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Investigation of the Synthesis, Antioxidant, DNA Binding and DNA Cleavage Properties of Sodium 2-((2-hydroxy-5-methylphenylimino) methyl) benzenesulfonate
(The International Society for Technology Education and Science, 2022) Duman, Merve; Demir, Neslihan; Yıldız, Mustafa; Dalgiç, Büşra
Sulfonate is known as a salt or ester of a sulfonic acid. It contains the sulfonate functional group R-SO-3. They are stable in water, non-oxidizing and colorless. The interaction of sodium-2-formylbenzenesulfonate with 2-amino-4-methyl-phenol produced 2-((2-hydroxy-5-methylphenylimino) methyl) benzenesulfonate in this investigation. Nuclear Magnetic Resonance spectroscopy (NMR), Fourier Transform Infrared (FTIR) Spectroscopy, Ultraviolet visible spectroscopy (UV-Vis) and Mass Spectroscopy (MS) techniques were used to identify the properties of the compound. The antimicrobial activity of the schiff base was tested using the Minimum Inhibitor Concentration (MIC) method. The reaction of the compound with for DNA were identified by DNA Cleavage and DNA Binding methods. The compound was observed to reaction electrostatically with Calf Thymus-DNA (CT-DNA) and further cleaved it hydrolytic and oxidative. The antioxidant activity of the synthesized base was examined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) technique. It has been determined that as the concentration of the chemical increases, so does its antioxidant activity. © CRES 2022.All rights reserved.