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  • Küçük Resim
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    Assessing spinel zinc ferrite nanoparticles in aquatic ecosystems: Toxic threat or beneficial detoxifier for aquatic life?
    (Elsevier B.V., 2025) Ertürk Gürkan, Selin; Gürkan, Mert; Yanık, Ece Büşra; Kutlu, Elif; Sarıtunç, Volkan; Güneş, Berkay; İbiş, Ezgi Can
    The effectiveness of magnetic nanoparticles in removing pollutants during water treatment is well established, but their introduction into aquatic ecosystems raises significant toxicity concerns. This study investigates the histological and physiological effects of zinc ferrite magnetic nanoparticles (ZnFe2O4−MNPs) on the Mediterranean mussel (Mytilus galloprovincialis) and examines the impact of concurrent exposure to these nanoparticles and the insecticide thiomethoxam (TMX). Mussels were exposed to nominal concentrations of ZnFe2O4−MNPs (1, 10, 100 mg/L) both individually and with TMX. Physiological assessments included measuring antioxidant enzyme levels (superoxide dismutase, catalase, glutathione S-transferase) and oxidative stress markers (malondialdehyde). Results showed that ZnFe2O4−MNPs increased antioxidant activity but also caused dose-dependent pathological changes. In contrast, combined exposure with TMX significantly (p < 0.05) reduced antioxidant defenses, indicated by lower superoxide dismutase (SOD) levels and higher malondialdehyde (MDA) concentrations, suggesting oxidative stress and potential cellular damage. These findings highlight the need for comprehensive toxicity assessments of nanoparticles in aquatic environments and advocate for their complete removal from water sources post-treatment. Further research is crucial to define the toxicity profiles of spinel ferrites to ensure their safe application in environmental remediation.
  • Küçük Resim
    Öğe
    Çinko Oksit (ZnO) nanopartiküllerinin, Akdeniz midyesi (Mytilus galloprovincialis LAMARCK, 1819) dokuları üzerindeki histopatolojik etkilerinin araştırılması
    (Çanakkale Onsekiz Mart Üniversitesi, Lisansüstü Eğitim Enstitüsü, 2022) Güneş, Berkay; Gürkan, Mert
    Nanopartiküller bir çok alanda kullanılmaları, özgünlükleri ve yüksek miktarda reaksiyon aktivitesi göstermeleri nedeniyle artan bir öneme sahiptir. Farklı faaliyetlerde kullanımı olan çinko oksit (ZnO) nanopartiküllerinin, özellikle sucul ekosistemler üzerinde olumsuz etkilerinin olduğu bilinmektedir. Mytilus galloprovincialis (Kara midye veya Akdeniz midyesi) ülkemiz denizlerinde dağılış gösteren ve insan tarafından besin olarak tüketilmesi sebebiyle ekonomik önemi olan bir türdür. Ayrıca biyoindikatör bir tür olan M. galloprovincialis, filtrasyonla beslenmesi nedeniyle birçok kirleticiyi bünyesinde biriktirmektedir. Bu çalışmada; midyeler ZnO nanopartiküllerinin farklı konsantrasyonlarına (0; 0,01; 0,1 ve 1 mg/l) 96 saat süreyle maruz bırakılarak sonrasında oluşan toksik etkiler histopatolojik bulgular açısından değerlendirildi. ZnO nanopartiküllerine maruz bırakılan midyelerin histolojik incelemelerinde; solungaçlarda lipofuskin agregatları, genişlemiş merkezi toplardamar ve lamellar füzyon, mantoda hemosit infiltrasyonları, sindirim bezinde lipofuskin agregatları, hemosit infiltrasyonları ve hipertrofi tespit edildi. Sonuç olarak ZnO nanopartiküllerinin, Akdeniz midyeleri üzerinde olumsuz histopatolojik etkileri olduğu sonucuna ulaşıldı.
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    Öğe
    Dual and multiple exposures to metal oxide nanomaterials: Unveiling histological and oxidative stress dynamics in Mytilus galloprovincialis
    (Elsevier B.V., 2025) Ertürk Gürkan, Selin; Gürkan, Mert; Kutlu, Elif; Yanik, Ece Büşra; Saritunç, Volkan; Güneş, Berkay
    Due to their increasing industrial applications, metal oxide nanoparticles (NPs) have emerged as significant environmental pollutants with potential ecotoxicological effects on aquatic organisms. This study evaluated the acute effects of binary and ternary mixtures of ZnFe?O? (10 mg/L), SiO? (10 mg/L), and NiO (100 mg/L) NPs on Mytilus galloprovincialis. Following 96-hour exposures, oxidative stress biomarkers (SOD, CAT, GST, MDA) and histopathological alterations were assessed in gill and digestive gland tissues. Notably, the ternary mixture induced significant elevations in MDA levels. Among binary combinations, SiO?–NiO NPs enhanced antioxidant responses, whereas NiO–ZnFe?O? NPs caused pronounced tissue damage. The results underscore that NPs in the environment may not act independently but rather interact additively or synergistically, thereby amplifying their toxic potential. These findings highlight the need to consider mixture effects in ecotoxicological risk assessments, reflecting the complex and multicomponent nature of nanoparticle pollution in real-world aquatic environments. © 2025 Elsevier B.V.
  • Küçük Resim
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    Evaluation of Possible Toxic Effects of Boric Acid in Palourde Clam (Ruditapes decussatus) Through Histological Changes and Oxidative Responses
    (Springernature, 2024) Ertürk Gürkan, Selin; Gürkan, Mert; Sarıtunç, Volkan; İbiş, Ezgi Can; Güneş, Berkay
    The extensive utilization of boric acid, particularly in industrial and agricultural sectors, also engenders concerns regarding the toxicity of boron and its derivatives. Particularly, the behavior of boric acid at increasing concentrations in aquatic ecosystems remains poorly understood. In light of these concerns, this study aimed to investigate the toxicity of boric acid in bivalves, which occupy a critical position in the food chain. Specimens of Ruditapes decussatus, which had not been previously exposed to any pollutants and were cultivated under controlled conditions, were subjected to three different concentrations of boric acid (0.05 mg/L, 0.5 mg/L, and 5 mg/L) in vitro for 96 h. Following the exposure period, the specimens were assessed for histological changes (the mantle, gill, and digestive gland) and specific oxidative parameters (the gill and digestive gland), including superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase, and lipid peroxidation (LPO). The research findings indicated that boric acid primarily induced oxidative damage at the applied concentrations and increased antioxidant levels (p < 0.05). Moreover, although no significant histopathological abnormalities were observed in the examined histological sections, subtle changes were noted. This study evaluated the potential adverse effects of boric acid on bivalves, which are crucial components of the aquatic food chain, utilizing histological and specific physiological parameters following its introduction into aquatic environments. It is anticipated that the findings of this study will contribute to the development of new insights and perspectives regarding the extensive use of boric acid.