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Öğe A questionaire study evaluating the knowledge and approach by physicians about arterial blood gas(Societa Editrice Universo, 2014) Cikman, Oztekin; Ozkan, A.; Kiraz, H.A.; Karacaer, M.A.; Ocakli, M.M.; Hanci, V.; Karaayvaz, M.Background and Aims: Arterial blood pressure analysis is a frequently applied method in the diagnosis and follow-up of respiratory insufficiency and in the treatment of patients under risk. It is very important to take and analyze the blood gas sample properly. Therefore, a questionary study was performed which evaluated the knowledge and the approach of doctors working in various specialties. Materials and Methods: A questionary form consisting of 27 questions were filled by 100 specialist physicians who participated in the study. Results: It was observed that doctors participating in our study had partly sufficient knowledge regarding administration and evaluation of arterial blood gas. It was considered that in intensive care unit experience of participant doctors during their intern periods was a very important factor. But it was observed that most of the participant specialist physicians performed Allen test before radial artery puncture, and they frequently preferred femoral artery for their first puncture option, and they did not pay attention in the proper transportation of the samples and in sending cultures from arterial cannula against risk of infection. The majority of doctors who participated in our study stated that they would like to receive training in arterial blood gas administration and evaluation. Discussion: In conclusion, to take samples from arterial blood gas is an invasive operation and if not performed correctly it can cause complications to develop. Transportation and evaluation is as much important as sampling. It is very important to provide sufficient education to candidates of specialist physicians and to organize training courses aimed to increase their knowledge and experience during the period of their speciality without taking their speciality into account. Clin Ter 2014; 165(3):e194-198. doi: 10.7417/CT.2014.1718. © Società Editrice Universo (SEU).Öğe A Rare Reason of Mechanical Intestinal Obstruction; Phytobezoar Images for Clinicians(Modestum Ltd, 2014) Cikman, Oztekin; Ozkan, Omer Faruk; Adam, Gurhan; Tas, Sukru; Ademoglu, Serkan; Karaayvaz, MuammerMechanical intestinal obstruction is defined as the partial or total blockage of the passage of digested food in gastrointestinal system towards the distal. If intestinal obstruction is not treated properly it can cause high incidences of morbidity and mortality. The most frequent cause is adhesion after surgery but etiological cause changes frequently with age. Known symptoms of intestinal obstructions are nausea, vomiting, abdominal ache and distention in the abdomen. In our study we aimed to present a 70 year old patient with intestinal obstruction due to phytobezoar who developed sepsis, with the help of current literature.Öğe Agenesis of Isthmus of the Thyroid Gland in a Patient with Graves-Basedow Disease and a Solitary Nodule(Hindawi Ltd, 2013) Ozkan, Omer Faruk; Asik, Mehmet; Toman, Huseyin; Ozkul, Faruk; Cikman, Oztekin; Karaayvaz, MuammerThe thyroid is a vascular endocrine gland with two lateral lobes connected by a narrow, median isthmus. Although a wide range of congenital anomalies of the thyroid gland has been reported in the literature, agenesis of the thyroid isthmus is a very rare congenital anomaly Thyroid isthmus agenesis does not manifest clinical symptoms, and it can be confused with other thyroid pathologies. We describe a patient with no isthmus of the thyroid, associated with Graves-Basedow disease. Thyroid isthmus agenesis should be kept in mind in order for surgical procedures involving thyroid pathologies to be carried out safely.