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    Benserazide Applications Cause to the Hypertension in Salt Loaded Rats
    (Wiley-Blackwell, 2015) Aksulu, Hakki Engin; Akdur, Secil; Gungor, Buket; Sılan, Coşkun
    [Anstract Not Available]
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    Öğe
    Buthionine Sulfoximine (BSO) Applications Decrease Sodium Clearance and Cause to the Development of the Hypertension in Rats Treated with Low Doses of N-Nitro-L-Arginine (L-NNA)
    (Wiley-Blackwell, 2015) Aksulu, Hakki Engin; Sılan, Coşkun; Gungor, Buket; Akdur, Secil
    [Anstract Not Available]
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    Öğe
    Changes of the Renal Dopaminergic Activity during the Hypertension Generation with L-NNA Application and Salt Load in Rats
    (Wiley-Blackwell, 2015) Aksulu, Hakki Engin; Sılan, Coşkun; Gungor, Buket; Akdur, Secil
    [Anstract Not Available]
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    Effects of Resveratrol on Hypertension Developing by NOS inhibition
    (Wiley-Blackwell, 2015) Aksulu, Hakki Engin; Sılan, Coşkun; Gungor, Buket; Akdur, Secil
    [Anstract Not Available]
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    Öğe
    Enhancing pharmacology education through role-play: impact on student attitudes
    (Bmc, 2025) Tekes, Ender; Gungor, Buket; Silan, Coskun; Toraman, Cetin
    Background Pharmacology is a cornerstone of medical education, essential for rational prescribing and patient safety. However, students often perceive it as abstract and overwhelming due to its memorization-heavy nature and limited clinical relevance. This study aimed to evaluate the impact of a role-play-based clinical pharmacology internship on medical students' attitudes towards learning the pharmacology course. Methods A mixed-methods interventional design was employed. In the quantitative phase, a one-group pretest-posttest design was used with 97 fifth-year medical students. Participants completed the Attitude Scale Toward the Pharmacology Course for Medical School Students before and after a one-week internship focused on rational drug use and structured around role-play activities. Paired sample t-tests were used to assess attitudinal change. In the qualitative phase, semi-structured focus group interviews were conducted with eight students selected based on pre-post changes in attitude scores. Data were analysed using inductive content analysis. Results There was a statistically significant improvement in students' attitudes following the role-play-based internship (pretest mean = 37.24, posttest mean = 41.15; p < .001), with a large effect size (Cohen's d = 0.959). Qualitative findings revealed three major themes: (1) pharmacology as difficult but essential, (2) burden of memorization, and (3) the need for clinically relevant, functional learning. Students appreciated the realism and interactivity of role-play, which enhanced their understanding of drug interactions and rational prescribing. However, some still viewed pharmacology as anxiety-provoking and overly burdensome, indicating a need for longitudinal curricular integration. Conclusions Role-play-based clinical pharmacology education significantly improves medical students' attitudes toward learning pharmacology. Embedding realistic, scenario-based learning within pharmacology curricula may enhance student engagement, promote rational prescribing, and contribute to safer clinical practice. This positive change was supported by a high effect size of Cohen's d = 0.96, demonstrating the significant educational impact of the intervention.
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    Öğe
    Intensive Exercise Developt Hypertension in Rats Fed with High Salty Diet
    (Wiley-Blackwell, 2015) Sılan, Coşkun; Gungor, Buket; Akdur, Secil; Aksulu, Hakki Engin
    [Anstract Not Available]
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    Öğe
    Resveratrol did not alter blood pressure in rats with nitric oxide synthase-inhibited hypertension
    (Clinics Cardive Publ Pty Ltd, 2017) Aydin, Mehmet; Gungor, Buket; Akdur, A. Secil; Aksulu, Hakki Engin; Sılan, Coşkun; Susam, Ibrahim; Cabuk, Ali Kemal
    Background: Inhibition of nitric oxide synthase (NOS) is a well-known experimental model of hypertension (HT). It was shown that oxidative stress contributes to the pathogenesis of HT. Resveratrol is a potent anti-oxidant that is found in red grapes, peanuts and red wine. It improves the NO response and increases endothelial NOS expression, which causes endothelium-dependent vasorelaxation as well as renal vasodilation. We aimed to explore the effects of resveratrol on blood pressure, the water-salt balance and sodium excretion as a reflection of renal function in NOS-inhibited rat models. Methods: Thirty-five male Sprague-Dawley rats (200-250 g) were used in this study. In order to obtain hypertension models, an NOS inhibitor, N-nitro-L-arginin (L-NNA) was used. The rats were randomly divided into five groups: controls (given water and 0.8% salty diet) and four groups [given L-NNA, resveratrol (RSV) eluent, RSV, and L-NNA + RSV]. Blood pressures were measured indirectly by the tail-cuff method on the first, seventh and 10th days. At the end of the study protocol (10th day), fluid balance, glomerular filtration rate, fractional sodium excretion, and blood and urine sodium and creatinine levels were measured. Results: At the end of the study protocol, blood pressures were higher in only the L-NNA group (117.8 +/- 3.5 vs 149.5 +/- 2.1 mmHg; p < 0.05), as expected. Additional applications of RSV with L-NNA could not prevent the increase in blood pressure (122.8 +/- 7.3 vs 155.4 +/- 4.4 mmHg; p < 0.05). There were no remarkable changes in water-salt balance and renal function with the application of resveratrol. Conclusion: Resveratrol was unable to prevent or reverse blood pressure increase in NOS-inhibited rats.