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    Cell-free dna methylation evaluation in patients with thyroid diseases
    (Bayrakol Medical Publisher, 2022) Cilgin, Guner Begum; Cil, Ozge Caglar; Uslu, Atilla; Cayir, Akin
    Aim: The main aim of the study was to evaluate the DNA 5-methylcytosine (m5C) level, measured in circulating cell-free DNA (ccfDNA) as a distinct feature of thyroid gland-related disorders, including thyroiditis, benign nodule, and malignant nodule.Material and Methods: The study included 75 patients with 30 benign nodules, 30 thyroiditis, and 15 thyroid cancers; 19 subjects were evaluated as a control group. We collected peripheral blood samples from three disease groups and the controls, and then separated the plasma from the whole blood. We measured m5C in ccfDNA purified from plasma samples of patients and healthy individuals.Results: The level of m5C, measured in thyroiditis patients was significantly different from those measured in the control group, malignant and benign patients. We observed hypomethylation in benign and malignant patients when compared with the control group. However, there was no significant difference between the malignant patients and the control group and between the benign patients and the control group. After comparison of disease groups, we observed that there was no statistically significant difference between benign and malignant patients. We observed a statistically significant difference between thyroiditis and malignant patients (p<0.01) and between thyroiditis and benign patients (p=0.001).Discussion: Very few studies have reported that DNA methylation is an epigenetic mechanism in thyroiditis patients. Here, we reported that the level of m5C of ccfDNA could be used as a biomarker for thyroiditis. Further studies are required with the higher number of malign and benign patients to investigate the differences between patients with nodules and healthy individuals.
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    Evaluation of Mitochondrial Copy Number in Thyroid Disorders
    (Elsevier Science Inc, 2022) Cil, Ozge Caglar; Metin, Ozge Karakas; Cayir, Akin
    Objective. The purpose of this study was to determine whether the mitochondrial DNA (mitDNA) copy number in blood samples of patients with thyroiditis, benign nodules or malignant nodules is different from that in healthy individuals, and to examine whether mtDNAcn has the ability to distinguish between different thyroid diseases. Materials and Method. This study consists of principal groups as thyroid patients and control group. The thyroid patient group comprised 30 patients with malignant nodules, 33 with benign nodules and 31 with thyroiditis, whereas the control group was com-posed of 21 healthy individuals. Blood samples were collected from the patients before treatment. Results were evaluated between groups. Results. We could not find an adequate number of participants for inclusion to match the groups. Similarly, since there is a gender difference in terms of disease prevalence, it was not possible to pair the populations in terms of gender. Instead, the results were analyzed with an adjusted model, including man characteristics as cofounders. We found that the mtDNAcn of the thyroid patients was significantly lower than that measured for the control group ( p = 0.01). Furthermore the mtDNAcn of the benign group was significantly lower than that measured in the control group ( p = 0.0001). A similar significant difference was found between the thyroiditis group and the control group ( p = 0.005). Conclusion. It was observed that mtDNAcn in the malignant group was significantly higher than that measured in the benign group ( p = 0.004), which would indicate that it may be used as a diagnostic and therapeutic marker in thyroid diseases. (c) 2022 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved.
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    Evaluation of von Willebrand factor and protein/creatinine ratio in idiopathic sudden hearing loss
    (Elsevier Espana Slu, 2023) Cil, Ozge Caglar; Bakirdogen, Serkan; Cakir, Dilek Ulker; Gul, Hasan; Oymak, Sibel
    Objective: The objective of this study was to evaluate the levels of von Willebraund Factor (vWF) in plasma and the protein/creatinine ratio in urine in patients with idiopathic sudden acute hearing loss, which we think to be caused by epithelial dysfunction. Materials-Methods: Thirty patients with a sudden hearing loss and thirty healthy individuals were included in the study. Before the treatment, blood and urine were collected from the patients and the control group to investigate the levels of the protein/creatinine ratio and the levels of vWF. The test results of the patients group were compared with those of the control group. Results: We found that the levels of vWF increased in the patient group, which was statistically significant (P <.05). The protein/creatinine ratio in the urine increased in the patient group, but this was not statistically significant (P >.05). In addition, we found that the vWF and urine protein/creatin ratio of the patients who benefited from treatment were lower than those who did not benefit. Conclusions: This study showed that sudden sensorineural hearing loss may result from endothelial dysfunction. However, more studies that include more patients are needed in order to support this. (c) 2022 Published by Elsevier Espana, S.L.U. on behalf of Sociedad Espanola de Otorrinolaringolog ' ia y Cirug ' ia de Cabeza y Cuello.
