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Öğe Acute Progressive Dyspnea in a Patient With Chronic Obstructive Pulmonary Disease(Marmara Univ, Inst Health Sciences, 2020) Gonlugur, Ugur; Gonlugur, TanseliThe cause of acute dyspnea in chronic obstructive pulmonary disease is challenging. A 69-year old man complained of dyspnea, and cough. He had a diagnosis of chronic obstructive pulmonary disease for 6 years. Oxygen therapy started for respiratory failure. At the 6th day of hospitalization, dyspnea progressively increased. Chest X-ray showed a right-sided radiolucency. The preliminary diagnosis was spontaneous pneumothorax but chest computerized tomography-scan demonstrated a space-occupying lesion in left main bronchus. The latter diagnosis was mucoid impaction but bronchoscopy revealed a malignant lesion. In conclusions, lung cancer can be a rare cause of acute dyspnea.Öğe Benign metastasizing leiomyoma(Springer, 2008) Sapmaz, Feride; Ergin, Makbule; Katrancioglu, Ozgur; Gonlugur, Tanseli; Gonlugur, Ugur; Elagoz, SahendeA 41-year-old woman presented with chest pain and a cough. There was a solitary pulmonary nodule in the upper-left lobe. The patient had no history of neoplasm except a hysterectomy for uterine leiomyoma five years before. Six months after the first presentation, the tumor showed a gradual increase in size; an explorative thoracotomy was performed. The histopathologic examination showed a tumor consisting of well-differentiated spindle-shaped cells with intervening collagen. She was readmitted 8 months after the operation because of right-sided spontaneous pneumothorax. Multiple pulmonary nodules appeared when the lung was re-expanded by chest tube drainage. In conclusion, uterine leiomyomas can metastasize to various organs, such as lungs, despite having a benign pathologic appearance.Öğe COVID-19 or not?(Doc Design Informatics Co Ltd, 2022) Gonlugur, Ugur; Resorlu, Mustafa; Sener, Alper; Gonlugur, TanseliBilateral multilobar ground-glass opacities are characteristic features of COVID-19 pneumonia. However, the dif-ferential diagnosis of ground-glass opacities is challenging. The aim of this paper was to share our experiences with other colleagues. The first patient presented with anosmia and loss of taste. Legionella antigen in urine was positive. The second patient had bilateral ground-glass opacities, which predominantly involved the upper lung zones and lym-phopenia. Radiological findings were the same with the radiological control of 8 months ago, and she had a diagnosis of sarcoidosis. The third patient complained of dyspnoea. The inspection of national health system records showed a histological diagnosis of nonspecific interstitial/organizing pneumonia. The fourth patient had findings suggestive of congestive heart failure such as bilateral pleural effusion, peribronchial cuffing, and interlobular septa thickening. The co-existence of multiple ill-defined centrilobular ground-glass opacities suggested a concomitant disease but lesions disappeared with furosemid infusion within 5 days. The fifth patient presented with only right upper lobe consolida-tion. The opacities did not exceed the horizontal fissure. The intact fissure suggested a bacterial aetiology, but PCR tests of the nasopharyngeal samples were positive for COVID-19. This finding suggested that pulmonary infiltrate of COVID-19 was inflammatory rather than infective in nature. In conclusion, old imaging studies were more useful in the differential diagnosis.Öğe Kronik Obstrüktif Akciğer Hastalığı Alevlenmelerinde Mevsimsel Varyasyonlar(2020) Gonlugur, Uğur; Gonlugur, TanseliHer alevlenme ile hastanın sağlık durumu ve prognozukötüleştiğinden kronik obstrüktif akciğer hastalığı (KOAH)tedavisinde ana amaç alevlenmelerin sıklığını ve ağırlığınıazaltmaktır. Kış mevsiminde KOAH alevlenmelerinde vehastane başvurularında artış olduğu uzun zamandan beribiliniyor olsa da meteorolojik faktörlere maruz kalmanın hangimekanizmalarla morbidite riskini arttırdığı belli değildir. Sıcakveya soğuk algı eşiğinin coğrafik lokalizasyona göre değişmesinedeniyle bazı araştırmalar birbirleriyle çelişen ilişkilerbulmuşlardır. Soğuğun KOAH üzerine etkisi sıcaktan dahafazla olup bu etki özellikle yaşlılarda belirgindir. Sıcaklığabağlı mortalitede latent bir süreç bulunmaktadır. Solunum yoluenfeksiyonları ve hava kirliliği sıcaklığın etkisini arttırıpazaltabilir. Alevlenme için risk faktörlerinin erkendensaptanması yüksek riskli KOAH hastalarının alevlenmedenkorunmasına ve yaşam kalitelerinin iyileşmesine yardımcıolabilir.