Yazar "Demir, N." seçeneğine göre listele

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    Öğe
    DFT Calculation, Molecular Docking, Biological Activity, and Crystal Structure of (E)-2-((4-tert-Butylbenzylimino)Methyl)-4-Methoxy-Phenol
    (Pleiades Publishing Inc, 2019) Zeyrek, C. T.; Tumer, Y.; Kiraz, A.; Demir, N.; Yapar, G.; Boyacioglu, B.; Yildiz, M.
    (E)-2-((4-tert-butylbenzylimino)methyl)-4-methoxyphenol is synthesized by the reaction of 4-tert-buthylbenzylamine with 5-methoxysalicylaldehyde. The structure of the Schiff base is investigated by FT-IR, UV-visible, and H-1 NMR, C-13 NMR, and X-ray data. Moreover, the molecular structure, molecular electrostatic potential surfaces (MEP), frontier molecular orbitals, and nonlinear optical properties (NLO) are also investigated by density functional theory (DFT) calculations. The experimental and calculated results show that the phenol-imine form of the compound is more favoured than the keto-amine form. The most energy favourable docked structures are obtained from the rigid molecular docking of the compound with DNA. The compound binds at the active site of DNA proteins by weak non-covalent interactions. UV-Vis spectroscopy studies of the interactions between the compounds and calf thymus DNA (CT-DNA) show that the compounds interact with CT-DNA via the electrostatic and intercalative binding. The compound inhibits the frameshift and base pair mutations in the absence of S9 mix with a high inhibition rate. Also, the molecular docking is made to identify the interaction between the ligand and DNA.
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    Öğe
    DNA binding, DNA cleavage, antimicrobial activities, antimutagenic and anticancer studies of a Schiff base and its complexes
    (Wiley-Blackwell, 2016) Yildirim, N.; Demir, N.; Yildiz, M.
    [Anstract Not Available]
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    Öğe
    Synthesis and spectral, antimicrobial, anion sensing, and DNA binding properties of Schiff base podands and their metal complexes
    (Maik Nauka/Interperiodica/Springer, 2015) Yildiz, M.; Tan, E.; Demir, N.; Yildirim, N.; Unver, H.; Kiraz, A.; Mestav, B.
    Schiff base podands have been synthesized by reaction of triethylene glycol bis(4-aminophenyl) ether with salicylaldehyde, 5-substituted salicylaldehydes, and 2-hydroxy-1-naphthaldehyde. Manganese(II), iron(II), cobalt(II), nickel(II), and copper(II) complexes have been prepared from the salicylaldehyde-based podand via reaction with MCl2 center dot nH(2)O. The structures of the ligands and complexes have been studied by elemental analysis, FT-IR and UV-visible spectroscopy, H-1 and C-13 NMR, and thermogravimetric analysis. The UV-visible spectral and TG data suggest tetrahedral geometry of the metal complexes. The antimicrobial activities of the ligands and metal complexes have been evaluated as minimum inhibitory concentrations with respect to bacteria and yeast cultures. The interaction of the Schiff base podands with calf thymus DNA has been investigated by UV-visible spectroscopy, and intercalative binding to DNA has been found. The anion recognition ability of all Schiff base podands has been examined by UV-visible spectroscopy. A visually detectable color change has been observed upon addition of fluoride, cyanide, hydroxide, and acetate ions due to formation of 1: 1 H-complexes and/or deprotonation of the receptor. No significant color change has been observed upon addition of other anions such as dihydrogen phosphate, bromide, iodide, thiocyanate, perchlorate, and hydrogen sulfate.
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    Öğe
    Synthesis, antimicrobial activity, genotoxicity, DNA binding and DNA cleavage studies of new glycine methyl ester derivative Schiff base
    (Wiley-Blackwell, 2016) Yildirim, M. A.; Demir, N.; Yildiz, M.; Unver, H.
    [Anstract Not Available]