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    Öğe
    Electrochemical Investigation of Isoniazid on Poly (p-Aminobenzene Sulfonic Acid) Film Modified Glassy Carbon Electrode
    (Esg, 2015) Demirbilek, Esra; Saglikoglu, Gulsen; Yilmaz, Selehattin
    Isoniazid is a tuberculostatic agent effective active compound. A glassy carbon electrode (GCE) was modified with an electropolymerized film of p-aminobenzene sulfonic acid (p-ABSA) in phosphate buffer solution (PBS). The electrochemical properties of isoniazid on modified electrode were studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The polymer film-modified electrode was used to electrochemically detect isoniazid. The polymer film had excellent electrocatalytic activity for the oxidation of isoniazid. A linear calibration curve for DPV analysis was constructed in the isoniazid concentration range 2x10(-5) - 1x10(-4) mol L-1. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 3.05x10(-6) and 1.01x10(-5) mol L-1 respectively. Isoniazid was determined in tablet dosage form. The proposed method exhibits good recovery and reproducibility. The mechanisms of electropolymerization were also suggested.
  • [ X ]
    Öğe
    Electrochemical investigation of isoniazid on poly (p-aminobenzene sulfonic acid) film modified glassy carbon electrode
    (Electrochemical Science Group, 2014) Demirbilek, Esra; Saglikoglu, Gulsen; Yilmaz, Selehattin
    Isoniazid is a tuberculostatic agent effective active compound. A glassy carbon electrode (GCE) was modified with an electropolymerized film of p-aminobenzene sulfonic acid (p-ABSA) in phosphate buffer solution (PBS). The electrochemical properties of isoniazid on modified electrode were studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The polymer film-modified electrode was used to electrochemically detect isoniazid. The polymer film had excellent electrocatalytic activity for the oxidation of isoniazid. A linear calibration curve for DPV analysis was constructed in the isoniazid concentration range 2x10-5- 1x10-4 mol L-1. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 3.05x10-6 and 1.01x10-5 mol L-1 respectively. Isoniazid was determined in tablet dosage form. The proposed method exhibits good recovery and reproducibility. The mechanisms of electropolymerization were also suggested. © 2015 The Authors.
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    Öğe
    İsoniazid' in poli(P-aminobenzen sülfonik asit)-modifiye camsı karbon elektrotta ilaç dozaj formlarından miktarının belirlenmesi
    (Çanakkale Onsekiz Mart Üniversitesi, 2014) Demirbilek, Esra; Yılmaz, Selehattin
    Bu çalışmada, isoniazid adlı etken maddenin, elektrokimyasal yükseltgenme özelliğinden faydalanarak modifiye camsı karbon elektrotta, ticari formundan miktarı belirlendi. Optimum şartları belirlemek için, farklı destek elektrolitlerde diferansiyel puls voltametrisi ve dönüşümlü voltametri ile yükseltgenme özelliği incelendi. Camsı karbon elektrot, elektropolimerizasyon tekniği kullanılarak p-aminobenzensülfonik asit ile modifiye edildi. İsoniazid için modifiye camsı karbon elektrotta keskin pikin ve maksimum akımın gözlendiği pH=9,00 BRT çözeltisi, destek elektrolit olarak seçildi. İsoniazid'in pik akımına ve pik potansiyeline pH' ın etkisi diferansiyel puls voltametri tekniği (DPV) ve tarama hızının pik akımına etkisi ise dönüşümlü voltametri tekniği (CV) ile incelendi. Kantitatif tayin sınırı (LOQ), belirme sınırı (LOD) ve konsantrasyon aralığı gibi analitik parametreler belirlendikten sonra ilaç tabletlerindeki isoniazid miktarı belirlendi. Uygulanan voltametrik yöntemin, doğruluk ve kesinliğini kontrol etmek amacı ile ilaç tabletinden isoniazid'in geri kazanım çalışmaları yapıldı. Ayrıca isoniazid'in yükseltgenme mekanizması önerildi. Anahtar Kelimeler: İsoniazid, Voltametrik Yöntem, Diferansiyel Puls Voltametrisi (DPV), Dönüşümlü Voltametri (CV), Modifiye Camsı Karbon Elektrot, Ticari İlaç Tabletleri.