Yazar "Doğan, Durmuş" seçeneğine göre listele
Listeleniyor 1 - 11 / 11
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Adrenocortical hormone profiles do not predict the molecular etiology in non-CAH primary adrenal insufficiency(Karger, 2021) Menevşe, Tuba Seve; Demirkol, Yasemin Kendir; Tosun, Büşra Gürpınar; Bayramoğlu, Elvan; Yıldız, Melek; Acar, Sezer; Karaca, Seda Erişen; Orbak, Zerrin; Önder, Asan; Sobu, Elif; Anik, Ahmet; Atay, Zeynep; Bugrul, Fuat; Demir, Korcan; Doğan, Durmuş; Emeksiz, Hamdi Cihan; Kırmızıbekmez, Heves; Murat, Nurhan Özcan; Yaman, Akan; Turan, Serap; Bereket, Abdullah; Güran, TülayPrimary adrenal insufficiency other than congenital adrenal hyperplasia (non-CAH PAI) is very uncommon in children but associated with a variety of molecular defects. Biosynthesis of adrenocortical hormones is reduced although the relation of steroid profiles with underlying molecular etiology is not yet studied. Objective: Investigation of clinical and steroid hormone profiles of a multicenter cohort of children with non-CAH PAI. Design: Patients with CAH, adrenoleukodystrophy, autoimmune adrenal insufficiency or obvious syndromic PAI on clinical and biochemical assessment were excluded. Genetic analysis was performed using either targeted gene panel or whole-exome sequencing. Plasma adrenal steroids were quantified by liquid chromatography-mass spectrometry and compared to that of controls. Setting: Sixteen tertiary pediatric endocrinology clinics. Patients: Forty-one children (19 females, median age: 3 months, range: 0-8 years) with non-CAH PAI of unknown etiology. Results: A genetic diagnosis was obtained in 29 (68%) patients by targeted gene panel. Further molecular diagnosis could not be achieved by WES. The range of etiologies was: MC2R (n = 6), StAR (n = 6), NNT (n = 3), NR0B1 (n = 3), CYP11A1 (n = 2), MRAP (n = 2), SGPL1 (n = 2), ABCD1 (n = 1), AIRE (n = 1), AAAS (n = 1), HSD3B2 (n = 1). Steroid profiling demonstrated low levels in all adrenocortical steroid hormones irrespective of age and not varied among the genetic etiologies except two patients with new-onset symptoms of PAI due to homozygous c.518T>A(p.Leu173Gln) SGPL1, and hemizygous c.1772G>T(p.Arg591Leu) ABCD1 defects, and another patient with non-classic non-CAH PAI due to homozygous c.1351C>T (p.Arg451Trp) variant in CYP11A1. Compared to age-matched healthy control group in whom steroid hormone concentrations are physiologically low, the patient group had even lower steroid concentrations, most significantly in cortisone, cortisol, and corticosterone (P < 0.0001, area under the ROC curve: 0.96, 0.88, 0.87, respectively). Plasma cortisol<4 ng/ml, cortisone<11 ng/ml, and corticosterone<0.11 ng/ml had >95% specificity to segregate non-CAH PAI patients compared to control groups. Conclusion: Adrenocortical hormone profiles are highly sensitive for the diagnosis of non-CAH PAI, while, in contrast to CAH, they are unlikely to point out a specific molecular diagnosis. Targeted gene panel sequencing is an undisputed optimal approach in the molecular diagnosis of non-CAH PAI with low cost and high efficacy, while little additional benefit is expected from whole-exome sequencing. Further progress can be made, mainly by more collaboration and exchanging knowledge for delineation of rare causes of primary adrenal insufficiency.