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Öğe Acne severity and the Global Acne Grading System in polycystic ovary syndrome(Elsevier Ireland Ltd, 2013) Hacivelioglu, Servet; Gungor, Ayse Nur Cakir; Gencer, Meryem; Uysal, Ahmet; Hizli, Deniz; Koc, Evrim; Cosar, EmineObjective: To evaluate the association between acne, quantified by the Global Acne Grading System (GAGS), and abnormal clinical and laboratory markers of androgen excess in patients with polycystic ovary syndrome (PCOS). Methods: The retrospective study included 133 patients with PCOS. Acne severity was quantified with the GAGS score, alopecia was graded with the Ludwig classification, and hirsutism was quantified with a modified Ferriman-Gallwey (FG) score. Results: The mean GAGS score was significantly greater in younger women, those with a lower BMI, and those with a higher FG score. There was no relation between the mean GAGS score and waist circumference, waist/hip ratio, androgen hormone levels (free testosterone, total testosterone, or dehydroepiandrosterone sulfate), sex-hormone-binding globulin level, or menstrual irregularity. Alopecia was significantly associated with an increased waist/hip ratio; there was no relation between alopecia and age, waist circumference, body mass index, FG score, androgen hormone levels, or menstrual irregularity. A weak positive correlation was observed between the GAGS and FG scores. Conclusion: The GAGS may provide more precise and comprehensive information about acne severity in obese or hirsute patients with PCOS because this grading system includes evaluation of the type (comedones, papules, pustules, nodules) and location (anatomic area) of acne lesions. (c) 2013 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.Öğe Comparison of olive oil and lanolin in the prevention of sore nipples in nursing mothers(2013) Gungor, Ayse Nur Cakir; Oguz, Sevilay; Vurur, Gulsen; Gencer, Meryem; Uysal, Ahmet; Hacivelioglu, Servet; Uludag, Aysegul[No abstract available]Öğe Cord blood S100B levels in low-risk term pregnancies with meconium-stained amniotic fluid(Taylor & Francis Ltd, 2013) Hizli, Deniz; Altinbas, Sadiman Kiykac; Kosus, Aydin; Kosus, Nermin; Uysal, Sema; Hacivelioglu, Servet; Gelisen, OrhanObjective: The aim of this study was to compare cord blood S100B levels and cord blood gas parameters of term infants with meconium-stained amniotic fluid (MSAF) to those infants with clear amniotic fluid. Methods: Term pregnant women at an active phase of labor and having MSAF were defined as the study group (n = 35) and pregnant women with clear amniotic fluid, and matched for age, parity, and gestational age were defined as the control group (n = 35). Cord blood S100B levels and gas parameters were measured. Results: LogS100B values of study and control groups were 2.40 +/- 0.21 and 2.43 +/- 0.29 pg/ml, respectively. The difference was not statistically significant (p = 0.675). LogS100B levels slightly increased as meconium thickened. (2.32 +/- 0.16, 2.41 +/- 0.17, and 2.44 +/- 0.28 pg/ml, respectively). However, no difference was found between groups (p = 0.438). Moreover, the study group had a statistically lower HCO3 level (21.80 vs 23.60 mmol/l) and a higher rate of base deficit (4.85 vs 3.25 mmol/l) than the control group. However, median HCO3 and base deficit values were within normal limits in both groups. Conclusion: The present study showed that cord blood S100B levels of infants born through MSAF were not different from those with clear amniotic fluid. This finding suggests that MSAF, regardless of its thickness, may not be related to brain damage in low risk term pregnancies.