Yazar "Cosar, M." seçeneğine göre listele

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    Short aggrecan gene repetitive alleles associated with lumbar degenerative disc disease in Turkish patients
    (Funpec-Editora, 2011) Eser, O.; Eser, B.; Cosar, M.; Erdogan, M. O.; Aslan, A.; Yildiz, H.; Solak, M.
    We investigated a possible association between aggrecan gene polymorphism and lumbar degenerative disc disease in Turkish patients. One hundred 20-30-year-old patients with or without low back pain were selected for the study. Lumbar magnetic resonance imaging was performed on all patients. The patient group had low back pain clinically and degenerative disc disease radiographically. The control group included patients with and without low back pain: all were negative radiographically for degenerative disc disease. Genomic DNA was extracted from all participants. A PCR assay were used to evaluate variable number of tandem repeat polymorphism of aggrecan gene alleles to determine if there was any correlation with degenerative disc disease. Significant associations were found between short repeated alleles of the aggrecan gene and severe disc degeneration. A significant association was also found between short repeated alleles of the aggrecan gene and multilevel disc herniation as well as extrusion and sequestration types of disc herniation. In Turkish population, short repeated alleles of the aggrecan gene are associated with increased disc degeneration and disc herniation.
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    The effect of glycyrrhizic acid on traumatic spinal cord injury in rats
    (C M B Assoc, 2016) Sehitoglu, M. H.; Guven, M.; Yuksel, Y.; Akman, T.; Aras, A. Bozkurt; Farooqi, A. A.; Cosar, M.
    Spine injury associated with traumatic spinal cord injury eventuates in oxidative stress, inflammation and neuronal apoptosis. The aim of this study is to find out whether the glycyrrhizic acid treatment protects spinal cord from traumatic injuries in rats. To this end, the rats were divided into three groups: group I; control group (no drug or operation, n=8), group II; traumatic spinal cord injury group (TSCI, n=8) and group III; glycyrrhizic acid group (TSCI-GA, 80 mg/kg, n=8). Total laminectomy was performed at T10 level. A balloon angioplasty catheter was inserted into the T9 level thoracic spinal cord extradurally. The rats were evaluated with the Tarlov Scale. After 24 hours, spinal cord tissues were taken for biochemical and histopathological examinations. TSCI effectuates unwanted results on tissues, antioxidant systems and cell membranes. Antioxidant enzyme level decreased and lipid peroxidation increased. However, TSCI led to inflammation and apoptosis. Glycyrrhizic acid treatment provided a significant decrease in lipid peroxidation in group III in comparison with group II. Moreover, nuclear respiratory factor 1 levels and superoxide dismutase activity of group III were significantly higher than group II (p<0.05). The histopathological and immunohistochemical results revealed that the numbers of apoptotic and necrotic neuron, edema, hemorrhage, inflammatory cells, NF-kappa B and S100B expressions were significantly lower than group II (p<0.05). Our study showed that the glycyrrhizic acid treatment reduced oxidative stress and inflammation, and promoted the neuronal functions in traumatic spinal cord injury.
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    Öğe
    Thoracic vertebra and rib destruction: What if not cancer?
    (2012) Alar, T.; Kosar, S.; Degirmenci, Y.; Alkan, B.; Cosar, M.
    An 18-year-old female presented at our hospital with complaints of fatigue for the last 4-5 months, together with numbness and weakness in both lower extremities in the last month. Neurological examination revealed hypoesthesia in the lower right extremity, paraparesis of bilateral lower extremities, a hyperactive deep tendon reflex (DTR) and positive bilateral Babinski sign. The radiology examinations showed septated multiple cystic lesions, with the largest 36x28 mm, destructing the proximal 3rd rib together with the 3 rdthoracic vertebra body, extending to the lower level of 7 th cervical vertebra in the subdural region and compressing the spinal cord. The patient was taken to surgery immediately and the described cystic lesions were removed without being ruptured, together with corpectomy to T3 vertebra and partial resection of the third rib. Posterior transpedicular fusion was performed to the T2-6 spaces. There was no peroperative or postoperative complication. Histopathological examination of the material revealed "hydatid cyst". The patient was followed-up on 10 mg/kg albendazole treatment. Postoperative follow-ups at 1, 2 and 3 months revealed normal function tests and no motor deficit or pathological reflex besides DTR hyperactivity.