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    The Levels of Serum Mg, NO and IMA in Chronic Kidney Disease
    (2020) Bakırdöğen, Serkan; Demir, Sabire Ceren; Türkon, Hakan; Çakir, Dilek Ülker; Tok, Burak
    NTRODUCTION: In chronic kidney disease (CKD) patients, serum levels of ischemia-modified albumin (IMA), are found to be higher compared to the normal population. As oxidative stress increases, nitric oxide (NO) production reduces linked to endothelial dysfunction. Magnesium (Mg) increases NO production by endothelium. The aim of the study was to compare serum IMA, NO, and Mg levels in patients with CKD (stage 1-4).METHODS: The study included 29 CKD patients with stage 1-4. Additionally, a control group comprised 40 healthy volunteers. Serum IMA, NO, and Mg testing was performed in both groups. Serum Mg was analyzed with the colorimetric method, IMA was analyzed with the rapid colorimetric method, while NO was analyzed with ELISA. Statistical significance was accepted as p < 0.05.RESULTS: Serum IMA levels were significantly higher in the patient group than in the control group. (p=0.023), while there were no differences between the groups in terms of serum NO and Mg (p>0.05). In the patient group a statistically significant and positive correlation was identified betweenserum IMA and NO (p=0.023, r=0.421). There was no statistically significant correlation between serum IMA and Mg (p=0.96). There was a statistically significant and negative correlation between serum NO and Mg (p=0.02, r=-0.43).DISCUSSION AND CONCLUSION:Examination of the serum NO and Mg levels in CKD patients (stage 1-4) was not found to be beneficial to predict oxidative stress.