Öğe Detection of fetal keratin with high molecular weight cytokeratin immunostaining in lung biopsy material from a patient with amniotic fluid embolism(2013) Hacivelioglu, Servet; Oguzalp, Huseyin; Muratli, Asli; Asgun, Fatih; Kirilmaz, Bahadir; Omur, DilekAmniotic fluid embolism (AFE) is a rare and fatal disorder in which the diagnosis can be challenging for clinicians and pathologists. A healthy 36-year-old woman (gravida 4, para 2) was admitted for delivery in the 40th week of gestation. At the fifth minute following birth, during expulsion of the placenta, the patient suddenly collapsed with bradycardia, shallow respiration, and loss of consciousness. After evaluation, an emergent pulmonary embolectomy for acute thrombo-embolism was performed, however the patient could not be weaned from cardiopulmonary bypass, and died of severe right ventricular dysfunction following the operation. Microscopic examination of the biopsy material detected clearly visible fetal epithelial squames inside pulmonary vessels, both with routine hematoxylin-eosin (HE) staining and immunostaining for high molecular weight cytokeratin (HMW-CK). The diagnosis of amniotic fluid embolism (AFE) was made, which was confirmed as the cause of death. We show that HMW-CK staining can be a useful means of detecting amniotic fluid-derived fetal keratin within alveolar tissue. We suggest that this technique, used in addition to HE staining and in combination with sudden-onset clinical findings, may increase the accuracy of diagnosis in AFE.Öğe Does Omegaven have beneficial effects on a rat model of ovarian ischemia/reperfusion?(Elsevier Science Bv, 2014) Gungor, Ayse N. Cakir; Turkon, Hakan; Albayrak, Aynur; Ovali, Mehmet; Islimye, Mine; Gencer, Meryem; Hacivelioglu, ServetObjective: The beneficial effects of omega-3 fatty acids on an intestinal ischemia/reperfusion (I/R) model was shown previously. Therefore, we aimed to examine the potential beneficial effects of parenteral omega-3 fatty acids, a safe and inexpensive product, on a rat model of ovarian I/R. Study design: A group of 39 rats was divided into six groups. Group 1 (Sham Group; n = 6) underwent two laparotomies with a 3-h interval and their ovaries were removed 3 h later. Group 2 (torsion detorsion Group; n = 7) had their ovaries torsioned clockwise and fixed at 7200; 3 h later a detorsion operation was done and after another 3 h, their ovaries were removed. Group 3 (n = 7) and Group 4 (n = 7) received the same treatment as Group 2; however, half an hour prior to detorsion, these rats received Omegaven at 1 mL/kg and 5 mL/kg, respectively. Group 5 (n = 6) and Group 6 (n = 6) received the same treatment as Group 1; however, half an hour prior to the second laparotomy, these rats received Omegaven at 1 mL/kg and 5 mL/kg, respectively. One ovary from each rat was evaluated histologically by hematoxylin and eosin (H&E) staining and the other ovary was homogenized and evaluated for total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI). Results: While we failed to show any significant relationship among groups in oxidative parameters, there was a significant worsening in the torsion detorsion group in histological evaluation. High Omegaven doses, but not low doses, improved tissue injury scores of torsioned and detorsioned ovaries to the levels observed in the control group. Conclusion: Omegaven improves the detrimental effects of ovarian I/R when used in sufficient doses. Its effects and dose adjustment on women with ovarian torsion must be investigated by further studies. (C) 2014 Elsevier Ireland Ltd. All rights reserved.Öğe Giant vulvar hematoma during pregnancy after sexual intercourse: A case report(Yuzuncu Yil Universitesi Tip Fakultesi, 2011) Hacivelioglu, Servet; Haydardedeoglu, Bulent; Simsek, Erhan; Cok, TayfunLower genital tract hematomas are rarely seen in clinical practice. Although one can frequently see vulvar hematomas when delivering a baby, there are few reports on vulvar hematomas in pregnant patients. Here the authors present a case on a giant vulvar hematoma in a pregnant patient that developed after usual sexual intercourse. Due to the enlarging hematoma and unbearable pain, an operation was offered to the patient. Under general anesthesia, a 5-cm vertical incision was made on the thinnest portion of the vaginal mucosa, and the hematoma was evacuated. As the case reported here is very uncommon, the usual recommendations about sexual intercourse during pregnancy should not change.