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Öğe Agenesis of Submandibular Glands: A Report of Two Cases with Review of Literature(Hindawi Ltd, 2014) Kara, Medine; Guclu, Oluz; Derekoy, Fevzi Sefa; Resorlu, Mustafa; Adam, GurhanBackground. Congenital absence of the submandibular gland (SMG) is a rare condition. Although complaints such as dry mouth, dental problems, or difficulty in swallowing may be seen, the subjects may also be asymptomatic. The absence of the SMG may be associated with hypertrophy of the contralateral SMG. Case Report. We report the case of a 44-year-old woman with incidentally detected left SMG aplasia, with contralateral SMG hypertrophy mimicking a mass, and the case of a 46-year-old woman with incidentally detected bilateral SMGaplasia, demonstrated by computerized tomography (CT) andmagnetic resonance imaging (MRI). Conclusion. It is important for the clinician to know that this very rare abnormality may exist. When such a case is encountered, symptoms and findings should be reevaluated and, if necessary, conservative therapy should be initiated. The possibility of observing additional deformities should be kept in mind and an evaluation should be done for other cases in the family.Öğe Comparison of Different Treatment Methods for Idiopathic Sudden Sensorineural Hearing Loss(Galenos Publ House, 2018) Toroslu, Tolgahan; Erdogan, Halil; Caglar, Ozge; Guclu, Oguz; Derekoy, Fevzi SefaObjective: To evaluate the effectiveness of different therapies for idiopathic sudden sensorineural hearing loss and prognostic factors, and determine the most successful treatment according to the audiogram type and time from onset to treatment. Methods: A total of 90 cases from February 2009 to January 2015 were classified under Group I oral treatment (methylprednisolone, acyclovir, betahistine-dihydrochloride, and vitamin B12); Group II oral treatment + intratympanic steroids (ITS); Group III oral treatment + hyperbaric oxygen; and Group IV only ITS. A pure tone average (PTA) improvement of less than 10 dB was assessed as noimprovement, a PTA of 10 dB or more or a 10% or more increase in the speech discrimination score (SDS) as partial improvement, and a hearing threshold within 10 dB and SDS within 5%-10% of the unaffected ear as full improvement. Results: Overall, 32.2% patients showed full and 28.9% showed partial improvement, whereas 38.9% showed no improvement. There was no significant difference in terms of mean hearing gain between the different treatment methods. As the degree of hearing loss and time from onset to treatment increased, improvement worsened (p<0.05). Descending audiogram had lower mean hearing gains compared to other groups (p=0.014). There was no significant effect of age, sex, tinnitus and/or vertigo, and systemic disease on treatment success (p>0.05). Conclusion: The most important factors affecting prognosis were the time from onset to treatment, hearing loss severity, and audiogram type. Only ITS avoided side effects and reduced hospitalization. ITS in the first two weeks, followed by hyperbaric oxygen were considered as the treatment priority.Öğe Congenital Hairy Polyp of the Nasopharynx(Derman Medical Publ, 2014) Kara, Medine; Toroslu, Tolgahan; Guclu, Oguz; Derekoy, Fevzi SefaThis study presents a rare congenital nasopharynx lesion in an infant with feeding difficulties and respiratory distress. A two-month old girl with wheezing and difficulty feeding had a pedicular polypoid mass hanging from the nasopharynx posterior to the tongue completely removed. Histopathological investigation of the lesion reported a hairy polyp. Patients with complaints of respiratory distress and feeding difficulties in the early newborn period should be considered for a diagnosis of hairy polyp and diagnosis should include endoscopic examination.Öğe Does the maxillary sinus have a triggering role in nasal nitric oxide synthesis?