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Öğe Acne severity and the Global Acne Grading System in polycystic ovary syndrome(Elsevier Ireland Ltd, 2013) Hacivelioglu, Servet; Gungor, Ayse Nur Cakir; Gencer, Meryem; Uysal, Ahmet; Hizli, Deniz; Koc, Evrim; Cosar, EmineObjective: To evaluate the association between acne, quantified by the Global Acne Grading System (GAGS), and abnormal clinical and laboratory markers of androgen excess in patients with polycystic ovary syndrome (PCOS). Methods: The retrospective study included 133 patients with PCOS. Acne severity was quantified with the GAGS score, alopecia was graded with the Ludwig classification, and hirsutism was quantified with a modified Ferriman-Gallwey (FG) score. Results: The mean GAGS score was significantly greater in younger women, those with a lower BMI, and those with a higher FG score. There was no relation between the mean GAGS score and waist circumference, waist/hip ratio, androgen hormone levels (free testosterone, total testosterone, or dehydroepiandrosterone sulfate), sex-hormone-binding globulin level, or menstrual irregularity. Alopecia was significantly associated with an increased waist/hip ratio; there was no relation between alopecia and age, waist circumference, body mass index, FG score, androgen hormone levels, or menstrual irregularity. A weak positive correlation was observed between the GAGS and FG scores. Conclusion: The GAGS may provide more precise and comprehensive information about acne severity in obese or hirsute patients with PCOS because this grading system includes evaluation of the type (comedones, papules, pustules, nodules) and location (anatomic area) of acne lesions. (c) 2013 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.Öğe Fetal Vegf Genotype is More Important for Abortion Risk than Mother Genotype(Cellular & Molecular Biology Research Center, 2014) Yalcintepe, Sinem Atik; Sılan, Fatma; Hacivelioglu, Servet Ozden; Uludağ, Ahmet; Cosar, Emine; Özdemir, ÖztürkVEGF gene has been reported to be related with many diseases and recurrent pregnancy loss in various studies. Concerning the role of VEGF polymorphisms in pregnancy losses, generally mothers genotypes have been analyzed. To evaluate the association between VEGF A +405G/C (rs2010963), -460T/C (rs833061), +936C/T (rs3025039) and - 2578A/C (rs699947) polymorphisms and spontaneous abortion, we studied the genotypes of spontaneously aborted fetuses, their mothers and healthy controls. 23 spontaneously aborted fetal materials, 22 mothers who had these abortions and 86 healthy controls were included in this study. rs2010963, rs833061, rs3025039 and rs699947 polymorphisms were analyzed by Real Time PCR technique after genomic DNA isolation from all subjects. The frequencies of VEGF A rs2010963 GG genotype and rs2010963 G allele were higher in fetuses compared both with mothers and healthy controls. VEGF A rs3025039 TT genotype and rs3025039 T allele frequencies were higher in fetuses comparing with mothers. VEGF A rs833061 CT and TT genotypes frequencies were higher in fetuses comparing with mothers. We ascertained that VEGF A rs2010963, rs833061 and rs3025039 are the risk factors for spontaneous abortion in fetal genotypes comparing with their mothers and healthy controls.Öğe High frequency of chromosomal anomalies and a novel chromosomal insertion associated with infertility and recurrent miscarriages (reproductive failure) in West Turkey(Gene Therapy and Molecular Biology, 2014) Sılan, Fatma; Yalcintepe, Sinem; Uysal, Digdem; Urfali, Mine; Uludağ, Ahmet; Cosar, Emine; Gungor, Ayse Nur CakirNumerical and/or structural chromosomal abnormalities may be a reason of high infertility rates and recurrent pregnancy losses (RPLs) in humans. Karyotype and karyogram profiles of patients with RPLs are presented in current results. A total of 722 patients; 161(44.5%) infertile and 200(55.5%) RPL couples were included in the study. Karyotype and structural chromosome analyses of both patient groups in Canakkale population were made between May 2011-December 2013, using peripheral lymphocyte cell culture and GTG banding technique. High frequency of chromosomal abnormalities(%7.45) were detected in 24 patients of the infertility group(n:322). 