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Öğe Accompanying Infections in Hospitalized Children with Neurological Disease(Galenos Publ House, 2022) Cokyaman, Turgay; Kasap, Tolga; Celik, TaylanIntroduction: Infections in children with neurological disease often require hospitalization and are treated with antibiotics. In this study, it was aimed to determine the accompanying infections, antibiotics used and pathogenic microorganisms grown in cultures in hospitalized children with neurological disease. Materials and Methods: Digital medical files of patients between one month and 18 years old admitted to the pediatric neurology service were retrospectively analyzed. Diagnoses of neurological and infectious disease, antibiotics and antiepileptics used, and culture antibiogram results were recorded. Results: The most common infectious disease in children with neurological disease was lower respiratory tract infections (50%). Antibiotic use rate in children with neurological diseases was 51.9% (32.4% single and 19.4% combined). Lower respiratory tract infections (50%) were the leading antibiotic indications. Third generation cephalosporins (46%) were the most used in mono antibiotherapy, carbapenems (26.6%), gylicopeptides (26.6%) and broad-spectrum penicillins (10%) were used at higher rates in combined antibiotherapy. Pathogenic microorganisms such as Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Morganella morganii and Enterococcus raffinosus were grown in urine cultures, Staphylococcus aureus and Enterococcus faecium in blood cultures. 59.3% of the children with neurological diseases were receiving antiepileptic treatment. Valproic acid 24.6%, levetiracetam 20.0%, phenobarbital and carbamazepine were used at 10.8% frequency. Conclusion: The most common infectious disease in hospitalized children with neurological disease is lower respiratory tract infections. Although cephalosporin is mostly preferred in mono-antibiotherapy, carbapenem and glycopeptides come to the fore in combined therapy. It is important to know the infections that may develop in the follow-up of this group of patients and the possible causative pathogens for rapid and effective treatment and to reduce health costs.Öğe Bibliometric Analysis of Human Metapneumovirus Studies(Doc Design Informatics Co Ltd, 2023) Aliravci, Isil Deniz; Celik, Taylan; celik-Ekinci, Semiha; Hamidi, Aziz AhmadObjective: This study aimed to estimate research productivity and general characteristics of research in different regions of the world in the field of human metapneumovirus (hMPV). Materials and Methods: We used the Web of Science (WoS) electronic database to retrieve articles on human metapneumovirus, published up to March 31, 2023. Parameters such as research productivity, the total number of publications, average citation counts of all ar-ticles, research productivity by top publishing countries and affiliated organizations, links between countries/organizations, and top keywords were assessed. Results: We found 826 articles in the WoS database. The first article on hMPV was pub-lished in 2002, and 2008 was the year that the most articles on hMPV were published, with 70 articles. The articles were cited 26,797 times (14,498 times without self-citations) and 32.25 times on average per article. Hirsch (H)-index was 80. The year 2008 also had the highest number of citations, with more than 1800. The United States was the most pro-ductive country, producing 295 documents (35.714%), one-third of all publications in this field worldwide. Canada (6.5%) and Japan (6.5%) followed the United States regarding total hMPV publications worldwide. The leading funding agencies for hMPV research were from the United States, Europe, China, and Japan. Conclusion: Our findings imply that developed countries should assist developing countries in enhancing their research infrastructures.Öğe COVID-19 Vaccine Hesitancy of Parents of Children with Type 1 Diabetes in Turkiye: A Mixed-Methods Study(Aves Yayincilik, Ibrahim Kara, 2023) Celik, Taylan; Dogan, DurmusObjective: In this study, we aimed to investigate the attitudes of parents who have children with type 1 diabetes mellitus to get their children vaccinated against COVID-19.Material and Methods: The target population of the study consisted of 124 parents of children followed in canakkale Onsekiz Mart Univer-sity Hospital, Pediatric Endocrinology Clinic with the diagnosis of type 1 diabetes. We used an online questionnaire to determine the attitudes of parents.Results: A total of 102 parents, 76 of whom were mothers, were includ-ed in the study. Mean age of the parents was 40.5 & PLUSMN; 7.27, and children were 12 & PLUSMN; 