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Öğe Does topical use of autologous serum help to reduce post-tonsillectomy morbidity? A prospective, controlled preliminary study(Cambridge Univ Press, 2016) Kara, M.; Erdogan, H.; Altinisik, H. B.; Aylanc, H.; Guclu, O.; Derekoy, F. S.Background: To evaluate the effects of autologous serum usage on throat pain, haemorrhage and tonsillar fossa epithelisation in patients after tonsillectomy. Methods: Thirty-two patients (aged 4-15 years) were included in the study. Tonsillectomy was performed and autologous serum was administered topically to the right tonsillar fossa during the operation, and at 8 and 24 hours post-operatively. The left side served as the control. A visual analogue scale was used to record the patient's pain every day. Each patient's oropharynx was observed on the 5th and 10th post-operative days to examine bleeding and epithelisation. Results: The pain scores for the side administered autologous serum were significantly lower than those for the control side, on the night following the operation and on the 1st, 2nd, 5th and 6th post-operative days. Tonsillar fossa epithelisation was significantly accelerated on the study side compared with the control side on the 5th and 10th post-operative days. Conclusion: In tonsillectomy patients, topically administered autologous serum contributed to throat pain relief and tonsillar fossa epithelisation during the post-operative period.Öğe Effect of glucocorticoids on nasal polyposis, with detection of inflammatory response by measurement of nitric oxide levels in nasal polyp tissue(Cambridge Univ Press, 2013) Bulbul, T.; Bulbul, O. Gumustekin; Guclu, O.; Bilsel, A. Serpil; Gursan, S. OnalObjective: To investigate endoscopic staging, and nitric oxide levels in the polyp tissue, in patients with nasal polyposis undergoing glucocorticoid therapy. Methods: Nasal polyposis was evaluated using endoscopic staging and measurement of polyp tissue nitric oxide levels (chemiluminescence method). Forty-five nasal polyposis patients received either nasal therapy (n = 15), oral therapy (n = 15) or combined therapy (n = 15). Pre-treatment and post-treatment staging and nitric oxide levels were evaluated. Results: Endoscopic grading indicated significant post-treatment staging improvements in the oral (p = 0.016) and combined (p = 0.016) groups. Post-treatment staging differed significantly between the three groups (p = 0.041), with greater improvements in the oral and combined groups. All groups showed significantly lower post-treatment nitric oxide levels, compared with baseline, but post-treatment levels did not differ significantly between groups. A significant association was found between treatment response and nitric oxide level alteration. Conclusion: This study demonstrates the favourable effects of glucocorticoids on nasal polyposis, and alteration in nitric oxide tissue levels post-treatment. Nitric oxide level in nasal polyp tissue could be an indicator of treatment response, and may aid surgical decision-making by detecting cases that probably will not respond to medical treatment.Öğe Effects of nonsteroidal anti-inflammatory drugs on hearing(Galenos Yayincilik, 2012) Guclu, O.; Sargin, R.; Duman, K.; Aycicek, A.; Derekoy, F. S.; Kavuncu, V.Objectives: Non steroidal anti-inflammatory drugs (NSAID) use with high dose and long time for chronic inflammation. It was well known that these drugs have ototoxic effects. The more study about ototoxic effects of acetyl salicylic acid (ASA) and quinine has been at the literature. In this study, the effects to hearing of NSAID except ASA and quinine were evaluated. Methods: Twenty-three patients with started chronic medication for the pathology of muscle-skeleton system were included the study. Pure tone audiometry and otoacoustic emissions were made in the beginning and a month after using dugs. Results: Audiometric findings were compared by considering frequency scale and the hearing loss over 10 dB was accepted significant. At the low frequencies (250, 500, 1000 Hz) were not observed any statistically significant change (p>0.05). There was a significant hearing loss at 12 ear (26%) in 8 kHz, 9 ear (19.5%) in 4 kHz, 6 ear (13%) in 2 kHz (p<0.05). Conclusion: After using the medication emissions of only two ears were lost. NSAID like diclofenac potasium, etadolac, meloxicam ve diflunisal have ototoxic effects and especially high frequencies are affected. In our opinion if clinicians prefer NSAID especially for long term and high dose, they must be careful for ototoxicity.Öğe The effect of fibromyalgia treatment on tinnitus(W B Saunders Co-Elsevier Inc, 2020) Cil, O. Caglar; Zateri, C.; Guclu, O.; Oymak, S.; Tezcan, E.Objectives: We investigated the frequency of tinnitus in fibromyalgia patients and the effect of drugs used for routine fibromyalgia on tinnitus. Methods: We included 101 diagnosed fibromyalgia patients. After detailed ear nose throat examination, audiometric tests and tinnitus handicap index (THI) were performed. After the tests, routine treatment for fibromyalgia was started by the physical therapy and rehabilitation department. Two months after the beginning of the treatment, THI were repeated again and the results were statistically evaluated. Results: All patients included in the study were women. 74.3% of the patients had tinnitus. Pregabalin and selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant-treated patients were evaluated; In both groups, there was a statistically significant difference between pre- and post-treatment tinnitus levels (p < .001). However, there was no statistically significant difference between pregabalin group and diloxetine group according to treatment results. Conclusions: The incidence of tinnitus is high in fibromyalgia patients. That pregabalin and duloxetine agents routinely used in fibromyalgia require further experimental and human studies in order to be able to use in tinnitus.