10 patients(42%) of this group(n:24) had numerical and 14 patients(58%) had balanced structural choromosomal abnormalities. A novel choromosomal insertion was found in an infertile male, one of the 22th choromosome was totally inserted in 9th choromosome [ins(9;22)(9pter-q12Öğe Is there any relationship between adverse pregnancy outcome and first trimester nuchal translucency measurements in normal karyotype fetuses?(Informa Healthcare, 2015) Uysal, Fatma; Cosar, Emine; Yucesoy, Kaya; Gencer, Meryem; Cevizci, Sibel; Gungor, Aysenur; Hacivelioglu, ServetAim: This study aims to research whether there is a relationship between first trimester nuchal translucency (NT) measurements and pregnancy complications such as gestational diabetes mellitus (GDM), gestational hypertension (GHT), intrauterine growth restriction (IUGR) and oligohydramnios. Method: This study included 225 singleton pregnancies attending Canakkale Onsekiz Mart University Obstetrics and Gynecology clinic for all monitoring and examinations, and gave birth at our clinic between January 2011 and December 2012. Data sources were clinical records and the hospital's automation system, and the study was planned as retrospective cohort. NT measurement was made between 10 weeks 3 days and 13 weeks 6 days gestation. For data analysis, the chi-square, Mann-Whitney U test and Spearman correlation were used. Results: Of pregnancies, in the study, 5 (2.2%) developed GDM, 6 (2.6%) developed GHT, 2 (0.89%) developed IUGR and 10 (4.4%) developed oligohydramnios. There was no correlation identified between NT measurements and development of GDM, GHT, IUGR and oligohydramnios. Conclusion: There was no relationship found between first trimester NT measurements and complications that could develop in pregnancy. For the first time in the literature, NT and oligohydramnios were studied and no relationship was observed.Öğe Is There Any Relationship Between Platelet Functions, Red Cell Distribution Width and Recurrent Pregnancy Loss?(Derman Medical Publ, 2015) Uysal, Ahmet; Incebiyik, Adnan; Hacivelioglu, Servet; Gencer, Meryem; Gungor, Aysenur; Cosar, EmineAim: Recurrent pregnancy loss (RPL) affects 1% pregnancies and its etiology is multi-factorial. Hypercoagulability might result in recurrent abortions; anticoagulant therapy could potentially increase the live-birth rate in subsequent pregnancies in women with unexplained recurrent abortions. Mean platelet volume (MPV) and platelet distribution width (PDW), are a parameter of platelet functions and may be a marker for increased platelet aggregability. In this study we aimed to determine whether MPV, PDW and red cell distribution width (RDW) values differ between patients with RPL and in healthy participants. Material and Method: A total of 50 RPL patients and 49 age matched healthy women were enrolled into the study. For all subjects following tests were performed: Hemoglobin, hematocrit, white blood cells counts (WBC), MPV, PDW, platelet count, RDW and thyroid stimulating hormone (TSH). Results: Compared with healthy controls there were no statistically differences in MPV and PDW between (p > 0.05, respectively) in women with RPL. However, RDW was significantly lower in patients with RPL than in group with control (p = 0.023,). Discussion: It was first shown in the literature that patients with RPL have no significance MPV and PDW than control subjects. However RDW levels were found that it was significantly related to recurrent pregnancy loss.