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Öğe An effective treatment for prevention and impediment of atrial fibrillation after cardiac surgery(Pulsus Group Inc., 2014) Yener, Ali Umit; Ozkan, Turgut; Cicek, Mustafa Cuneyt; Cicek, Tugba; Baysal, Erkan; Genc, Bahadir; Dogan, EmreAtrial fibrillation is a common rhythm disorders after open heart surgery and associated with increased morbidity and mortality. Advanced age, hypertension, COPD are known to be the causes of postoperative atrial fibrillation. However, reactive oxygen radicals formed after open heart surgery have been shown to be involved in the etiology of AF. Besides its expectorant feature, NAC is a molecule known to be an antioxidant. In this retrospective study, we compared the incidence of postoperative AF and onset time of AF in patients who used preoperatively NAC because of COPD and who did not use NAC. In this study, the incidence of atrial fibrillation was significantly lower in patients using NAC preoperatively. Also onset time of AF was significantly longer in patients who used NAC.Öğe Magnesium; the electrolyte that delays the formation of atrial fibrillation(Pulsus Group Inc., 2014) Yener, Ali Umit; Ozkan, Turgut; Cicek, Mustafa Cuneyt; Baysal, Erkan; Dogan, Emre; Cicek, Omer Faruk; Genc, BahadirAtrial fibrillation is one of the most common undesirable situation seen after open-heart surgery because of increasing the length of hospital stay, morbidity and mortality. It is revealed that atrial fibrillation may occur as a result of various electrolyte deficiencies such as magnesium. In this retrospective study, we aimed to compare the rhythm outputs of different cardiopulmonary bypass protocols,magnesium included in study group and without magnesium used patients was inserted in control group. The incidence of atrial fibrillation between 2 groups was not statistically significant. Furthermore magnesium treatment delayed the onset of atrial fibrillation in patients after coronary bypass graft surgery.Öğe Protective role of heparin in the injury of the liver and kidney on the experimental model of ischemia/reperfusion(BMC, 2014) Yener, Ali Umit; Cicek, Mustafa Cuneyt; Genc, Serhat Bahadir; Ozkan, Turgut; Dogan, Emre; Bilgin, Bulent Caglar; Akin, TezcanBackground: Surgery of thoracoabdominal aortic aneurysms (TAAA) is associated with high incidence of serious complications. Ischemia/reperfusion (I/R) injury may be responsible for these complications. We investigated the effect of degree of anticoagulation on remote organ I/R injuries and whether heparin is protective against I/R injury in addition to its anticoagulant properties. Methods: Spraque Dawley rats were used to determine both liver and kidney concentrations of HSP-70, IL-6, MPO in four groups: ischemic control (operation with cross-clamping and intraperitoneal administration of 0.9% saline, n = 7), sham (operation without cross-clamping, n = 7), heparin (ACT level about 200), and high dose heparin (ACT level up to 600). Histological analyses of the organs were performed. Results: Histopathological evaluation of kidney presented significant differences between groups with regards to the cytoplasmic vacuole formation, hemorrhage, tubular cell degeneration and tubular dilatation while heparinized group had best results. The kidney MPO and HSP-70 levels significantly decreased (p < 0.05), but IL-6 level was not significant (p > 0.05) in heparinized group when compared to ischemic control group. No statistically significant intergroup differences were detected in the tissue samples of liver. Immunohistochemical markers of the liver were compared and no statistically significant difference was found among the groups. Conclusion: Heparin is an important anticoagulation agent in TAAA surgical procedures but the use of higher levels of heparin in the present study revealed no beneficial effects. Bleeding complications is much less when heparin is used in the real-world clinical practice as ACT levels of 200.Öğe Vasorelaxant effects of dobutamine and levosimendan on rat aorta rings(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2015) Dogan, Emre; Peker, Recep Oktay; Yener, Ali Umit; Donmez, Soner; Gokalp, OsmanBackground: In this experimental study, the vasorelaxant effects of levosimendan and dobutamine on isolated rat thoracic aorta preparations were compared. Methods: Sixteen Wistar albino type male rats were used. The thoracic aortas were removed carefully and were transferred to petri dishes containing Krebs solution. Aortic rings of approximately 5 mm in length were prepared and placed in the organ bath. Contraction and relaxation forces of the aortic rings were recorded. Contraction response was obtained by applying 10(-5)M phenylephrine to aortic rings. Subsequently, cumulative doses of levosimendan (10(-8)M-10(-4)M) was applied to eight aortic rings and cumulative doses of dobutamine (10(-8)M-10(-3)M) was applied to the other eight aortic rings and dose-response curves were recorded. The EC50 and pD2 values were calculated by the computer program named Graph Pad Prisim 4.0. The Mann-Whitney U-test was performed for statistical analysis. Results: The relaxation response of the aortic rings with levosimendan 10(-4)M administration was %92.33 while the relaxation response with dobutamine 10-4M administration was %82.48. It did not show a significant difference between both relaxation responses (p=0.059). The EC50 value was calculated as 6.605x10(-6)M for dobutamine and 5.093x10(-5)M for levosimendan. The pD2 value was found to be 5.2 +/- 0.4 for levosimendan and 4.3 +/- 0.2 for dobutamine. Conclusion: Levosimendan and dobutamine molecules in vitro rat aortic rings have similar vasorelaxant effects.
