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Which is More Important and Insidious in Dialysis Patients? Occult Hepatitis B or Occult Hepatitis C?
(Galenos Yayincilik, 2020) Gazel, Ozlem Zanapalioglu; Sener, Alper
Objectives: The aim of this study was to investigate the presence of occult hepatitis B infection (OBI) and Occult hepatitis C infection (OCI) in hemodialysis patients and to determine whether there is an activation in the follow-up or not. Materials and Methods: Demographic data, causes of renal failure, access to hemodialysis, duration of hemodialysis, alanine aminotransferase (ALT) levels, hepatitis indicators of 100 HD patients with normal ALT levels were recorded in this study. Serum anti-hepatitis B core antibody (anti-HBc) immunoglobulin G (IgG) was tested with ELISA (Architecht, Abbott). Serum hepatitis B virus (HBV)-DNA, HCV-RNA [in peripheral blood mononuclear cells (PBMNC)] were studied with real-time polymerase chain reaction method. Results: Anti-HBc IgG positivity was detected in 27% of patients, but with no isolated anti-HBc IgG positivity. In 4% of the patients, HBV-DNA positivity and OBI infection were detected. None of the patients showed HCV-RNA positivity in serum and in PBMNC, therefore OCI was not detected. None of the patients developed OBI or OCI activation in five-years follow-up. Renal transplantation was performed in one of the OBI patients and lifelong prophylaxis was planned with oral antiviral medication. Conclusion: Presence of OCI is lower than OBI in hemodialysis patients.