Öğe Infertility Associated with the Familial Mediterranean Fever (vol 20, 2019)(Galenos Yayincilik, 2019) Hacivelioglu, Servet; Gungor, Ayse Nur Cakir; Pek, Eren[Anstract Not Available]Öğe Is abnormal glucose metabolism during pregnancy related to endothelial dysfunction?(Taylor & Francis Ltd, 2015) Gungor, Omer; Gazi, Emine; Ozkececi, Gulay; Gungor, Ayse Nur Cakir; Cevizci, Sibel; Hacivelioglu, Servet; Temiz, AhmetObjective: Endothelial dysfunction is an independent risk factor for cardiovascular events. We aimed to investigate the relationship between endothelial dysfunction and gestational diabetes mellitus and impaired glucose tolerance. Methods: Pregnant women who had impaired glucose metabolism in the 75-g oral glucose tolerance test (OGTT) and their age-and body mass index-matched controls were included in the study and assessed for flow-mediated vasodilatation to evaluate endothelial dysfunction. Results: A total of 51 patients participated in the study. There were 20 patients in the control group, 13 in the impaired glucose tolerance group and 18 in the gestational diabetes mellitus group. Flow-mediated vasodilatation measured at the 60th and 120th seconds were significantly lower in the impaired glucose tolerance and gestational diabetes mellitus groups than in the control group (8.5 +/- 5.7 and 8.9 +/- 6.5 versus 14.9 +/- 9.0, p = 0.022 and 6.2 +/- 6.7 and 5.2 +/- 5.0 versus 12.0 +/- 8.3, p = 0.011, respectively). Conclusions: Patients with gestational diabetes mellitus and impaired glucose tolerance have impaired endothelial dysfunction. Delivery might have protective effects on endothelial functions. The significance of impaired endothelial dysfunction for pregnant women must be investigated, and if needed, lifestyle changes might be suggested, according to the determined importance of the endothelial dysfunction.Öğe Is there an advantage of three dimensional computed tomography scanning over plain abdominal radiograph in the detection of retained needles in the abdomen?(Elsevier Science Bv, 2013) Hacivelioglu, Servet; Karatag, Ozan; Gungor, Aysenur Cakir; Gencer, Meryem; Kosar, Sule; Kizildag, Betul; Yildiz, Yavuz[Anstract Not Available]Öğe Is there any relationship between adverse pregnancy outcome and first trimester nuchal translucency measurements in normal karyotype fetuses?(Informa Healthcare, 2015) Uysal, Fatma; Cosar, Emine; Yucesoy, Kaya; Gencer, Meryem; Cevizci, Sibel; Gungor, Aysenur; Hacivelioglu, ServetAim: This study aims to research whether there is a relationship between first trimester nuchal translucency (NT) measurements and pregnancy complications such as gestational diabetes mellitus (GDM), gestational hypertension (GHT), intrauterine growth restriction (IUGR) and oligohydramnios. Method: This study included 225 singleton pregnancies attending Canakkale Onsekiz Mart University Obstetrics and Gynecology clinic for all monitoring and examinations, and gave birth at our clinic between January 2011 and December 2012. Data sources were clinical records and the hospital's automation system, and the study was planned as retrospective cohort. NT measurement was made between 10 weeks 3 days and 13 weeks 6 days gestation. For data analysis, the chi-square, Mann-Whitney U test and Spearman correlation were used. Results: Of pregnancies, in the study, 5 (2.2%) developed GDM, 6 (2.6%) developed GHT, 2 (0.89%) developed IUGR and 10 (4.4%) developed oligohydramnios. There was no correlation identified between NT measurements and development of GDM, GHT, IUGR and oligohydramnios. Conclusion: There was no relationship found between first trimester NT measurements and complications that could develop in pregnancy. For the first time in the literature, NT and oligohydramnios were studied and no relationship was observed.Öğe Is There Any Relationship Between Platelet Functions, Red Cell Distribution Width and Recurrent Pregnancy Loss?