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Öğe Achromobacter Xylosoxidans’a Bağlı Akut Prostatit: Bir Olgu Sunumu(2014) Eren, Ali Erhan; Baştürk, Gökhan; Akçalı, Alper; Oktun, MüşerrefAchromobacter xylosoxidans üriner sistem enfeksiyonlarının nadir görülen bir nedenidir ve sıklıkla immunsüpresif tedavi alan hastalarda ortaya çıkar. Biz burada ürodinamik inceleme sonrası akut prostatit gelişen, idrar örneğinde üreme olan ve etken ajan olarak Achromobacter xylosoxidans saptanan bir olgu sunuyoruzÖğe Association between the androgen levels and erectile function, cognitive functions and hypogonadism symptoms in aging males(Taylor & Francis Ltd, 2011) Kocoglu, Hasan; Alan, Cabir; Soydan, Hasan; Ates, Ferhat; Adayener, Cuneyt; Eren, Ali Erhan; Ersay, Ahmet ResitPurpose: Aging in men is characterized by a moderate decrease in plasma testosterone (T) levels. However, the association between partial androgen deficiency of the aging male and clinical symptoms and the ideal screening test are controversial. In this study, we investigated the association between the androgen levels and erectile function, cognitive functions and hypogonadism symptoms in aging males. Materials and methods: We investigated the association between total (TT), calculated free (FT) and bioavailable (BT) testosterone, and various clinical and laboratory parameters in 103 healthy males, 50-80 years old. Biochemical assessment was done after overnight fasting. Questionnaires were used to test for hypogonadism symptoms, erectile and cognitive functions. Results: TT levels were not correlated with aging in this study. However, FT and BT were found to decrease with age due to rising sex hormone binding globulin. TT levels were strongly correlated with FT and BT levels (respectively p = 0.0001, p = 0.0001). TT, FT and BT were only correlated with cognitive functions (p = 0.012, p = 0.004, p = 0.02 respectively). There was no correlation between TT, FT and BT levels and erectile function and hypogonadism symptoms. Conclusion: T values in our study sample did not correlate with clinical signs and symptoms of hypogonadism. Thus, according to our data, symptoms in the aging male should not be indiscriminately assigned to a decrease in TT, FT or BT levels.Öğe Biofeedback in the Treatment of Nocturnal Enuresis: May Be an Alternative Method of Treatment?(Derman Medical Publ, 2015) Topaloglu, Naci; Alan, Cabir; Ersay, Ahmet Resit; Eren, Ali Erhan; Basturk, Gokhan; Alan, HandanAim: Biofeedback is re-education of correct voiding to children with visual, tactile and sensorial stimuli. Biofeedback in the treatment of dysfunctional voiding and urinary incontinence can be used. However, in the treatment of nocturnal enuresis is not included in the routine treatment options. We aimed to investigate the feasibility and effectiveness of biofeedback in the treatment of nocturnal enuresis. Material and Method: 50 children aged 5 years or older, who suffered a case of not wetting more than six-month period and admitted complaints of nocturnal urinary incontinence were included in the study. The mean age of patients was 9,4 +/- 2,52 (6-15). 27 patients (54%) were female and 23 patients (46%) were males. Biofeedback treatment performed to patients as 4 sessions. Each sessions were 30 minutes long every week. All patients were informed and advised to do the same exercise for 30 minutes every day at home. Results: Following the biofeedback treatment, incidence of wetting was found to have decreased significantly. 13% (3) of male patients and 11,1% (3) of female patients have not benefits from treatment. 87% (20) of male and 88,9% (24) of female patients have benefits from the treatment, frequency of urinary incontinence was reduced. Following the treatment, clinical improvement was 88%, while the rate of completely dryness was 54%. Statistical difference was found significantly at the incidence of wetting between before and after the treatment (p<0,05). Discussion: The positive results achieved in a short time indicates that the biofeedback method including the active participation of the child and the family in an environment of play, without medication, is candidate for the alternative treatment to nocturnal enuresis treatment.