(Int Rhinologic Soc, 2012) Guclu, Oguz; Uludağ, Ahmet; Alper Akçalı; Tekin, Kazim; Erdogan, Halil; Sılan, Fatma; Derekoy, Fevzi SefaObjectives: We investigated whether the maxillary sinus plays a stimulatory role in nasal nitric oxide (NO) synthesis. Research on sinusitis and nasal polyps has found low NO levels in exhaled air and linked this to obstruction of the ostium. However, the major source of NO in exhaled air is thought to be the nasal mucosa. In this study, Streptococcus pneumoniae was applied to the maxillary sinus to investigate changes in NO synthesis of the nasal mucosa. Methods: An experimental study was performed with New Zealand white rabbits. Three groups, pneumococcus, control and sham, were created. The maxillary sinus of the pneumococcal group was exposed to Streptococcus pneumoniae suspension. Before and after the exposure, bilateral biopsy specimens were taken from the inferior turbinate. Specimens were examined by RT-PCR for expressions of endothelial nitric oxide synthase (e-NOS) and inducible nitric oxide synthase (i-NOS). Physiological saline solution was administered to the maxillary sinus in the control group and biopsies were obtained. The sham group underwent only biopsy. Results: A significant increase in i-NOS expression of tissue samples from the pneumococcal group on the same and opposite sides were detected. There was no increase in e-NOS expression in this group. The control and sham groups had no significant change in i-NOS or e-NOS expression. Conclusion: In the acute period after the maxillary sinus is exposed to a pathogen, i-NOS expression increases in the nasal mucosa, but endothelial NOS expression is not affected. Consequently, a combined response in the maxillary sinus and the nasal mucosa for nitric oxide synthesis is shown in the present study.Öğe Evaluation of nasal airways by objective methods in chronic otitis media(Springer, 2013) Guclu, Oguz; Şahin, Erkan Melih; Tekin, Kazim; Derekoy, Fevzi SefaOtitis media (OM) is a common health problem. Nasal airways play an important role in etiopathogenesis of OM. The aim of this study is to evaluate nasal airways by objective methods in chronic otitis media (COM) cases. The relationship between the course of the disease and nasal parameters is also investigated. Fifty-six patients who had chosen an operation for chronic otitis media were included in the study. The control group was composed of 30 healthy patients. Patients were subjected to acoustic rhinometry and rhinomanometry. Nasal airway resistance and cross-sectional area measurements were taken. The results of the COM group and the control group were compared. Cases were classified by the course of the disease such as suppurative/progressive/active and non-suppurative/inactive and the nasal parameters of these sub-groups were compared. In cases with unilateral COM, nasal cavity results from both sides were compared. The nasal airway resistance of the COM group was statistically significantly higher than the control group (p < 0.05). However, there was no difference in cross-sectional area measurements. There was no significant difference between the suppurative/progressive/active and non-suppurative/inactive groups. However, the suppurative group had higher nasal resistance (p > 0.05). There was no statistical difference between the measurements of each side in unilateral COM cases. This study found that COM cases have greater nasal airway resistance. No significant difference was found in cross-sectional area measurements so the increase in resistance may be linked to mucosal rather than structural changes. There was no evidence for a relationship between the course of the OM and nasal airway parameters.Öğe Evaluation of Sleep Quality in Patients With Nasal Septal Deviation via the Pittsburgh Sleep Quality Index(Lippincott Williams & Wilkins, 2016) Kara, Medine; Erdogan, Halil; Guclu, Oguz; Sahin, Hasan; Derekoy, Fevzi SefaObjective:To investigate the effect of nasal septum deviation, without obstructive sleep apnea, on sleep quality.Methods:The present case-controlled study enrolled patients older than 16 years with nasal septum deviation who attended the Otorhinolaryngology Clinic between December 2013 and July 2014. The control group was selected from patients attending the clinic for another complaint. Sleep quality was evaluated via the Pittsburgh Sleep Quality Index, and differences between the groups were compared using the Mann-Whitney U test.Results:During the study period, 55 patients with nasal septum deviation were included in the study group, and the control group consisted of 51 patients with no complaints of nasal obstruction. Compared with the control group, patients with nasal septum deviation were found to be significantly higher (P<0.05) in all parameters of Pittsburgh Sleep Quality Index.Conclusion:The presence of nasal septum deviation with nasal obstruction should be investigated in patients with sleep disorders. If any pathology is present, opening the nasal passages should be ensured and sleep disorders reevaluated.