(Derman Medical Publ, 2015) Uysal, Ahmet; Incebiyik, Adnan; Hacivelioglu, Servet; Gencer, Meryem; Gungor, Aysenur; Cosar, EmineAim: Recurrent pregnancy loss (RPL) affects 1% pregnancies and its etiology is multi-factorial. Hypercoagulability might result in recurrent abortions; anticoagulant therapy could potentially increase the live-birth rate in subsequent pregnancies in women with unexplained recurrent abortions. Mean platelet volume (MPV) and platelet distribution width (PDW), are a parameter of platelet functions and may be a marker for increased platelet aggregability. In this study we aimed to determine whether MPV, PDW and red cell distribution width (RDW) values differ between patients with RPL and in healthy participants. Material and Method: A total of 50 RPL patients and 49 age matched healthy women were enrolled into the study. For all subjects following tests were performed: Hemoglobin, hematocrit, white blood cells counts (WBC), MPV, PDW, platelet count, RDW and thyroid stimulating hormone (TSH). Results: Compared with healthy controls there were no statistically differences in MPV and PDW between (p > 0.05, respectively) in women with RPL. However, RDW was significantly lower in patients with RPL than in group with control (p = 0.023,). Discussion: It was first shown in the literature that patients with RPL have no significance MPV and PDW than control subjects. However RDW levels were found that it was significantly related to recurrent pregnancy loss.Öğe Men's Perspectives on Family Planning and Their Knowledge on Reproductive Health(Derman Medical Publ, 2014) Gungor, Ayse Nur Cakir; Uludag, Aysegul; Hacivelioglu, Servet; Gencer, Meryem; Ors, Polat; Yucesoy, Kaya; Uysal, AhmetAim: Many training programs for females about contraception have been developed. In this study, we aimed to investigate the perspectives of males on contraception and their knowledge on reproductive health. Material and Method: Husbands of pregnant women who presented in our obstetric clinic were invited to complete a questionnaire. Results: A total of 178 men answered our questionnaire. Among their wives, 11.1% (17/153) terminated their at least one unintended pregnancy. 142 of them (79.8%) knew about modern contraceptive methods, and 104 (58.4%) of them used at least one of these methods. Condoms were perceived as the best contraceptive method for 46.1% (35/76) because of their easiness to use and cheapness, and 41.7% (25/60) of the participants stated that they would like to use condom from then on. 55.6% (40/72) stated that they would never use oral contraceptives because of their possible side effects on their wives. 20 of the questions addressed to the participants were about reproductive health. The participants answered approximately 70% of all questions correctly. The correct answering rate for every question ranged between 39.6% and 96.1%. Discussion: In our study, we investigated attitudes and knowledge about contraception and reproductive health among men who were married and fertile. The findings from this study can provide a foundation for further education programs for men in these areas.Öğe Predictive value of striae gravidarum severity for intraperitoneal adhesions or uterine scar healing in patients with previous caesarean delivery(Taylor & Francis Ltd, 2014) Gungor, Ayse Nur Cakir; Oguz, Sevilay; Hacivelioglu, Servet; Isik, Selda; Uysal, Ahmet; Gencer, Meryem; Cosar, EmineObjective: Previous abdominal operations might cause severe intraperitoneal adhesions (IPA), which can complicate caesarean section (CS) procedures. When selecting the mode and timing of delivery, obstetricians are also curious about uterine scar healing if the previous operation was a CS. Uterine scar thickness is an indicator of uterine scar healing. We aimed to evaluate the possible predictive value of striae gravidarum (SG) on IPA formation and uterine scar thickness (UST). Methods: Fifty-five women with a previous CS history were evaluated for SG Davey