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    A Humanized Anti-Interleukin 6 Receptor Monoclonal Antibody, Tocilizumab, for the Treatment of Endometriosis in a Rat Model
    (Sage Publications Inc, 2016) Taşkın, Mine Islimye; Gungor, Aysenur Cakir; Adali, Ertan; Yay, Arzu; Önder, Gözde Özge; İnceboz, Ümit
    Objective: The aim of this study was to investigate the efficacy of anti-interleukin 6 (IL-6) therapy in the treatment of endometriosis in a rat model. Study Design: After the peritoneal implantation of autologous endometrial tissue, 22 Wistar female rats were divided to create 2 intervention groups: the tocilizumab group (n = 13) and the control group (n = 9). After measuring implant volume, saline was administered to the rats in the control group and 8 mg/kg tocilizumab was administered intraperitoneally to the rats in the tocilizumab-treated group every 2 weeks. After a 4-week treatment period, the volumes and histopathological properties of the implants were evaluated. A scoring system was used to evaluate the preservation of epithelia. Fibrosis score was assessed between the groups. Ectopic and eutopic endometrium were evaluated immunohistochemically for IL-6 and vascular endothelial growth factor (VEGF). Results: There was a significant difference between the volumes of implants before and after treatment in the tocilizumab group (P < .05). The posttreatment volumes of lesions were smaller in the tocilizumab group than in the control group. Histologic and fibrosis scores were lower in the tocilizumab group than in the control group. Immunoreactivity intensity for VEGF was significantly decreased in the tocilizumab group for ectopic and eutopic endometrium (P < .05). Interleukin 6 levels and endometrial thickness for ectopic and eutopic endometrium were similar between the groups. Conclusion: Tocilizumab treatment had a regressive effect on the endometriotic implants.
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    Applicability of fetal renal artery Doppler values in determining pregnancy outcome and type of delivery in idiopathic oligohydramnios and polyhydramnios pregnancies
    (Via Medica, 2013) Akin, Ibrahim; Uysal, Ahmet; Uysal, Fatma; Oztekin, Ozgur; Sanci, Muzaffer; Gungor, Aysenur Cakir; Kurtulmus, Secil
    Aims: To investigate the relationship between fetal renal artery Doppler results and pregnancy outcomes in patients with idiopathic abnormal amniotic fluid indices. Material and method: A total of 110 patients without signs of fetal distress were included in the study: 31 idiopathic oligohydramnios and 29 idiopathic polyhydramnios pregnancies (study group) and 50 normal pregnancies (controls). Doppler investigation of the umbilical artery (UA), middle cerebral artery (MCA), fetal descendant thoracic aorta (DTA) and fetal renal artery (RA) was performed in all patients. Fetal RA resistive index (RI) and pulsatile index (PI) values were measured. Values pertaining to type of birth, newborn weight and APGAR scores were compared. Results: Average patient age, gravidity and week of pregnancy were 25 +/- 4, 1.6, and 37.4 +/- 1, respectively. There were no statistically significant differences between the groups as far as UA S/D, MCA S/D, DTA S/D, DTA RI, DTA PI, and RA S/D measurements were concerned. However, in the oligohydramnios group RA RI and RA PI values were significantly higher than the other two groups. Birth weight in the polyhydramnios group and cesarean section rate due to fetal distress in the oligohydramnios group were significantly higher. Conclusions: In the oligohydramnios group, without affecting fetal distress parameters, Doppler USG evaluation identified an increase in the RA resistance. Also in that group, cesarean rate due to fetal distress during labor was significantly higher than in the remaining two groups. Due to the predictive potential of values of fetal renal artery Doppler of fetal outcome further large sample-sized studies on the subject ought to be carried out.
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    Atrial electromechanical coupling intervals in pregnant subjects
    (Clinics Cardive Publ Pty Ltd, 2014) Altun, Burak; Tasolar, Hakan; Gazi, Emine; Gungor, Aysenur Cakir; Uysal, Ahmet; Temiz, Ahmet; Barutcu, Ahmet
    Objective: The aim of this study was to evaluate atrial conduction abnormalities obtained by tissue Doppler imaging (TDI) and electrocardiogram analysis in pregnant subjects. Methods: A total of 30 pregnant subjects (28 +/- 4 years) and 30 controls (28 +/- 3 years) were included. Systolic and diastolic left ventricular (LV) function was measured using conventional echocardiography and TDI. Inter-atrial, intra-atrial and intra-left atrial electromechanical coupling (PA) intervals were measured with TDI. P-wave dispersion (PD) was calculated from a 12-lead electrocardiogram. Results: Atrial electromechanical coupling at the septal and left lateral mitral annulus (PA septal, PA lateral) was significantly prolonged in pregnant subjects (62.1 +/- 2.7 vs 55.3 +/- 3.2 ms, p < 0.001; 45.7 +/- 2.5 vs 43.1 +/- 2.7 ms, p < 0.001, respectively). Inter-atrial (PA lateral - PA tricuspid), intra-atrial (PA septum - PA tricuspid) and intra-left atrial (PA lateral - PA septum) electromechanical coupling intervals, maximum P-wave (P-max) duration and PD were significantly longer in the pregnant subjects (26.4 +/- 4.0 vs 20.2 +/- 3.6 ms, p < 0.001; 10.0 +/- 2.0 vs 8.0 +/- 2.6 ms, p = 0.002; 16.4 +/- 3.3 vs 12.2 +/- 3.0 ms, p < 0.001; 103.1 +/- 5.4 vs 96.8 +/- 7.4 ms, p < 0.001; 50.7 +/- 6.8 vs 41.6 +/- 5.5 ms, p < 0.001, respectively). We found a significant positive correlation between inter-atrial and intra-left atrial electromechanical coupling intervals and P-max (r = 0.282, p = 0.029, r = 0.378, p = 0.003, respectively). Conclusion: This study showed that atrial electromechanical coupling intervals and PD, which are predictors of AF, were longer in pregnant subjects and this may cause an increased risk of AF in pregnancy.
