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    An analysis of the impact of buthionine sulfoximine and N-nitro-L-arginine on blood pressure
    (Biomedpress, 2023) Gungor, Buket; Akdur, Secil; Sılan, Coşkun; Coskun, Ozlem; Aksulu, Hakki Engin
    Introduction: The presence of weaknesses in the efficacy of endogenous natriuretic and vasodilator agents plays a significant role in developing high blood pressure. It is often suggested that oxidative stress is critical in developing hypertension due to nitric oxide synthase (NOS) inhibition. This study aimed to investigate the intrarenal dopaminergic system activities, involvement of oxidative stress, and blood pressure changes resulting from NOS inhibition with N-nitro-L-arginine (L-NNA) and/or L-buthionine sulfoximine (BSO).Methods: Male Wistar albino rats (n = 24) were administered water containing 50 mg/L L-NNA for 21 days and/or intraperitoneal injections of BSO (125 mg/kg twice daily) for seven days; control rats were administered tap water. The rats' blood pressure; water and salt balance; total oxidant and antioxidant capacities; and urinary dopamine, adrenaline, and noradrenaline levels were measured.Results: While L-NNA and BSO alone did not significantly alter blood pressure, their coadministration caused rats to develop hypertension and significantly reduced the fractional excretion of sodium, increasing its tubular reabsorption. Urinary dopamine levels, indicators of intrarenal dopamine synthesis, did not change significantly Conclusion: These results indicate the importance of the weakness of endogenous natriuretic systems such as nitric oxide in hypertension development. While BSO did not induce oxidative stress in the measured parameters, it was shown for the first time as an actor in hypertension development in subjects with NOS inhibition to the extent that such inhibition did not increase blood pressure.
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    Benserazide Applications Cause to the Hypertension in Salt Loaded Rats
    (Wiley-Blackwell, 2015) Aksulu, Hakki Engin; Akdur, Secil; Gungor, Buket; Sılan, Coşkun
    [Anstract Not Available]
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    Buthionine Sulfoximine (BSO) Applications Decrease Sodium Clearance and Cause to the Development of the Hypertension in Rats Treated with Low Doses of N-Nitro-L-Arginine (L-NNA)
    (Wiley-Blackwell, 2015) Aksulu, Hakki Engin; Sılan, Coşkun; Gungor, Buket; Akdur, Secil
    [Anstract Not Available]
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    Changes of the Renal Dopaminergic Activity during the Hypertension Generation with L-NNA Application and Salt Load in Rats
    (Wiley-Blackwell, 2015) Aksulu, Hakki Engin; Sılan, Coşkun; Gungor, Buket; Akdur, Secil
    [Anstract Not Available]
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    Effects of Resveratrol on Hypertension Developing by NOS inhibition
    (Wiley-Blackwell, 2015) Aksulu, Hakki Engin; Sılan, Coşkun; Gungor, Buket; Akdur, Secil
    [Anstract Not Available]
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    Intensive Exercise Developt Hypertension in Rats Fed with High Salty Diet
    (Wiley-Blackwell, 2015) Sılan, Coşkun; Gungor, Buket; Akdur, Secil; Aksulu, Hakki Engin
    [Anstract Not Available]
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    Moxifloxacin-Impregnated Contact Lenses for Treatment of Keratitis in Rabbit Eyes
    (Wiley, 2025) Erdogan, Hakika; Gungor, Buket; Suner, Selin S.; Silan, Coskun; Saraydin, Serpil U.; Saraydin, Dursun; Ayyala, Ramesh S.
