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    Comparison of Osteoporosis in Two Different Regions of Turkey
    (Galenos Yayincilik, 2014) Golge, Umut Hatay; Komurcu, Erkam; Kaymaz, Burak; Goksel, Ferdi; Guzel, Yunus; Adam, Gurhan; Erbay, Piril
    Objective: The aim of the study was to investigate the effect of different climate and geographic conditions on bone mineral density. Materials and Methods: The patients who had been examined with Dual X-ray Absorptiometry (DXA) for the suspicion of osteoporosis in two different regions of Turkey were included in the study. Medical records of these 2457 patients were evaluated retrospectively. Age, gender, body mass index (BMI) and osteoporosis etiology of these patients were recorded. Results: Dual X-ray Absorptiometry measurements of the femoral neck and lomber vertebras of these patients were investigated. 927 of the patients were found to be osteoporotic and 907 of the patients to be osteopenic. There was no difference between the groups in terms of age, gender and BMI. Lumbar vertebras (L1-4) and femoral neck T scores of the patients with similar age and gender in these 2 different regions were compared and the difference between the groups was found to be statistically significant (p<0.001). Conclusion: The effect of geography and climate conditions on the bone quality is well known. In this respect regional strategies in the prevention and treatment of the osteoporosis may be judicious.
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    Effects of Boric Acid on Fracture Healing: An Experimental Study
    (Humana Press Inc, 2015) Golge, Umut Hatay; Kaymaz, Burak; Arpaci, Rabia; Komurcu, Erkam; Goksel, Ferdi; Guven, Mustafa; Guzel, Yunus
    Boric acid (BA) has positive effects on bone tissue. In this study, the effects of BA on fracture healing were evaluated in an animal model. Standard closed femoral shaft fractures were created in 40 male Sprague-Dawley rats under general anesthesia. The rats were allocated into five groups (n= 8 each): group 1, control with no BA; groups 2 and 3, oral BA at doses of 4 and 8 mg/kg/day, respectively; group 4, local BA (8 mg/kg); and group 5, both oral and local BA (8 mg/kg/day orally and 8 mg/kg locally). After closed fracture creation, the fracture line was opened with a mini-incision, and BA was locally administered to the fracture area in groups 4 and 5. In groups 2, 3, and 5, BA was administered by gastric gavage daily until sacrifice. The rats were evaluated by clinical, radiological, and histological examinations. The control group (group 1) significantly differed from the local BA-exposed groups (groups 4 and 5) in the clinical evaluation. Front-rear and lateral radiographs revealed significant differences between the local BA-exposed groups and the control and other groups (p< 0.05). Clinical and radiological evaluations demonstrated adequate agreement between observers. The average histological scores significantly differed across groups (p= 0.007) and were significantly higher in groups 4 and 5 which were the local BA (8 mg/kg) and both oral and local BA (8 mg/kg/day orally and 8 mg/kg locally), respectively, compared to the controls. This study suggests that BA may be useful in fracture healing. Further research is required to demonstrate the most effective local dosage and possible use of BA-coated implants.
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    Öğe
    The Efficacy of Boric Acid Used to Treat Experimental Osteomyelitis Caused by Methicillin-Resistant Staphylococcus aureus: an In Vivo Study
    (Humana Press Inc, 2016) Guzel, Yunus; Golge, Umut H.; Goksel, Ferdi; Vural, Ahmet; Akcay, Muruvvet; Elmas, Sait; Turkon, Hakan
    We explored the ability of local and systemic applications of boric acid (BA) to reduce the numbers of methicillin-resistant Staphylococcus aureus (MRSA) in a rat model of tibial osteomyelitis (OM), and compared boric acid with vancomycin (V). Implant-associated osteomyelitis was established in 35 rats. After 4 weeks, at which time OM was evident both radiologically and serologically in all animals, the rats were divided into five groups of equal number: group 1, control group (no local application of BA or other medication); group 2, V group; group 3, local BA + V group; group 4, local BA group; and group 5, local + systemic BA group. Serum total antioxidant status, and the levels of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, were measured. Pathological changes attributable to bone OM were evaluated using a grading system. Bacterial colony-forming units (CFUs) per gram of bone were counted. The lowest bacterial numbers were evident in group 3, and the bacterial numbers were significantly lower than that of the control group in all four test groups (p < 0.001). Group 3 also had the least severe bone infection (OM score 1.7 +/- 1.1, p < 0.05). Upon histological and microbiological evaluation, no significant difference was evident between groups 2 and 3. Total antioxidant levels were significantly different in all treatment groups compared to the control group. Microbiological and histopathological evaluation showed that systemic or local application of BA was effective to treat OM, although supplementary V increased the effectiveness of BA.