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    Acne severity and the Global Acne Grading System in polycystic ovary syndrome
    (Elsevier Ireland Ltd, 2013) Hacivelioglu, Servet; Gungor, Ayse Nur Cakir; Gencer, Meryem; Uysal, Ahmet; Hizli, Deniz; Koc, Evrim; Cosar, Emine
    Objective: To evaluate the association between acne, quantified by the Global Acne Grading System (GAGS), and abnormal clinical and laboratory markers of androgen excess in patients with polycystic ovary syndrome (PCOS). Methods: The retrospective study included 133 patients with PCOS. Acne severity was quantified with the GAGS score, alopecia was graded with the Ludwig classification, and hirsutism was quantified with a modified Ferriman-Gallwey (FG) score. Results: The mean GAGS score was significantly greater in younger women, those with a lower BMI, and those with a higher FG score. There was no relation between the mean GAGS score and waist circumference, waist/hip ratio, androgen hormone levels (free testosterone, total testosterone, or dehydroepiandrosterone sulfate), sex-hormone-binding globulin level, or menstrual irregularity. Alopecia was significantly associated with an increased waist/hip ratio; there was no relation between alopecia and age, waist circumference, body mass index, FG score, androgen hormone levels, or menstrual irregularity. A weak positive correlation was observed between the GAGS and FG scores. Conclusion: The GAGS may provide more precise and comprehensive information about acne severity in obese or hirsute patients with PCOS because this grading system includes evaluation of the type (comedones, papules, pustules, nodules) and location (anatomic area) of acne lesions. (c) 2013 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
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    Comparison of olive oil and lanolin in the prevention of sore nipples in nursing mothers
    (2013) Gungor, Ayse Nur Cakir; Oguz, Sevilay; Vurur, Gulsen; Gencer, Meryem; Uysal, Ahmet; Hacivelioglu, Servet; Uludag, Aysegul
    [No abstract available]
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    Does three-dimensional prenatal ultrasound necerrasy: pregnant women's point of view
    (Via Medica, 2014) Koken, Gulengul; Gungor, Ayse Nur Cakir; Celik, Fatih; Batmaz, Gonca; Unlu, Serdar; Arioz, Dagistan; Yilmazer, Mehmet
    Objectives: The role and applicability of three-dimensional ultrasound (3D-US) in perinatology has been repeatedly discussed in the literature. Regardless, our knowledge about patient expectations remains limited. We aimed at determining the expectations, perception and knowledge of pregnant women about 3D-US. Material and Methods: Upon admission to the labor unit, the women filled out a questionnaire, with the help of a doctor, investigating sociodemographic data, pregnancy and delivery history previous experiences and expectations for US imaging. Results: A total of 644 pregnant women were included in the study Respondents declared that approximately 70% of all kinds of structural abnormalities could be detected by 3D-US and estimated its reliabilityat nearly 70%. While 60% of the participants underwent 3D-US, 70% of them believed that every pregnant woman should undergo such test. Also, 457 (70.9%) of the participants were of the opinion that every pregnant woman must undergo 3D-US imaging, whereas 173 (26.8%) did not think 3D-US imaging was necessary Conclusions: To the best of our knowledge, this has been the first study on patient opinions regarding the need for 3D-US imaging during pregnancy Although the participants were not certain about the harmful effects of 3D-US, the majority believed that it was necessary for every pregnant woman to undergo such testing. Obviously patients must be instructed on the limitations of US imaging before the examination to clarify any misunderstandings about the possibilities such a technique may offer.
