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    Effect of Quercetin on Colonic Anastomosis Wound Healing
    (Wiley-Blackwell, 2015) Demir, Ufuk; Edremitlioglu, Mustafa; Kandas, Emel; Sehitoglu, Muserref Hilal
    [Anstract Not Available]
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    Healing Effects of L-Carnitine on Colon Anastomosis Wound on Experimental Colon Anastomosis
    (Wiley-Blackwell, 2015) Kandas, Emel; Edremitlioglu, Mustafa; Demir, Ufuk; Erbil, Guven; Sehitoglu, Muserref Hilal
    [Anstract Not Available]
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    Quercetin associated with dimethylsulfoxide has a curative effect on experimental colon anastomosis injury
    (Acta Cirurgica Brasileira, 2020) Demir, Ufuk; Edremitlioglu, Mustafa; Kanda, Emel; Sehitoglu, Muserref Hilal; Kilinc, Nihal
    Purpose: To examine the effects of quercetin on healing of experimental colon anastomosis injury in early and late period. Methods: Eighty male Wistar-Albino rats were divided into 8 groups. For all groups, left colons of the rats were resected and for the rest end-to-end anastomosis was performed. Two of the groups for which the experiment protocol was ended on the 3rd and 7th day following the anastomosis were not administered with either quercetin or dimethylsulfoxide DMSO, whereas two other groups were administered with DMSO only, and four other groups were administered with quercetin dissolved in DMSO in doses of 20 and 100 mg/kg during the protocol. At the end of the study, anastomosis line was resected, histopathological evaluation was performed and bursting pressure, malondialdehyde, superoxide dismutase, catalase, and hydroxyproline levels were measured. Results: Quercetin significantly increased hydroxyproline, superoxide dismutase, catalase levels, histopathological healing score, bursting pressure values and decreased malondialdehyde level in early period. It also significantly increased superoxide dismutase, catalase, and hydroxyproline levels and decreased malondialdehyde level in late period. Conclusion: it was seen that quercetin speeds up the injury healing process and reveals an antioxidant effect, specifically in early period.
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    Quercetin, a Powerful Antioxidant Bioflavonoid, Prevents Oxidative Damage in Different Tissues of Long-Term Diabetic Rats
    (Galenos Publ House, 2012) Edremitlioglu, Mustafa; Andic, Mehmet Fatih; Korkut, Oguzhan
    Objective: The role of oxidant damage on the development of end-organ injuries caused by diabetic rat is well known. The aim of this study is to examine the effect of quercetin, which is a strong antioxidant bioflavonoid, on oxidant damage and antioxidant capacity in various organs in the case of medium-term or long-term diabetic rat. Material and Methods: Forty-eight male Wistar rats were divided into five groups, namely, control group, diabetic group of 8-weeks, diabetic group of 16-weeks, quercetin treated diabetic group of 8-weeks, and quercetin treated diabetic group of 16-weeks. At the end of the experiment, malondialdehyde levels, superoxide dismutase, catalase, and glutathione peroxidase activities, were measured in the lung, aorta, heart, spleen, liver, and kidney tissues. Results: MDA levels were elevated in all tissues except in the lung in non-treated diabetic groups. Quercetin treatment increased the antioxidant enzyme capacities and considerably reduced oxidant damage. Conclusion: We suggest that quercetin has a protective effect on the aorta, heart, brain, liver, and kidneys from oxidant damage in the case of medium-term or long-term diabetic rat. It can be argued that quercetin is effective by increasing the antioxidant defence capacity in this process.