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    Assessment of the anticancer function of Coronilla orientalis MILLER through comprehensive in vitro and computational studies
    (Walter De Gruyter Gmbh, 2025) Ciftci, Halilibrahim; Oral, Ayhan; Coskun, Yalcin; Renda, Gulin; Otsuka, Masami; Fujita, Mikako; Sever, Belgin
    Objectives Although many synthetic anticancer drugs are available, a significant proportion of human therapeutics in the anticancer armamentarium are derived from natural products. The aim of this study to examine the anticancer effects of natural compounds against non-small cell lung cancer (NSCLC) and breast cancer, which remain among the world's greatest obstacles.Methods Coronilla orientalis MILLER (CO) was collected in Erzincan, T & uuml;rkiye, prepared, and extracted with 70 % ethanol. CO was then tested against A549 NSCLC and MCF-7 breast cancer cells using the MTT assay. To explore its potential anticancer mechanism, the apoptotic effects of CO in A549 and MCF-7 cells and the kinase inhibitory effects of CO were investigated using the Annexin V/ethidium homodimer III staining assay and the ADP-Glo kinase assay, respectively. Molecular docking studies were also performed for several major components of CO in the ATP binding site of EGFR.Results The results showed that CO, with IC50 values of 2.37 +/- 0.59 mu g/mL and 7.60 +/- 1.18 mu g/mL, exhibited anticancer activity against A549 cells and MCF-7 cells, respectively. CO was also selectively cytotoxic between Jurkat cells and PBMCs (healthy). CO-treated A549 and MCF-7 cells were found to undergo significant apoptosis and CO was found to inhibit EGFR. Molecular docking studies revealed the interaction of some defined components of CO with key residues in the ATP binding site of EGFR.Conclusions Taken together, this research has shown that CO has a great deal of potential as an inhibitor of the anticancer function against NSCLC and breast cancer, and warrants further investigation.
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    Determination of Germination Threshold Value of Chickpea Varieties with GGE Biplot Method Under Different Irrigation Water Salinity Conditions
    (Ankara Univ, Fac Agr, 2022) Tas, Ismail; Tutenocakli, Tulay; Coskun, Yalcin; Akcura, Mevlut
    For sustainable agricultural production, besides drought, plant resistance to irrigation water and soil salinity should be investigated. Researchers mostly focused on salinity and drought resistance of common species such as wheat, barley, maize, etc. However, the number of studies on chickpea with various uses is quite limited. In the present study, 11 chickpea varieties (Aksu, Arda, Hasanbey, Azkan, Cagatay, Aslanbey, Inci, Seckin, 21C, 42C and EN1867) were subjected to germination tests under different levels of irrigation water salinity (ECi) conditions to identify irrigation water salinity resistant and sensitive varieties. In germination tests, besides control treatment (0 dS/m), five different EC levels (6, 8 10, 12 and 16 dS/m) were used in germination solution. The sodium absorption ratio of saline waters was adjusted to be below 3. GGE biplot method was used for visual assessment of genotype response to saline irrigation waters. The threshold salinity value for germination was identified as 12 dS/m based on germination ratios and seedling dry weights, 8 dS/m based on seedling stem lengths and 10 dS/m based on seedling root lengths. Based on germination ratios and seedling dry weights, Azkan cultivar was identified as the most resistant and Cagatay cultivar was identified as the most sensitive cultivar to irrigation water salinity.
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    EVALUATION OF DIFFERENT SIGMOIDAL GROWTH MODELS AND CLIMATE PARAMETERS FOR DRY MATTER ACCUMULATION OF OAT
    (Serbian Genetics Soc, 2018) Coskun, Yalcin
    The monitoring of the biological growth of field crops is important for planning and scheduling agricultural applications. In order to assess biological growth pattern and, dry matter accumulation of Yeniceri oat variety were obtained in canakkale conditions in 2012-2013 and 2013-2014 growing seasons with continuous plant samplings from seedling emergence until seed maturation. Gompertz, Logistic, Logistic Power, Weibull, and Ratkowsky sigmoidal growth models are fitted to actual growth data and their predictions were compared. Results suggested that all sigmoidal growth models successfully explained oat dry matter accumulation a high R-2 values (over 99%) and low mean square errors, Weibull model fitted lower than others for first year with an R-2 value under 99%. Dry matter accumulation was also investigated as a result of average temperature and precipitation with stepwise regression. Results indicated that average weather temperature has a similar pattern across both growing seasons and has a major influence on dry matter accumulation.
