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Öğe ASSESSMENT OF HEALTH-RELATED QUALITY OF LIFE IN CHRONIC HEPATITIS B INFECTION PATIENTS IN TURKEY: A MULTICENTER STUDY(Elsevier Science Bv, 2016) Karacaer, Z.; Cakir, B.; Erdem, H.; Ugurlu, K.; Durmus, G.; Ince, N. K.; Ozturk, C.[Anstract Not Available]Öğe Effects of tenoxicam in experimental corrosive esophagitis model(Oxford Univ Press Inc, 2015) Erbas, M.; Kiraz, H. A.; Kucuk, A.; Topaloglu, N.; Erdem, H.; Sahin, H.; Toman, H.Esophageal stricture, one of the important complications of corrosive esophagus, develops following edema and granulation tissue that forms during and after the inflammatory reactions. Tenoxicam, a non-steroid anti-inflammatory drug with a long half-life, prevents various leukocyte functions including phagocyte and histamine secretion by inhibiting prostaglandin synthesis and removes various oxygen radicals in the region of inflammation. We designed this as a histopathological study using tenoxicam in rats for which we created a corrosive esophagus model. After necessary authorizations were obtained, the study was performed in Canakkale 18 Mart University experimental animal laboratory. Twenty-four Wistar albino rats, weighing 220-240g, were used for the experiment. Experimental animals were randomized into three groups: tenoxicam group (group T, n:8), control group (group C, n:8), and sham group (group S, n:8). Tenoxicam 0.5mg/kg/day was administered to animals in group T, where esophageal burn was developed experimentally, 5mg/kg 0.9% NaCL was administered i.p. to rats in group C for 15 days, once in 24 hours. No procedure was applied to rats in group S. After 15 days, all animals were sacrificed under general anesthesia and their esophagi were extracted. As a result of histopathological evaluation, inflammation and fibroblast proliferation was not observed in rats in the sham group (group S). Intense inflammation was observed in six rats (6+/2-) in the control group, and fibroblast proliferation was observed as 5+/3-. And in treatment groups, inflammation was evaluated as 3+/5-, and fibroblast proliferation as 3+/5-. In our study, histopathologic damage score was higher in the control group (P < 0.005). We deduce that tenoxicam can be useful in the treatment of caustic esophageal injuries in the acute phase, but think that these drugs require further researches and clinical studies before routine clinical use.Öğe Growth, behavioural and haematological responses to poultry red mite infestation in Japanese quail(Eugen Ulmer Gmbh Co, 2020) Erdem, H.; Konyali, C.; Akbag, H. I.; Savas, T.The aim of the study was to investigate the effects of poultry red mite (PRM) infestation on Japanese quail. Two trials were carried out under same conditions, each using 80 one-week-old quail chicks. Half of the chicks were experimentally infested with PRM and the other half functioned as control group. The conditions of the two trial rooms were the same. Low infestation was observed in Trial I, while high infestation was seen in Trial II. Live weight (LW) and daily feed intake (DFI) were not significantly affected in Trial I (P = 0.2190). However, infested birds scratched themselves 2.46 times more than the control birds (P = 0.0002). Haemoglobin (Hg) of control and infested birds were 9.58 g.dl(-1) and 7.72 g.dl(-1) (P = 0.0017), and eosinophil proportions 5.79% and 18.58% (P = 0.0004), respectively. In Trial II differences of LW between control and infested birds reached a significant level at the 5th week (P = 0.0038). DFI of control birds was higher than in infested birds (P < 0.0001). Infested birds showed 4.22 times more scratching behaviour than the control (P = 0.0003). Hg, erythrocyte and haematocrit were 5.52 g.dl(-1), 1.79.10(6).mu l(-1) and 29.36% in infested birds, respectively; 11.28 g.dl(-1), 3.78.10(6).mu l(-1) and 43.47% in the control (P = 0.0001). Ratio of the spleen to carcass weight was 0.08% in control and 0.10% in infested birds (P = 0.0595). The ratio of gizzard to carcass weight was higher in infested birds (P = 0.0008). A higher mortality in infested birds was observed in Trial II compared to Trial I (P < 0.0001). The carcasses of infested birds showed lower dry matter content than carcasses of control birds (P = 0.0006). In conclusion, a low level of infestation did not lead to major negative effects, but decreased haemoglobin levels and increased scratching behaviour of the infested birds, indicating a negative impact on welfare. However, high infestations of PRM had severe effects on the quail.