Score. They were investigated for IPAs and lower segment uterine scar thickness during the current CS operation. Results: Out of the patients with no SG (n = 11), mild SG (n = 10) and severe SG (n = 34), 1 (9.1%), 3 (30%) and 17 (50%) had IPA, respectively (p = 0.044). The mean uterine scar thicknesses in the no SG, mild SG and severe SG groups were 3.82 +/- 4.04, 5.20 +/- 4.13 and 5.18 +/- 3.52, respectively (p = 0.561). Conclusions: To the best of our knowledge, this was the first study to investigate the relationship between SG and IPA and uterine scar thickness. The SG status of a patient with a previous delivery and abdominal operation history might help predict IPA status before planning a new operation.Öğe Restless legs syndrome is related to obstructive sleep apnea symptoms during pregnancy(Springer Heidelberg, 2015) Terzi, Hasan; Terzi, Rabia; Zeybek, Burak; Ergenoglu, Mete; Hacivelioglu, Servet; Akdemir, Ali; Yeniel, OzgurTo investigate the relation between restless legs syndrome (RLS) and obstructive sleep apnea symptoms during pregnancy. A questionnaire consisting of diagnostic criteria of restless legs syndrome, demographic characteristics, personal behavior, muscle cramps during pregnancy, past medical illnesses, family history of RLS, and the major symptoms of obstructive sleep apnea syndrome was administered during a face-to-face interview. Pregnant women with and without RLS were compared in terms of serum hemoglobin, hematocrit, calcium, phosphor, iron, folate, vitamin B12 levels, and obstructive sleep apnea symptoms. There were statistically significant differences between two groups in terms of two of the obstructive sleep apnea symptoms (witnessed apnea and fatigue) (p < 0.01). No statistically significant difference was found with regard to serum calcium, magnesium, iron, hemoglobin, hematocrit, vitamin B12, phosphor, and folate levels; however, there were significant differences in terms of total iron-binding capacity. Increasing awareness of restless legs syndrome among obstetricians is essential as it might be related to obstructive sleep apnea syndrome, which is associated with adverse pregnancy outcomes.Öğe Scleroderma renal crisis and ovarian hyperstimulation syndrome related to the use of clomiphene in a patient with scleroderma(Elsevier Doyma Sl, 2014) Kobak, Senol; Hacivelioglu, Servet; Gungor, SelenThis paper presented a 28-year-old female with systemic sclerosis who developed scleroderma renal crisis and ovarian hyperstimulation syndrome following clomiphene administration. Urgent therapy including angiotensin-converting enzyme (ACE) inhibitors and supportive care resulted in regression and eventually resolution of all the clinical and laboratory symptoms. Although scleroderma renal crisis is a fatal complication of high-dose corticosteroids, rarely is this seen with the use of ACE inhibitors. This case report aimed to investigate the potential capacity of the selective oestrogen receptor modulator clomiphene to induce scleroderma renal crisis as well as corticosteroids. (C) 2012 Elsevier Espana, S.L. All rights reserved.Öğe The comparison of the degree of apoptosis in ovaries and fallopian tubes between two different surgical interventions for tubal ligation: A rat model(Galenos Yayincilik, 2018) Mumusoglu, Sezcan; Hacivelioglu, Servet; Sokmensuer, Lale Karakoc; Karatayli, Rengin; Suzer, Aysegul; Kaymaz, FigenObjective: To compare the degree of apoptosis in ovaries and tubal epithelium observed secondary to tubal ligation either by Pomeroy's method or bipolar electrocauterization in a rat model. Material and Methods: A total of 24 female Sprague-Dawley rats were randomly assigned into 3 study groups: control (n=8), Pomeroy (n=8), and the electrocauterization group (n=8). Apoptotic cells were detected on the primary, secondary, tertiary follicles of the ovaries, and on the tubal epithelium using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labeling. The apoptotic index was calculated for each group by the percentage