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    Is there an advantage of three dimensional computed tomography scanning over plain abdominal radiograph in the detection of retained needles in the abdomen?
    (Elsevier Science Bv, 2013) Hacivelioglu, Servet; Karatag, Ozan; Gungor, Aysenur Cakir; Gencer, Meryem; Kosar, Sule; Kizildag, Betul; Yildiz, Yavuz
    [Anstract Not Available]
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    Quality of Life in the Third Trimester of Pregnancy in Patients with Gastroesophageal Reflux Disease
    (Galenos Publ House, 2023) Beyazit, Fatma; Gungor, Aysenur Cakir; Beyazit, Yavuz; Unsal, Mesut Abduelkerim
    BACKGROUND/AIMS: Health-related quality of life (QoL) relating to mental, physical and social functioning in pregnant women with gastroesophageal reflux disease (GERD) may depend on several factors. The aim of this study was to investigate the impact of GERD on the QoL in the advanced stages of pregnancy.MATERIALS AND METHODS: A total of 53 pregnant women suffering from GERD (group 1) and 54 age, body mass index (BMI) and gestational age-matched pregnant controls (group 2) were enrolled. The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) was completed to measure of health-related QoL, and the Gastroesophageal Reflux Disease Questionnaire was used to assess the classical symptoms of reflux disease. Socio-demographic variables including age, gravidity, parity, BMI and previous history of GERD were noted.RESULTS: SF-36 scores were found to be significantly lower in the pregnant women with GERD in regard to the following domains: their general health (p<0.01), mental health (p<0.01), and their mental component score (p=0.01). Educational status and GERD symptoms before pregnancy were not found to have an impact on QoL in pregnant women with GERD.CONCLUSION: Pregnant women with GERD seem to have a poorer QoL in many respects.
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    Sleep disturbance among women with chronic pelvic pain
    (Elsevier Ireland Ltd, 2014) Cosar, Emine; Gungor, Aysenur Cakir; Gencer, Meryem; Uysal, Ahmet; Hacivelioglu, Servet O.; Ozkan, Adile; Sen, Halil Murat
    Objective: To investigate the effect of chronic pelvic pain (CPP), a debilitating condition, on sleep quality. Methods: The present case-control study enrolled women older than 18 years attending the Gynecology Clinic of Canakkale Onsekiz Mart University Hospital, Canakkale, Turkey, with CPP between August 2011 and August 2012. The control group was selected from women attending the clinic for another complaint. Sleep quality was evaluated via the Pittsburgh Sleep Quality Index, and differences between the groups were compared by t and chi(2) tests. Results: During the study period, 157 women were enrolled. Seventy-two had CPP symptoms, and 85 attended the clinic for other complaints. Poor sleep quality was found in 80% (n = 58) of the women with CPP, and 55% (n = 47) of the control group (P < 0.05). Conclusion: Women with CPP were found to have poor sleep quality. Sleep education should be recommended in psychiatry and neurology clinics to increase the awareness of sleeping problems among these women. (C) 2014 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
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    True Cyclopia and Proboscis: an Interesting Prenatal Condition with Normal Nose
    (Derman Medical Publ, 2016) Uysal, Fatma; Uysal, Ahmet; Gungor, Aysenur Cakir; Cosar, Emine
    Cyclopia is a deformation of the facial skeleton with one eye orbit formed in the place where both eyes should be present. Its rate is almost 1 in 100,000 births including stillbirths are identified as cyclopean. To our knowledge a cyclopean which is including true cyclopia, proboscis, HPE, but normal nose has been never reported. In this current study we describe a second trimester fetus with, single bony orbit, proboscis; but normal nose.
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    Use of progestogens in pregnant and infertile patients
    (Springer Heidelberg, 2012) Ozlu, Tulay; Gungor, Aysenur Cakir; Donmez, Melahat Emine; Duran, Bulent
    Progesterone is an essential hormone in the occurence and maintenance of pregnancy. Natural or synthetic progestogens are commonly used in pregnant patients or patients undergoing infertility treatments for various indications. Most frequently put indications for the use of progestogens in these patient populations are the prevention of spontaneous preterm birth, the prevention of pregnancy loss in pregnancies with an unexplained recurrent pregnancy loss and in patients with threatened abortion. It is also used in pregnant women undergoing nonobstetric surgery, for infertility or recurrent pregnancy loss that is thought to be due to luteal phase defect or as a luteal support in stimulated IVF cycles. We aimed to review the current evidence for the use of progestogens in each of these settings.