Öğe Protective effect of glucagon-like peptide-2 in experimental corrosive esophagitis(Oxford Univ Press Inc, 2015) Tekin, M.; Topaloglu, N.; Kucuk, A.; Deniz, M.; Yildirim, S.; Erdem, H.Corrosive esophageal injuries are one of the life-threatening morbidities leading to esophageal stricture and perforation affecting all age groups but especially children due to accidental ingestions in this age group. Glucagon-like peptide-2 (GLP-2) is an intestinal polypeptide with potent anti-inflammatory effects. Its effects are studied in various studies but not in corrosive esophagitis. We aimed to investigate whether it has protective effect in experimental corrosive esophagitis, in the absence of existing studies into possible links. Twenty-four Wistar-albino rats, weighing 220-240 g, were randomized into three groups (n=8 in each). First group is control, second one is sham operated, and the third one is treatment group. Median laparotomy was made in all groups. In sham and treatment groups, esophagus was loosened and suspended from 1cm proximal to the esophageal junction. The esophagus segment between suspenders was exposed to 0.1mL 5% NaOH for 10 seconds. In the treatment group, rats were given GLP-2 for 7 days intraperitoneally. After 7 days, all rats were sacrified and esophagi were totally removed. In the histopathologic examination, esophageal tissues were compared in terms of inflammation, muscularis mucosa injury, and collagen deposition of tunica muscularis. Histopathologic changes in the esophageal tissues of groups were compared. Histopathologic injury in the GLP-2 treated group was significantly less than sham group (P<0.05). There was statistically significant healing in the GLP-2 treatment group. It is concluded that GLP-2 has a preventive effect on inflammation and collagen accumulation in an experimental corrosive esophagitis. In the light of the information that initial lesions in the early phase are predictors of complications, GLP-2 is a promising agent that has an anti-inflammatory effect in caustic injuries.Öğe The features of infectious diseases departments and anti-infective practices in France and Turkey: a cross-sectional study(Springer, 2014) Erdem, H.; Stahl, J. P.; Inan, A.; Kilic, S.; Akova, M.; Rioux, C.; Pierre, I.The aim of this study was to assess the infectious diseases (ID) wards of tertiary hospitals in France and Turkey for technical capacity, infection control, characteristics of patients, infections, infecting organisms, and therapeutic approaches. This cross-sectional study was carried out on a single day on one of the weekdays of June 17-21, 2013. Overall, 36 ID departments from Turkey (n = 21) and France (n = 15) were involved. On the study day, 273 patients were hospitalized in Turkish and 324 patients were followed in French ID departments. The numbers of patients and beds in the hospitals, and presence of an intensive care unit (ICU) room in the ID ward was not different in both France and Turkey. Bed occupancy in the ID ward, single rooms, and negative pressure rooms were significantly higher in France. The presence of a laboratory inside the ID ward was more common in Turkish ID wards. The configuration of infection control committees, and their qualifications and surveillance types were quite similar in both countries. Although differences existed based on epidemiology, the distribution of infections were uniform on both sides. In Turkey, anti-Gram-positive agents, carbapenems, and tigecycline, and in France, cephalosporins, penicillins, aminoglycosides, and metronidazole were more frequently preferred. Enteric Gram-negatives and hepatitis B and C were more frequent in Turkey, while human immunodeficiency virus (HIV) and streptococci were more common in France (p < 0.05 for all significances). Various differences and similarities existed in France and Turkey in the ID wards. However, the current scene is that ID are managed with high standards in both countries.