Öğe Investigation of the effects of chronic hypertrophic adenotonsillitis on olfaction and quality of life(Deomed Publ, Istanbul, 2013) Guclu, Oguz; Yazici, Ibrahim; Toroslu, Tolgahan; Derekoy, Fevzi SefaObjective: To investigate the effects of the chronic hypertrophic adenotonsillitis on olfaction and quality of life. Methods: Pediatric patients, aged 7-8 years, were prospectively included in three groups; Group I-Adenotonsillar diseases (n=15), Group II-Control (n=15) and Group III-Postoperative group (n=15). Patients were evaluated with the Sniffin' Sticks 12 item smell identification test and obstructive sleep disorder-6 (OSD-6) quality of life survey. Results: Total smell identification (SI) scores were 6.93 +/- 1.75 in the adenotonsillar disease, 8.73 +/- 1.10 in the control and 7.67 +/- 1.59 in the postoperative groups, respectively. Total SI score in the adenotonsillar disease group was significantly lower than the control group (p<0.05). The postoperative group SI scores were higher, but not at the level of the control group. Total OSD-6 scores were 18.80 +/- 4.75 for the adenotonsillar disease, 5.20 +/- 2.40 for the control and 5.07 +/- 2.02 for the postoperative groups, respectively. The adenotonsillar disease group score was significantly higher than the scores of the other two groups (p<0.05). Conclusion: Adenotonsillar diseases affect both quality of life and smell function. Six months after surgery quality of life reaches normal standards. Smell function is observed to have partially recovered by the sixth month. This situation may be due to obstructive symptoms resolving in the early postoperative period, while symptoms related to mucosal or inflammatory pathologies recover more slowly.Öğe Prognostic Value of Acoustic Rhinometry and Rhinomanometry in Tympanoplasty Surgery(Aves, 2016) Tekin, Kazim; Kara, Medine; Guclu, Oguz; Erdogan, Halil; Derekoy, Fevzi SefaOBJECTIVE: Chronic otitis media (COM) is a disorder characterized by perforation of the eardrum and hearing loss following chronic inflammation of the middle ear cavity, ossicules, and mastoid cells. Eustachian dysfunction plays an important role in COM etiopathogenesis and postoperative prognosis. The determinants of postoperative prognosis are still being researched. This study aimed to research the prognostic value of acoustic rhinometry (ARM) and rhinomanometry (RMM) in COM surgery in terms of eradication of the infection after operation, graft success, and hearing gain in operated cases. MATERIALS and METHODS: This study included 58 patients who underwent surgery with a diagnosis of COM. Patients were assessed in terms of age, gender, COM type, treatment methods used, eradication of infection, graft success, and hearing gain. ARM and RMM measurements were performed in the preoperative period. ARM and RMM values were statistically compared in terms of the existence of postoperative infection, graft success, and hearing gain. RESULTS: In terms of ARM and RMM measurements, there was no statistically significant difference between cases where postoperative infection control was assured and cases with ongoing infection; successful and failed cases in terms of grafting; or successful and failed cases in terms of postoperative hearing. When preoperative and postoperative air-bone gap averages were compared, statistically significant differences were observed. CONCLUSION: In the presence of a nasal obstruction in cases with chronic otitis, elimination of this situation is the first line of treatment. Infection control, graft success, and improvement of hearing will be possible to a greater extent in the postoperative period for patients with the nasal pathology remedied.Öğe Relationship between Helicobacter pylori Adenotonsillar Colonization and Frequency of Adenotonsillitis in Children(Galenos Publ House, 2013) Guclu, Oguz; Alper Akçalı; Şahin, Erkan Melih; Tekin, Kazim; Barutcu, Ozan; Otkun, Muserref Tatman; Derekoy, Fevzi SefaBackground: There are insufficient data in the literature on the presence of Helicobacter pylori in tonsil and adenoid tissue of patients with only airway obstruction. This study examined the presence of H. pylori in surgical cases with airway obstruction or recurrent infection. Aims: To investigate the relationship between H. pylori adenotonsillar colonisation and the frequency of adenotonsillitis and to compare