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    ACTIVITY OF THREE ENDEMIC VERBASCUM SPECIES AGAINST HOSPITAL ISOLATES OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS
    (Taylor & Francis Ltd, 2009) Dulger, B.; Hacioglu, N.
    Aqueous and ethanol extracts obtained from three endemic Verbascum species (V. obtusifolium, V. chinophyllum and V. linearilobum) used as traditional medicine in Turkey have been investigated for their ability to inhibit 35 hospital isolates of methicillin-resistant Staphylococcus aureus (MRSA). The antibacterial activity of the extracts was tested by disk diffusion and modified agar dilution method. Ethanolic extracts of the plants were most effective with MICs for MRSA isolates of 0.2-0.4, 0.1-0.4 and 0.4-1.6 mg/mL, respectively, and for S. aureus ATCC 25923 of 1.6, 0.2 and 1.6 mg/mL respectively. MBCs for MRSA isolates were 0.8-1.6, 0.4-1.6 and 6.3-12.5 mg/mL, respectively and for S. aureus ATCC 25923 were 12.5, 1.6 and 25 mg/mL, respectively.
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    ANTIBACTERIAL ACTIVITY OF THREE ENDEMIC HYPERICUM SPECIES USED IN FOLKLORIC MEDICINE AGAINST METHICILIN-RESISTANT STAPHYLOCOCCUS AUREUS
    (Taylor & Francis Ltd, 2009) Dulger, B.; Hacioglu, N.
    Aqueous and ethanolic extracts obtained from three endemic Hypericum species (H. rupestre, H. vacciniifolium and H. imbricatum) used as traditional medicine in Turkey have been investigated for their ability to inhibit 35 hospital isolates of methicillin resistant Staphylococcus aureus (MRSA). Both aqueous and ethanolic extracts of the plants were effective on MRSA. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of the ethanolic extract with the greatest antibacterial activity were those of Hypericum imbricatum (MIC 0.1-0.4 mg/mL and MBC 0.4-1.6 mg/mL).
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    Antibiotic Susceptibility of Motile Aeromonas spp. Isolated from Saricay Stream (Canakkale, Turkey)
    (Dr M N Khan, 2013) Hacioglu, N.; Dulger, B.
    This study was carried out for the determination of the physico-chemical and microbiological quality and antibiogram profiles of the Aeromonas spp. isolated from Saricay stream in Canakkale - Turkey. The results indicated that water from this stream were of poor microbiological quality and unfit for human consumption. A total of 13 Aeromonas species were isolated from sixty (21.66%) water samples. This strains were identified as Aeromonas caviae (53.84%), A. hydrophila (23.07%), A. veronii by. sobria (23.07%). All aeromonads (100%) strains were resistant to erythromycin, amoxycillin, ampicillin (except one A.hydrophila strain), but susceptible to gentamicin.
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    Antibiotic susceptibility of motile Aeromonas spp. isolated from Saricay stream (Canakkale, Turkey)
    (2013) Hacioglu, N.; Dulger, B.
    This study was carried out for the determination of the physico-chemical and microbiological quality and antibiogram profiles of the Aeromonas spp. isolated from Saricay stream in Canakkale -Turkey. The results indicated that water from this stream were of poor microbiological quality and unfit for human consumption. A total of 13 Aeromonas species were isolated from sixty (21.66%) water samples. This strains were identified as Aeromonas caviae (53.84%), A. hydrophila (23.07%), A. veronii bv. sobria (23.07%). All aeromonads (100%) strains were resistant to erythromycin, amoxycillin, ampicillin (except one A.hydrophila strain), but susceptible to gentamicin.
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    Antifungal Activity of Endemic Salvia tigrina in Turkey
    (Pharmacotherapy Group, 2008) Dulger, B.; Hacioglu, N.
    Purpose: The ethanol extracts obtained from the leaves, rootstock and the combined formulation of endemic Salvia tigrina Hedge & Hub.-Mor. (Labiatea) have been investigated for their antifungal activities. Method: The antifungal activity of the extract was tested against Candida species (C. albicans ATCC 10231, C. tropicalis ATCC 13803 and C. guilliermondii ATCC 6260 and Cryptococcus species (C. neoformans ATCC 90112 and C. laurentii 34142), Aspergillus flavus, Penicillium frequentans, Botrytis cinerea, Geotrichum candidum, Fusarium oxysporum and Alternaria alternara by the visual broth macrodilution method. Ketoconazole was used as a positive reference standard to determine the sensitivity of the strains. Results: The minimum inhibitory concentration (MIC) ranged from 3.12 to 25 mg/mL. All the extracts exhibited a strong antifungal effect against the fungal cultures. The extracts exhibited greater antifungal effect against C. albicans, C. neoformans and B. cinarea. Conclusion: The findings provide support for the use of this plant in traditional medicine for fungal infections especially against candidiasis.