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    Clinical features and comorbidities in psoriasis. A retrospective study
    (Termedia Publishing House Ltd, 2022) Cicekliyurt, Meliha Merve Hiz; Ogretmen, Zerrin
    Introduction: Patients with psoriasis may develop several comorbidities. Objective: To determine the clinical characteristics and comorbidities associated with psoriasis. Material and methods: This retrospective case-control study involved 422 adult patients with psoriasis and 444 healthy individuals. The inclusion criteria for patients were: over 18 years old and at least one-year history of confirmed psoriasis. Data, such as age, gender, body mass index, smoking, and alcohol consumption habits were analyzed in addition to detailed physical and dermatological examination. Results: The common comorbidities in patients with psoriasis were depression (n = 144, 34%), hypertension (n = 168, 39.81%), diabetes mellitus (n = 100, 23.7%), coronary artery disease (n = 59, 13.9%) and metabolic syndrome (n = 67, 15.88%). The most common conditions in the control group were hypertension (n = 62, 13.96%), hyperlipidemia (n = 62, 13.96%), diabetes mellitus (n = 42; 9.46%), metabolic syndrome (n = 32; 7.21%) and coronary artery disease (5.41%). Patients with psoriasis are at a higher risk for obesity compared to healthy controls (OR = 1.99; p < 0.0001). In addition, smoking and alcohol consumption were significantly higher in patients with psoriasis (p < 0.0001). Conclusions: These results indicate an increased prevalence of obesity, hyperlipidemia, hypertension, cardiovascular diseases, diabetes, metabolic syndrome, and depression in patients with psoriasis.
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    DNA methylation in bryophytes as a biomarker for monitoring environmental pollution
    (Natl Inst Science Communication-Niscair, 2022) Cicekliyurt, Meliha Merve Hiz; Yayintas, Ozlem Tonguc
    Rapidly growing industrialization and increased need for transportation have led to environmental pollution, particularly heavy metals. Efficient monitoring would help planning effective strategies to curb such increasing pollution. In this context, we studied the epigenetic changes in the bryophyte Greater Fork-moss, Dicranum majus Turner so as to use to monitor the environmental stress conditions due to accumulation of heavy metals and toxic organic compounds. The hypothesis is that the DNAm (DNA methylation) signatures reflect changes in the environmental conditions, and thus could serve as an alternate monitoring tool to study environmental pollution. The vegetative form of D. majus was collected from two different geographical locations where one was near the main road (MR) and another in the forest area (FS). DNAm rate was found 10.41 +/- 2.009 and 23.37 +/- 2.94 in MR and FS, respectively (P <0.005). The only difference between the two samples were traffic related pollutants. Thus, the reuslts suggest that vehicle pollution induces epigenetic changes in bryophytes, particularly DNA methylation, and could serve as a valuable biomarker to assess pollution risk due to vehicle traffic.