Öğe AN EXTREMELY RARE COMPLICATION OF MECKEL'S DIVERTICULUM: ENTEROCUTANEOUS FISTULIZATION OF UMBILICAL HERNIA(Colegio Brasileiro Cirurgia Digestiva-Cbcd, 2015) Cikman, Oztekin; Kiraz, Hasan Ali; Ozkan, Omer Faruk; Adam, Gurhan; Celik, Ahmet; Karaayvaz, Muammer[Anstract Not Available]Öğe Antioxidant Activity of Syringic Acid Prevents Oxidative Stress in L-arginine-Induced Acute Pancreatitis: An Experimental Study on Rats(Int College Of Surgeons, 2015) Cikman, Oztekin; Soylemez, Omer; Ozkan, Omer Faruk; Kiraz, Hasan Ali; Sayar, Ilyas; Ademoglu, Serkan; Taysi, SeyithanThe aim of this study was to investigate the possible protective role of antioxidant treatment with syringic acid (SA) on L-arginine-induced acute pancreatitis (AP) using biochemical and histopathologic approaches. A total of 30 rats were divided into 3 groups. The control group received normal saline intraperitoneally. The AP group was induced by 3.2 g/kg body weight L-arginine intraperitoneally, administered twice with an interval of 1 hour between administrations. The AP plus SA group, after having AP induced by 3.2 g/kg body weight L-arginine, was given SA (50 mg kg(-1)) in 2 parts within 24 hours. The rats were killed, and pancreatic tissue was removed and used in biochemical and histopathologic examinations. Compared with the control group, the mean pancreatic tissue total oxidant status level, oxidative stress index, and lipid hydroperoxide levels were significantly increased in the AP group, being 30.97 +/- 7.13 (P < 0.05), 1.76 +/- 0.34 (P < 0.0001), and 19.18 +/- 4.91 (P < 0.01), respectively. However, mean total antioxidant status and sulfhydryl group levels were significantly decreased in the AP group compared with the control group, being 1.765 +/- 0.21 (P < 0.0001) and 0.21 +/- 0.04 (P < 0.0001), respectively. SA reduces oxidative stress markers and has antioxidant effects. It also augments antioxidant capacity in L-arginine-induced acute toxicity of pancreas in rats.Öğe Does protocatechuic acid, a natural antioxidant, reduce renal ischemia reperfusion injury in rats?(Turkish Assoc Trauma Emergency Surgery, 2017) Yuksel, Melih; Yildar, Murat; Basbug, Murat; Cavdar, Faruk; Cikman, Oztekin; Aksit, Hasan; Aslan, FigenBACKGROUND: Protocatechuic acid (PCA), which has antioxidant property, is a simple phenolic compound commonly found in many plants, vegetables, and fruits, notably in green tea and almonds. Present study was an investigation of the effects of PCA on rat kidney with ischemia/reperfusion (IR) injury. METHODS: Sprague-Dawley rats were randomly divided into 4 groups: (1) Sham, (2) Renal IR, (3) Renal IR+ Vehicle, and (4) Renal IR+ PCA. Renal reperfusion injury was induced by clamping renal pedicle for 45 minutes after right nephrectomy was performed, followed by reperfusion for 3 hours. Dose of 80 mg/kg PCA was intraperitoneally administered to 1 group immediately before renal ischemia; 33% polyethylene glycol was used as vehicle. Total antioxidant status (TAS), malondialdehyde (MDA), superoxide dismutase (SOD), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 levels were measured in blood and kidney tissue samples taken from sacrificed rats. Kidney tissue samples were examined and scored histopathologically. Terminal deoxynucleotidyltransferase-mediated dUTP digoxigenin nick end labeling assay method was used to detect apoptotic cells. RESULTS: It was found that PCA significantly reduced serum MDA, TNF-alpha, and kidney MDA levels, while it increased serum and kidney TAS and SOD levels. Histopathological scores were significantly higher for the group given PCA. CONCLUSION: PCA reduced oxidative stress and can be used as an effective agent in treatment of renal IR injury.Öğe ENDOMETRIOMA LOCALIZED IN THE RECTUS ABDOMINIS MUSCLE: A CASE REPORT AND REVIEW OF LITERATURE(Colegio Brasileiro Cirurgia Digestiva-Cbcd, 2014) Ozkan, Omer F.; Cikman, Oztekin; Kidraz, Hasan Ali; Roach, Emir C.; Karacaer, Mehmet Ali; Karaayvaz, Muammer[Anstract Not Available]Öğe Endometrioma localized in the rectus abdominis muscle: a case report and review of literature(2014) Ozkan, Omer F.; Cikman, Oztekin; Kiraz, Hasan A.li; Roach, Emir C.; Karacaer, Mehmet A.li; Karaayvaz, Muammer[No abstract available]Öğe Fournier's gangrene current approaches(Wiley, 2016) Ozkan, Omer F.; Koksal, Neset; Altinli, Ediz; Celik, Atilla; Uzun, Mehmet A.; Cikman, Oztekin; Akbas, AlpaslanFournier's gangrene is a rare but highlymortal infectious disease characterised by fulminant necrotising fasciitis involving the genital and perineal regions. The objective of this study is to analyse the demographics, clinical feature and treatment approaches as well as outcomes of Fournier's gangrene. Data were collected retrospectively