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    High frequency of chromosomal anomalies and a novel chromosomal insertion associated with infertility and recurrent miscarriages (reproductive failure) in West Turkey
    (Gene Therapy and Molecular Biology, 2014) Sılan, Fatma; Yalcintepe, Sinem; Uysal, Digdem; Urfali, Mine; Uludağ, Ahmet; Cosar, Emine; Gungor, Ayse Nur Cakir
    Numerical and/or structural chromosomal abnormalities may be a reason of high infertility rates and recurrent pregnancy losses (RPLs) in humans. Karyotype and karyogram profiles of patients with RPLs are presented in current results. A total of 722 patients; 161(44.5%) infertile and 200(55.5%) RPL couples were included in the study. Karyotype and structural chromosome analyses of both patient groups in Canakkale population were made between May 2011-December 2013, using peripheral lymphocyte cell culture and GTG banding technique. High frequency of chromosomal abnormalities(%7.45) were detected in 24 patients of the infertility group(n:322). 10 patients(42%) of this group(n:24) had numerical and 14 patients(58%) had balanced structural choromosomal abnormalities. A novel choromosomal insertion was found in an infertile male, one of the 22th choromosome was totally inserted in 9th choromosome [ins(9;22)(9pter-q12
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    Infertility Associated with the Familial Mediterranean Fever (vol 20, 2019)
    (Galenos Yayincilik, 2019) Hacivelioglu, Servet; Gungor, Ayse Nur Cakir; Pek, Eren
    [Anstract Not Available]
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    Is abnormal glucose metabolism during pregnancy related to endothelial dysfunction?
    (Taylor & Francis Ltd, 2015) Gungor, Omer; Gazi, Emine; Ozkececi, Gulay; Gungor, Ayse Nur Cakir; Cevizci, Sibel; Hacivelioglu, Servet; Temiz, Ahmet
    Objective: Endothelial dysfunction is an independent risk factor for cardiovascular events. We aimed to investigate the relationship between endothelial dysfunction and gestational diabetes mellitus and impaired glucose tolerance. Methods: Pregnant women who had impaired glucose metabolism in the 75-g oral glucose tolerance test (OGTT) and their age-and body mass index-matched controls were included in the study and assessed for flow-mediated vasodilatation to evaluate endothelial dysfunction. Results: A total of 51 patients participated in the study. There were 20 patients in the control group, 13 in the impaired glucose tolerance group and 18 in the gestational diabetes mellitus group. Flow-mediated vasodilatation measured at the 60th and 120th seconds were significantly lower in the impaired glucose tolerance and gestational diabetes mellitus groups than in the control group (8.5 +/- 5.7 and 8.9 +/- 6.5 versus 14.9 +/- 9.0, p = 0.022 and 6.2 +/- 6.7 and 5.2 +/- 5.0 versus 12.0 +/- 8.3, p = 0.011, respectively). Conclusions: Patients with gestational diabetes mellitus and impaired glucose tolerance have impaired endothelial dysfunction. Delivery might have protective effects on endothelial functions. The significance of impaired endothelial dysfunction for pregnant women must be investigated, and if needed, lifestyle changes might be suggested, according to the determined importance of the endothelial dysfunction.
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    Letrozole usage adjuvant to gonadotropins for ovulation induction for patients with clomiphene citrate failure
    (Springer Heidelberg, 2013) Ozdemir, Ulku; Ozaksit, Gulnur; Gungor, Ayse Nur Cakir; Aydogan, Munibe
    To compare cycle properties of ovulation induction (OI) with gonadotropin alone or combined with letrozole in the patients with previous clomiphene citrate (CC) failure. In this prospective study, 40 patients with previous at least three times CC cycle failure were evaluated. Half of them received 2.5 mg letrozole on days 3-7 of the menstrual cycle and recombinant follicle stimulating hormone (rFSH) starting on day 5. The other half of the patients received only rFSH starting on day 3. Groups were compared according to the OI duration, gonadotropin dosage, endometrial thickness, estradiol (E2) levels on day of human chorionic gonadotropin (HCG) administration and follicle count. Total rFSH dose, the E2 levels on the day of HCG and > 18 mm follicle count was significantly lower and OI duration was significantly shorter in rFSH + letrozole group. Mean endometrial thickness was not different between groups. Adding letrozole to gonadotropin in OI cycles decreases total gonadotropin dose and induction duration without any adverse effects on endometrial thickness. Monoovulation is better achieved by adding letrozole to gonadotropin stimulation without decreasing pregnancy rates.