4.07. Mean duration elapsed since the diagnosis of type 1 diabetes was 4.5 & PLUSMN; 3.3 years. About half of the parents thought that type 1 diabetes mellitus was a risk factor for COVID-19. While the rate of parents who were not vaccinated for COVID-19 was 21.6%, 46.1% were hesitant to vaccinate their children. The parental-related factors causing vaccine hesitation were fathers, young parents, those who weren't wor-ried about their children being infected with COVID-19, did not think children with type 1 diabetes mellitus were more at risk, or were unvac-cinated. Child-related factors were young age or short duration of ill-ness. In qualitative analysis, vaccination-hesitant parents' main concern was vaccine side effects, and they expected clear evidence-based confi-dence-building recommendations for vaccination.Conclusion: In conclusion, it is seen that especially young parents, whose children are small or newly diagnosed, will have problems in their motivation about vaccination.Öğe Evaluation of Childhood Fever Management(Bilimsel Tip Publishing House, 2024) Celik, Taylan; Arikan, Kamile Otiken; Arisoy, Emin Sami; Bursal, Burcu; Erdeniz, Emine Hafize; Hacimustafaoglu, Mustafa; Kara, Manolya[Anstract Not Available]Öğe Herpes Zoster in Children; Should the Varicella Vaccine be Administered as a Single Dose or a Double Dose?(Galenos Publ House, 2022) Celik, Taylan; Inan, Dogan BahadirIntroduction: In this study, we aimed to evaluate the clinical and epidemiological characteristics of children followed up with the diagnosis of herpes zoster, together with the data of our country. Materials and Methods: Patients who were followed up with the diagnosis of Herpes Zoster in the Pediatric Infectious Diseases Clinic of Kayseri Training and Research Hospital between 2016-18 were analysed retrospectively. Results: Twenty (69%) of 29 patients included in the study were female. The mean age of the patients, whose ages ranged from 2 to 16 years, was 8.86 +/- 0.6 years. Twenty (69%) of the patients had varicella infection and 6 (20.7%) had a history of single-dose varicella vaccination. The mean age of those who had varicella vaccine was 4.33 +/- 0.5, and those who had the varicella infection were 9.9 +/- 0.6 years. Four of the patients (13.8%) presented with only rash. Along with the rash, 25 patients (85.8%) had pruritus and 14 (48.3%) described pain. Thoracic dermatomes were most frequently involved with 69%, followed by cervical (17.3%), lumbar (10.3%) and trigeminal (3.4%) dermatomes, respectively. The patients had no known chronic disease, immunodeficiency (primary or secondary) or history of surgical intervention. Conclusion: This study, emphasizes that varicella vaccination can change the epidemiology of HZ in healthy children, causing it to be seen at an earlier age, and emphasizes the importance of two-dose vaccination.Öğe Parents' Knowledge and Management of Fever: Parents Versus Fever!(Aves, 2024) Celik, Taylan; Guzel, YusufObjective: Parents' lack of knowledge about fever causes fear and incorrect practices. This study aims to investigate the fever knowledge level, concerns, and practices of parents of preschool children. Materials and Methods: In this descriptive, cross-sectional study, conducted between July 2021 and July 2022, a survey was conducted among parents of children aged 6 months to 5 years who did not have a history of febrile seizure and/or chronic disease, either in themselves or their siblings. Results: A total of 386 parents, with a mean age of 33.6 +/- 6.38 years and a mean number of children of 1.85 +/- 0.9, participated in the study. Approximately one-third of parents started giving antipyretics to their child before the body temperature reached 38 degrees C (32.4%) and/or used them alternately (34.5%). Moreover, approximately two-thirds (67.1%) tended to seek medical help within the first 12 hours. Parents who could not define fever correctly (66.6%) were more likely to start giving antipyretics before the child's body temperature reached 38 degrees C [odds ratio (OR) 2.83 (1.70-4.71), P < .001] and seek medical help within the first 12 hours [OR 1.81 (1.16-2.82), P = .008]. As the number of children or length of parenting increased, parents started giving antipyretics before the body temperature reached 38 degrees C [OR 1.61 (1.26-2.06), P < .001; OR 1.04 (1.01-1.08), P = .048] and used them alternately [OR 1.07 (1.03-1.11), P = .001; OR 1.28 (1.02-1.62), P = .031]. Conclusion: This study demonstrates that a substantial proportion of parents still cannot define fever correctly, and inappropriate antipyretic use is more prevalent among experienced parents with multiple children and/or longer lengths of parenting.