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Öğe Akut Lenfoblastik Lösemiye Bağlı Gelişen Seröz Dekolman: Nadir Bir Olgu(2024) Arıcan, Esra; Alyörük, Furkan; Erdoğan, Hakika; Turgut, BurakHematolojik hastalıklar genellikle asemptomatik olmakla birlikte ön segment ve retinada ayırt edici olmayan bulgular gözlenebilir. Hızlı tanı, tedavi gerektiren ve kalıcı görme kaybına sebep olabilecek rahatsızlıkların gözden geçirilmesi önemlidir. İlk şikayeti görmede azal- ma olan genç erkek hastanın, yapılan tam oftalmolojik muayenesi ile sistemik tedavi gerektiren ve hayatı tehdit eden bir hastalık olan T- hücreli akut lenfoblastik lösemi tanısı aldığı vakayı sunmayı amaçladık.Öğe Drug-impregnated contact lenses via supercritical carbon dioxide: A viable solution for the treatment of bacterial and fungal keratitis(Elsevier, 2024) Güngör, Buket; Erdoğan, Hakika; Sağbaş Suner, Selin; Sılan, Coşkun; Saraydın, Serpil U.; Şahiner, NurettinKeratitis is a corneal infection caused by various bacteria and fungi. Eye drop treatment of keratitis involves significant challenges due to difficulties in administration, inefficiencies in therapeutic dosage, and frequency of drug applications. All these are troublesome and result in unsuccessful treatment, high cost, time loss, development of drug resistance by microorganisms, and a massive burden on human health and the healthcare system. Most of the antibacterial and antifungal medications are non-water-soluble and/or include toxic drug formulations. Here, the aim was to develop drug-loaded contact lenses with therapeutic dosage formulations and extended drug release capability as an alternative to eye drops, by employing supercritical carbon dioxide (ScCO2) as a drug impregnation solvent to overcome inefficient ophthalmic drug use. ScCO2, known as a green solvent, has very low viscosity which provides high mass transfer power and could enhance drug penetration into contact lenses much better with respect to drug loading using other solvents. Here, moxifloxacin (MOX) antibiotic and amphotericin B (AMB) antifungal medicines were separately loaded into commercially available silicone hydrogel contact lenses through 1) drug adsorption from the aqueous solutions and 2) impregnation techniques via ScCO2 and their efficacies were compared. Drug impregnation parameters, i.e., 8-25 MPa pressure, 310-320 K temperature, 2-16-hour impregnation times, and the presence of ethanol as polar co-solvent were investigated for the optimization of the ScCO2 drug impregnation process. The highest drug loading and long-term release kinetic from the contact lenses were obtained at 25 MPa and 313 K with 2.5 h impregnation time by using 1 % ethanol (by volume). Furthermore, antibacterial/antifungal activities of the MOX- and AMBimpregnated contact lenses were effective against in vitro Pseudomonas aeruginosa (ATCC 10145) bacteria and Fusarium solani (ATCC 36031) fungus for up to one week. Consequently, the ScCO2 method can be effectively used to impregnate commercial contact lenses with drugs, and these can then be safely used for the treatment of keratitis. This offers a sustainable delivery system at effective dosage formulations with complete bacterial/ fungal inhibition and termination, making it viable for real animal/human applications.Öğe Moxifloxacin-Impregnated Contact Lenses for Treatment of Keratitis in Rabbit Eyes(Wiley, 2025) Erdoğan, Hakika; Güngör, Buket; Sağbaş Suner, Selin; Sılan, Coşkun; Saraydın, Serpil U.; Saraydın, Dursun; Ayyala, Ramesh S.; Şahiner, NurettinMoxifloxacin (MOX) was loaded into commercial contact lenses (CLs) via supercritical carbon dioxide (ScCO2) to attain MOX-impregnated CL for keratitis treatment. This study aimed to investigate Pseudomonas keratitis treatment with MOX-impregnated CL compared to the traditional eyedrop administration. MOX impregnation was accomplished employing optimum parameters of 2.5 h drug exposure time, 25 MPa pressure, and 313 K for ScCO2 conditions using ethanol co-solvent rendering sustainable delivery, up to 7 days at effective dosage formulation. The MOX-impregnated CL was found to be safe with no significant toxicity on fibroblast cells after 5 days of contact time. Bacterial viability in vivo keratitis treatment in rabbit eyes was significantly decreased to 10(2) from 10(9) CFU/cornea for MOX-impregnated CL treatment, almost similar to exhaustive conventional 0.5% MOX eye drop treatments. The MOX-impregnated CL treatment revealed no conjunctival hyperemia, edema, or secretion for all eyes in the relevant group, and transparent cornea with no keratitis focus was obtained for two of the eyes (n = 6). The normal histological structure was seen with MOX-impregnated CL treatment on healthy eyes. Moreover, polymorphonuclear cell infiltration observed in keratitis eyes without any treatment was significantly decreased to a few polymorphonuclear cells in the groups treated with MOX eyedrops and MOX-impregnated CL.Öğe Synthesis and characterization of poly(Maltodextrin) microgel from maltodextrin as drug delivery system(Elsevier B.V., 2024) Şahiner, Mehtap; Güngör, Buket; Sılan, Coşkun; Demirci, Şahin; Erdoğan, Hakika; Ayyala, Ramesh S.; Şahiner, NurettinMicrogels of maltodextrin (MDex) as poly(maltodextrin) (p(MDex)) were prepared by reverse-micelle crosslinking technique at various crosslinking ratios, 25, 50, and 100% based on the repeating unit of MDex using divinylsulfone (DVS) as crosslinker and were designated as p(MDex)-1, p(MDex)-2, and p(MDex)-3 respectively. The prepared p(MDex) microgels were blood compatible with <2% hemolysis and > 80%blood clotting index values at 1.0 mg/mL concentration. Also, p(MDex) microgels were found as biocompatible with >90% cell viability against L929 fibroblast cells at 1.0 mg/mL concentrations. Furthermore, p(MDex)-3 microgels were modified with ethylenediamine (EDA) and pentaethylenehexamine (PEHA) to generate new amine groups on microgels surface to obtain p(MDex)-EDA and p(MDex)-PEHA, respectively to render new surface functionality and features. The drug delivery potentials of p(MDex)-3, p(MDex)-EDA, and p(MDex)-PEHA microgels were tested employing amoxicillin (Amox) for loading and release studies at pH 7.4 and 37 degrees C. Higher drug loading amount, loading content%, and encapsulation efficiency% values were attained for p(MDex)-PEHA microgels with 112.5 +/- 9.9 mg/g, 12.8 +/- 1.1%, and 63.4 +/- 4.1%, respectively. The Amox-loaded p(MDex)-3, p(MDex)-EDA, and p(MDex)-PEHA microgels released 90.8 +/- 0.9, 86.2 +/- 10.8, and 87.2 +/- 9.6% of the loaded Amox at pH 7.4 PBS in 125 h. Controlled and extended drug delivery system at the therapeutic window is of paramount significance in treatment of various diseases. P(MDex)-PEHA microgels revealed almost a linear Amox release profile for up to 28 h. The Amox release from the p(MDex) microgels was fitted with the Korsmeyer-Peppas model with n values <0.5.