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    Men's Perspectives on Family Planning and Their Knowledge on Reproductive Health
    (Derman Medical Publ, 2014) Gungor, Ayse Nur Cakir; Uludag, Aysegul; Hacivelioglu, Servet; Gencer, Meryem; Ors, Polat; Yucesoy, Kaya; Uysal, Ahmet
    Aim: Many training programs for females about contraception have been developed. In this study, we aimed to investigate the perspectives of males on contraception and their knowledge on reproductive health. Material and Method: Husbands of pregnant women who presented in our obstetric clinic were invited to complete a questionnaire. Results: A total of 178 men answered our questionnaire. Among their wives, 11.1% (17/153) terminated their at least one unintended pregnancy. 142 of them (79.8%) knew about modern contraceptive methods, and 104 (58.4%) of them used at least one of these methods. Condoms were perceived as the best contraceptive method for 46.1% (35/76) because of their easiness to use and cheapness, and 41.7% (25/60) of the participants stated that they would like to use condom from then on. 55.6% (40/72) stated that they would never use oral contraceptives because of their possible side effects on their wives. 20 of the questions addressed to the participants were about reproductive health. The participants answered approximately 70% of all questions correctly. The correct answering rate for every question ranged between 39.6% and 96.1%. Discussion: In our study, we investigated attitudes and knowledge about contraception and reproductive health among men who were married and fertile. The findings from this study can provide a foundation for further education programs for men in these areas.
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    Obstetric outcomes of patients with abortus imminens in the first trimester
    (Springer Heidelberg, 2014) Evrenos, Ayse Nur; Gungor, Ayse Nur Cakir; Gulerman, Cavidan; Cosar, Emine
    We aimed to find out the effect of abortus imminens (AI) on obstetric outcomes of pregnancies which continued beyond the 24th week of gestation. In this prospective study, 309 patients with AI were divided into high-risk group (with a risk factor for spontaneous abortus) (n = 92) and low-risk group (without a risk factor) (n = 217). The control group (n = 308) was chosen randomly. In AI group, preterm delivery, preterm premature rupture of membranes (PPROM), cesarean section (C/S) delivery, postpartum uterine atony and need of a neonatal intensive care unit (NICU) rates were significantly higher than control group. Gestational diabetes mellitus, PPROM, still birth, low APGAR scores were seen more frequently in the high-risk patients than in the control group. Furthermore in the high-risk group, preterm delivery, malpresentation, C/S delivery and need of NICU were increased much more than in the low-risk group. Gestational hypertension/preeclampsia, oligo/polyhydramniosis, intrauterine growth retardation, placenta previa, abruption of placenta, chorioamnionitis, congenital abnormalities, delivery induction, cephalopelvic disproportion, fetal distress and manual removal of placenta were not different among the groups. Patients with AI history, especially with high-risk factors can have adverse obstetric and neonatal results. So their antenatal follow-up has to be done cautiously for the early signs and symptoms of these complications.
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    Predictive value of striae gravidarum severity for intraperitoneal adhesions or uterine scar healing in patients with previous caesarean delivery
    (Taylor & Francis Ltd, 2014) Gungor, Ayse Nur Cakir; Oguz, Sevilay; Hacivelioglu, Servet; Isik, Selda; Uysal, Ahmet; Gencer, Meryem; Cosar, Emine
    Objective: Previous abdominal operations might cause severe intraperitoneal adhesions (IPA), which can complicate caesarean section (CS) procedures. When selecting the mode and timing of delivery, obstetricians are also curious about uterine scar healing if the previous operation was a CS. Uterine scar thickness is an indicator of uterine scar healing. We aimed to evaluate the possible predictive value of striae gravidarum (SG) on IPA formation and uterine scar thickness (UST). Methods: Fifty-five women with a previous CS history were evaluated for SG Davey Score. They were investigated for IPAs and lower segment uterine scar thickness during the current CS operation. Results: Out of the patients with no SG (n = 11), mild SG (n = 10) and severe SG (n = 34), 1 (9.1%), 3 (30%) and 17 (50%) had IPA, respectively (p = 0.044). The mean uterine scar thicknesses in the no SG, mild SG and severe SG groups were 3.82 +/- 4.04, 5.20 +/- 4.13 and 5.18 +/- 3.52, respectively (p = 0.561). Conclusions: To the best of our knowledge, this was the first study to investigate the relationship between SG and IPA and uterine scar thickness. The SG status of a patient with a previous delivery and abdominal operation history might help predict IPA status before planning a new operation.
