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    Assessment of atrial electromechanical delay in patients with polycystic ovary syndrome in both lean and obese subjects
    (Wiley, 2014) Tasolar, Hakan; Mete, Turkan; Balli, Mehmet; Altun, Burak; Cetin, Mustafa; Yuce, Tuncay; Tasolar, Sevgi
    AimEven though polycystic ovary syndrome (PCOS) is characterized by increased inflammatory activity and insulin resistance, there is no clinical data about whether risk of atrial fibrillation are increased in these patients. We aimed to evaluate atrial conduction parameters predicting atrial involvement in this patient group. MethodsThe study population comprised 50 women 18-40 years of age who had been diagnosed with PCOS. The patients were divided into two groups: lean women (L-PCOS) with a body mass index (BMI) under 25kg/m(2) and obese women (O-PCOS) with a BMI greater than 30kg/m(2). Twenty-five age-matched lean healthy women were enrolled voluntarily as the control group. Difference between maximum and minimum P-wave duration was calculated and was defined as P-wave dispersion (Pd). Inter- and intra-atrial electromechanical delays (inter-AED, intra-AED, respectively) were measured with tissue Doppler imaging. ResultsInter- and intra-AED parameters were higher in the L-PCOS group when compared with control subjects (anova, P=0.004 and P=0.013, respectively), and were also significantly higher in the O-PCOS group compared with other groups (anova, P<0.001 for both). The regression analyses indicated that Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR) (=0.603, P<0.001) and BMI (=0.379, P<0.001) were the independent predictors of inter-AED, HOMA-IR (=0.835, P<0.001) was an independent predictor of intra-AED, and BMI (=0.457, P=0.006) and the left atrial diameter (=0.350, P<0.034) were independent predictors of Pd. ConclusionConsequently, our findings provide data regarding prolonged atrial conduction parameters in PCOS patients, especially when accompanied by obesity.
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    Assessment of Diastolic Function with Mitral Annular Plane Systolic Excursion in Obese Adults
    (Elsevier Science Inc, 2013) Tasolar, Hakan; Mete, Turkan; Cetin, Mustafa; Altun, Burak; Balli, Mehmet; Bayramoglu, Adil; Otlu, Omur
    [Anstract Not Available]
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    Effect of smoking on Tp-e interval, Tp-e/QT and Tp-e/QTc ratios as indices of ventricular arrhythmogenesis
    (Elsevier Science Inc, 2013) Tasolar, Hakan; Balli, Mehmet; Cetin, Mustafa; Altun, Burak; Cakici, Musa; Bayramoglu, Adil; Otlu, Omur
    [Anstract Not Available]
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    Effect of Smoking on Tp-e Interval, Tp-e/QT and Tp-e/QTc Ratios as Indices of Ventricular Arrhythmogenesis
    (Elsevier Science Inc, 2014) Tasolar, Hakan; Balli, Mehmet; Bayramoglu, Adil; Otlu, Yilmaz Omur; Cetin, Mustafa; Altun, Burak; Cakici, Musa
    Background Smoking may lead to ventricular arrhythmias and sudden cardiac death via altering ventricular recovery time dispersion indices such as QT interval and QT dispersion (QTd). The Tp-e/QT and Tp-e/QTc ratios are also known as predictors of ventricular arrhythmogenesis. The aim of this study was to evaluate the relationship between cigarette smoking and ventricular repolarisation dispersion using these novel electrocardiographic parameters. Methods One hundred and twenty-one chronic smokers and 70 age- and sex-matched non-smoker controls were included in our study. The Tp-e interval and Tp-e/QT ratio were measured by 12-lead electrocardiogram, and corrected for heart rate. Results QTd (34.2 +/- 8.4, 27.2 +/- 10.4, P < 0.001) and corrected QTd (37.3 +/- 8.9, 29.8 +/- 11.2, P < 0.001) were significantly increased in the smokers compared to the non-smoker control group. The Tp-e interval (76.5 +/- 6.3, 70.3 +/- 6.8, P < 0.001), cTp-e interval (83.5 +/- 8.0, 77.1 +/- 8.7, P <0.001), Tp-e/QT (0.20 +/- 0.03, 0.19 +/- 0.02, P < 0.001) and Tp-e/QTc ratios (0.19 +/- 0.02, 0.17 +/- 0.02, P < 0.001) were increased in the patient group when compared to the controls. Significant positive correlations were also found between the level of smoking with the cTp-e interval (r = 0.836, P <0.001), and Tp-e/QT (r = 0.714, P <0.001) and Tp-e/QTc ratios (r = 0.448, P < 0.001). Conclusion We found in our study that cTp-e interval, Tp-e/QT and Tp-e/QTc ratios were increased in smokers and significantly correlated to the amount of smoking.