Öğe Maternal and fetal leptin and ghrelin levels: relationship with fetal growth(Springer Heidelberg, 2011) Saylan, Filiz; Koken, Gulengul; Cosar, Emine; Koken, Tulay; Saylan, Arif; Arioz, Dagistan Tolga; Sahin, FigenIn our study, we investigated the influence of plasma levels ghrelin, leptin and other metabolic hormones (ILGF-1 and ILGF-2) in pregnants in regulating fetal body weight and mode of delivery. A total of 36 appropriately healthy pregnants 19-36-year-old were involved in the study. Demographic chracteristics, serum ghrelin, leptin, IGF-1 and IGF-2 levels of the pregnants were studied. Plasma ghrelin and leptin levels did not differ significantly among trimesters and delivery, in contrast to IGF-I and IGF-II concentrations were significantly higher in the first half of the pregnancy (P < 0.05). Serum leptin was significantly associated with mode of delivery (r = 0.231; P = 0.008), BMI (r = 0.462; P = 0.004). Metabolic factors are associated with fetal growth, but in AGA babies, there were no differences between any parameter and clinical factor.Öğe Mean Platelet Volume and Ischemia Modified Albumin Levels in Cord Blood of Infants of Diabetic Mothers(Elsevier Taiwan, 2014) Topaloglu, Naci; Yildirim, Sule; Tekin, Mustafa; Kaymaz, Nazan; Tutunculer, Funda; Ozdemir, Cem; Cosar, EmineBackground: Gestational diabetes mellitus (GDM) is a risk for the health of both the pregnant women and her infant. Its unfavorable effects start in utero and continue after birth. It is known that GDM increases oxidative stress and decreases antioxidant enzyme activities. In this study we aimed to investigate cord blood mean platelet volume (MPV) and ischemia-modified albumin (IMA) levels of infants of diabetic mothers (IDM). Methods: Twenty-nine pregnant women with GDM between 37 and 41 gestational weeks who gave birth by spontaneous vaginal delivery were enrolled as study participants together with 20 healthy pregnant women as a control group. Weight, length, and head circumference of babies were measured by the same standard tape immediately after birth. Five milliliters of umbilical venous blood were obtained to study MPV and IMA levels. Results: There was statistically significant difference in levels of MPV (p = 0.037) and IMA < 0.001) between groups. They increased in IDM compared with their healthy peers. Conclusion: Evaluation of MPV and IMA together is useful for representing the potential oxidative stress of IDM. Copyright (C) 2014, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.Öğe Multiple Inherited Thrombophilic Gene Polymorphisms in Spontaneous Abortions in Turkish Population(Cellular & Molecular Biology Research Center, 2015) Yalcintepe, Sinem; Özdemir, Öztürk; Hacivelioglu, Servet Ozden; Akurut, Cisem; Koc, Evrim; Uludağ, Ahmet; Cosar, EmineThe aim of this study was to investigate the possible role of multiple inherited thrombophilic gene variations in women with unexplained spontaneous abortions. For this purpose, the Factor V Leiden (FVL) (rs6025), Prothrombin G20210A (rs1799963), MTHFR C677T (rs1801133), PAI-1 4G/5G (rs1799889), ACE I/D (rs1799752), eNOS E298D (rs1799983), and Apo E E2/E3/E4 (rs429358) polymorphisms were genotyped and correlated in spontaneously aborted fetal materials, their mothers and fertile women. Twenty three abortion materials, 22 women with >= 1 unexplained fetal loss, and 22 control subjects with at least two healthy term infants as a control group were studied. Target SNPs for each gene were analyzed by real time-PCR technique after genomic DNA isolation from maternal blood-EDTA, control group blood-EDTA and spontaneously aborted fetal tissues. Some cases had a single thrombophilic polymorphism, but the rest of the patients and fetal materials had combined thrombophilic polymorphisms. The PAI-1 4G/5G+4G/4G (P=0.0017), 4G/4G (P=0.0253), eNOS 894GT+894TT (P=0.0011) genotypes and T allele (P=0.0185), Apo E E3/E4+E3/E2+E2/E4 (P<0.0001) genotypes, E2 (P<0.0001) and E4 (P<0.0001) alleles were higher in spontaneously aborted fetal materials when compared to their mothers and control group. The Factor V Leiden rs6025, Prothrombin G20210A, MTHFR C677T, ACE I/D genotypes were different for each group but not statistically significant due to relatively small size of the samples (P>0.05). Our results indicated that combined thrombophilic gene variations may be associated with increased risk for spontaneous abortions and results need to be confirmed by larger sample size.