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    Scolicidal Potency of Bile Against Echinococcus granulosus
    (Knowledgeworks Global Ltd-Kgl, 2025) Aydın, İsa Caner; İlhan, Noyan; Şeker, Ahmet; Ofluoğlu, Cem Batuhan; Mulkut, Fırat; Göret, Nuri Emrah; Çetin, Kenan
    Cysto-biliary fistulas are commonly diagnosed, either before or after surgical intervention, in patients with enlarged or advanced-stage hydatid cysts (HCs). Analysis of cystic contents in these patients shows that diminished scolex vitality is more common in patients with cysto-biliary fistulas. This study aims to demonstrate the scolicidal effects of bile on Echinococcus granulosus (EG) scolices at various bile concentrations and over specific periods. The time- and concentration-based scolicidal potency was analyzed in EG scolex samples obtained from HC patients. The integrity of the cyst wall and the scolicidal effect of the contents were evaluated using a vital staining technique with 0.1% eosin. Bile samples were collected from patients with cholelithiasis who were scheduled for surgery. Scolicidal efficacy of 100% was observed in all samples at the 1/4 bile concentration after 10 min and at the 1/8 concentration after 60 min. At a 1/16 concentration, scolicidal efficacy was 66% at 1 min, 89% at 10 min, 93% at 30 min, and 98% at 60 min. At a 1/32 bile concentration, scolicidal efficacy was 59% at 1 min, 68% at 10 min, 89% at 30 min, and 95% t 60 min. At a 1/64 concentration, the scolicidal efficacy was 53% at 1 min, 58% at 10 min, 77% at 30 min, and 93% at 60 min. After 1 hr, reasonable scolicidal efficacy was determined up to a 1/64 concentration; however, significant decreases in scolicidal efficacy were observed at 1/128 and 1/256 bile concentrations. Theoretically, bile, which is an endogenous secretion, can be used as a suitable and potent scolicidal agent. This study lays the groundwork for future in vivo clinical trials utilizing synthetic bile acids for scolicidal purposes or for studies evaluating the scolicidal effects of bile in patients who develop cysto-biliary fistulas.
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    The activity of topical coenzyme Q10 (Ubiquinol) in burned rats: Results from an experimental study
    (Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Göret, Ceren Canbey; Kiraz, Aslı; Göret, Nuri Emrah; Kılıç, Sevilay Oğuz; Özkan, Ömer Faruk; Karaayvaz, Muammer
    The objective of this study was to investigate the effectiveness of topically applied coenzyme Q10 (CoQ10) (ubiquinol) for wound healing in rats with experimentally induced burn injuries. A total of 27 rats were divided into three groups, and administered general anesthesia. No further intervention was performed for Group 1 (Control). Hot water (95°C) was applied to rats in Groups 2 and 3 for 10 seconds. The rats in Group 2 received silver sulfadiazine, whereas those in Group 3 received topical CoQ10. Biopsy samples were obtained at days 3 and 10. In the group treated with CoQ10 (Group 3), there was no statistically significant difference among between Days 3 and 10 in terms of inflammation and epidermal/vascular/collagen damage. In terms of edema, there was a statistically significant distinction among the CoQ10 group (Group 3) at Day 10 and the silver sulfadiazine group (Group 2) at Day 3. In terms of oxygen radicals, there was a statistically meaningful difference among the CoQ10 group and the silver sulfadiazine group at Day 10. This investigation did not demonstrate a beneficial role of treatment with CoQ10 for the healing of burn wounds for most parameters. But in the long term (10 day); immunohistochemical analysis performed to determine edema and oxidative stress showed that treatment with CoQ10 reduced the levels of oxygen radicals in biopsies. The limitation of our study is that the duration is limited to 10 days. For this reason longer term studies were required. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All Rights Reserved.