Öğe COVID-19 Vaccine Hesitancy of Parents of Children with Type 1 Diabetes in Türkiye: A Mixed-Methods Study( Pediatric Infectious Diseases and Immunization Society, 2023) Çelik, Taylan; Doğan, DurmuşObjective: In this study, we aimed to investigate the attitudes of parents who have children with type 1 diabetes mellitus to get their children vaccinated against COVID-19. Material and Methods: The target population of the study consisted of 124 parents of children followed in Çanakkale Onsekiz Mart University Hospital, Pediatric Endocrinology Clinic with the diagnosis of type 1 di-abetes. We used an online questionnaire to determine the attitudes of parents. Results: A total of 102 parents, 76 of whom were mothers, were included in the study. Mean age of the parents was 40.5 ± 7.27, and children were 12 ± 4.07. Mean duration elapsed since the diagnosis of type 1 diabetes was 4.5 ± 3.3 years. About half of the parents thought that type 1 diabetes mellitus was a risk factor for COVID-19. While the rate of parents who were not vaccinated for COVID-19 was 21.6%, 46.1% were hesitant to vaccinate their children. The parental-related factors causing vaccine hesitation were fathers, young parents, those who weren’t worried about their children being infected with COVID-19, did not think children with type 1 diabetes mellitus were more at risk, or were unvaccinated. Child-related factors were young age or short duration of illness. In qual-itative analysis, vaccination-hesitant parents’ main concern was vaccine side effects, and they expected clear evidence-based confidence-build-ing recommendations for vaccination. Conclusion: In conclusion, it is seen that especially young parents, whose children are small or newly diagnosed, will have problems in their motivation about vaccination.Öğe Exploring Serum Vitamin D Binding Protein Levels in Type 1 Diabetes: Assessing the Impact of Glycemic Control and Disease Duration(2023) Özcan, Eda Gül; Doğan, DurmuşAim: Patients with type 1 diabetes mellitus (T1DM) are known to be more prone to vitamin D deficiency. Vitamin D studies in this patient population have traditionally been performed using serum 25OHD levels. However, vitamin D binding protein (VDBP) has been less studied. This study aims to compare serum VDBP levels in T1DM with healthy controls. It also aims to investigate the factors affecting VDBP levels such as disease duration, HbA1c, insulin dose, and age in diabetic subjects. Material and Methods: A research study was conducted at Çanakkale Onsekiz Mart University Health Practice and Research Hospital. The study included 11-17 years old children with T1DM and healthy controls. Serum VDBP and 25OHD concentrations were compared with appropriate statistical methods according to the normal distribution of relevant parameters. For the diabetic subjects, insulin doses and duration of diabetes were recorded. Spearman’s correlation test was utilized to assess associations between continuous variables, and regression analysis was employed to determine predictors of serum VDBP levels. Results: The study enrolled 89 subjects, including 40 with diabetes. Serum 25OHD levels were similar in the T1DM group and control group (17.03 IQR:12.89-22.08) and (17.62 IQR:11.68-24.48), respectively (p=0.701). However, VDBP levels were significantly lower in the T1DM group (335 ?g/ml, IQR: 199.8-517.2 ?g/ml) compared to the control group (471.2 ?g/ml, IQR: 368.3-533.2 ?g/ml) (p < 0.015). In the entire group, only the presence of diabetes affected VDBP levels (B=87.236, SE=34.802, p=0.014). On the other hand, HbA1c, duration of diabetes, and insulin dose had no influence on VDBP in the diabetes group. Conclusion: Serum VDBP levels were significantly lower in T1DM patients but in this group, disease duration, insulin dose, and metabolic control did not affect serum VDBP levels. Serum VDBP concentrations in T1DM may be affected by other parameters rather than metabolic parameters. Therefore, future studies should focus on addressing this knowledge gap.