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Öğe Do 100-and 500-?T ELF magnetic fields alter beta-amyloid protein, protein carbonyl and malondialdehyde in rat brains?(Taylor & Francis Inc, 2013) Akdag, Mehmet Zulkuf; Dasdag, Suleyman; Cakir, Dilek Ulker; Yokus, Beran; Kizil, Goksel; Kizil, MuratSeveral studies still state that presently accepted safety standards for extremely low-frequency magnetic fields (ELF-MFs) do not provide adequate protection, and therefore the standards are still open to question. To help resolve this question, the aim of this study was to illuminate the interaction between biomolecules and ELF-MFs by investigating the effect of ELF-MFs on beta-amyloid protein (BAP), protein carbonyl (PC) and malondialdehyde (MDA) in rat brain. For this study, 30 adult male Sprague-Dawley rats were used, which were divided into two experimental groups and a sham exposed group. Rats in two experimental groups were exposed to 100- and 500-mu T ELF-MFs (50 Hz) for 2 h/day for 10 months, which are the generally accepted safety standards for public and occupational exposures. The same procedures were applied to the rats in the sham group, but with the generator turned off. The results of this study showed that neither ELF-MFs used in this study altered BAP level significantly (p > 0.05). However, PC and MDA levels were increased by the exposure to 100- and 500-mu T ELF-MFs (p < 0.0001). In conclusion, both PC and MDA levels were altered by long-term exposure to either 100 or 500 mu T ELF-MF. However, many further and more comprehensive studies will be required to elucidate the interaction mechanisms between ELF-MFs exposure and living organisms.Öğe Effect of 900 MHz radio frequency radiation on beta amyloid protein, protein carbonyl, and malondialdehyde in the brain(2012) Dasdag, Suleyman; Akdag, Mehmet Zulkuf; Kizil, Goksel; Kizil, Murat; Cakir, Dilek Ulker; Yokus, BeranRecently, many studies have been carried out in relation to 900 MHz radiofrequency radiation (RF) emitted from a mobile phone on the brain. However, there is little data concerning possible mechanisms between long-term exposure of RF radiation and biomolecules in brain. Therefore, we aimed to investigate long-term effects of 900 MHz radiofrequency radiation on beta amyloid protein, protein carbonyl, and malondialdehyde in the rat brain. The study was carried out on 17 Wistar Albino adult male rats. The rat heads in a carousel were exposed to 900 MHz radiofrequency radiation emitted from a generator, simulating mobile phones. For the study group (n: 10), rats were exposed to the radiation 2 h per day (7 days a week) for 10 months. For the sham group (n: 7), rats were placed into the carousel and the same procedure was applied except that the generator was turned off. In this study, rats were euthanized after 10 months of exposure and their brains were removed. Beta amyloid protein, protein carbonyl, and malondialdehyde levels were found to be higher in the brain of rats exposed to 900 MHz radiofrequency radiation. However, only the increase of protein carbonyl in the brain of rats exposed to 900 MHz radiofrequency radiation was found to be statistically significant (p < 0.001).In conclusion, 900 MHz radiation emitted from mobile/cellular phones can be an agent to alter some biomolecules such as protein. However, further studies are necessary. © Informa Healthcare USA, Inc.Öğe Effects of Extremely Low Frequency Magnetic Fields on Periodontal Tissues and Teeth in Rats(Medwell Online, 2011) Kaya, Filiz Acun; Akdag, Mehmet Zulkuf; Kaya, Can Ayhan; Dasdag, Suleyman; Yavuz, Izzet; Kilinc, Nihal; Dogru, Arzum GulerThe aim of this study is to research the effects of ELF magnetic fields on periodontal tissues and teeth in rats histopathologically. The experiments were performed on 27 male Sprague-Dawley rats, aged 4 months at the beginning of the study, weighing (342.4 +/- 38.89) g and fed with standard pelleted food. The rats were divided into three groups; two experimental and one control (sham). Experimental groups were exposed to 100 and 500 mu T ELF magnetic fields during 10 months, 2 h a day, respectively. Third group was sham that were treated like experimental group except ELF magnetic fields exposure in methacrylate boxes. There was no statistical difference between the experimental groups among all tissues (p>0.05). Alveolar bone, pulp and gingiva there were statistically significant differences among the groups of sham and 1st experimental, sham and 2nd experimental (p<0.05). The statistical difference between the experimental and sham groups in the study makes us to think that ELF magnetic fields may have effects on periodontal tissues and teeth.Öğe Effects of Radiofrequency Radiation by 900 MHz Mobile Phone on Periodontal Tissues and Teeth in Rats(Medwell Online, 2008) Kaya, Filiz Acun; Dasdag, Suleyman; Kaya, Can Ayhan; Akdag, Mehmet Zulkuf; Yavuz, Izzet; Kilinc, Nihal; Kaya, SadullahThe aim of this study, is to research an answer to the question of have mobile phones effects on periodontal tissues and teeth. Twenty eight Wistar Albino adult male rats (4 months) with initial average weight of 267 +/- 15 g were obtained from the Medical Science Application and Research Center, caged individually and fed with standard pelletted food (TAVAS Inc. Adana, TR). They were separated into three groups such as cage control (n = 7), sham exposed (n = 7) and experimental (n = 14) and kept on a 14/10 h light/dark schedule. The rats were confined in a Plexiglas carousel and rat heads in the carousel exposed to 900 MHz microwave exposure emitted from generator. For the study group, rats exposed to the radiation 2 h per day (7 days in a week) for 10 months. Although, there was no statistical difference determined among the groups of experimental and sham groups (p>0.05), there were numerically more individuals effected of RF radiation in the experimental group. In our study is the statistically significant difference among the groups of experimental, sham and control groups in the case of vasodilatation in periodontal ligament and alveolar bone (p<0.05). By the histopathologic evaluation abnormal changes like vasodilatation and focal bleeding areas were determined in periodontal ligament, alveolar bone, gingiva and pulpa among some individuals. These degenerations were in different levels. These findings of our study indicates that there is need to more animal, human being and epidemiologic studies including much more individuals.Öğe Extremely low frequency magnetic fields cause oxidative DNA damage in rats(Taylor & Francis Ltd, 2008) Yokus, Beran; Akdag, M. Zulkuf; Dasdag, Suleyman; Cakir, Dilek Ulker; Kizil, MuratPurpose: To detect the genotoxic effects of extremely low frequency (ELF) -magnetic fields (MF) on oxidative DNA base modifications [8-hydroxyguanine (8-OH-Gua), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) and 4,6-diamino-5-formamidopyrimidine (FapyAde)] in rat leucocytes, measured following exposure to ELF-MF. Materials and methods: After exposure to ELF-MF (50Hz, 100 and 500 mu T, for 2 hours/day during 10 months), DNA was extracted, and measurement of DNA lesions was achieved by gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS). Results: Levels of FapyAde, FapyGua and 8OHdG in DNA were increased by both 100 mu T and 500 mu T ELF-MF as compared to a cage-control and a sham group; however, statistical significance was observed only in the group exposed to 100 mu T. Conclusion: This is the first study to report that ELF-MF exposure generates oxidatively induced DNA base modifications which are mutagenic in mammalian cells, such as FapyGua, FapyAde and 8-OH-Gua, invivo. This may explain previous studies showing DNA damage and genomic instability. These findings support the hypothesis that chronic exposure to 50-Hz MF may be potentially genotoxic. However, the intensity of ELF-MF has an important influence on the extent of DNA damage.