from medical records and operative notes. Patient data were analysed by demographics, aetiological factors, clinical features, treatment approaches and outcomes. Twelve patients (five female and seven male) were enrolled in this study. The most common aetiology was perianal abscess (41.6%). Wound cultures showed a mixture of microorganisms in six (50%) patients. For faecal diversion, while colostomywas performed in six cases (50%), Flexi-Seal was used in two cases (16.6%). In four patients (33.4%), no faecal diversion was performed. Negative pressure wound therapy (NPWT) system was effective in the last four patients (33.4%). The mean hospitalisation period in patients who used NPWT was 18 days, while it was 20 days in the others. NPWT in Fournier's gangrene is a safe dressing method. It promotes granulation formation. Flexi-Seal faecal management is an alternative method to colostomy and provides protection from its associated complications. The combination of two devices (Flexi-Seal and NPWT) is an effective and comfortable method in the management of Fournier's gangrene in appropriate patients.Öğe Intraoperative Endoscopic Retrograde Cholangiopancreatography in patients with complex benign biliary tract pathologies A case series(Edizioni Luigi Pozzi, 2018) Ozkan, Omer Faruk; Akbal, Erdem; Goret, Ceren Canbey; Goret, Nuri Emrah; Ozturk, Aydin; Cikman, Oztekin; Kocak, ErdemINTRODUCTION: This study presents data about the intraoperative performance of Endoscopic Retrograde Cholangiopancreatography (ERCP) for different types of cases with acute, complex pathologies of the biliary tract. MATERIALS AND METHODS: We retrospectively enrolled cases with intraoperative ERCP performed for different acute complex bile duct pathologies (including injury and cystic stump leak). All patients were analyzed according to demographic findings, etiologies, management and results. RESULTS: Intraoperative ERCP was performed in 4 patients of whom 2 (50%) were female and 2 (50%) were male with different diagnoses. The median age of patients was 468 (range of 28-75) years. The diagnosis was bile duct injury in three patients and one had a complicated hydatid cyst with jaundice (T Bil: 18 mg dl(-1)). All patients were in septic condition. Patients underwent laparotomy and intraoperative ERCP was performed successfully by using the Rendezvous technique. For the last patient, intraoperative ERCP was used for diagnosis and management of bile leak in the cavity. CONCLUSION: Intraoperative endoscopic retrograde cholangiopancreatography is a safe and effective method for treatment of acute complex bile duct pathologies.Öğe Isolated omental panniculitis: two case reports and review of literature(Modestum Ltd, 2017) Tas, Sukru; Cikman, Oztekin; Ozdil, Asli; Akgun, Yilmaz; Karaayvaz, MuammerIsolated omental panniculitis (IOP), a rare form of acute abdominal syndrome, is defined as intraabdominal panniculitis that involves only omentum without extraabdominal fat necrosis, inflammatory bowel disease and pancreatitis. In the search made using PubMed English database, only 4 cases are determined with IOP. IOP is conceptually confused with idiopathic omental infarction (IOI). However, omental infarctions that are rare causes of acute abdominal syndromes were published by Bush for the first time in 1986 and less than 400 cases were reported. In this article we aimed to publish 2 IOP patients who applied with acute abdominal manifestation and were treated with laparoscopic omental resection to discuss the other 4 IOP cases comparing with IOP together with literature.Öğe L-carnitine has a protective effect on the colonic mucosa during abdominopelvic radiotherapy in rats(Acta Cirurgica Brasileira, 2016) Tas, Sukru; Ozkan, Omer Faruk; Cikman, Oztekin; Kiraz, Asli; Akgun, Yilmaz; Karaayvaz, MuammerPURPOSE: To evaluate histopathologically the radioprotective effect of L-carnitine on the colonic mucosa in rats undergoing abdominopelvic irradiation. METHODS: Thirty-two rats were randomly assigned to four experimental groups: intraperitoneal administration of normal saline (group 1) or L-carnitine (300 mL/kg; group 2), followed in groups 3 and 4, respectively, by one dose of abdominopelvic radiation (20 Gy) 30 min later. Rats were sacrificed 5 days after radiation, and their descending