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    Structural characterization and antimicrobial activity of 1,3-bis(2-benzimidazyl)-2-thiapropane ligand and its Pd(II) and Zn(II) halide complexes
    (Elsevier France-Editions Scientifiques Medicales Elsevier, 2005) Agh-Atabay, NM; Dulger, B; Gucin, F
    1,3-Bis(2-benzimidazyl)-2-thiapropane(L) forms 5-coordinate square pyramidal and 4-coordinate tetrahedral, monometallic complexes with PdCl2 and ZnX2 (X = Cl, Br, I) respectively. In the palladium complex, the ligand acts as a chelating tridentate, through two of the nitrogen atoms in the imidazole ring and the sulfur atom of the bridging group together with two chloride ions forming a rare five coordinate complex. In the zinc halide complexes, the ligand acts as chelating bidentate, via two of the nitrogen atoms combined with two halide ions giving common tetrahedral complexes. The ligand and its complexes are characterized by analytical data and spectroscopic methods such as FT-aman, FT-IR (mid-IR, far-IR), H-1 and C-13 NMR. Their antimicrobial activities are evaluated by the minimal inhibitory concentration (MIC) against 10 bacteria, each with multiple, fresh clinical isolates (10-15), and the results are compared with those of ampicillin, ciprofloxacin, cefazolin, ofloxacin, and piperacillin antibacterial agents. The compound's antifungal activities are reported on Candida albicans, Candida utilis, and Cryptococcus neoformans yeasts, each with multiple isolates (10), and the results are referenced with amphotericin-B, fluconazole and flucytosine antifungal agents. In most cases, the compounds show broad-spectrum (Gram(+) and Gram(-)) activities that are either, more active, or equipotent to, the antibiotic and antifungal agents in the comparison tests. (c) 2005 Elsevier SAS. All rights reserved.
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    Öğe
    Structural characterization and antimicrobial activity of 2-(5-H/methyl-1H-benzimidazol-2-yl)-4-bromo/nitro-phenol ligands and their Fe(NO3)3 complexes
    (Springer, 2006) Tavman, A; Agh-Atabay, NM; Neshat, A; Gucin, F; Dulger, B; Haciu, D
    2-(5-H/methyl-1H-benzimidazol-2-yl)-4-bromo/nitro-phenol (HLx:X=1-4) ligands and their iron(III) nitrate complexes have been synthesized and characterized. In all of the complexes, the ligands are bidentate, via one imine nitrogen atom and a phenolate oxygen atom. The coordination is completed with a bidentate nitrate anion, and a water molecule. Elemental analysis, molar conductivity, magnetic susceptibility, FT-Raman, FT-IR (mid i.r., far i.r.), UV-visible and as well as quantum chemical calculations performed with CACHE are in agreement with a 1:1 electrolyte structures that are mononuclear, and distorted 5-coordinate square pyramidal. The antimicrobial activities of free ligands, their hydrochloride salts and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) toward nine bacteria, each with multiple, fresh clinical isolates, and the results are compared with those for penicillin-g, ampicillin, cefotaxime, vancomycine, oflaxacin and tetracycline. Antifungal activities were reported for Kluyveromyces fragilis, Rhodotorula rubra, Candida albicans, Hanseniaspora Guilliermondii and Debaryomyces hansenii yeasts, each with multiple isolates, and the results were referenced against nystatin, ketaconazole and clotrimazole antifungal agents. In most cases, the compounds tested showed broad-spectrum (Gram(+) and Gram(-)) activities that were either more active or as potent as the references particularly as antifungal agents.
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    Öğe
    Synthesis and investigation of antimicrobial activity of some bisbenzimidazole-derived chelating agents
    (Elsevier France-Editions Scientifiques Medicales Elsevier, 2003) Agh-Atabay, NM; Dulger, B; Gucin, F
    The 1,2-bis(2-benzimidazyl)-1,2-ethanediol (1), 1,4-bis(2-benzimidazyl)-1,2,3,4-butanetetraol (2), 1,3-bis(2-benzimidazyl)-2-thiapropane (3), 1,3-bis(2-benzimidazyl)-2-thia-propane-dihydrochloride (4), 1,5-bis(2-benzimidazyl)-3-thiapentane (5), and 1,5-bis(2-benzimidazyl)-3-thiapentane dihydrochloride (6) chelating ligands are synthesised and characterised by using analytical data and modem spectroscopic methods such as FT-Raman, FT-IR, H-1- and C-13-NMR spectrometers. Their antimicrobial activities are reported by comparing the in vitro activities, with those of ofloxacin, ciprofloxacin, piperacillin, ampicillin and cefazolin antibacterial agents against fresh clinical isolates. Antifungal activities are reported on Candida albicans, Candida utilis, Cryptococcus neoformans fungi, and the results are referenced with amphotericin-B, fluconazole and flucytosine antifungal agents. It has been found that all the compounds have broad spectra activity and was either more active or equipotent to those compared antibiotic and antifungal agents. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.