Öğe Nausea and vomiting in early pregnancy: Relationship with temperament, character(Universitatsverlag Ulm Gmbh, 2011) Koken, Gulengul; Cosar, Emine; Sahin, Figen Kir; Emul, H. Murat; Guler, Ozkan; Yesildager, Evren; Gecici, OmerObjective: In this study, we aimed to investigate the temperament and character dimensions of women with nausea and vomiting in early pregnancy. Methods: A hundred consecutive women with or without nausea and vomiting of pregnancy (NVP) enrolled in the study. They were examined by using the temperament and character inventory and prospectively scored NVP of them using the Rhodes' system. These scores and demographic data were compared and P < 0.05 was considered significant. Results: Women with NVP were scored lower in HA4 (less fatigability and asthenia; P = 0.029), C2 (less emphatic; P = 0.001) compared to women without NVP. Among 74 pregnant women with NVP 29 of them had mild, 41 had moderate and four of them had severe NVP according to the Rhodes' score. NS2 (impulsiveness), NS3 (extravagance) and total NS scores showed negative correlation with Rhodes scores (r = -0.246, P = 0.014; r = -0.216, P = 0.031 and r = -0.219, P = 0.029, respectively). C3 (helpfulness) scores were positively correlated with Rhodes' scores (r = 0.234, P = 0.019). Conclusion: These results suggest that NVP in early pregnancy has distinctive temperament and character dimensions compared to non-NVP women in early pregnancy. (C) 2011 Elsevier GmbH. All rights reserved.Öğe Obstetric outcomes of patients with abortus imminens in the first trimester(Springer Heidelberg, 2014) Evrenos, Ayse Nur; Gungor, Ayse Nur Cakir; Gulerman, Cavidan; Cosar, EmineWe aimed to find out the effect of abortus imminens (AI) on obstetric outcomes of pregnancies which continued beyond the 24th week of gestation. In this prospective study, 309 patients with AI were divided into high-risk group (with a risk factor for spontaneous abortus) (n = 92) and low-risk group (without a risk factor) (n = 217). The control group (n = 308) was chosen randomly. In AI group, preterm delivery, preterm premature rupture of membranes (PPROM), cesarean section (C/S) delivery, postpartum uterine atony and need of a neonatal intensive care unit (NICU) rates were significantly higher than control group. Gestational diabetes mellitus, PPROM, still birth, low APGAR scores were seen more frequently in the high-risk patients than in the control group. Furthermore in the high-risk group, preterm delivery, malpresentation, C/S delivery and need of NICU were increased much more than in the low-risk group. Gestational hypertension/preeclampsia, oligo/polyhydramniosis, intrauterine growth retardation, placenta previa, abruption of placenta, chorioamnionitis, congenital abnormalities, delivery induction, cephalopelvic disproportion, fetal distress and manual removal of placenta were not different among the groups. Patients with AI history, especially with high-risk factors can have adverse obstetric and neonatal results. So their antenatal follow-up has to be done cautiously for the early signs and symptoms of these complications.Öğe Predictive value of striae gravidarum severity for intraperitoneal adhesions or uterine scar healing in patients with previous caesarean delivery(Taylor & Francis Ltd, 2014) Gungor, Ayse Nur Cakir; Oguz, Sevilay; Hacivelioglu, Servet; Isik, Selda; Uysal, Ahmet; Gencer, Meryem; Cosar, EmineObjective: Previous abdominal operations might cause severe intraperitoneal adhesions (IPA), which can complicate caesarean section (CS) procedures. When selecting the mode and timing of delivery, obstetricians are also curious about uterine scar healing if the previous operation was a CS. Uterine scar thickness is an indicator of uterine scar healing. We aimed to evaluate the possible predictive value of striae gravidarum (SG) on IPA formation and uterine scar thickness (UST). Methods: Fifty-five women with a previous CS history were evaluated for SG Davey Score. They were investigated for IPAs and lower segment uterine scar thickness during the current CS operation. Results: Out of the patients with no SG (n = 11), mild SG (n = 10) and severe SG (n = 34), 1 (9.1%), 3 (30%) and 17 (50%) had IPA, respectively (p = 0.044). The mean uterine scar thicknesses in the no SG, mild SG and severe SG groups were 3.82 +/- 4.04, 5.20 +/- 4.13 and 5.18 +/- 3.52, respectively (p = 0.561). Conclusions: To the best of our knowledge, this was the first study to investigate the relationship between SG and IPA and uterine scar thickness. The SG status of a patient with a previous delivery and abdominal operation history might help predict IPA status before planning a new operation.