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    Effects of nonsteroidal anti-inflammatory drugs on hearing
    (Galenos Yayincilik, 2012) Guclu, O.; Sargin, R.; Duman, K.; Aycicek, A.; Derekoy, F. S.; Kavuncu, V.
    Objectives: Non steroidal anti-inflammatory drugs (NSAID) use with high dose and long time for chronic inflammation. It was well known that these drugs have ototoxic effects. The more study about ototoxic effects of acetyl salicylic acid (ASA) and quinine has been at the literature. In this study, the effects to hearing of NSAID except ASA and quinine were evaluated. Methods: Twenty-three patients with started chronic medication for the pathology of muscle-skeleton system were included the study. Pure tone audiometry and otoacoustic emissions were made in the beginning and a month after using dugs. Results: Audiometric findings were compared by considering frequency scale and the hearing loss over 10 dB was accepted significant. At the low frequencies (250, 500, 1000 Hz) were not observed any statistically significant change (p>0.05). There was a significant hearing loss at 12 ear (26%) in 8 kHz, 9 ear (19.5%) in 4 kHz, 6 ear (13%) in 2 kHz (p<0.05). Conclusion: After using the medication emissions of only two ears were lost. NSAID like diclofenac potasium, etadolac, meloxicam ve diflunisal have ototoxic effects and especially high frequencies are affected. In our opinion if clinicians prefer NSAID especially for long term and high dose, they must be careful for ototoxicity.
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    The effect of fibromyalgia treatment on tinnitus
    (W B Saunders Co-Elsevier Inc, 2020) Cil, O. Caglar; Zateri, C.; Guclu, O.; Oymak, S.; Tezcan, E.
    Objectives: We investigated the frequency of tinnitus in fibromyalgia patients and the effect of drugs used for routine fibromyalgia on tinnitus. Methods: We included 101 diagnosed fibromyalgia patients. After detailed ear nose throat examination, audiometric tests and tinnitus handicap index (THI) were performed. After the tests, routine treatment for fibromyalgia was started by the physical therapy and rehabilitation department. Two months after the beginning of the treatment, THI were repeated again and the results were statistically evaluated. Results: All patients included in the study were women. 74.3% of the patients had tinnitus. Pregabalin and selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant-treated patients were evaluated; In both groups, there was a statistically significant difference between pre- and post-treatment tinnitus levels (p < .001). However, there was no statistically significant difference between pregabalin group and diloxetine group according to treatment results. Conclusions: The incidence of tinnitus is high in fibromyalgia patients. That pregabalin and duloxetine agents routinely used in fibromyalgia require further experimental and human studies in order to be able to use in tinnitus.