Öğe Genetic influence on urinary vitamin D binding protein excretion and serum levels: a focus on rs4588 C>A polymorphism in the GC gene(Frontiers Media Sa, 2023) Doğan, Durmuş; Özcan, Eda Gül; Çakır, Dilek Ülker; Sılan, FatmaIntroduction: Vitamin D binding protein (VDBP) plays a crucial role in vitamin D transport and metabolism. The rs4588-A polymorphism of the GC gene, encoding VDBP, has been associated with altered serum VDBP and 25-hydroxyvitamin D (25OHD) levels. However, the mechanisms underlying these effects remain unclear. We aimed to investigate the relationship between urinary VDBP excretion and serum VDBP and 25OHD levels in individuals with and without the rs4588-A allele. Methods: A cross-sectional study was conducted on 109 children (mean age: 11.96 years) to explore the impact of rs4588-A on vitamin D metabolism and urinary VDBP excretion. Biochemical analyses determined serum 25OHD and VDBP levels, and urinary VDBP-to-creatinine ratio (u-VDBP/Cr). Genotyping for rs4588 SNP was performed using LightSNiP assay. Statistical analyses included correlation, linear regression, and comparison between allele groups. Results: Participants carrying the rs4588-A allele exhibited lower serum 25OHD levels compared to non-carriers (median (IQR): 11.85 (3.5) vs. 12.86 (4.9), p = 0.023). However, no statistically significant differences were observed in serum VDBP levels (126.34 ± 59.3 in rs4588-A vs. 136.49 ± 51.3 in non-rs4588-A, p = 0.141) or in u-VDBP/Cr (median (IQR): 0.4 (0.35) in rs4588-A vs. 0.386 (0.43) in non-rs4588-A, p = 0.189) between the two allele groups. A significant inverse correlation between u-VDBP/Cr and serum VDBP levels was found only in rs4588-A carriers (r = -0.367, p = 0.024). No such correlation was observed in non-carriers or the entire cohort. A linear regression analysis confirmed the impact of u-VDBP/Cr on serum VDBP levels in rs4588-A carriers (B = -0.269, t = -2.185, p = 0.035). Conclusion: Individuals with the rs4588-A allele in the GC gene had lower serum 25OHD levels. An inverse correlation between urinary VDBP excretion and serum VDBP levels was observed, suggesting a partial role of the renal pathway in altered serum VDBP and 25OHD levels linked to the rs4588-A allele.Öğe Patterns of Endocrine Disorders in a Neonatal Intensive Care Unit: A Single-Center Retrospective and Descriptive Study(Briefland, 2024) Candaş, Gökay; Doğan, DurmuşBackground: Endocrine disorders in infants in neonatal intensive care units (NICU) represent a significant clinical concern. Understanding the frequency and variety of these disorders is crucial for effective patient management. Objectives: This single-center retrospective study was conducted to examine the frequency and patterns of endocrine disorders among neonates in the NICU. Methods: We performed a retrospective review of 1 845 patient records over five years from the NICU at & Ccedil;anakkale Onsekiz Mart University Health Practice and Research Hospital. The study included patients admitted between January 1, 2016, and March 31,2021, who were diagnosed with endocrine disorders according to the international classification of diseases (ICD). Diagnostic criteria were used to identify and categorize endocrine disorders, primarily focusing on hypoglycemia, congenital hypothyroidism, hypothyroxinemia of prematurity, neonatal hyperthyrotropinemia (HTT), and disorders of calcium and magnesium metabolism. Data analysis was conducted using descriptive statistics. Results: Endocrine disorders were identified in 14.6% (CI: 13.15 - 16.38) of the neonates. The most prevalent were thyroid disorders(5.15%, CI: 4.23 - 6.25), disorders of calcium metabolism (3.68%, CI: 2.92 - 4.64), and disorders of glucose homeostasis (3.63%, CI: 2.87- 4.58). Notably, neonatal HTT was more frequent than previously reported. The majority of endocrine issues occurred in premature infants. Hypoglycemia was the most frequent glucose homeostasis disorder, affecting 24.7% (CI: 19.9 - 30.2) of those diagnosed with endocrine issues. Among the cases with calcium metabolism disorders, hypocalcemia was predominant (79.4%,CI: 68.3 - 87.3), with the majority (89%, CI: 80.1 - 95.9) being classified as early neonatal hypocalcemia. Conclusions: Endocrine disorders, particularly those related to thyroid, calcium, and glucose homeostasis, remain prevalent issues in the NICU. Prematurity significantly contributes to these complications. The frequency and variety of endocrine disorders are likely to evolve with improvements in laboratory techniques and diagnostic methods. Future larger-scale studies could provide more comprehensive insights into these disorders.Öğe Plasma Amino Acid Levels in Obese Adolescents: A Case-Control Study and the Review of the Literature(2025) Soylu Ustkoyuncu, Pembe; Doğan, Durmuş; Kardas, Fatih; Kendirci, Mustafa; Dündar, Mehmet Akif; Canpolat, Arife; Altuner Torun, YaseminOptimal balance among amino acids in the circulation is important for body homeostasis. This study aims to evaluate and define the amino acids associated with obesity and insulin resistance. Fifty obese and 42 healthy adolescents aged 10-18 years were included in this study. Fasting plasma glucose, liver enzymes, thyroid function tests, insulin, and lipid levels were studied as routine laboratory examinations, and 26 plasma amino acids were studied as specific laboratory examinations. Isoleucine, leucine, lysine, tryptophan, glutamate, tyrosine, phenylalanine, alanine, methionine, argininosuccinic acid, histidine and valine were significantly higher in patients with obesity. Asparagine and citrulline levels were lower in patients with insulin resistance. The metabolic pathways of various amino acids are significantly impaired in obesity. Plasma concentrations of essential, non-essential, branched-chain, and aromatic amino acids were elevated in this study.Öğe Research trends on the gut microbiota in endocrine metabolism: a thematic and bibliometric analysis(Frontiers Media Sa, 2024) Doğan, Durmuş; Çelik, TaylanBackground Gut microbiota studies in the field of endocrinology metabolism have attracted increasing attention in recent years. To comprehensively assess the evolving landscape of this research field, we conducted a thorough bibliometric analysis of gut microbiota studies in endocrinology metabolism indexed in the Web of Science database.Methods We collected and analyzed 3,339 original research articles and reviews published from 1972 to 2023. Using various bibliometric indicators, we investigated publication trends, country contributions, international collaborations, prolific authors, top journals, and influential articles.Results Our analysis revealed a significant upsurge in publications after 2010, indicating a growing scientific interest in microbiota and endocrinology metabolism. Keyword and thematic analyses have identified gut microbiota, obesity, diabetes, and inflammation as core research themes. Additionally, the roles of probiotics and prebiotics are increasingly researched for their therapeutic effects in shaping the microbiota.Conclusion This study reveals that research in endocrinology metabolism is increasingly decoding the connection between gut microbiota and diseases. There's also a growing focus on microbiota manipulation, which points to a shift towards personalized medicine. Future research should focus on integrating these findings into clinical practice, moving from lab-based studies to real-world patient care.