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Öğe Anatomy, morphology, palynology and antimicrobial activity of Amsonia orientalis Decne. (Apocynaceae) growing in Turkey(2006) Akyalçin, Hanife; Özen, Fazil; Dülger, BaşaranIn this study, anatomy, morphology, palynology and antimicrobial activity of Amsonia orientalis Decne., which is distributed only three localities in Turkey and evaluated as critically endangered according to IUCN categories, have been investigated. Leaf and stem sections were investigated anatomically. The leaf has a thick cuticula layer. The inflorecense, the leaf and floral morphology were studied morphologically. The inflorescence is corymbose, leaves have an alternate order and almost without petiols. The pollen grains are trizonoporate and the ornamentation is psilate. Leaves are glabrous except for margin and midrib, pubescent when young. The extras obtained from the plant have strong antimicrobial activity against the tested microorganism used in this study. © 2006 Asian Network for Scientific Information.Öğe ANTIMICROBIAL ACTIVITY OF THE LEAVES OF Ballota acetabulosa ON MICROORGANISMS ISOLATED FROM URINARY TRACT INFECTIONS(2012) Dülger, Başaran; Dülger, GörkemBallota acetabulosa (L.) Bentham (Lamiaceae) yapraklarından elde edilen metanol ekstrelerinin, komplike idrar yolu enfeksiyonları oluşturan (Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis ve Candida albicans) patojenlere karşı antimikrobiyal aktiviteleri disk difuzyon ve mikrodiliisyon metotları kullanılarak araştırılmıştır. Test mikroorganizmalarının duyarlılığını belirlemede, bazı antibakteriyal ve antıfungal referans antibiyotikler pozitif kontrol olarak kullanılmıştır. Ekstraktlar, Escherichia coli bakterisine karşı 18.6 mm inhibisyon zonu, 32(64) ,ag/mL MIC ve MBC değeri oluşturarak giiçlii antimikrobiyal aktivite göstermiştir. Buna ilaveten, ekstraktlar diğer test mikroorganizmalarına karşı ise orta derecede bir aktivite oluşturmuşlardır. Bulgular, Ballota acetabulosa yapraklarının metanol ekstratları belirli bir aktiviteye sahip olduğunu, enfeksiyonların tedavisinde yararlı olabileceğini göstermiştir.Öğe Antimicrobial activity of Turkish Citrus peel oils(2009) Gülay Kirbaşlar, F.; Tavman, Aydin; Dülger, Başaran; Türker, GülenThe samples of the Citrus fruits viz., lemon (Citrus limon (L.) Burm. f.), grapefruit (Citrus paradisi Macfayden), bergamot (Citrus bergamia Risso et Poit.), bitter orange (Citrus aurantium L.), sweet orange (Citrus sinensis (L.) Osbeck), mandarin (Citrus reticulata Blanco) were collected from southern Turkey (Antalya) in November 2006 and their peel oils were obtained by cold-pressing process. The antimicrobial activities of Turkish Citrus peel oils were evaluated using the disk diffusion method toward 9 bacteria and the results compared with those for penicilling, ampicillin, cefotaxime, vancomycine, oflaxacin and tetracycline. Antifungal activities were reported for Kluyveromyces fragilis, Rhodotorula rubra, Candida albicans, Hanseniaspora guilliermondii and Debaryomyces hansenii yeasts, and the results were referenced against nystatin, ketaconazole and clotrimazole antifungal agents. The Citrus peel oils showed strong antimicrobial activity against the test organisms. Lemon and bergamot peel oils have a little higher activity than the other Citrus peel oils.Öğe Bozcaada (Çanakkale) miksomisetleri(2006) Dülger, Başaran; Ergül, C. Cem; Süerdem, Tülay Bican; Oran, Raşit BaturBu çalışma 2003-2004 yılları arasında Bozcaada’dan (Çanakkale) tespit edilen miksomiset örneklerine dayanarak yapılmıştır. Arazi çalışmasında hem doğal örnekler hem de ağaç, kabuk ve döküntü materyalleri toplanmıştır. Kabuk-döküntü materyalleri laboratuarda nem odası tekniğine tabi tutulmuştur. Laboratuarda üretilen ve doğal olarak bulunan miksomisetler üzerinde yapılan çalışmalar sonucu 4 familyaya ait 12 takson belirlenmiştir. Bunlardan Arcyria oerstedtii Türkiye miksobiyotası için yeni kayıttır.