Öğe The microbiological diagnosis of tuberculous meningitis: Results of Haydarpasa-1 study(Blackwell Publishing Ltd, 2014) Erdem, H.; Ozturk-Engin, D.; Elaldi, N.; Gulsun, S.; Sengoz, G.; Crisan, A.; Johansen, I.S.We aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa-1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria and Turkey between 2000 and 2012. A positive culture, PCR or Ehrlich-Ziehl-Neelsen staining (EZNs) from the cerebrospinal fluid (CSF) was mandatory for inclusion of meningitis patients. A total of 506 TBM patients were included. The sensitivities of the tests were as follows: interferon-? release assay (Quantiferon TB gold in tube) 90.2%, automated culture systems (ACS) 81.8%, Löwenstein Jensen medium (L-J) 72.7%, adenosine deaminase (ADA) 29.9% and EZNs 27.3%. CSF-ACS was superior to CSF L-J culture and CSF-PCR (p <0.05 for both). Accordingly, CSF L-J culture was superior to CSF-PCR (p <0.05). Combination of L-J and ACS was superior to using these tests alone (p <0.05). There were poor and inverse agreements between EZNs and L-J culture (? = -0.189); ACS and L-J culture (? = -0.172) (p <0.05 for both). Fair and inverse agreement was detected for CSF-ADA and CSF-PCR (? = -0.299, p <0.05). Diagnostic accuracy of TBM was increased when both ACS and L-J cultures were used together. Non-culture tests contributed to TBM diagnosis to a degree. However, due to the delays in the diagnosis with any of the cultures, combined use of non-culture tests appears to contribute early diagnosis. Hence, the diagnostic approach to TBM should be individualized according to the technical capacities of medical institutions particularly in those with poor resources. © 2013 European Society of Clinical Microbiology and Infectious Diseases.Öğe Update on treatment options for spinal brucellosis(Blackwell Publishing Ltd, 2014) Ulu-Kilic, A.; Karakas, A.; Erdem, H.; Turker, T.; Inal, A.S.; Ak, O.; Turan, H.We evaluated the efficacy and tolerability of antibiotic regimens and optimal duration of therapy in complicated and uncomplicated forms of spinal brucellosis. This is a multicentre, retrospective and comparative study involving a total of 293 patients with spinal brucellosis from 19 health institutions. Comparison of complicated and uncomplicated spinal brucellosis was statistically analysed. Complicated spinal brucellosis was diagnosed in 78 (26.6%) of our patients. Clinical presentation was found to be significantly more acute, with fever and weight loss, in patients in the complicated group. They had significantly higher leukocyte and platelet counts, erythrocyte sedimentation rates and C-reactive protein levels, and lower haemoglobulin levels. The involvement of the thoracic spine was significantly more frequent in complicated cases. Spondylodiscitis was complicated, with paravertebral abscess in 38 (13.0%), prevertebral abscess in 13 (4.4%), epidural abscess in 30 (10.2%), psoas abscess in 10 (3.4%) and radiculitis in 8 (2.7%) patients. The five major combination regimens were: doxycycline 200 mg/day, rifampicin 600 mg/day and streptomycin 1 g/day; doxycycline 200 mg/day, rifampicin 600 mg/day and gentamicin 5 mg/kg; doxycycline 200 mg/day and rifampicin 600 mg/day; doxycycline 200 mg/day and streptomycin 1 g/day; and doxycycline 200 mg/day, rifampicin 600 mg/day and ciprofloxacin 1 g/day. There were no significant therapeutic differences between these antibiotic groups; the results were similar regarding the complicated and uncomplicated groups. Patients were mostly treated with doxycycline and rifampicin with or without an aminoglycoside. In the former subgroup, complicated cases received antibiotics for a longer duration than uncomplicated cases. Early recognition of complicated cases is critical in preventing devastating complications. Antimicrobial treatment should be prolonged in complicated spinal brucellosis in particular. © 2013 European Society of Clinical Microbiology and Infectious Diseases.