Öğe Perianal Abscess in Children: Are Resistant Microorganisms a Real Problem?(Aves Yayincilik, Ibrahim Kara, 2022) Celik, Taylan; Kaan, Emre; Caglar, OzgurObjective: Perianal abscess is a common purulent disease in daily pediatric practice caused by infection of perianal tissues and cavities. There is a strong male dominance in affected children less than two years old. In our study, we aimed to investigate the clinical and laboratory studies of cases diagnosed with perianal abscess in childhood. Material and Methods: Medical data followed by the diagnosis of perianal abscess by Kayseri Training and Research Hospital, Pediatric Infectious Diseases between October 2016, and June 2018, were retrospectively analyzed. Results: A total of 15 patients were followed up with a diagnosis of perianal abscess. Fourteen (93.3%) of the patients were male. Their average age was 19.10 +/- 8.86 months. Seven (46.6%) of the patients were less than six months old and 11 (73.3%) were younger than one year old. Fever was associated with only one (6.7%) correspondence complaints, 13 (86.6%) patients were brought close to perianal row swelling. Surgical drainage was applied to all 12 (80%) patients who were hospitalized and followed up. There was growth in the abscess culture in 10 (83.3%) of the patients. In 60% of the patients with culture growth, the agents were resistant microorganisms. In 50% of our hospitalized cases, treatment change was required according to the culture antibiogram results, and the combined use of meropenem and amikacin was preferred in these patients. Conclusion: In conclusion, although perianal abscesses are common in children, data on the management and treatment of the disease are limited. Our study highlights the benefit of routine abscess culture in the treatment of perianal abscesses.Öğe Research trends on the gut microbiota in endocrine metabolism: a thematic and bibliometric analysis(Frontiers Media Sa, 2024) Dogan, Durmus; Celik, TaylanBackground Gut microbiota studies in the field of endocrinology metabolism have attracted increasing attention in recent years. To comprehensively assess the evolving landscape of this research field, we conducted a thorough bibliometric analysis of gut microbiota studies in endocrinology metabolism indexed in the Web of Science database.Methods We collected and analyzed 3,339 original research articles and reviews published from 1972 to 2023. Using various bibliometric indicators, we investigated publication trends, country contributions, international collaborations, prolific authors, top journals, and influential articles.Results Our analysis revealed a significant upsurge in publications after 2010, indicating a growing scientific interest in microbiota and endocrinology metabolism. Keyword and thematic analyses have identified gut microbiota, obesity, diabetes, and inflammation as core research themes. Additionally, the roles of probiotics and prebiotics are increasingly researched for their therapeutic effects in shaping the microbiota.Conclusion This study reveals that research in endocrinology metabolism is increasingly decoding the connection between gut microbiota and diseases. There's also a growing focus on microbiota manipulation, which points to a shift towards personalized medicine. Future research should focus on integrating these findings into clinical practice, moving from lab-based studies to real-world patient care.Öğe Retrospective Evaluation of Cases Accepted by Inter-hospital Transfer to the Pediatric Emergency Clinic(Galenos Publ House, 2022) Celik, Taylan; Guzel, Sinan; Canakkale, Fatih BattalIntroduction: Inter-hospital transport is an important process of pediatric emergency and pediatric intensive care; the patient is transferred to another center with the emergency medical services. Inter-hospital transport can be life-saving for pediatric patients, but the process can logistically be difficult and risky. The actions required to prevent unwanted events during transport depend mostly on the accurate and reliable data obtained. We think that research on the transport of pediatric patients is limited in our country. Our study investigated the characteristics of pediatric patients transferred to our unit by ambulance and the problems during transport.Methods: One hundred and eighty-three patients under the age of 18 who were referred to the pediatric emergency service between June 2017 and June 2019, whose data were regularly recorded, were included in our study. Data of patients who were sent to the external center for consultation via 112 were excluded. The list of the transferred patients was obtained from 112 command centers in our city and the