Öğe Chemical composition, antioxidant, antimicrobial and anticancer activities of endemic Cephalaria tuteliana(Elsevier, 2024) Kılıçcıoğlu, İlker; Dülger, Görkem; Şentürk, Fatih; Bozyel, Mustafa Eray; Canlı, Kerem; Dülger, BaşaranIntroduction The genus Cephalaria, belonging to the Caprifoliaceae family, is a rich source of secondary metabolites, including mainly saponins which display a variety of biological activities, such as antimicrobial, antioxidant, and anticancerous effects. This study was carried out to observe the biochemical composition and to evaluate the biological activities of Cephalaria tuteliana Kus & Gokturk. Methods The composition of endemic C. tuteliana was determined through gas chromatography-mass spectrometry (GC–MS) studies. Antimicrobial effect were determined by the disk diffusion and dilution methods for test bacteria and test fungi. The antioxidant potential of the ethanol extract was also investigated. Cell proliferation and apoptosis analysis were investigated by WST-1 and ELISA methods. The migration level of PC-3 prostate cancer cells after plant extract application was examined by wound healing assay. Also, molecular docking experiments were performed to investigate the anticancer activity of the major component found in the C.tuteliana extract. Results GC–MS analysis showed that the predominant compounds were Phenol, 2,2′-methylenebis [6-(1,1dimethyl ethyl)-4-methyl- (23.54 %), 9,12,15-octadecatrien-1-ol, (Z,Z,Z)-(6.06 %) and n-Hexadecanoic acid (3.03 %). The ethanolic extract of C. tuteliana displayed moderate antimicrobial activity against a spectrum of tested microorganisms. Also, it exhibited significant antiproliferative effects on PC-3 human prostate cancer cells while having no harmful effects on healthy control HUVEC cells. Furthermore, enhanced expressions of Caspase-3, 8, and 9 were observed in PC-3 cells after plant extract treatment. Also, cell migration level was notably reduced, especially at a dose of 400 µg/mL in PC-3 cells. The DPPH free radical scavenging activity of ethanolic extracts of C. tuteliana showed higher activity than ascorbic acid. Molecular docking experiments showed potential binding of the major aromatic compound in C.tuteliana extract to human androgen receptor 1E3G protein. Conclusion These findings highlight the potential of C. tuteliana as a valuable natural resource and pave the way for further in vivo prostate cancer investigations.Öğe COLL 490-Colloidal p(4-VP) particles and composites for biomedical application(Amer Chemical Soc, 2009) Özay, Özgür; Aktaş, Nahit; Dülger, Başaran; Sılan, Coşkun; John, Vijay T.; Şahiner, Nurettin[Anstract Not Available]Öğe Spectroscopic studies, antimicrobial activities, and crystal structure of N-[2-hydroxy-1-naphthylidene]3,5-bis(trifluoromethyl)aniline(Springer/Plenum Publishers, 2006) Ünver, Hüseyin; Yıldız, Mustafa; Kiraz, Aşkın; İskeleli, Nazan Ocak; Erdönmez, Ahmet; Dülger, Başaran; Durlu, Tahsin NuriA new Schiff base compound has been synthesized by the reaction of 2-hydroxy-1-naphthaldehyde with 3,5-bis(trifluoromethyl)aniline.The title compound was characterized by elemental analysis, IR, H-1 NMR, C-13 NMR, and UV-Visible techniques.Its UV-Vis spectra was examined in polar and nonpolar solvents and in acidic and basic media. The crystal structure of the compound showed the OH group to be ortho to the imine group. It crystallizes in the monoclinic space group P2(1) with a = 11.328(2), b = 6.125(1), c = 11.937(2) angstrom, V = 825.1(2) angstrom(3), D (x) = 1.543 g cm(-3) and Z = 2. An intramolecular O1- H center dot center dot center dot N1 [2.558(7) angstrom] hydrogen bond stabilizes the molecule. The compound has also been characterized by its antimicrobial activities. The ligand has been screened in vitro against the organisms Escherichia coli ATCC 11230, Staphylococcus aureus ATCC 6538, Klebsiella pneumoniae UC57, Micrococcus luteus La 2971, Proteus vulgaris ATCC 8427, Pseudomonas aeruginosa ATCC 27853, Mycobacterium smegmatis CCM 2067, Bacillus cereus ATCC 7064, and Listeria monocytogenes ATCC 15313, the yeast cultures Candida albicans ATCC 10231, Kluyveromyces fragilis NRRL 2415, Rhodotorula rubra DSM 70403, Debaryomyces hansenii DSM 70238, and Hanseniaspora guilliermondii DSM 3432.