paediatric and adult patients according to H. pylori tonsillar colonisation. Study Design: Prospective clinical trial. Methods: Patients scheduled for adenoidectomy or tonsillectomy were classified into three groups based on indications: paediatric infection (n=29), paediatric obstruction (n=29) and adult infection (n=12). Tissue samples obtained from patients were examined for the presence of H. pylori by culture, rapid urease test and polymerase chain reaction. Results: Forty-nine tonsil tissues were examined. Positive results were found in two specimens with the rapid urease test (4.1%) and three with polymerase chain reaction examination (6.1%). Only three positive polymerase chain reaction results (5.8%) were identified in 52 adenoid tissue samples. There were no statistically significant differences in the presence of H. pylori between paediatric infection and obstruction groups or between paediatric infection and adult infection groups. Conclusion: In our study, there was a low incidence of H. pylori colonisation in tonsil and adenoid tissues. Regarding H. pylori colonisation, there was no significant difference between paediatric infection and obstruction groups. Also, no significant difference was found between adult and paediatric cases.Öğe Sclerotic effect of bleomycin on the submandibular gland: An experimental model(Elsevier Ireland Ltd, 2013) Guclu, Oguz; Muratli, Asli; Arik, Deniz; Tekin, Kazim; Erdogan, Halil; Derekoy, Fevzi SefaObjectives: To evaluate the sclerotic effect of bleomycin on the submandibular gland histopathologically and assess it as a possible alternative therapy for sialorrhea. Methods: An experimental model was designed and 18 New Zealand white rabbits were used. The rabbits were divided into two groups: a bleomycin group (n = 9) and a sham group (n = 9). The submandibular glands of the bleomycin group were injected with 0.3 ml bleomycin (3 mg/ml) while the sham group received 0.3 ml saline. Four weeks after the procedure, the glands were removed. Histopathological studies including hematoxylin-eosin and Masson's trichrome stain were carried out. The glands were evaluated for tissue inflammation, fibrosis, edema, lipomatosis, atrophy and congestion. To investigate apoptosis, terminal deoxynucleotidyl transferase (TdT)-mediated digoxigenin-11-dUTP nick-end labeling (TUNEL) immunohistochemical staining was used. Results: In the group injected with bleomycin, inflammation (n = 8), edema (n = 4), fibrosis (n = 3), congestion (n = 4) and lipomatosis (n = 7) were observed. In the sham group, only lipomatosis was observed. The TUNEL assay results were 5.06 +/- 1.18 (p < 0.05) for acinar cells and 8.46 +/- 0.82 (p < 0.05) for ductal cells in the bleomycin group. This was significantly different from the results in the sham group. Conclusions: Apoptosis, inflammation, fibrosis, edema, lipomatosis and congestion were observed in the ductal and acinar cells of the bleomycin group. Bleomycin may be an alternative treatment for sialorrhea cases. However, more research is needed. (C) 2013 Elsevier Ireland Ltd. All rights reserved.Öğe Sclerotic effect of oxytetracycline on the submandibular gland: An experimental model(Vendome Group Llc, 2016) Guclu, Oguz; Muratli, Asli; Arik, Deniz; Tekin, Kazim; Erdogan, Halil; Derekoy, Fevzi SefaOxytetracycline has been suggested as an alternate therapy for chronic recurrent sialadenitis and sialorrhea. We conducted an experimental study to investigate the sclerotic effect of this drug on the submandibular gland by histopathologic methods. Our subjects were 20 New Zealand white rabbits, which were divided into two groups of 10. The right submandibular gland of the rabbits in the active treatment group was injected with 0.3 ml of oxytetracycline (100 mg/ml), and that of the controls was injected with saline. Four weeks after the injections, all the glands were removed. Histopathologic studies, including hematoxylin and eosin and Masson trichrome staining, were carried out. The glands were evaluated for tissue inflammation, congestion, fibrosis, edema, lipomatosis, and atrophy. To investigate apoptosis, terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick-end labeling (TUNEL) immunohistochemical staining was used. In the study group, inflammation (n = 9), congestion (n = 9), fibrosis (n = 6), edema (n = 6), and lipomatosis (n = 4) were observed; in the sham group, only lipomatosis was seen (n = 5). The TUNEL assay results for acinar cells were 4.51 +/- 1.41% in the oxytetracycline group and 2.08 +/- 1.76% in the control group (p = 0.006); the corresponding figures for the duct cells were 7.05 +/- 0.87% and 3.10 +/- 2.26% (p = 0.001). Based on our findings, we conclude that oxytetracycline might be a viable alternative for the treatment of chronic recurrent sialadenitis and sialorrhea. However, more research in this area is needed.