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    The effects of ozone therapy on extremity ischemia-reperfusion injury in a rabbit model
    (Yusuf Haydar ERTEKİN, 2019) Kaymaz, Burak; Coban, Ganime; Goksel, Ferdi; Toman, Huseyin; Golge, Umut Hatay; Komurcu, Erkam
    Introduction: Ischemia is reversible or irreversible cell/tissue damage that is secondary to insufficient blood flow to tissues or organs. Ischemia causes many metabolic and structural changes at the cellular level. Ozone therapy is often used as an antioxidant remedy. This study aimed to investigate the effects of ozone therapy on extremity ischemia-reperfusion (IR) injury. Methods: Twenty-four New Zealand White (NZW) rabbits were randomly allocated into three groups. Each group consisted of eight rabbits. Group I was the control group, Group II was the ischemia group, and Group III, the ozone group.  Femoral arteries of the right legs were dissected, and femoral arterial occlusion was performed in Group II and III.  Hematological and histopathological evaluation was performed in all groups. Results: The levels of total antioxidant status (TAS) after the surgical procedure was higher in the ozone group compared to the ischemia group (p=0.036). In addition, the levels of malondialdehyde (MDA) after the surgical procedure were lower in the ozone group compared to the ischemia group but not statistically significant (p=0.093). The control and ozone groups were histopathologically similar. Conclusions: Ozone therapy may be used as an alternative treatment modality with its anti-inflammatory and antioxidant effects for the treatment of extremity IR injury