Öğe Spectroscopic study, antimicrobial activity and crystal structures of N-(2-hydroxy-5-nitrobenzalidene)4-aminomorpholine and N-(2-hydroxy-1-naphthylidene)4-aminomorpholine(Elsevier, 2005) Yıldız, Mustafa; Ünver, H.; Dülger, Başaran; Erdener, Diğdem; Ocak, N.; Erdönmez, A.; Durlu, Tahsin NuriSchiff bases N-(2-hydroxy-3-nitrobenzalidene)4-aminomorpholine (1) and N-(2-hydroxy- I -naphthylidene)4-aminomorpholine (2) were synthesized from the reaction of 4-aminomorpholine with 2-hydroxy-5-nitrobenzaldehyde and 2-hydroxy- 1 -naphthaldehyde. Compounds 1 and 2 were characterized by elemental analysis, IR, H-1 NMR, C-13 NMR and UV-Visible techniques. The UV-Visible spectra of the Schiff bases with OH group in ortho position to the imino group were studied in polar and nonpolar solvents in acidic and basic media. The structures of compounds 1 and 2 have been examined cyrstallographically, for two compounds exist as dominant form of enol-imines in both the solutions and solid state. The title compounds 1 and 2 crystallize in the monoclinic space group P2(1)/c and P2(1)/n with unit cell parameters: a=8.410(1) and 11.911(3), b=6.350(9) and 4.860(9), c=21.728(3) and 22.381(6) angstrom, beta=90.190(1) and 95.6(2)degrees, V=1160.6(3) and 1289.5(5) angstrom(3), D-x = 1.438 and 1.320 g cm(-3), respectively. The crystal structures were solved by direct methods and refined by full-matrix least squares. The antimicrobial activities of compounds 1 and 2 have also been studied. The antimicrobial activities of the ligands have been screened in vitro against the organisms Escherichia coli ATCC 11230, Staphylococcus aureus ATCC 6538, Klebsiella pneumoniae UC57, Micrococcus luteus La 297 1, Proteus vulgaris ATCC 8427, Pseudomonas aeruginosa ATCC 27853, Mycobacterium smegmatis CCM 2067, Bacillus cereus ATCC 7064, Listeria monocytogenes ATCC 15313, Candida albicans ATCC 1023 1, Kluyveromyces fragilis NRRL 2415, Rhodotorula rubra DSM 70403, Debaryomyces hansenii DSM 70238 and Hanseniaspora guilliennondii DSM 3432. 0 2004 Elsevier B.V. All rights reserved.Öğe Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones(2008) Ölmez, Nevin Arıkan; Sümengen, Doğan; Dülger, BaşaranN-Substituted pyridine carboxamide oximes (2) were obtained from the reactions of pyridine hydroxamic acid chloride hydrochlorides (1) with primary amines. The reactions of carboxamide oximes with chloroacetyl chloride in the presence of triethylamine gave the corresponding 3,4-disubstituted- 1,2,4-oxadiazin-5-ones (3), which on treatment with P2S5 gave in moderate yielded the corresponding 3,4-disubstituted-1,2,4-oxadiazin-5-thiones (4). The reaction of pyridine carboxamide oximes with $\\alpha$- aminoacid ester led to the formation of 3,5-disubstituted-1,2,4-oxadiazin-6-ones (5) in moderate yields. The structures of the prepared compound were evaluated by spectroscopy. Some of the representatives of 3,4-disubstituted-1,2,4-oxadiazin-5-ones, thiones, and 3,5-disubstituted-1,2,4-oxadiazin-6-ones were screened for antibacterial activity using disc diffusion. It was found that all the tested compounds have good antimicrobial activities.Öğe Two new myxomycetes records for the myxobiota of Turkey(2008) Dülger, BaşaranBadhamia gracilis (T.Macbr.) T.Macbr. and Diderma crustaceum Peck are recorded for the first time from Turkey. © TÜBİTAK.