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    Olfactory Dysfunction in Patients with Ischemic Heart Failure
    (Taiwan Soc Cardiology, 2020) Aksit, Ercan; Cil, Ozge Caglar
    Background: Heart failure (HF) is one of the leading causes of morbidity and mortality in the elderly. Early recognition, treatment, and elimination of potentially modifiable risk factors for HF are crucial for improving both survival and health-related life quality in those with HF. We aimed to investigate whether or not there is an association between olfactory function and the presence and severity of ischemic HF. Methods: The study included 40 patients with ischemic HF and 40 controls with coronary artery disease but without HF. All patients and controls underwent detailed physical and echocardiographic examinations. The Sniffin' Stick test was used to evaluate olfactory function. Results: Threshold-discrimination-identification (TDI) score was significantly lower in the patients with HF than in the controls (16.4 +/- 7.8 vs. 33.3 +/- 5.2, p < 0.001). When patients with ischemic HF were categorized according to New York Heart Association (NYHA) class, the TDI scores were significantly higher in the patients with NYHA class 1 HF compared to those with NYHA class 3 HF (23.4 +/- 0.9 vs. 8.8 +/- 7.0, p <0.001). We also found a significant negative correlation between the TDI score and NYHA class (r = -0.769, p < 0.001) and a positive correlation between the TDI score and left ventricular ejection fraction (r = 0.902, p < 0.001). Conclusions: Olfactory function was severely impaired in the patients with ischemic HF in this study. In addition, olfactory dysfunction in the patients with ischemic HF was significantly correlated with the severity of HF.
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    Olfactory dysfunction may predict myocardial injury in COVID-19 patients
    (Churchill Livingstone, 2020) Aksit, Ercan; Cil, Ozge Caglar; Kaya, Hakki
    [Anstract Not Available]
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    Polysomnographic and Clinical Features of Positional and Non-positional Sleep Apnea Syndrome in Turkish Adult Population: Experience from a Single Institution
    (Springer, 2024) Aksoy, Selma; Cil, Ozge Caglar
    Purpose: The purpose of the study is to determine prevalence of positional obstructive sleep apnea (POSA) and non-POSA among obstructive sleep apnea syndrome (OSAS) cases. Additionally, it aims to compare the sociodemographic and polysomnographic characteristics in the city of Canakkale, located in the northwest of Turkey. Method: We included 263 patients diagnosed with OSAS by polysomnography (PSG) between January 2021 and November 2022. OSAS was defined as AHI ? 5. The severity of OSAS was assessed as normal (AHI < 5); mild (AHI 5–15); moderate (AHI 16–30); and severe (AHI > 30). Sociodemographic characteristics such as gender, weight, and height, along with and polysomnographic features were evaluated and compared between two groups. Results: Our final sample was 227 after applying exclusion criteria. The rate of POSA was 48 and 52% of patients had non-POSA. The body mass index (BMI) of the POSA group were significantly lower. Male gender was dominant in both groups. In POSA cases, 25.7% had mild, 38.5% moderate, and 35.8% severe OSA levels. In non-POSA cases, the same ratios were 8.5, 22.9, and 68.6% retrospectively. Positional stage was a risk factor for the severity of AHI score in our study (B = 14.49, p < 0.001, 95% CI 9.66–19.33) according to our analysis. Conclusion: We found significant characteristic sociodemographic and polysomnographic features which differentiate these two conditions. Male gender and high BMI constituted considerable risk of severe OSA. Although gender presents an unchangeable risk factor, it has been shown that the most important risk factor for non-POSA is body weight which is a modifiable risk factor. © The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd. 2023.