of the stained cells. Results: The apoptotic index of tubal epithelium was significantly higher in the bipolar electrocauterization group compared with the control and Pomeroy groups (3.1 +/- 0.8 vs. 1.4 +/- 1.0, p=0.018 and 2.0 +/- 1.2, p=0.03, respectively) whereas there was no significant difference between Pomeroy's method and the control group. The apoptotic index of primary follicles was higher in the bipolar electrocauterization group compared with the control and Pomeroy's method groups (3.4 +/- 0.5 vs. 1.2 +/- 0.4, p<0.001 and 1.8 +/- 0.8, p=0.005, respectively), but there was no significant difference between Pomeroy's method and the control group. The apoptotic index of secondary and tertiary follicles was similar for each group. Conclusion: Pomeroy's technique, as a permanent contraception method, is associated with lower apoptotic index on ovary and fallopian tube when compared with bipolar electrocauterization.Öğe The Effect of Body Mass Index on Acne, Hirsutism and Menstrual Irregularity Symptoms in Turkish Adolescent Girls(Gazi Univ, Fac Med, 2013) Hizli, Deniz; Kosger, Hatice; Hacivelioglu, Servet; Kosus, Nermin; Kosus, Aydin; Kamalak, Zeynep; Akcal, BanuPurpose: The aim of the present study was to determine whether body mass index (BMI) influences polycystic ovary syndrome (PCOS) related symptoms such as acne, hirsutism and menstrual irregularity in a large healthy adolescent population. Methods: Self-administered questionnaires were distributed to all volunteer female students at 15 different secondary schools. The subjects' BMI, birthweight, age at menarche, pattern of menstrual cycle and presence of acne or hirsutism complaints were recorded. Subjects with BMI of = 18.4 kg/m 2, 18.5-24.9 kg/m(2), 25-29.9 kg/m(2) and > 30 kg/m(2) were defined as group 1, group 2, group 3 and group 4, respectively. The relation between BMI and the symptoms of acne, hirsutism and menstrual irregularity was analyzed. Results: A total of 1309 students filled the questionnaires properly and included in the study. Of these students, 314 were in group 1, 899 in group 2, 81 in group 3 and 15 in group 4. The median ages of participants were 16 years (range 13-20 years) and median age at menarche was 13 years (range of 11-16 years). A total of 106 (8.1%) participants reported various menstrual irregularity. Underweighed girls had significantly less acne (p= 0.001) and hirsutism problems (p<0.001) compared to normo weighed girls. Hirsutism incidence was significantly higher in overweighed girls than in normo weighed subjects (p<0.001). Conclusion: The present study provided the prevalence of PCOS related symptoms in population, including menstrual irregularity, acne and hirsutism according to BMI in a large adolescent population. Our results showed that menstrual irregularity was not significantly increased as BMI increased, however acne and hirsutism problems were significantly increased as BMI increased.Öğe The effect of hesperetin on ischemia-reperfusion injury in rat ovary(Springer Heidelberg, 2014) Gungor, Ayse Nur Cakir; Gencer, Meryem; Karaca, Turan; Hacivelioglu, Servet; Uysal, Ahmet; Korkmaz, Fatma; Demirtas, SelimHesperidin (HES), a citrus fruit extract, has beneficial effects on various ischemia/reperfusion (I/R) models. We aimed to evaluate the possible positive effects of hesperetin (HPT), an active metabolite of HES, on a rat ovarian I/R model. We divided 24 Wistar Albino rats into four groups. Group I (n = 6) was sham operated, Group II (n = 6) was the I/R group, Group III (n = 6) was the I/R + solvent group and Group IV (n = 6) was the I/R + HPT group. Three hours of ischemia and 3 h of reperfusion were performed on each rat in Groups II, III, and IV. Dimethyl sulfoxide (DMSO) was given intraperitoneally to the rats in the III. Group, and 50 mg/kg of HPT dissolved in DMSO was given intraperitoneally to the rats in the IV. Group 30 min before reperfusion. After 3 h of reperfusion, the ipsilateral ovaries of the rats were examined immunohistochemically