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    Effects of Coronary Collateral Circulation on Tp-e interval, Tp-e/QT and Tp-e/QTc Ratios in Coronary Artery Disease Patients
    (Elsevier Science Inc, 2013) Tasolar, Hakan; Otlu, Omur; Bayramoglu, Adil; Balli, Mehmet; Cetin, Mustafa; Altun, Burak; Pekdemir, Hasan
    [Anstract Not Available]
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    Effects of the Coronary Collateral Circulation on the Tp-e Interval and Tp-e/QT Ratio in Patients with Stable Coronary Artery Disease
    (Wiley, 2015) Tasolar, Hakan; Balli, Mehmet; Cetin, Mustafa; Otlu, Yilmaz Omur; Altun, Burak; Bayramoglu, Adil
    BackgroundThe clinical utility of the Tp-e interval and Tp-e/QT ratio in the risk stratification of ventricular arrhythmic events is controversial. Therefore, we investigated the impact of CCC on these electrocardiographic indexes in the course of stable CAD. MethodsTwo hundred three consecutive patients with stable CAD who underwent coronary angiography and had documented total occlusion of one of the major coronary arteries were enrolled in this prospective cross-sectional study. The Tp-e interval and Tp-e/QT ratio were measured by 12-lead electrocardiogram. ResultsThe Tp-e interval, cTp-e interval, Tp-e/QT ratio, and cTp-e/QT ratio were lower in the grade 3 CCC group compared with the others in all leads. Multivariate linear regression analyses was performed to identify the clinical factors affecting the cTp-e interval and was indicated that age ( = 0.261, P < 0.001), male sex ( = 0.334, P < 0.001), poor Rentrop grade ( = -0.228, P < 0.001), and NLR ( = 0.137, P = 0.027) were independent predictors of a prolonged cTp-e interval. ConclusionIt could be concluded that the decreased dispersion of ventricular repolarization might contribute to the lower incidence of ventricular arrhythmias and SCD in CAD patients with a good CCC.
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    Is the level of resistin appropriate for predicting atrial fibrillation?
    (Elsevier Science Bv, 2014) Tasolar, Hakan; Balli, Mehmet; Cetin, Mustafa; Altun, Burak
    [Anstract Not Available]
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    Mitral annular plane systolic excursion in the assessment of left ventricular diastolic dysfunction in obese adults
    (Turkish Soc Cardiology, 2015) Tasolar, Hakan; Mete, Turkan; Cetin, Mustafa; Altun, Burak; Balli, Mehmet; Bayramoglu, Adil; Otlu, Yilmaz Omur
    Objective: Mitral annular plane systolic excursion (MAPSE) is a simple way to assess left ventricle (LV) function. MAPSE is also correlated to parameters, illustrating the close relation between systolic and diastolic function of LV. In this study, we evaluated whether MAPSE could help us in the determination the LV diastolic dysfunction (DD) in obese adults. Methods: Our study was a prospective cross-sectional study. Obese patients who were referred from the endocrinology clinic were enrolled into this study. The participants included 40 obese patients with early-stage DD (grade I and II) and 40 obese patients with normal diastolic function, with an equal number of males and females. The patients with DD were further divided into Obese DD+I, who had grade I DD, and Obese DD+II, who had grade II DD. Student t-test, Mann-Whitney U test, one-way analysis of variance, ROC curve analysis, and pairwise comparisons of the ROC curves were used for statistical analysis. Results: MAPSE was different in all groups, with the lowest value in the Obese DD+II group (p<0.001). E/Em ratio was also different among all groups and was highest in the Obese DD+II group (p<0.001). Furthermore, MAPSE was negatively correlated with E/Em ratio (r=-0.368, p=0.020). The optimal threshold point of MAPSE in the diagnosis of left ventricle diastolic dysfunction (LVDD) was <= 1.45 cm, with 92.5% sensitivity (95% CI 79.6-98.4) and 77.5% specificity (95% CI 61.5-89.2) in the ROC curve analysis. There was no difference in the pairwise comparisons of the ROC curves of MAPSE and E/Em ratio in the diagnosis of DD [area under the ROC curve 0.902 (0.033) vs. 0.927 (0.027); p=0.54]. Conclusion: Consequently, we found significantly a close relationship between MAPSE with conventional echocardiographic parameters, especially with E/Em, in the detection of left ventricle diastolic dysfunction (LVDD) in obese adults with normal LV ejection fraction. We think that MAPSE is a simple, easily acquired and less time consuming measurement and may help us in the stratification of LVDD in obese adults.