the three treatment groups received 10, 50, or 100 mu g/kg of dexmedetomidine intraperitoneally 30 min before ANTU application. The rat body weight (BW), pleural effusion (PE), and lung weight (LW) of each group were measured 4 h after ANTU administration. The histopathologic changes were evaluated using hematoxylin-eosin staining. Results: The mean PE, LW, LW/BW, and PE/BW measurements in the ANTU group were significantly greater than in the control groups and all dexmedetomidine treatment groups (P < 0.05). There were also significant decreases in the mean PE, LW, LW/BW and PE/BW values in the dexmedetomidine 50-mu g/kg group compared with those in the ANTU group (P < 0.01). The inflammation, hemorrhage, and edema scores in the ANTU group were significantly greater than those in the control or dexmedetomidine 50-mu g/kg group (P < 0.01). Conclusion: Dexmedetomidine treatment has demonstrated a potential benefit by preventing ANTU-induced acute lung injury in an experimental rat model. Dexmedetomidine could have a potential protective effect on acute lung injury in intensive care patients. (C) 2012 Elsevier Inc. All rights reserved.Öğe Relationship of QT dispersion with sex hormones and insulin in young women with polycystic ovary syndrome: an observational study(Turkish Soc Cardiology, 2013) Gazi, Emine; Gencer, Meryem; Hanci, Volkan; Temiz, Ahmet; Altun, Burak; Gungor, Ayse Nur Cakir; Ozturk, UfukObjective: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in reproductive women. Cardiovascular disease risk factors are more frequent in this population. We aimed in this study to investigate presence of QT dispersion and effects of sex hormones and insulin on QT duration in young PCOS patients. Methods: This present study was cross-sectional observational study. A total of 47 women, 25 patients with PCOS and 22 healthy, were included. Serum testosterone, estradiol and insulin levels were studied and electrocardiography was performed at 2nd or 3th days of menstrual cycle. The study population was divided into groups according to serum testosterone and estradiol levels. Sub-groups and pairwise groups were compared by Mann-Whitney U or student t-test. The associations of QTc durations with hormone levels were calculated using Spearman rank correlation analysis. The results were evaluated at the p<0.05 significance level. Results: No differences found between groups regarding to demographic parameters. Estradiol and testosterone levels were higher in patients with PCOS (41.12 +/- 13.59 vs. 35.57 +/- 19.29 pg/mL, p=0.09 and 105 +/- 58.5 vs. 17.6 +/- 10.9 ng/dL, p=0.01, respectively). QT dispersion was significantly longer in PCOS patients (47.1 vs. 32.7 ms, p=0.01). A positive correlation was found between the serum insulin level and QTc min, QTc max, and QTc mean (r=0.402, p=0.011; r=0.341, p=0.033; r=0.337, p=0.036; respectively). QT dispersion with serum testosterone and estradiol levels were positively correlated (r=0.525, p=0.001and r=0.326, p=0.046; respectively). Conclusion: Our results suggest that QT dispersion is prolonged and testosterone, estradiol and insulin are associated with QT duration in young PCOS patients.Öğe Reply to: 'passive smoking increases pain perception in children undergoing venous catheterization'(Wiley-Blackwell, 2013) Topaloglu, Naci; Tekin, Mustafa; Yildirim, Sule; Kuecuek, Adem; Goenuellue, Burcin; Hanci, Volkan[Anstract Not Available]Öğe The analgesic efficacy of ultrasound-guided transversus abdominis plane block on postoperative pain and morphine consumption in varicocelectomy(Saudi Med J, 2016) Omur, Dilek; Oguzalp, Huseyin; Kiraz, Hasan A.; Ekin, Serpil; Alan, Cabir; Ersay, Ahmet R.; Hanci, VolkanObjectives: To evaluate the analgesic effect of transversus abdominis plane (TAP) block administered before varicocele surgery. Methods: This study was completed at the Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey, between January 2011 and April 2013. In a prospective, double blind, randomized, placebo controlled clinical study, 40 male patients scheduled for elective varicocele operations were randomized to group T (treatment group) or group C (controls). After receiving general anesthesia, group T received a TAP block using 20 mL 0.25% bupivacaine on the operation side, whereas group C received a control block using 20 mL 0.9% Sodium chloride. During the first 24 hours after surgery, the patient pain was evaluated using the visual analogue scale (VAS) at rest and while coughing. Postoperative patient controlled analgesia morphine consumption, VAS scores, and side effects were recorded. Results: Of 34 patients, Group T (n=18) had significantly lower VAS pain scores than Group C (n=16) both at rest and while coughing. The total morphine consumed was lower (7.7 +/- 4.0) versus 21.6 +/- 12.4 mg, p<0.001) in the 24 hours after surgery. Conclusion: As part of a multimodal analgesic regime after varicocelectomy surgery, morphine consumption and VAS pain scores were significantly lower among those receiving 20 mL 0.25% bupivacaine administered for a TAP block than among controls.Öğe The comparison of levobupivacaine in continuous or single dose spinal anesthesia for transurethral resection of prostate surgery(Elsevier Science Inc, 2014) Baydilek, Yunus; Yurtlu, Bulent Serhan; Hanci, Volkan; Ayoglu, Hilal; Okyay, Rahsan Dilek; Kayhan, Gulay Erdogan; Tokgoz, HusnuBackground: The aim of the study is to compare the efficacy of levobupivacaine induced continuous spinal anesthesia (CSA) versus single dose spinal anesthesia (SDSA) in patients who are planned to undergo transurethral prostate resection. Methods: Sixty years or older, ASA I-II or III, 50 patients were included in the study. 