Öğe Loculated transudate(Cukurova Univ, Fac Medicine, 2020) Gonlugur, Ugur; Gonlugur, Tanseli; Ozer, Sule[Anstract Not Available]Öğe Middle Lobe Syndrome Associated with Bronchial Anthracofibrosis(Vilnius University Press, 2020) Gonlugur, Ugur; Gonlugur, Tanseli; Ozer, SuleBronchial anthracofibrosis has been defined as airway narrowing associated with dark pigmentation on bronchoscopy without an appropriate history of pneumoconiosis or smoking. We present a case of a 67-year-old, non-smoking female patient who was referred to our clinic for two years of persistent cough. Spirometry was within normal limits. Radiological evaluation showed right middle lobe atelectasis and positron emission tomography-positive mediastinal lymph nodes. Bronchoscopy revealed black airway discoloration and distortions. In conclusion, we propose monthly radiological controls before an invasive procedure in such cases if a strong suspicion of malignancy/tuberculosis is not present. © 2020 Ugur Gonlugur, Tanseli Gonlugur, Sule Ozer. Published by Vilnius University Press.Öğe Middle lobe syndrome in left lower lobe(Inst Investigacion Clinica, 2019) Gonlugur, Ugur; Gonlugur, TanseliMiddle Lobe Syndrome is a term that refers to a persistent or recurrent collapse of a lung lobe, especially the right middle lobe. A 66-year-old woman presented with chronic cough with sputum and recurrent attacks of pneumonia. She was treated with antibiotics. Chest CT-scan showed a left lobe atelectasis and multiple foci of bronchiectasis. Bronchoscopy revealed a patent left lower lobe bronchus. In conclusions, middle lobe syndrome can rarely affect left lower lobe. It should be kept in mind in the differential diagnosis of recurrent pneumonia.Öğe Pulmonary barotrauma during hookah diving: a case report(Undersea & Hyperbaric Medical Soc Inc, 2020) Korpinar, Sefika; Gonlugur, Ugur; Kapicibasi, Oguz; Gonlugur, Tanseli; Toklu, Akin SavasWhen commercial sea harvesters have dive accidents, it is sometimes difficult to obtain an accurate dive history and make a definitive diagnosis. We report a sea harvest diver who dived to collect sea snails (Rapana venosa) by using a hookah dive system. He experienced mediastinal and subcutaneous emphysema due to interruption of breathing airflow. Thoracic computed tomography performed one year prior to the accident revealed paramediastinal subpleural blebs on both lung apices. Emphysema was resolved by administering normobaric oxygen.Öğe Pulmonary lymphangitic sarcomatosis and a review of the literature(Springer, 2009) Gonlugur, Tanseli; Sapmaz, Feride; Katrancioglu, Ozgur; Gonlugur, Ugur; Elagoz, SahendeIntrapulmonary spread of a sarcoma via lymphatics is a rare cause of death in a young adult. A 31-year old man was admitted to our hospital complaining of dyspnea and malaise of 2 months' duration. A chest radiography revealed bilateral hilar enlargement, and reticulonodular infiltrations. Thoracic CT-scans demonstrated mediastinal lymphadenopathy, thickening of interlobular septa, polygonal lines, and thickening of bronchovascular bundles. The diagnosis was made by open-lung biopsy. The patient died within 3 months after diagnosis. Pulmonary lymphangitic sarcomatosis is a rare but important manifestation of an angiosarcoma. Optimal treatment of these patients is not well defined, but a trial of chemotherapy may be warranted.Öğe TUBERCULOSIS DRUG RESISTANCE IN CANAKKALE, TURKEY(Natl Inst Public Health, 2020) Gonlugur, Tanseli; Basol, Gulin; Gonlugur, Ugur[Anstract Not Available]Öğe Unilateral opaque or 'white out' hemithorax(Wiley-Blackwell, 2014) Gonlugur, Ugur; Gin, Makbule; Gonlugur, Tanseli; Mirici, Arzu[Anstract Not Available]Öğe Warfarin Resistance: A Case Report(Emergency Medicine Physicians Assoc Turkey, 2019) Gonlugur, Ugur; Gonlugur, Tanseli; Özdemir, Öztürk; Sılan, FatmaWarfarin is the most widely prescribed anticoagulant in the world. Patients who need more than 15 mg per day should be considered warfarin-resistant. Nearly 30 genes have been reported in association with warfarin pharmacogenetics but genetic polymorphisms in the genes encoding CYP2C9 and VKORC1 have been shown to act as the most important determinants of drug dosage requirements. The major enzyme responsible for the metabolism of S-warfarin, the more potent of warfarin's two stereoisomers, is CYP2C9. Warfarin inhibits vitamin K epoxide reductase (VKOR). A 30-year-old woman was referred to our clinic for pulmonary embolism. She was treated with low molecular weight heparin. The warfarin dose was titrated up to 15 mg daily but after one week, the INR (international normalized ratio) was still subtherapeutic level at 1.8. In this paper, we discuss underlying genetic polymorphisms about warfarin resistance.