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    Relationship of QT dispersion with sex hormones and insulin in young women with polycystic ovary syndrome: an observational study
    (Turkish Soc Cardiology, 2013) Gazi, Emine; Gencer, Meryem; Hanci, Volkan; Temiz, Ahmet; Altun, Burak; Gungor, Ayse Nur Cakir; Ozturk, Ufuk
    Objective: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in reproductive women. Cardiovascular disease risk factors are more frequent in this population. We aimed in this study to investigate presence of QT dispersion and effects of sex hormones and insulin on QT duration in young PCOS patients. Methods: This present study was cross-sectional observational study. A total of 47 women, 25 patients with PCOS and 22 healthy, were included. Serum testosterone, estradiol and insulin levels were studied and electrocardiography was performed at 2nd or 3th days of menstrual cycle. The study population was divided into groups according to serum testosterone and estradiol levels. Sub-groups and pairwise groups were compared by Mann-Whitney U or student t-test. The associations of QTc durations with hormone levels were calculated using Spearman rank correlation analysis. The results were evaluated at the p<0.05 significance level. Results: No differences found between groups regarding to demographic parameters. Estradiol and testosterone levels were higher in patients with PCOS (41.12 +/- 13.59 vs. 35.57 +/- 19.29 pg/mL, p=0.09 and 105 +/- 58.5 vs. 17.6 +/- 10.9 ng/dL, p=0.01, respectively). QT dispersion was significantly longer in PCOS patients (47.1 vs. 32.7 ms, p=0.01). A positive correlation was found between the serum insulin level and QTc min, QTc max, and QTc mean (r=0.402, p=0.011; r=0.341, p=0.033; r=0.337, p=0.036; respectively). QT dispersion with serum testosterone and estradiol levels were positively correlated (r=0.525, p=0.001and r=0.326, p=0.046; respectively). Conclusion: Our results suggest that QT dispersion is prolonged and testosterone, estradiol and insulin are associated with QT duration in young PCOS patients.
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    The effect of hesperetin on ischemia-reperfusion injury in rat ovary
    (Springer Heidelberg, 2014) Gungor, Ayse Nur Cakir; Gencer, Meryem; Karaca, Turan; Hacivelioglu, Servet; Uysal, Ahmet; Korkmaz, Fatma; Demirtas, Selim
    Hesperidin (HES), a citrus fruit extract, has beneficial effects on various ischemia/reperfusion (I/R) models. We aimed to evaluate the possible positive effects of hesperetin (HPT), an active metabolite of HES, on a rat ovarian I/R model. We divided 24 Wistar Albino rats into four groups. Group I (n = 6) was sham operated, Group II (n = 6) was the I/R group, Group III (n = 6) was the I/R + solvent group and Group IV (n = 6) was the I/R + HPT group. Three hours of ischemia and 3 h of reperfusion were performed on each rat in Groups II, III, and IV. Dimethyl sulfoxide (DMSO) was given intraperitoneally to the rats in the III. Group, and 50 mg/kg of HPT dissolved in DMSO was given intraperitoneally to the rats in the IV. Group 30 min before reperfusion. After 3 h of reperfusion, the ipsilateral ovaries of the rats were examined immunohistochemically to detect apoptosis. Hematoxylin and eosin (H and E) staining demonstrated less edema and hemorrhage in the group where HPT was applied. Caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining showed significantly lower apoptosis in the group where HPT was used when compared to either the I/R or solvent group. To the best of our knowledge, this is the first study that shows the beneficial effects of HPT in an ovarian I/R injury. HPT improved tissue damage and apoptosis caused by I/R injury. To identify the possible positive effects of HPT in ovarian torsion of humans and use in clinical practice, more studies must be performed.