Öğe Comparison of Effects of Alpha Receptor Blockers on Endothelial Functions and Coagulation Parameters in Patients with Benign Prostatic Hyperplasia(Elsevier Science Inc, 2011) Alan, Cabir; Kirilmaz, Bahadir; Kocoglu, Hasan; Ersay, Ahmet Resit; Ertung, Yunus; Eren, Ali ErhanOBJECTIVE To investigate the effects of alpha receptor blockers used in the treatment of benign prostatic hyperplasia (BPH) on endothelial functions, coagulation parameters, and arterial blood pressure. MATERIALS AND METHODS One-hundred fifteen patients admitted to the treatment protocol because of symptomatic BPH were included in this prospective study. Patients were given the following treatments: doxazosin 4 mg/d (n = 25), terazosin 5 mg/d (n = 26), alfuzosin 10 mg/d (n = 26), tamsulosin 0.4 mg/d (n = 21), and observation (n = 17). All cases were evaluated before treatment and in the 12th week of treatment, according to biochemical parameters, endothelial functions, and arterial blood pressure. Biochemical parameters were bleeding time, coagulation time, prothrombin time, activated partial thromboplastin time, total prostate-specific antigen (PSA), and free PSA. Endothelial functions were evaluated with ultrasonography of the brachial artery. RESULTS When coagulation tests were evaluated, there were significant increases in bleeding and coagulation times in the groups using doxazosin and terazosin. Doxazosin and terazosin lowered arterial blood pressure significantly compared with other treatments. With regard to effects on endothelial function, there were significant differences in flow-mediated dilation rates of the brachial artery at 60 and 90 seconds before and during treatment in the alfuzosin and terazosin groups. CONCLUSIONS Alpha receptor blockers can decrease the risk of cardiovascular complications by both reducing platelet aggregation and protecting endothelial functions in patients with prostatic hyperplasia. The only drug with a favorable effect in all 4 areas of interest, including BPH symptoms, blood pressure, platelet aggregation, and endothelial functions, was terazosin. UROLOGY 77: 1439-1443, 2011. (C) 2011 Elsevier Inc.Öğe Diagnostic Value of Plasma Pentraxin3- Level For Diagnosis of Erectile Dysfunction(2018) Eren, Ali Erhan; Ersay, Ahmet Reit; Demirci, Emrah; Alan, Cabir; Basturk, GökhanPURPOSE: Erectile dysfunction (ED) is a sexual dysfunction described as the inability to develop or maintain an erection of the penis adequate for sexual intercourse, and its prevalence increases with age. Seen as a common sexual disorder worldwide, organic causes are the underlying reason for 80 percent of ED cases, with the most characteristic pathology responsible for organic ED being atherosclerosis. This study investigates the diagnostic value of plasma PTX-3 levels in arterial ED. MATERIALS AND METHODS: This study included a total of 45 patients who were admitted to the urology and cardiologyoutpatient clinics of the Medical Faculty of Canakkale Onsekiz Mart University (COMU) and consented to participate in this study. Patients were categorized into three equal groups in number: (1) patients with ED diagnosed with coronary artery disease (CAD) (15 patients in total); (2) patients with ED not having coronary artery disease or any other equivalent diseases (diabetes mellitus, hypertension and hyperlipidemia) (15 patients in total);and (3) ordinary patients with no ED (15 patients in total). An interview was conducted at the andrology polyclinic with each patient in order to ascertain detailed information on their medical and sexual history and on demographic characteristics. All patients were also administered the International Index of Erectile Function (IIEF) questionnaire. RESULT: The findings from this study investigating the diagnostic value of plasma PTX-3 levels in ED were statistically significant for two comparisons: the differences between the peripheral blood and cavernous blood values of the patient groups (group 1 and 2) and the control group (group 3), and the differences between the peripheral blood and cavernous blood values of group 2 (patients with ED who do not have CAD) and the control group (group 3). CONCLUSION: As PTX-3 is more specific than the formerly recognized biochemical markers in endothelial dysfunction, it can be used in the diagnosis of vascular originated ED.