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    Antibacterial Activity of the Seeds of Hyoscyamus niger L. (Henbane)
    (Asian Journal Of Chemistry, 2010) Dulger, Basaran; Goncu, Beyza S.; Gucin, Fahrettin
    The methanolic extract obtained from the seeds of Hyoscyamus niger L. (Solanaceae) was investigated for its antibacterial activity against Bacillus subtilis ATCC 6633, Bacillus cereus ATCC 7064, Staphylococcus aureus ATCC 6538P, Escherichia coli ATCC 10538, Proteus vulgaris ATCC 6899, Salmonella typhimurium CCM 5445 and Pseudomonas aeruginosa ATCC 27853 by disc diffusion and microdilution method. The extracts showed strong antibacterial activity against Staphylococcus aureus, with inhibition zones of 25.0 mm and with minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of 16 (32) mu g/mL, respectively. Also, the extracts exhibited moderate activity the other test bacteria. The results demonstrate that the methanolic extract of the seeds of H. niger has significant activity and suggest that it may be useful in the treatment of infections.
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    Antifungal Activity of Seeds of Hyoscyamus niger L. (Henbane) Against Some Clinically Relevant Fungal Pathogens
    (Asian Journal Of Chemistry, 2010) Dulger, Basaran; Hacioglu, Nurcihan; Goncu, Beyza S.; Gucin, Fahrettin
    The methanolic extracts obtained from the seeds of Hyoscyamus niger L. (Solanaceae) used as traditional medicine in Turkey were investigated for their ability to inhibit clinically relevant fungal pathogens as six Candida species (C. albicans ATCC 10231, C. tropicalis ATCC 13808, C. guilliermondii ATCC 6260, C. krusei ATCC 20298, C. glabrata ATCC 2001 neoformans ATCC 90112 and C. laurentii ATCC 34142) by microbroth dilution method. The plant displayed activity against all fungal cultures tested. The extracts possessed a strong antifungal potency Greater activity was observed against both Cryptococcus species, with MIC values of 15 mu g/mL.
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    Antifungal activity of seeds of hyoseyamus niger L. (Henbane) against some clinically relevant fungal pathogens
    (Chemical Publishing Co., 2010) Dulger, Basaran; Hacioglu, Nurcihan; Goncu, Beyza S.; Gucin, Fahrettin
    The methanolic extracts obtained from the seeds of Hyoscyamus niger L. (Solanaceae) used as traditional medicine in Turkey were investigated for their ability to inhibit clinically relevant fungal pathogens as six Candida species (C. albicans ATCC 10231, C. tropicalis ATCC 13808, C. guilliermondii ATCC 6260, C. krusei ATCC 20298, C. glabrata ATCC 2001 and C. parapsilosis ATCC 22019) and two Cryptococcus species (C. neoformans ATCC 90112 and C. laurentii ATCC 34142) by microbroth dilution method. The plant displayed activity against all fungal cultures tested. The extracts possessed a strong antifungal potency. Greater activity was observed against both Cryptococcus species, with MIC values of 15 ?g/mL.