colons were resected for histopathological evaluation of the presence and severity of damage. RESULTS: Average damage scores did not differ significantly between groups 1 and 2 (0.13 +/- 0.35 and 0.25 +/- 0.46, respectively); the group 3 score was highest (10.25 +/- 0.71), and the group 4 score (3.63 +/- 1.41) was significantly lower than that of group 3 (both p = 0.0001). Pre-radiation L-carnitine administration significantly reduced mucosal thinning, crypt distortion, reactive atypia, inflammation, cryptitis, and reactive lymph-node hyperplasia (all p < 0.01). CONCLUSIONS: L-carnitine had a radioprotective effect on rat colonic mucosa. L-carnitine use should be explored for patients with gastrointestinal cancer, who have reduced serum L-carnitine levels.Öğe Patients with Chiari Malformation Type 2 in VP Shunt Rare Complication(Derman Medical Publ, 2014) Akman, Tarik; Guven, Mustafa; Aras, Adem Bozkurt; Cikman, Oztekin; Safak, Ozbey; Karaaslan, Oznur; Akman, CananSpontaneous perforation of the bowel caused by VP shunt is a very rare complication, and if unnoticed will be fatal. Two years previously our case with Chiari malformation type 2 had revision of the distal end of the VP shunt and also myelomeningocele ends on at the end of the infant period. The case was examined laparoscopically and found to have rare spontaneous intestinal perforation at the transverse colon splenic flexure level, followed by anal prolapse of the peritoneal catheter.Öğe Perianal Giant Condyloma Acuminatum-Buschke-Lowenstein Tumor: A Case Report(Hindawi Ltd, 2012) Tas, Sukru; Arik, Muhammet Kasim; Ozkul, Faruk; Cikman, Oztekin; Akgun, YilmazCondyloma acuminatum caused by Human Papillomavirus is the most commonly occurring sexually transmitted infection in the anogenital region. Buschke-Lowenstein tumor (BLT) known also as giant condyloma acuminatum is a rare disease. The disease, for which the most important treatment method is the surgical excision, differs from normal condyloma acuminatum cases with its high degree of malignancy. The purpose of this paper is to present the case that reached huge dimensions in the perianal region and that was treated with wide resection in the literature.Öğe Radioprotective effects of nigella sativa oil against oxidative stress in liver tissue of rats exposed to total head irradiation(Informa Healthcare, 2014) Cikman, Oztekin; Ozkan, Adile; Aras, Adem Bozkurt; Soylemez, Omer; Alkis, Hilal; Taysi, Seyithan; Karaayvaz, MuammerObjective: Many cancer patients treated with radiotherapy suffer severe side effects during and after their treatment. The aim of this study was to investigate the effects of irradiation and the addition of Nigella sativa oil (NSO) on the oxidant/antioxidant system in the liver tissue of irradiated rats. Methods: A total of 24 Sprague-Dawley rats were randomly distributed into three groups of equal numbers. The control group received neither NSO nor irradiation but received 1-ml saline orally. The irradiation group (IR) received total head 5 gray (Gy) of gamma irradiation as a single dose, plus 1-ml saline orally. The IR plus NSO group received both total head 5 Gy of gamma irradiation as a single dose and 1 g/kg/day NSO orally through an orogastric tube starting one hour before irradiation and continuing for 10 days. Results: While liver tissue total oxidant status (TOS), lipid hydroperoxide (LOOH) level, and oxidative stress index (OSI) were significantly increased in the IR group compared to the control group, total antioxidant status (TAS), sulfhydryl (-SH) levels, and PON activity were significantly decreased. Cp activity in the IR plus NSO and IR groups was higher than in the control group. ARYL activity in the IR plus NSO supplemented group was higher than that in other groups. Conclusions: NSO reduces oxidative stress markers and has antioxidant effects, which also augments the antioxidant capacity in the liver tissue of rats. © 2014 Informa Healthcare USA, Inc.