Öğe Revised one-bag IV fluid protocol for pediatric DKA: a feasible approach and retrospective comparative study(Oxford Univ Press, 2024) Doğan, Durmuş; Gökalp, Hatice; Eren, Erdal; Sağlam, Halil; Tarım, ÖmerBackground This study compared the effectiveness of the traditional and revised one-bag protocols for pediatric diabetic ketoacidosis (DKA) management. Methods This single-center retrospective cohort study included children diagnosed with DKA upon admission between 2012 and 2019. Our institution reevaluated and streamlined the traditional one-bag protocol (revised one-bag protocol). The revised one-bag protocol rehydrated all pediatric DKA patients with dextrose (5 g/100 ml) containing 0.45% NaCl at a rate of 3500 ml/m2 per 24 h after the first 1 h bolus of normal saline, regardless of age or degree of dehydration. This study examined acidosis recovery times and the frequency of healthcare provider interventions to maintain stable blood glucose levels. Results The revised one-bag protocol demonstrated a significantly shorter time to acidosis recovery than the traditional protocol (12.67 and 18.20 h, respectively; p < 0.001). The revised protocol group required fewer interventions for blood glucose control, with an average of 0.25 dextrose concentration change orders per patient, compared to 1.42 in the traditional protocol group (p < 0.001). Insulin rate adjustments were fewer in the revised protocol group, averaging 0.52 changes per patient, vs. 2.32 changes in the traditional protocol group (p < 0.001). Conclusion The revised one-bag protocol for pediatric DKA is both practical and effective. This modified DKA management achieved acidosis recovery more quickly and reduced blood glucose fluctuations compared with the traditional one-bag protocol. Future studies, including randomized controlled trials, should assess the safety and effectiveness of the revised protocol in a broad range of pediatric patients with DKA.Öğe The prevalence and prognostic effect of hyponatremia in children with COVID-19 pneumonia: a retrospective study(Hacettepe University Institute of Child Health, 2023) Çelik, Taylan; Doğan, Durmuş; Parlak, Cağrı FurkanBackground. The aim of the study was to examine the effect of hyponatremia at admission as a negative prognostic factor in children hospitalized with COVID-19 pneumonia. Methods. The data of patients aged 1 month-18 years, who were followed with the diagnosis of pneumonia at Çanakkale Onsekiz Mart University Hospital, Department of Pediatrics, between January 2018 and May 2021 were examined, retrospectively. Patients (n=661) were divided into two main groups; COVID-19 pneumonia (n=158) and the other pneumonias [other viral pneumonia (n=161) and pneumonia of unknown etiology (n=342)]. Results. Six hundred and twenty-three patients with a median (Q1-Q3) age of 4 (1.5-8) years, 59.4% of whom were male were included in the study. The overall prevalence of hyponatremia at admission was 11.2% and was lower in those with COVID-19 pneumonia than in those with other viral pneumonia (6.4% vs. 15.2%, p=0.013). When evaluated irrespective of their COVID-19 status, hyponatremic patients had a higher supplemental oxygen requirement (OR 2.5 [1.4-4.3], p < 0.001), higher need for intensive care unit (ICU) admission (OR 3.7 [1.3-10.2], p=0.009) and longer duration of hospitalization (p=0.016) than the normonatremic patients. In patients with COVID-19 pneumonia, being hyponatremic had no effect on supplemental oxygen requirements or the duration of hospitalization. When hyponatremic patients were evaluated, the supplemental oxygen requirements and duration of hospitalization of those with COVID-19 pneumonia were similar to the other pneumonias (p > 0.05 for all comparisons). However, normonatremic COVID-19 pneumonias had higher supplemental oxygen requirements than other viral pneumonias and pneumonia of unknown etiology (OR 4.7 [2.2-10.3], p < 0.001; OR 1.6 [1 -2.7], p=0.043, respectively). Conclusion. This study found that hyponatremia at admission is rarer in children with COVID-19 pneumonia than other viral pneumonias and has no effect on supplemental oxygen requirements or the duration of hospitalization.