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    Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces
    (Doc Design Informatics Co Ltd, 2023) Gokce, Oruc Numan; Cetin, Kenan; Alkan, Sevil; Tas, Sukru; Dinc, Ugur
    Objective: We aimed to determine the scolicidal effect of hypochlorous acid and its efficiency at different concentrations. Materials and Methods: We tested the effectiveness of hypochlorous acid in -vitro on sterile gauze at different concentrations in test tubes. In addition, we compared its effectiveness with the scolicidal activity of other agents, povidone-iodine 10% and chlorhexidine-gluconate 0.04%. Results: Hypochlorous acid was 100% effective in 5 minutes at 1/1 (200 ppm/mL), 1/10 (20 ppm/mL), and 1/100 (2 ppm/mL) concentrations and in 10 minutes at 1/1000 (0.2 ppm/ mL) concentration. Povidone-iodine 10%, and chlorhexidine-gluconate 0.04% were studied undiluted and were effective at all study times. Hypochlorous acid maintained the same scolicidal activity on gauze at all study times at the described dilutions. Conclusion: Hypochlorous acid is an effective scolicidal agent in 5 minutes at even 1/100 concentrations. In addition, it maintains the same scolicidal activity on gauze used in surgery to wall the surgical site.
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    Öğe
    THE ROLE OF DIFFUSION-WEIGHTED MR IMAGING IN EVALUATING THE RESPONSE TO STEROID THERAPY IN IDIOPATHIC GRANULOMATOUS MASTITIS LESIONS
    (Istanbul Univ, Fac Medicine, Publ Off, 2022) Rona, Gunay; Arifoglu, Meral; Voyvoda, Nuray; Cetin, Kenan; Damgaci, Lale
    Objective: The aim of this study was to investigate the role of diffusion-weighted magnetic resonance imaging (DW MRI) with an apparent diffusion coefficient (ADC) map in evaluating the re-sponse to treatment of steroid-treated idiopathic granulomatous mastitis (IGM) lesions.Materials and Methods: This retrospective study included 99 le-sions of 58 female patients (average age: 32.91 years; range: 22-55 years) with biopsy-proven IGM. Patients were treated with oral and topical steroids. All pre-treatment and post-treatment MR exam-inations were evaluated. The maximal size of the masses and non-mass enhancement (NME) lesions were measured. Patients were classified as complete response (CR), partial response (PR), and non-response (NR) according to the dynamic contrast-enhanced (DCE) MR findings after treatment.Results: ADC values of areas occupied by IGM (0.933 +/- 0.317x10-3 mm2/sec) were lower than contralateral normal parenchyma (1.259 +/- 0.423x10-3 mm2/sec). Twenty-two (22.22%) of the lesions were in the NR group, 30 (30.30%) in the PR group, and 47 (47.47%) in the CR group. There was no significant difference between the pre-treatment ADC values in NR, PR, and CR groups (p=0.228). There was a significant difference between the pre-treatment and post-treatment ADC values in the PR groups (p=0.001).Conclusion: DW MR imaging in IGM is a useful method to monitor the response to treatment. However, it is not successful in predict-ing response to treatment.