Öğe The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model(Taylor & Francis Inc, 2015) Ercan, Umut; Kiraz, Asli; Cikman, Oztekin; Turkon, Hakan; Kilinc, Nihal; Otkun, Muserref Tatman; Ozkan, Omer FarukAim: This study aimed to investigate the effects of L-carnitine, with its known antioxidant properties and positive effects on wound healing, on the healing of colon anastomosis in a cecal ligation and puncture sepsis model in rats.Materials and Methods: A total of 40 Sprague-Dawley rats were used. The rats were randomly divided into four groups of 10 (n = 10). Groups 1 and 2 had laparotomy and colon anastomosis performed. Groups 3 and 4 had cecal ligation and puncture (CLP) and colon anastomosis performed. Rats in Groups 1 and 3 were given 15mL/kg intraperitoneal 0.9% isotonic NaCl, while the rats in Groups 2 and 4 were given 100mg/kg intraperitoneal L-carnitine. On the postoperative fifth day, the rats were sacrificed and the burst pressure of anastomosis, histopathological effects, and tissue hydroxyproline levels were investigated.Results: In Groups 2 and 4, the anastomosis burst pressure and histopathological results in both noninfected abdomen and presence of peritonitis were statistically high compared to the control group (p < 0.05). Though the hydroxyproline levels were also high, there was no statistically significant difference for this parameter (p > 0.05).Conclusions: The findings obtained from the experimental sepsis model showed that healing of anastomosis in both the presence of peritonitis and noninfected abdomen was positively affected by the systemic administration of L-carnitine and this may contribute to the safety of anastomosis.Öğe The Radio-protective effects of Caffeic Acid Phenethyl Ester and Thymoquinone in rats exposed to total head irradiation(Springer Wien, 2015) Cikman, Oztekin; Taysi, Seyithan; Gulsen, Murat Taner; Demir, Elif; Akan, Muslum; Diril, Halit; Kiraz, Hasan AliMany cancer patients treated with radiotherapy suffer severe side effects during and after their treatment. The aim of this study was to investigate the effects of irradiation and the addition of caffeic acid phenethyl ester (CAPE) and thymoquinone (TQ) on the oxidant/antioxidant system in the liver tissue of irradiated rats. A total of 40 Sprague-Dawley rats were divided into five groups to test the radioprotective effectiveness of thymoquinone and caffeic acid phenethyl ester administered by intraperitoneal injection. Appropriate control groups were also studied. While liver tissue total oxidant status, lipid hydroperoxide level, and oxidative stress index were significantly increased in the irradiated (IR) group, compared with other groups, total antioxidant status, sulfhydryl levels, and paraoxonase (PON) activity were significantly decreased. Ceruloplasmin activity in IR plus TQ and IR groups was higher than the control group. Arylesterase and PON activities in IR plus TQ- and IR plus CAPE-supplemented groups were lower than those of control groups. TQ and CAPE decrease oxidative stress markers and have antioxidant effects, which also augment antioxidant capacity in the liver tissue of irradiated rats.Öğe The Radioprotective Effect of Caffeic Acid Phenethyl Ester and Thymoquinone in Rats Exposed to Total Head Irradiation(Elsevier Science Inc, 2014) Cikman, Oztekin; Taysi, Seyithan; Gulsen, Murat Taner; Demir, Elif; Akan, Muslum; Diril, Halit; Kiraz, Hasan Ali[Anstract Not Available]Öğe The Radioprotective Effects of Caffeic Acid Phenethyl Ester and Thymoquinone against Oxidative and Nitrosative Stress in Liver Tissue of Rats Exposed to Total Head Irradiation(Elsevier Science Inc, 2014) Cikman, Oztekin; Taysi, Seyithan; Gulsen, Murat Taner; Demir, Elif; Akan, Muslum; Diril, Halit; Kiraz, Hasan Ali[Anstract Not Available]Öğe Wernicke's Encephalopathy Following Gastrointestinal Surgery: MRI and DWI Findings(Turkish Neurological Soc, 2014) Kizildag, Betul; Canan, Arzu; Sen, Halil Murat; Tas, Sukru; Cikman, Oztekin; Dagistan, EmineWernicke's encephalopathy (WE) is a neurologic disorder resulting from thiamine (vitamin B1) deficiency characterised by the ocular signs, altered consciousness and ataxia. It is usually associated with chronic alcohol abuse. Recently, it emerged as a complication following bariatric surgery. The classical clinical triad occurs in a small group of patients, and early replacement of thiamine is an important prognostic factor. Hence, magnetic resonance imaging (MRI) is useful to support the diagnosis. In this case, we report MRI and diffusion weighted imaging findings of WE in a patient without history of alcoholism after gastrointestinal surgery.
