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    EFFECTS OF CYP2C19 AND P2Y12 GENE POLYMORPHISMS ON CLINICAL RESULTS OF PATIENTS USING CLOPIDOGREL AFTER ACUTE ISCHEMIC CEREBROVASCULAR DISEASE
    (Macedonian Acad Sciences Arts, 2014) Sen, H. M.; Sılan, Fatma; Sılan, Coşkun; Degirmenci, Y.; Kamaran, Ozisik H., I
    The CY2C19 and P2Y12 gene polymorphisms are responsible for resistance to clopidogrel, known as drug unresponsiveness. In this study we researched the effect of gene polymorphism on clinical results of patients who began clopidogrel therapy after acute ischemic cerebrovascular disease. The study included 51 patients. The patient group included patients who had begun prophylactic clopidogrel due to acute ischemic cerebrovascular disease in the last 2 years. All patients were monitored by the Neurology Outpatient Clinic at Canakkale Onsekiz Mart University Research Hospital, Canakkale, Turkey, and only those monitored for at least 1 year were included in the study. When the *1, *2 and *3 alleles of the CYP2C19 gene polymorphism were evaluated, two patients were homozygotes for *2/*2, 13 patients were heterozygous for *1/*2 and 36 patients were homozygotes for the wild type *1/*1. No patient had the *3 allele. Three heterozygous patients, one for *2/*2 and two for *1/*2, stopped clopidogrel therapy due to repeated strokes and began taking warfarin. When evaluating P2Y12 52 (G>T) and 34 (C>T) polymorphisms, all alleles were of the wild type. The CYP2C19 and P2Y12 gene polymorphisms may cause recurring strokes linked to insufficient response to treatment of ischemic cerebrovascular disease. In our patient group, three patients suffered repeated strokes and these patients had the CYP2C19*2 gene polymorphism. As a result, before medication use, genetic testing is important for human life, quality of life and economic burden.
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    Electrophysiological changes in iron deficiency anemia
    (Univ Zagreb, School Medicine, Zagreb Univ Hospital Center,, 2011) Degirmenci, Y.; Kececi, H.
    Iron deficiency anemia (IDA) is the most common nutritional problem worldwide. Owing to the role of iron in brain energy metabolism, neurotransmitter function and myelin formation, IDA may lead to behavioral, developmental and cognitive dysfunctions. Iron is an essential element and has an important role in several metabolic and enzymatic processes including NADPH reductase activity and cytochrome oxidase system. Our aim was to investigate the electrophysiological effects of IDA on the peripheral nervous system, and to evaluate whether or not the possible electrophysiological abnormalities are reversible with appropriate doses of iron therapy. Electrophysiological evaluations were performed in 52 patients with newly diagnosed IDA and 30 age-matched healthy controls. Electrophysiological evaluations were repeated after 3 months of oral iron therapy. Normal electrophysiological findings were recorded in 38 (73.07%) patients, while 4 (7.69%) patients had polyneuropathy (PNP) and 10 (19.24%) had carpal tunnel syndrome (CTS) findings. Except for one patient with PNP and CTS findings each, the electrophysiological findings of all patients were found to have returned to normal ranges after 3 months of oral iron therapy. Detection of iron responsive neuropathic processes (PNP and CTS) in IDA patients suggested that IDA may cause peripheral nervous system involvement. It is important to emphasize the examinations for IDA as an etiologic factor on planning treatment for neuropathy patients. In cases where IDA is present, it would be beneficial to treat IDA with iron before applying other treatment options for neuropathy.
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    EPILEPSY AMONG THE STUDENTS OF CANAKKALE ONSEKIZ MART UNIVERSITY
    (Wiley-Blackwell, 2012) Karaman, H. I. Ozisik; Bakar, C.; Degirmenci, Y.
    [Anstract Not Available]
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    PERCEPTIONS OF EPILEPSY IN TURKEY, VIEWED IN THE LIGHT OF TWO DIFFERENT CITIES FROM WEST TO EAST
    (Wiley-Blackwell, 2011) Degirmenci, Y.; Kabay, Canbaz S.; Yilmaz, Z.; Bakar, C.; Karaman, Ozisik H., I
    [Anstract Not Available]
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    Thoracic vertebra and rib destruction: What if not cancer?
    (2012) Alar, T.; Kosar, S.; Degirmenci, Y.; Alkan, B.; Cosar, M.
    An 18-year-old female presented at our hospital with complaints of fatigue for the last 4-5 months, together with numbness and weakness in both lower extremities in the last month. Neurological examination revealed hypoesthesia in the lower right extremity, paraparesis of bilateral lower extremities, a hyperactive deep tendon reflex (DTR) and positive bilateral Babinski sign. The radiology examinations showed septated multiple cystic lesions, with the largest 36x28 mm, destructing the proximal 3rd rib together with the 3 rdthoracic vertebra body, extending to the lower level of 7 th cervical vertebra in the subdural region and compressing the spinal cord. The patient was taken to surgery immediately and the described cystic lesions were removed without being ruptured, together with corpectomy to T3 vertebra and partial resection of the third rib. Posterior transpedicular fusion was performed to the T2-6 spaces. There was no peroperative or postoperative complication. Histopathological examination of the material revealed "hydatid cyst". The patient was followed-up on 10 mg/kg albendazole treatment. Postoperative follow-ups at 1, 2 and 3 months revealed normal function tests and no motor deficit or pathological reflex besides DTR hyperactivity.