Öğe Diagnostic Value of Plasma Pentraxin3-Level For Diagnosis of Erectile Dysfunction(Urol & Nephrol Res Ctr-Unrc, 2018) Eren, Ali Erhan; Ersay, Ahmet Resit; Demirci, Emrah; Alan, Cabir; Basturk, GokhanPurpose: Erectile dysfunction (ED) is a sexual dysfunction described as the inability to develop or maintain an erection of the penis adequate for sexual intercourse, and its prevalence increases with age. Seen as a common sexual disorder worldwide, organic causes are the underlying reason for 80 percent of ED cases, with the most characteristic pathology responsible for organic ED being atherosclerosis. This study investigates the diagnostic value of plasma PTX-3 levels in arterial ED. Materials and Methods: This study included a total of 45 patients who were admitted to the urology and cardiology outpatient clinics of the Medical Faculty of Canakkale Onsekiz Mart University (COMU) and consented to participate in this study. Patients were categorized into three equal groups in number: (1) patients with ED diagnosed with coronary artery disease (CAD) (15 patients in total); (2) patients with ED not having coronary artery disease or any other equivalent diseases (diabetes mellitus, hypertension and hyperlipidemia) (15 patients in total); and (3) ordinary patients with no ED (15 patients in total). An interview was conducted at the andrology polyclinic with each patient in order to ascertain detailed information on their medical and sexual history and on demographic characteristics. All patients were also administered the International Index of Erectile Function (IIEF) questionnaire. Result: The findings from this study investigating the diagnostic value of plasma PTX-3 levels in ED were statistically significant for two comparisons: the differences between the peripheral blood and cavernous blood values of the patient groups (group 1 and 2) and the control group (group 3), and the differences between the peripheral blood and cavernous blood values of group 2 (patients with ED who do not have CAD) and the control group (group 3). Conclusion: As PTX-3 is more specific than the formerly recognized biochemical markers in endothelial dysfunction, it can be used in the diagnosis of vascular originated ED.Öğe Efficacy of early duloxetine therapy in urinary incontinence occurred after radical prostatectomy(Wiley-Blackwell, 2013) Eren, Ali Erhan; Alan, Cabir; Bastruk, Gokhan[Anstract Not Available]Öğe Erektil disfonksiyon tanısında plazma pentraxin-3 seviyesinin diagnostik değeri(Çanakkale Onsekiz Mart Üniversitesi, 2015) Eren, Ali Erhan; Ersay, Ahmet ReşitAmaç : Erektil Disfonsiyon (ED), cinsel ilişki için yeterli ereksiyonun sağlanamaması ve/veya sürdürülememesi durumudur ve sıklığı yaş ile birlikte artmaktadır. Tüm dünyada yaygın bir sağlık sorunu olarak karşımıza çıkan bu hastalığın etyolojisinde organik nedenler vakaların %80 ninden sorumludur. Organik nedenli ED den ise en sık sorumlu olan patoloji aterosklerozdur. Bu çalışmada plazma PTX-3 seviyesinin Organik nedenli ED da tanısal değeri araştırılmıştır. Yöntem : Araştırmamıza ÇOMÜ Tıp Fakültesi Hastanesi Üroloji ve Kardiyoloji Ana Bilim Dalına başvuran 45 hastayı dahil ettik Hastaları 3 gruba ayırdık ve 1. grupta koroner arter hastalığı (KAH) tanısı almış erektil disfonksiyon hastalarını, 2. grupta koroner arter hastalığı ya da koroner arter hastalığı eşdeğeri (DM,HT,Hiperlipidemi) bir hastalığı olmayan erektil disfonksiyon hastalarını ve 3. gruba da erektil disfonksiyonu olmayan normal hastaları dahil ettik. Hastaları üroloji ve kardiyoloji poliklinik başvurusu yapan hastalarından seçtik. Araştırmaya dahil olmayı kabül eden tüm hastalaradan androloji polikliniğinde ayrıntılı öykü ve cinsel öykü alındı, demografik özellikleri sorgulandı ve hastalara IIEF(International Index of Erectile Function ) sorgulama formu uygulandı. Daha sonra hastalardan 2 tüp kan alındı ve 3000 devirde 10 dakika santrifüj edildi. Elde edilen plazmadan PTX-3 değerleri elde edildi. Bulgular : Plazma PTX-3 seviyesinin ED da tanısal değeri araştırılan bu çalışmada sonuçlar iki karşılaştırmada istatistiksel olarak anlamlı bulundu. Bu iki karşılaştırma 1:tüm hasta grup ile (grup 1+grup 2) kontrol grubunda periferik kan ve kavernözal kan değerleri ,2:sadece ED nu olan, KAH olmayan (grup 2) ile kontrol grubunda periferik kan ve kavernözal kan değerleri arasındaki değerlendirmelerdir. Sonuç: PTX-3 endotel disfonksiyonunda daha önce bilinen biyokimyasal belirteçlerden daha spesifik olması nedeniyle vasküler kökenli ED hastalarının tanısında kullanılabilir.