to detect apoptosis. Hematoxylin and eosin (H and E) staining demonstrated less edema and hemorrhage in the group where HPT was applied. Caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining showed significantly lower apoptosis in the group where HPT was used when compared to either the I/R or solvent group. To the best of our knowledge, this is the first study that shows the beneficial effects of HPT in an ovarian I/R injury. HPT improved tissue damage and apoptosis caused by I/R injury. To identify the possible positive effects of HPT in ovarian torsion of humans and use in clinical practice, more studies must be performed.Öğe The immunohistochemical and histologic effects of contrast medium on uterus, fallopian tubes and ovaries, given during hysterosalpingography: rat study(Galenos Yayincilik, 2020) Pek, Eren; Goret, Ceren Canbey; Hacivelioglu, Servet; Adam, Gurhan; Unsal, Mesut AbdulkerimObjective: Previous studies have shown that damage occurs to internal genital tract during hysterosalpingography (HSG). The aim was to show that endometrial and tubal epithelium underwent free radical damage during HSG in an animal model. Material and Methods: Forty rats were evaluated in five different groups. Two groups received ionizing radiation (15-20 miliRad three times) only. Two further groups received ionizing radiation in combination with iohexol (1-2 mL). The remaining group served as control. Groups were evaluated after seven and forty-two days. Inflammation and cellular changes were evaluated histopathologically. Cellular activity of antioxidant enzymes was assessed immunohistochemically. Results: Inflammation, and cellular changes were detected at certain rates in all groups (p<0.001). Glutathione reductase, catalase, superoxide dismutase, glutathione S-transferase activities were found to be increased after the HSG (p<0.001). Conclusion: It is obvious that the cell suffers acute and chronic damage during HSG due to both radioactivity and chemicals. Although there is a lot of research done before, there is no definitive method yet to protect against the harmful effects of iodinated contrast agents and ionizing radiation. So, new methods need to be explored to protect cells and tissues from reactive oxygen radical damage caused by HSG.Öğe The relationship between subclinical cardiovascular disease and lipocalin-2 levels in women with PCOS(Elsevier, 2014) Gencer, Meryem; Gazi, Emine; Hacivelioglu, Servet; Binnetoglu, Emine; Barutcu, Ahmet; Turkon, Hakan; Temiz, AhmetObjective: In this study we aimed to investigate the relationship between lipocalin-2 (LCN2) levels and cardiovascular risk in patients with polycystic ovary syndrome (PCOS). Study design: Fifty patients with PCOS and 44 healthy women as controls were enrolled in the study. Laboratory and echocardiographic examinations were performed between the second and fifth days of the menstrual cycle. Serum LCN2 levels were measured with an enzyme-linked immunosorbent assay (ELISA) method. Results: Serum LCN2 levels were significantly lower in PCOS patients (75.8 [51.4-131.2] ng/ml vs. 853 [56.7-138.5] ng/ml, p = 0.038). Carotid intima-media thickness (CIMT) was increased in patients with PCOS compared to controls (0.61 +/- 0.13 mm vs. 0.50 +/- 0.07 mm, p = 0.001). Aortic strain was lower in patients with PCOS. Aortic stiffness (beta index) was significantly increased and distensibility was decreased in PCOS patients compared to control subjects. Serum LCN2 levels and the presence of PCOS were associated with CIMT in Spearman correlation analysis (p = 0.05 and p < 0.001) in all participants. There was no statistically significant relationship between LCN2 levels and CIMT in patients with PCOS (p = 0.238). Conclusion: In the present study, we found that LCN2 levels were low in women with PCOS. Although our patients with PCOS had elevated cardiac risk, there was no correlation between LCN2 levels and early findings of atherosclerosis. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
