Yazar "Cicekliyurt, Meliha Merve" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    CTLA4+rs231775 gene polymorphism increases PCOS, regardless of the levels of interleukin-6 and tumor necrosis factor-? in the serum
    (Bayrakol Medical Publisher, 2023) Beyazit, Fatma; Cicekliyurt, Meliha Merve; Turkon, Hakan; Unsal, Mesut Abdulkerim; Pek, Eren
    Aim: Polycystic ovarian syndrome (PCOS) is a long-standing inflammation-related disease with increased levels of circulating pro-inflammatory markers. By affecting inflammatory cytokine production, cytotoxic T lymphocyte-associated antigen (CTLA-4) polymorphism can alter the immune system and trigger distinct disease states. The aim of the study was to investigate if CTLA4 polymorphism is associated with PCOS, and if so, (2) whether this situation influences serum interleukin-6 (IL-6) and TNF-alpha in PCOS.Material and Methods: CTLA4+rs231775 gene polymorphism with IL-6 and TNF-a levels were determined in 92 PCOS women and 88 healthy controls. Study groups were further subdivided according to body mass index (BMI) and the degree of insulin resistance (IR), and comparisons were made within each study group.Results: The prevalence of the A allele of single nucleotide polymorphism (SNP) rs231775 was more frequent in PCOS women compared with healthy controls [OR: 1.99, 95% CI:1.273-3.107, p =0.0023]. The heterozygous genotype was also shown to be strongly associated with PCOS development [OR: 3.041, 95%CI:1.604-5.766, p=0.0005]. Although TNF-a levels of PCOS patients were detected to be elevated, no difference was found in the study groups with respect to serum IL-6 levels. In addition, no association was observed between CTLA4+rs231775 polymorphism and serum pro-inflammatory cytokine levels.Discussion: The present study demonstrates for the first time that CTLA4+rs231775 gene polymorphism increases susceptibility to PCOS 2 times more in the case of A allele carriage and 3 times more in heterozygous individuals, independent from the long-standing low-grade inflammatory disease state encountered in patients with PCOS.
  • [ X ]
    Öğe
    Genetic and immunological biomarkers in the diagnosis of pulmonary tuberculosis: A literature review for miRNA and cytokine characterization
    (Bayrakol Medical Publisher, 2023) Karadeli, Umit; Cicekliyurt, Meliha Merve
    There is a sensitive interaction in the relationship between the Mycobacterium tuberculosis that causes tuberculosis disease (TB) and its host. This interaction significantly affects the course of the infection. Unfortunately, scientific studies continue without slowing down this disease, which remains popular among the infectious diseases with the highest mortality rate. Although the importance of genetics and the immune system in the host-bacteria relationship is emphasized, immunopathological events still need to be fully elucidated. The molecular events between Mycobacterium tuberculosis and the host dictate the course of infection. Different expression levels of miRNAs in this infection continue until the polarization of macrophages. In addition, studies have shown that miRNAs also affect cytokine release in this cellular immune process. This review aimed to reveal how M. tuberculosis affects the course of host miRNAs during active infection and how cytokine levels change due to this interaction by reviewing the recent literature. This study will discuss the implications of using miRNA profiles and cytokine levels as biomarkers for the onset, maintenance, and termination of active TB.