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    EVALUATION OF DRY MATTER ACCUMULATION IN TRITICALE BY DIFFERENT SIGMOIDAL GROWTH MODELS IN WEST ANATOLIA OF TURKEY
    (Serbian Genetics Soc, 2018) Hocaoglu, Onur; Coskun, Yalcin
    Monitoring biological growth of field crops is important for planning and timing agricultural practices. In order to assess biological growth pattern of dry matter accumulation in triticale Egeyildizi triticale variety were grown in canakkale conditions in 2012-2013 and 2013-2014 growing seasons with continuous plant samplings from seedling emergence until seed maturation. Gompertz, Logistic, Logistic Power and Richards growth models are fitted to actual growth data and their predictions were compared. Results suggested that all sigmoidal growth models successfully explained triticale dry matter accumulation over 98 % R-2 values and low mean square errors, Richards model fitted best for both years with an R-2 value over 99 %. Dry matter accumulation were also investigated as a result of average temperature, precipitation, growth degree days and cumulative growth degree days with stepwise regression. Rresults indicated that average weather temperature had a similar pattern across both growing seasons and had a major influence on dry matter accumulation. Since Richards sigmoidal growth model may be adequately described growth pattern of triticale by generally high R-2 with lower Mean Square Error (MSE) values.
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    RESPONS OF WHEAT SPECIES TO IRRIGATION WATER SALINITY
    (Serbian Genetics Soc, 2017) Coskun, Yalcin; Tas, Ismail
    This study was conducted to investigate the effects of different irrigation water salinity level on chromosomes and shoots of wheat with three different ploidy level (diploid, tetraploid and hexaploid). Greenhouse experiment revealed that irrigation water salinity level had significant effects on shoot dry weight, root dry weight, shoot length and root length (P < 0.05). The effects of ploidy level and cultivar shoot dry weight and root dry weight were also found to be significant (P < 0.05), but the effects on shoot length and root length were not significant (P > 0.05). Negative effects of salinity on shoot and root were started at 8 dS m(-1). Also hexaploid wheat was more tolerant then tetraploid and diploid wheat to salinity. It was not determined that possible effects of irrigation water salinity to structure of chromosomes with current equipment and methods. Cell divisions were normal, but decreasing cell division rates were observed with increasing irrigation water salinity levels.
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    THE EFFECTS OF IRRIGATION WATER SALINITY ON THE SEED GERMINATION AND SEEDLING GROWTH OF RICE
    (Serbian Genetics Soc, 2022) Bayindir, Fikri; Coskun, Yalcin
    To determine the effects of irrigation water salinity on seed germination and seedling development of two rice cultivars, irrigation waters with low SAR (below 3) were prepared in different salinity levels (control [0.5], 2, 4, 8, 12, 16, and 20 dS m(-1)) from different salinity sources (NaCl, MgS0(4), and CaCl2 salts). The average germination rate was decreased for the cv. Baldo 20.19%, while for cv. Osmancik-97 it was 26.73%. The average of the single seedling dry weight of cv. Baldo was 0.2666 g, while for cv. Osmancik-97 it was 0.2569 g. The average single seedling dry weight was 0.2940 g in the control application. In parallel to the increased irrigation water salinity level, the single seedling dry weight decreased. The irrigation water salinity had not affected up to 4 dS m(-1) in terms of the germination rate decrease and the single seedling dry weight of rice, but it started to be affected when increased salinity level to 8 dS m(-1) and it was more effective at higher doses. Also, cv. Osmancik-97 was more sensitive to irrigation water salinity than cv. Baldo. In conclusion, it turns out that the irrigation water to be used in rice farming should not have salinity since the tolerance of the rice plant against irrigation water salinity is low.