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    Cell-free dna methylation evaluation in patients with thyroid diseases
    (Bayrakol Medical Publisher, 2022) Cilgin, Guner Begum; Cil, Ozge Caglar; Uslu, Atilla; Cayir, Akin
    Aim: The main aim of the study was to evaluate the DNA 5-methylcytosine (m5C) level, measured in circulating cell-free DNA (ccfDNA) as a distinct feature of thyroid gland-related disorders, including thyroiditis, benign nodule, and malignant nodule.Material and Methods: The study included 75 patients with 30 benign nodules, 30 thyroiditis, and 15 thyroid cancers; 19 subjects were evaluated as a control group. We collected peripheral blood samples from three disease groups and the controls, and then separated the plasma from the whole blood. We measured m5C in ccfDNA purified from plasma samples of patients and healthy individuals.Results: The level of m5C, measured in thyroiditis patients was significantly different from those measured in the control group, malignant and benign patients. We observed hypomethylation in benign and malignant patients when compared with the control group. However, there was no significant difference between the malignant patients and the control group and between the benign patients and the control group. After comparison of disease groups, we observed that there was no statistically significant difference between benign and malignant patients. We observed a statistically significant difference between thyroiditis and malignant patients (p<0.01) and between thyroiditis and benign patients (p=0.001).Discussion: Very few studies have reported that DNA methylation is an epigenetic mechanism in thyroiditis patients. Here, we reported that the level of m5C of ccfDNA could be used as a biomarker for thyroiditis. Further studies are required with the higher number of malign and benign patients to investigate the differences between patients with nodules and healthy individuals.
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    Evaluation of Mitochondrial Copy Number in Thyroid Disorders
    (Elsevier Science Inc, 2022) Cil, Ozge Caglar; Metin, Ozge Karakas; Cayir, Akin
    Objective. The purpose of this study was to determine whether the mitochondrial DNA (mitDNA) copy number in blood samples of patients with thyroiditis, benign nodules or malignant nodules is different from that in healthy individuals, and to examine whether mtDNAcn has the ability to distinguish between different thyroid diseases. Materials and Method. This study consists of principal groups as thyroid patients and control group. The thyroid patient group comprised 30 patients with malignant nodules, 33 with benign nodules and 31 with thyroiditis, whereas the control group was com-posed of 21 healthy individuals. Blood samples were collected from the patients before treatment. Results were evaluated between groups. Results. We could not find an adequate number of participants for inclusion to match the groups. Similarly, since there is a gender difference in terms of disease prevalence, it was not possible to pair the populations in terms of gender. Instead, the results were analyzed with an adjusted model, including man characteristics as cofounders. We found that the mtDNAcn of the thyroid patients was significantly lower than that measured for the control group ( p = 0.01). Furthermore the mtDNAcn of the benign group was significantly lower than that measured in the control group ( p = 0.0001). A similar significant difference was found between the thyroiditis group and the control group ( p = 0.005). Conclusion. It was observed that mtDNAcn in the malignant group was significantly higher than that measured in the benign group ( p = 0.004), which would indicate that it may be used as a diagnostic and therapeutic marker in thyroid diseases. (c) 2022 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved.
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    Olfactory Dysfunction in Patients with Ischemic Heart Failure
    (Taiwan Soc Cardiology, 2020) Aksit, Ercan; Cil, Ozge Caglar
    Background: Heart failure (HF) is one of the leading causes of morbidity and mortality in the elderly. Early recognition, treatment, and elimination of potentially modifiable risk factors for HF are crucial for improving both survival and health-related life quality in those with HF. We aimed to investigate whether or not there is an association between olfactory function and the presence and severity of ischemic HF. Methods: The study included 40 patients with ischemic HF and 40 controls with coronary artery disease but without HF. All patients and controls underwent detailed physical and echocardiographic examinations. The Sniffin' Stick test was used to evaluate olfactory function. Results: Threshold-discrimination-identification (TDI) score was significantly lower in the patients with HF than in the controls (16.4 +/- 7.8 vs. 33.3 +/- 5.2, p < 0.001). When patients with ischemic HF were categorized according to New York Heart Association (NYHA) class, the TDI scores were significantly higher in the patients with NYHA class 1 HF compared to those with NYHA class 3 HF (23.4 +/- 0.9 vs. 8.8 +/- 7.0, p <0.001). We also found a significant negative correlation between the TDI score and NYHA class (r = -0.769, p < 0.001) and a positive correlation between the TDI score and left ventricular ejection fraction (r = 0.902, p < 0.001). Conclusions: Olfactory function was severely impaired in the patients with ischemic HF in this study. In addition, olfactory dysfunction in the patients with ischemic HF was significantly correlated with the severity of HF.
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    Olfactory dysfunction may predict myocardial injury in COVID-19 patients
    (Churchill Livingstone, 2020) Aksit, Ercan; Cil, Ozge Caglar; Kaya, Hakki
    [Anstract Not Available]
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    The Effect of Oleuropein on the Treatment of Allergic Rhinitis
    (Georg Thieme Verlag Kg, 2025) Cil, Ozge Caglar; Buyuk, Basak; Eroglu, Huseyin Avni; Sehitoglu, Hilal
    Introduction Allergic rhinitis is a disease that negatively affects social and work life and sometimes does not respond to many treatments. Therefore, new treatments are needed. For the prevention and treatment of allergies, oleuropein has been emphasized, and positive results have been shown in the literature. Objective To investigate the effects of general and topical oleuropein during the allergic rhinitis period and the histopathological changes in the nasal mucosa compared with steroid nasal sprays and control group in rats. Methods We developed an experimental animal model with 44 rats divided into 6 groups. Except for the control group, the allergic rhinitis in the other five groups was created with ovalbumin. As treatment, saline was administered to group 3, steroids, to group 4, oleuropein, to group 5, and steroids and oleuropein were administered to group 6. The effects of the drugs were examined histopathologically and the levels of immunoglobulin E (IgE) in the blood were compared. Results Considering the symptomatic findings in rats, we could observe that allergic rhinitis occurred. Based on the IgE levels and histopathological findings, we have statistically shown that oleuropein may be effective in treatment of allergy rhinitis. Conclusion Oleuropein has been shown to be useful in the treatment of allergic rhinitis in an animal model, but further studies are needed before it is introduced into the medical practice.