Öğe Tip 1 Diyabetes Mellituslu Olguların Tanı ve Tedavilerinin Retrospektif Değerlendirilmesi(2021) Aydoğan, Zeynep Karaca; Battal, Fatih; Doğan, DurmuşAmaç: Çanakkale ili ve çevresindeki Tip 1 Diabetes Mellitus (T1D) tanılı olguların demografik özelliklerinin, klinik ve laboratuvar bulgularının, başvuru anında diyabetik ketoasidoz (DKA) durumlarının ve aldıkları tedavilerin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Çanakkale Onsekiz Mart Üniversitesi Tıp Fakültesi Hastanesi Çocuk Sağlığı ve Hastalıkları kliniğine 01.04.2011- 01.04.2019 tarihleri arasında en az bir kez başvurmuş 0-18 yaş arası, 165 DM tanılı hasta dosyası retrospektif tarandı. Dosya kayıtları eksik 68 hasta, Tip 2 DM tanılı dört hasta, Gençlerde Görülen Erişkin Tipi Diyabet (MODY) tanılı bir hasta olmak üzere 73 hasta çalışma dışı bırakıldı, 92 hasta çalışmaya alındı. Bulgular: Olgularımızın %54,35’i kız, ortalama tanı yaşı 7,6±3,9 yaş idi. En sık tanı alınan mevsimler sonbahar (%32,6) ve kış (%30,43) oldu. Olgularımızın %52,17’sinin merkeze 0-50 km, %42,39’unun 50-100 km, %3,27’sinin 100-150 km, %2,17’sinin ise 150 km’den daha uzak mesafede olduğunu tespit ettik. Diyabetik ketoasidoz ile başvuran olgularımızı hafif, orta ve ağır DKA olarak sınıflandırarak, tedavilerinde uygulanan protokollere göre DKA’dan çıkış sürelerini kıyasladığımızda, her üç grupta da Uluslararası Çocuk ve Ergen Diyabet Derneği (ISPAD) 2018 protokolü uygulanan olguların DKA’dan daha kısa sürede çıktığını saptadık. Sonuç: Tip 1 diyabetiklerde DKA, hiperglisemi gibi akut ve retinopati, nefropati, nöropati, ateroskleroz gibi kronik komplikasyonlar görülebildiği için tanı ve takip önemlidir. Hastalığın bölgesel özelliklerinin araştırılması, etiyolojide önemli yer tutan genetik ve çevresel faktörler açısından yol göstericidir. Bizim çalışmamız Güney Marmara bölgesinde çocukluk çağı yaş grubunda T1D tanısı ile takip edilen olguların incelendiği ilk çalışmalardan biridir. Tespit ettiğimiz bulgular yapılan benzer çalışmaların sonuçları ve literatürle uyumludur.Öğe Türkiye‘de Tip 1 Diyabetli Çocukların Ebeveynlerinin COVID-19 Aşı Tereddüdü: Karma Yöntemli Bir Çalışma(Çocuk Enfeksiyon Hastalıkları ve Bağışıklama Derneği, 2023) Çelik, Taylan; Doğan, DurmuşGiriş: Bu çalışmada, tip 1 diyabetli çocuğu olan ebeveynlerin çocuklarına COVID-19 aşısı yaptırmaya yönelik tutumlarını araştırmayı amaçladık. Gereç ve Yöntemler: Araştırmanın evrenini Çanakkale Onsekiz Mart Üniversitesi Hastanesi, Çocuk Endokrinoloji Kliniğinde tip 1 diyabet tanısıyla takip edilen çocukların 124 ebeveyni oluşturmuştur. Ebeveynlerin tutumlarını belirlemek için çevrim içi bir anket kullandık. Bulgular: Çalışmaya 76’sı anne olmak üzere toplam 102 ebeveyn dahil edildi. Ebeveynlerin yaş ortalaması 40.5 ± 7.27, çocukların 12 ± 4.07 idi. Tip 1 diyabet tanısından itibaren geçen ortalama süre 4.5 ± 3.3 yıldı. Ebeveynlerin yaklaşık yarısı tip 1 diyabetin COVID-19 için bir risk faktörü olduğunu düşündü. COVID-19 aşısı olmayan ebeveynlerin oranı %21.6 iken, %46.1’i çocuklarına aşı yaptırmakta tereddüt etti. Aşı tereddütüne neden olan ebeveynle ilgili faktörler: babalar, genç ebeveynler, çocuklarına COVID-19 bulaşmasından endişe etmeyen, tip 1 diyabetli çocukların daha fazla risk altında olduğunu düşünmeyenler veya aşısız olanlardı. Çocuklarla ilgili faktörler, genç yaş veya kısa hastalık süresiydi. Nitel analizde, aşı konusunda tereddütlü ebeveynlerin ana endişesi aşının yan etkileriydi ve aşı için açık, kanıta dayalı güven arttırıcı öneriler bekliyorlardı. Sonuç: Sonuç olarak, özellikle çocukları küçük veya yeni tanı almış genç ebeveynlerin aşıya yönelik motivasyonlarında sorun yaşayacakları görülmektedir.
