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    Association of Histopathology and Hemogram Findings Following Sleeve Gastrectomy
    (Mary Ann Liebert, Inc, 2019) Eroglu, Huseyin Avni; Adali, Yasemen; Beseren, Hatice; Guvendi, Gulname Findik; Binnetoglu, Kenan
    Objectives: This study aimed to evaluate the effects of histopathological findings observed in removed gastric tissues on the preoperative and postoperative hemogram data. Materials and Methods: Sixty patients with sleeve gastrectomy were included in the study. Histopathologic findings were compared with the hemogram values. Results: Preoperative hemoglobin (HGB) and hematocrit (HCT) values were significantly lower in patients with intestinal metaplasia (IM) compared to those without IM (p values 0.033 and 0.036, respectively). Preoperative red blood cell (RBC) and HCT values were significantly lower in women with Helicobacter pylori compared with those without H. pylori (p values 0.031 and 0.032, respectively). In contrast, in men with H. pylori, the preoperative RBC, HGB, and HCT values were significantly higher than those without H. pylori (p values 0.007, 0.031, and 0.027, respectively). Conclusion: We found that IM and presence of H. pylori had effects on hemogram values. We suggest that preoperative H. pylori assessment can yield use in the evaluation of postoperative anemia.
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    Comparison of tru-cut biopsy and fine-needle aspiration cytology in an experimental alcoholic liver disease model
    (Assoc Medica Brasileira, 2020) Adali, Yasemen; Eroglu, Huseyin Avni; Makav, Mustafa; Karayol, Sunay Sibel; Guvendi, Gulname Findik; Gok, Mustafa
    INTRODUCTION: Liver biopsies such as tru-cut (sharp needle) and fine-needle aspiration cytology (FNAC) are the most commonly preferred techniques to detect the grade and stage of certain liver diseases. In this study, we aimed to compare the efficiency of USG-guided tru-cut biopsy and fine-needle aspiration cytology in an experimental alcoholic liver disease model. METHODS: Thirty-six female Wistar albino rats, 4-6 months old, and weighing from 190 to 250 g, were used in this study. The animals were randomly divided into six equal groups: GI (control), G2 (tru-cut control), G3 (FNAC control), G4 (Alcoholic liver disease model), G5 (Alcoholic liver disease model + FNAC), and G6 (Alcoholic liver disease model + tru-cut biopsy). After a histopathological evaluation by light microscopy, the sensitivity, specificity, positive and negative predictive values of FNAC and tru-cut biopsy for the diagnosis of liver lesions were calculated. RESULTS: No pathology was detected in GI except for mild congestion. On the other hand, hepatocyte damage, periportal inflammation, congestion, and fatty changes were detected in all liver tissues of the alcoholic liver disease groups. The sensitivity of hepatocyte damage, inflammation, congestion, and fatty change parameters for FNAC were 33.3%, 80%, 0%, and 0%, respectively, while the sensitivity of the same variables for tru-cut were 66.7%, 40%, 100%, and 20%, respectively. DISCUSSION: Both techniques were superior in some aspects. FNAC can be an attractive alternative to tru-cut biopsy and applied in routine practice in the diagnosis of non-tumoral liver diseases.
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    Effects of bedside adequacy assessment in thyroid cytology on cytological sufficiency and the final histopathological diagnosis
    (Cukurova Univ, Fac Medicine, 2020) Toyran, Tugba; Guvendi, Gulname Findik; Adali, Yasemen; Ustun, Huseyin
    Purpose: The thyroid fine needle aspiration cytology (FNAC) is a fast, reliable, and economical method for interpretation of thyroid nodules. This method contributes to the later management of patients and reduces unnecessary surgical interventions. This study aimed to demonstrate the contribution of bedside adequacy assessment during FNAC to the accuracy rates of cytological competence and final histological diagnosis. Materials and Methods: The study included 443 patients who underwent FNAC in a university hospital between 2012 and 2015. Correlations between the histological diagnosis categories of patients who had and who did not have bedside adequacy assessment were compared per sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy. Results: As a result of comparison of cytological and histopathological diagnoses, 30.7% sensitivity, 75% specificity, 50% positive predictive value, 57.1% negative predictive value and 55.1% diagnostic accuracy were found in the group with bedside adequacy assesment. Whereas the group without bedside adequacy assessment, 50% sensitivity, 69.2% specificity, 42.8% positive predictive value, 75% negative predictive value, and 63.1% 1% diagnostic were found Conclusion: Bedside adequacy assessment increases the cytological adequacy proportion, but does not contribute to the diagnostic accuracy rate.
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    Efficacy of Ozone and Selenium Therapy for Alcoholic Liver Injury: An Experimental Model
    (Int Inst Anticancer Research, 2019) Adali, Yasemen; Eroglu, Huseyin Avni; Makav, Mustafa; Guvendi, Gulname Findik
    Background/Aim: Alcoholic liver disease is an important health problem which is reversible during early stages of liver damage, but becomes permanent with time. Nowadays, many studies focus on various agents that prevent, reduce or slow the progression of the toxic effects of alcohol. In our study, we investigated the efficiency of ozone and selenium against oxidative damage in a model of alcohol-induced liver damage. Materials and Methods: Forty-eight female Wistar Albino rats between 4 and 6 months of age and weighing 190-250 g were included in the study and were used as models of alcohol liver damage. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum and tissue total oxidant levels, serum and tissue total antioxidant levels, and the histopathological evaluation of the liver were performed in 8 groups. Results: In the statistical analysis, it was observed that ozone and/or selenium therapies decreased the AST levels. Total oxidant and antioxidant serum levels were found to vary in serum and tissue. Ozone and/or selenium therapies decreased liver damage, according to histopathological findings. Conclusion: Through ozone and/or selenium therapies, less damage was observed histopathologically compared to the alcohol group. It is thought that the results of our study can be used in individual treatments following confirmation of liver damage in alcoholic patients.
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    The Relationship Between Histopathologic Findings and Body Mass Index in Sleeve Gastrectomy Materials
    (Springer, 2019) Adali, Yasemen; Binnetoglu, Kenan; Eroglu, Huseyin Avni; Kaya, Nilhan; Guvendi, Gulname Findik
    ObjectiveFor treatment of obesity, which is one of the important health problems of the present time, lifestyle modification, pharmacotherapy, behavioral treatment methods, and surgical procedures are commonly used. Sleeve gastrectomy is widely used among surgical procedures. We aimed to investigate the relationship between histopathologic findings and body mass indices (BMIs) of cases with sleeve gastrectomy in our study.MethodsThirty-seven patients were included in our study who underwent sleeve gastrectomy and whose operation materials were examined histopathologically in our hospital. Two pathologists re-evaluated all gastrectomy materials. The relationship between BMI and the presence of gastritis, atrophy, intestinal metaplasia (IM), Helicobacter pylori (HPL), and other histopathological findings was investigated.ResultsThe mean age of patients included in the study was 34.7+9.3years. Of patients, 70.3% were female and 29.7% were male. There was a statistically significant difference between BMI and IM among the evaluated histopathologic parameters. Moreover, IM was significantly more present in patients with type 2 diabetes.ConclusionsThere is no previous study investigating the relationship between gastric histopathological findings and BMI in sleeve gastrectomy patients. We think that the statistically significant difference between BMI and IM that we found in our study may shed light on studies to be performed in the future.