Öğe Silent Petrous Apicitis(Mediterranean Soc Otology & Audiology, 2012) Guclu, Oguz; Karatag, Ozan; Tufan, Hasan Ali; Kosar, Sule; Derekoy, Fevzi SefaGradenigo syndrome is a quite rare complication of otitis media. Typical presentation of this syndrome includes sixth cranial nerve paralysis/paresis, acute or chronic otitis media, and trigeminal neuralgia. In this study, we report on a six-year-old child with incomplete Gradenigo syndrome consisting of petrous apicitis and abducent nerve paralysis without otitis media symptoms and trigeminal neuralgia.Öğe Sudden Hearing Loss after Rabies Vaccination(Galenos Publ House, 2013) Guclu, Oguz; Derekoy, Fevzi SefaBackground: Sudden hearing loss developing after immunisation is a very rare situation. Rabies is a viral disease characterised by encephalitis and death. Treatment involves active and passive immunisation. Neurologic complications including Guillain-Barre syndrome or facial paralysis are reported in the literature as a side effect after rabies immunisation. Case Report: Sudden hearing loss was detected in an 11 year-old male patient who had taken the medication for rabies immunisation. Conclusion: This study presents a case report of sudden hearing loss developing after rabies immunisation - no other aetiological factors were detected and clinical management is discussed in light of the literature.Öğe Tegmen height: preoperative value of CT on preventing dural complications in chronic otitis media surgery(Elsevier Science Inc, 2014) Karatag, Ozan; Guclu, Oguz; Kosar, Sule; Derekoy, Fevzi SefaObjective: The objective was to examine tegmen height in patients with iatrogenic dural exposure in chronic otitis media (COM) surgery. Methods: Computed tomographic (CT) scans of 50 patients who underwent COM surgery were retrospectively examined. Twelve patients with dural exposure were admitted to the dura group. The control group of 38 patients had no dural exposure. Tegmen heights in both groups were compared. Results: There was no statistically significant difference between opposite ears (P>.05). Significant difference was found in tegmen height between healthy and operated ears in unilateral COM patients (P=.001). Conclusion: Preoperative CT assessment of tegmen height is an important parameter in assessing risk of exposing dura during surgery. (C) 2014 Elsevier Inc. All rights reserved.Öğe The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma(Springer, 2017) Kara, Medine; Uysal, Sema; Altinisik, Ugur; Cevizci, Sibel; Guclu, Oguz; Derekoy, Fevzi SefaThe aim of this study was to identify the potential prognostic roles of the preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red cell distribution width (RDW) in patients with laryngeal squamous cell carcinoma (LSCC). 81 patients who underwent surgery for the larynx carcinoma were enrolled in the study. NLR, PLR and RDW were used as outcome measures. Local recurrence was detected in 30 (37.0 %) patients and neck lymph node metastasis was detected 6 (7.4 %) patients during follow-up period. Mortality was seen in 7 (8.6 %) patients. The mean PLR in the T1 and T2 stage tumors were significantly lower than the T4 stage. The mean RDW and PLR were significantly higher in the exitus group than the survivor group. The mean NLR in the patients with local recurrence was significantly higher than the non-recurrent patients. Progression-free survival (PFS) was lower in patients with high NLR. When analyzed by the Cox regression analysis of factors affecting the local recurrence, NLR was found to significantly affect the recurrence. According to ROC analysis for mortality, NLR was not found to be a prognostic factor, although the PLR and RDW were significant prognostic factors. According to Cox regression analysis, a high PLR increases mortality 4.2 times and a high RDW 4.6 times. Although in univariate analysis MCV, RDW and tumor grade were predictors of mortality, RDW and tumor grade independent predictors were found. Further studies involving large patient groups are required.