    Moxifloxacin (MOX) was loaded into commercial contact lenses (CLs) via supercritical carbon dioxide (ScCO2) to attain MOX-impregnated CL for keratitis treatment. This study aimed to investigate Pseudomonas keratitis treatment with MOX-impregnated CL compared to the traditional eyedrop administration. MOX impregnation was accomplished employing optimum parameters of 2.5 h drug exposure time, 25 MPa pressure, and 313 K for ScCO2 conditions using ethanol co-solvent rendering sustainable delivery, up to 7 days at effective dosage formulation. The MOX-impregnated CL was found to be safe with no significant toxicity on fibroblast cells after 5 days of contact time. Bacterial viability in vivo keratitis treatment in rabbit eyes was significantly decreased to 10(2) from 10(9) CFU/cornea for MOX-impregnated CL treatment, almost similar to exhaustive conventional 0.5% MOX eye drop treatments. The MOX-impregnated CL treatment revealed no conjunctival hyperemia, edema, or secretion for all eyes in the relevant group, and transparent cornea with no keratitis focus was obtained for two of the eyes (n = 6). The normal histological structure was seen with MOX-impregnated CL treatment on healthy eyes. Moreover, polymorphonuclear cell infiltration observed in keratitis eyes without any treatment was significantly decreased to a few polymorphonuclear cells in the groups treated with MOX eyedrops and MOX-impregnated CL.
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    Parental Vaccine Hesitancy;Which Childhood Vaccines Were Refused and Why?
    (2024) Gungor, Buket; Koparan, Sezen
    Objective: One of the main purposes of immunization services is to protect vaccinated children from vaccine-preventable disease, and the other is to ensure that disease factors can be brought under control in the society by reaching a certain immunization rate. This study aims to investigate which childhood vaccines were refused in the calendar and the reason for these refusals. Material and Methods: The files comprising the refusal to consent to child vaccination forms submitted to Antalya Provincial Directorate of Health in 2019 were reviewed to reveal which vaccines had been refused by parents besides the reasons for vaccination refusals. Results: In total, 286 parents made 977 vaccination refusals, with 80 of the parents refusing only one vaccine, and notably 77.5% of them (n=62) refused only the Hepatitis A vaccine. Moreover, 40.2% of the parents who refused to consent to their child’s vaccination stated that they refused the vaccination since they did not consider the vaccine necessary, along with 37.1% who did not trust the vaccines, 13.2% who were afraid of the adverse effects of vaccination, and 9.5% who had religious reasons. Conclusion: The increasing safety concerns of parents about vaccines should be addressed in order to inform parents about the contents, effects, adverse effects and requirements of vaccines so as to eliminate the false beliefs for the sake of protecting public health in general. This study is believed to act as a roadmap to prevent vaccination refusals, which are a major public health problem and are expected to increase.
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    Resveratrol did not alter blood pressure in rats with nitric oxide synthase-inhibited hypertension
    (Clinics Cardive Publ Pty Ltd, 2017) Aydin, Mehmet; Gungor, Buket; Akdur, A. Secil; Aksulu, Hakki Engin; Sılan, Coşkun; Susam, Ibrahim; Cabuk, Ali Kemal
    Background: Inhibition of nitric oxide synthase (NOS) is a well-known experimental model of hypertension (HT). It was shown that oxidative stress contributes to the pathogenesis of HT. Resveratrol is a potent anti-oxidant that is found in red grapes, peanuts and red wine. It improves the NO response and increases endothelial NOS expression, which causes endothelium-dependent vasorelaxation as well as renal vasodilation. We aimed to explore the effects of resveratrol on blood pressure, the water-salt balance and sodium excretion as a reflection of renal function in NOS-inhibited rat models. Methods: Thirty-five male Sprague-Dawley rats (200-250 g) were used in this study. In order to obtain hypertension models, an NOS inhibitor, N-nitro-L-arginin (L-NNA) was used. The rats were randomly divided into five groups: controls (given water and 0.8% salty diet) and four groups [given L-NNA, resveratrol (RSV) eluent, RSV, and L-NNA + RSV]. Blood pressures were measured indirectly by the tail-cuff method on the first, seventh and 10th days. At the end of the study protocol (10th day), fluid balance, glomerular filtration rate, fractional sodium excretion, and blood and urine sodium and creatinine levels were measured. Results: At the end of the study protocol, blood pressures were higher in only the L-NNA group (117.8 +/- 3.5 vs 149.5 +/- 2.1 mmHg; p < 0.05), as expected. Additional applications of RSV with L-NNA could not prevent the increase in blood pressure (122.8 +/- 7.3 vs 155.4 +/- 4.4 mmHg; p < 0.05). There were no remarkable changes in water-salt balance and renal function with the application of resveratrol. Conclusion: Resveratrol was unable to prevent or reverse blood pressure increase in NOS-inhibited rats.