Öğe Prenatal diagnosis of thrombocytopenia-absent radius syndrome(Walter De Gruyter Gmbh, 2012) Koeken, Guelenguel; Akbas, Pinar; Cosar, EmineThe prenatal diagnosis of thrombocytopenia-absent radius (TAR) syndrome by ultrasound is established. The sonographic findings showed bilateral absence of the radii and club hands with normal thumbs and metacarpals. Thrombocytopenia was identified from the postabortal cord blood. Three-dimensional computerized tomography images confirmed the sonographic diagnosis. This report, to our knowledge, is one of the few cases published in the literature about the prenatal diagnosis of TAR syndrome.Öğe Sleep disturbance among women with chronic pelvic pain(Elsevier Ireland Ltd, 2014) Cosar, Emine; Gungor, Aysenur Cakir; Gencer, Meryem; Uysal, Ahmet; Hacivelioglu, Servet O.; Ozkan, Adile; Sen, Halil MuratObjective: To investigate the effect of chronic pelvic pain (CPP), a debilitating condition, on sleep quality. Methods: The present case-control study enrolled women older than 18 years attending the Gynecology Clinic of Canakkale Onsekiz Mart University Hospital, Canakkale, Turkey, with CPP between August 2011 and August 2012. The control group was selected from women attending the clinic for another complaint. Sleep quality was evaluated via the Pittsburgh Sleep Quality Index, and differences between the groups were compared by t and chi(2) tests. Results: During the study period, 157 women were enrolled. Seventy-two had CPP symptoms, and 85 attended the clinic for other complaints. Poor sleep quality was found in 80% (n = 58) of the women with CPP, and 55% (n = 47) of the control group (P < 0.05). Conclusion: Women with CPP were found to have poor sleep quality. Sleep education should be recommended in psychiatry and neurology clinics to increase the awareness of sleeping problems among these women. (C) 2014 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.Öğe The Role of Endocrine and Endometrial Factors in Cases of Recurrent Miscarriage: A Tertiary Center Experience(Derman Medical Publ, 2015) Uysal, Ahmet; Taner, Cuneyt Eftal; Mun, Semih; Cosar, EmineAim: To investigate endocrinologic and endometrial factors in cases of recurrent abortions. Material and Method: In cases of recurrent abortions, clinical and ultrasonographic features, genetic, anatomic and immunologic factors, hormonal profiles and endometrial samplings were assessed. Chromosomal abnormalities and uterine anomalies were excluded. Results: In 8 (14%) of 57 cases with recurrent abortions, there were low progesterone levels. In 1 (1.75%) case there was a high androgen level. In 2 (3.5%) cases there was hyperprolactinemia and in another 2 (3.5%) cases there were high insulin levels. In 4 (7%) cases two scores of OGTT were high. In 51 cases where endometrial sampling was performed, only one (1.75%) case had delayed endometrial development. Discussion: We conclude that recurrent abortions have a complex etiology related to endocrinologic and endometrial factors.Öğe True Cyclopia and Proboscis: an Interesting Prenatal Condition with Normal Nose(Derman Medical Publ, 2016) Uysal, Fatma; Uysal, Ahmet; Gungor, Aysenur Cakir; Cosar, EmineCyclopia is a deformation of the facial skeleton with one eye orbit formed in the place where both eyes should be present. Its rate is almost 1 in 100,000 births including stillbirths are identified as cyclopean. To our knowledge a cyclopean which is including true cyclopia, proboscis, HPE, but normal nose has been never reported. In this current study we describe a second trimester fetus with, single bony orbit, proboscis; but normal nose.
