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    RELATIONSHIP BETWEEN PULSE WAVE VELOCITY AND SERUM YKL-40 LEVEL IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS
    (Bmj Publishing Group, 2013) Turkyilmaz, A. Kucukali; Devrimsel, G.; Kirbas, A.; Cicek, Y.; Karkucak, M.; Capkin, E.; Gokmen, F.
    [Anstract Not Available]
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    The Impact of socioeconomic status on clinical parameters in female psa patients
    (Clinical and Experimental Rheumatology, 2021) Tekeoglu, I.; Nas, K.; Keskin, Y.; Kilic, E.; Sargın, B.; Kasman, Acer S.; Alkan, H.; Şahin, N.; Cengiz, G.; Cuzdan, N.; Gezer, İlknur Albayrak; Keskin, D.; Mulkoglu, C.; Reşorlu, Hatice; Ataman, S.; Hastürk, Bal A.; Duruoz, Tuncay M.; Küçükkakkaş, O.; Yurdakul, Volkan O.; Melikoğlu, Alkan M.; Ayhan, Figen F.; Baykul, M.; Bodur, H.; Calış, M.; Çapkın, E.; Devrimsel, G.; Ecesoy, H.; Gök, K.; Hizmetli, S.; Kamanlı, A.; Kutluk, O.; Şen, N.; Şendur, Faruk O.; Toprak, M.; Tolu, S.; Tuncer, T.
    Psoriatic arthritis (PsA) is a chronic rheumatic disease associated with inflammatory arthritis and low quality of life. Different social status, which can often be ignored in daily practice, can adversely affect clinical parameters. In this study, it was aimed to investigate the effect of having different social status on the disease parameters in female patients with PsA.
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    The relationship between serum YKL-40 levels and arterial stiffness in patients with ankylosing spondylitis
    (Publisaude-Edicoes Medicas Lda, 2017) Turkyilmaz, Kucukali A.; Devrimsel, G.; Beyazal, Serdaroglu M.; Kirbas, A.; Cicek, Y.; Capkin, E.; Karkucak, M.
    Objective: Serum YKL-40 plays roles in inflammatory and vascular processes. Our aim was to evaluate serum YKL-40 levels in patients with ankylosing spondylitis (AS) and to investigate their potential relationship with arterial stiffness based on carotid-femoral pulse wave velocity (CF-PWV). Methods: Forty-three patients with AS and 41 healthy controls with no history or current signs of cardiovascular disease were included in the study. All patients were administered nonsteroidal anti-inflammatory drugs (NSAIDs), and none were prescribed anti-tumor necrosis factor agents. Serum YKL-40 levels were measured. CF-PWV and intima-media thickness of the common carotid artery (IMT-C) were evaluated. Results: The mean age of AS patients was 34.6 +/- 10.2 years and of controls was36.3 +/- 9.0 years. CF-PWV was significantly higher in AS patients than in controls (8.2 +/- 2.7 vs. 7.0 +/- 1.6 m/s, respectively; P=0.015). However, the IMT-C was not significantly different between AS patients and controls (0.6 +/- 0.3 vs. 0.5 +/- 0.2 mm, P=0.501). YKL-40 levels were significantly higher in AS patients than in controls (78.9 +/- 37.9 vs. 58.4 +/- 21.2 ng/mL, P=0.003) and were strongly correlated with CF-PWV (r=0.773, P<0.001) and IMT-C (r=0.548, P<0.001). A multiple linear regression analysis revealed that CF-PWV could be explained by serum YKL-40 levels and IMT-C (adjusted R-2 = 0.707, P=0.013 and P=0.001, respectively). AS patients with a higher disease activity score had higher YKL-40 levels, IMT-C, and CF-PWV than did those with a lower disease activity score (P<0.001, P=0.008, and P<0.001, respectively) Conclusion: AS patients had higher serum YKL-40 levels, CF-PWV, and IMT-C than did healthy controls. Additionally, there was an association between increased CF-PWV and serum YKL-40 levels. Therefore, we conclude that CF-PWV and YKL-40 levels may be used for early diagnosis of atherosclerosis in AS patients.