12.5 mg 0.5% levobupivacaine were administered intrathecally in SDSA group. In CSA group, initially 2 mL of 0.25% levobupivacaine were administered through spinal catheter. In order to achieve sensory block level at 110 dermatome, additional 1 mL of 0.25% levobupivacaine were administered through the catheter in every 10 min. Hemodynamic parameters and block characteristics were recorded. Preoperative and postoperative blood samples of the patients were drawn to determine plasma cortisone and plasma epinephrine levels. Results: CSA technique provided better hemodynamic stability compared to SDSA technique particularly 90 min after intrathecal administration. The rise in sensory block level was rapid and the time to reach surgical anesthesia was shorter in SDSA group. Motor block developed faster in SDSA group. In CSA group, similar anesthesia level was achieved by using lower levobupivacaine dose and which was related to faster recovery. Although, both techniques were effective in preventing surgical stress respond, postoperative cortisone levels were suppressed more in SDSA group. Conclusion: CSA technique with 0.25% levobupivacaine can be used as a regional anesthesia method for elderly patients planned to have TUR-P operation. (C) 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.Öğe The effects of dexmedetomidine on mesenteric arterial occlusion-associated gut ischemia and reperfusion-induced gut and kidney injury in rabbits(Academic Press Inc Elsevier Science, 2012) Kilic, Kemal; Hanci, Volkan; Selek, Sahbettin; Sozmen, Mahmut; Kilic, Nergiz; Citil, Mehmet; Yurtlu, Derya ArslanObjective: We assessed the antioxidant activity of dexmedetomidine (Dex) administered during the ischemic period in a rabbit model of mesenteric ischemia/reperfusion (I/R) injury using biochemical and histopathological methods. Methods: A total of 24 male New Zealand white rabbits weighing between 2.5 and 3.0 kg were randomly divided into three groups: the sham group (Group S, n = 8), the I/R group (Group I/R, n = 8), and the I/R plus Dex treatment group (Group Dex, n = 8). In the I/R group, ischemia was achieved with 60 min of mesenteric occlusion. The sham group provided normal basal values. The rabbits in Group I/R were operated to achieve I/R. Group Dex received intravenous Dex 30 min after the commencement of reperfusion (10 mu g/kg Dex was infused within 10 min, and then a maintenance dose of 10 mu g/kg/h Dex was infused intravenously). For the measurement of tissue malondialdehyde, total antioxidant status, total oxidant status, lipid hydroperoxide levels, superoxide dismutase, catalase, and myeloperoxidase activity levels in the renal tissue samples of animals, the rabbits in each group were sacrificed 3 h after reperfusion. The histopathological examination scores were determined using the intestinal and renal tissues. Results: The mean malondialdehyde, total oxidant status, myeloperoxidase, and lipid hydroperoxide levels were significantly higher in Group I/R than in Groups S and Dex (P < 0.05). There also were significant decreases in the mean total antioxidant status, catalase, and superoxide dismutase activities in Group I/R compared with Groups S and Dex (P < 0.05). The histopathological examination scores of the intestinal and renal tissues were significantly higher in Group I/R compared with Groups S and Dex (P < 0.05). Conclusion: Dex treatment may have biochemical and histopathological benefits by preventing I/R-related cellular damage of intestinal and renal tissues as shown in an experimental mesenteric ischemia model. The preference to use Dex for anesthesia during the mesenteric ischemia procedure may attenuate I/R injury in intestinal and renal tissues. (C) 2012 Elsevier Inc. All rights reserved.Öğe Tracheal intubation without use of muscle relaxants: Comparison of remifentanil and alfentanil(Brieflands, 2012) Hanci, Volkan[No abstract available]Öğe Turkish Anaesthesiologist's Experiences of Anaesthetic Management of Patients with Obstructive Sleep Apnea (OSA)(Aves, 2015) Erbas, Mesut; Kiraz, Hasan Ali; Simsek, Tuncer; Sahin, Hasan; Toman, Huseyin; Hanci, VolkanObjective: Obstructive sleep apnea (OSA) is an important health problem that is increasing with the increase in the incidence of obesity. For patients with OSA, it is reported that preoperative OSA diagnosis is made in only 10%-20% of the patients. Therefore, it gains importance that these patients are diagnosed in the preoperative period. The aim of this study is to analyze with a survey the experiences of anaesthesia experts working in Turkey about the diagnosis of patients with OSA, anaesthetic methods and postoperative care. Methods: The study was completed with an online survey form distributed via email. Survey participants were sent an email, and those experts who wished to participate clicked on the link, answered the questions and returned the survey via email. Results: A total of 134 anaesthesia experts participated in this study. While 97% of the participating anaesthetists considered diagnosis of patients with OSA to be important, only 53% trusted themselves to recognize this patient group. Of the total number of participants. 43% did not know the STOP-BANG test used in the preoperative period to diagnose patients with OSA. The percentage who thought that patients with OSA would increase the incidence of difficult intubation was 84%. In the intraoperative period, the percentage who chose inhalation anaesthetics was 35%, whereas the rate of those who chose total intravenous anesthesia (TIVA) was 48%. Conclusion: This study indicates that the medical knowledge of Turkish anaesthetists on the topic of OSA requires updating. In addition, we believe a practical guide to standardize the diagnosis and preoperative/perioperative management of patients with OSA should be prepared for Turkish anaesthetists.