patient records were analyzed retrospectively with the hospital information management system.Results: Fifty-nine percent of the 183 patients included in our study were male. The mean age of the patients was 62.2 +/- 39.1 months. Fourty-two percent of the patients were between 1 month and 3 years old. We found that the most frequent transports are in the spring with 42.6% and 50.9% of the transports took place between 16.00-00.00 hours. We found that the most common transported patients were pneumonia with 28.4% and respiratory distress was the most common adverse event during transport with 7.1%.Conclusion: In the transfer of pediatric patients between hospitals, every step, from the training of staff to the equipment in the ambulance, should be planned in detail. We believe that more studies are needed to examine transport protocols for children's emergency medical services, the level of education required by the transport team, the state of the medical device used in the transport process, the patient's pre and posttransport stability, and the safety of the patient during the transport period.Öğe The prevalence and prognostic effect of hyponatremia in children with COVID-19 pneumonia: a retrospective study(Turkish J Pediatrics, 2023) Celik, Taylan; Dogan, Durmus; Parlak, Cagri FurkanBackground. The aim of the study was to examine the effect of hyponatremia at admission as a negative prognostic factor in children hospitalized with COVID-19 pneumonia. Methods. The data of patients aged 1 month-18 years, who were followed with the diagnosis of pneumonia at Canakkale Onsekiz Mart University Hospital, Department of Pediatrics, between January 2018 and May 2021 were examined, retrospectively. Patients (n=661) were divided into two main groups; COVID-19 pneumonia (n=158) and the other pneumonias [other viral pneumonia (n=161) and pneumonia of unknown etiology (n=342)]. Results. Six hundred and twenty-three patients with a median (Q1-Q3) age of 4 (1.5-8) years, 59.4% of whom were male were included in the study. The overall prevalence of hyponatremia at admission was 11.2% and was lower in those with COVID-19 pneumonia than in those with other viral pneumonia (6.4% vs. 15.2%, p=0.013). When evaluated irrespective of their COVID-19 status, hyponatremic patients had a higher supplemental oxygen requirement (OR 2.5 [1.4-4.3], p 0.001), higher need for intensive care unit (ICU) admission (OR 3.7 [1.3-10.2], p=0.009) and longer duration of hospitalization (p=0.016) than the normonatremic patients. In patients with COVID-19 pneumonia, being hyponatremic had no effect on supplemental oxygen requirements or the duration of hospitalization. When hyponatremic patients were evaluated, the supplemental oxygen requirements and duration of hospitalization of those with COVID-19 pneumonia were similar to the other pneumonias (p 0.05 for all comparisons). However, normonatremic COVID-19 pneumonias had higher supplemental oxygen requirements than other viral pneumonias and pneumonia of unknown etiology (OR 4.7 [2.2-10.3], p<0.001; OR 1.6 [1 -2.7], p=0.043, respectively). Conclusion. This study found that hyponatremia at admission is rarer in children with COVID-19 pneumonia than other viral pneumonias and has no effect on supplemental oxygen requirements or the duration of hospitalization.Öğe Trust, distrust and skepticism: Parent's perspective on COVID-19 prevention and vaccination in children aged 0-5 years(Galenos Publ House, 2023) Celik, Taylan; Tarhan, Buket BasaranObjective: The study aimed to determine the attitudes of parents with children aged 0-5 years towards protecting their children from COVID-19, the rate of those who hesitated to have their children vaccinated, and the factors causing hesitation. Methods: In this descriptive, cross-sectional study, we conducted a survey with parents of children aged 0-5 years from July 2021 to May 2022. Results: Four hundred and sixty-four parents with children 0-5 years of age were analyzed. The mean age of the participants was 34.6 +/- 7.3 years and the mean number of children was 1.79 +/- 0.78, the majority (72%) of which were mothers. The main source of information for COVID-19 was television channels for the participants (68.5%). Parents most often chose to wash their hands (91%) to prevent their children from contracting COVID-19. Fiftyseven percent of parents, especially those whose source of information for COVID-19 was social media platforms (OR 1.45 [1-2.1], p= 0.048), distrusted the measures they took to prevent their children from contracting COVID-19. Fifty-one percent of parents distrusted hospital measures to prevent transmission of COVID-19, and 55% were hesitant to get their children vaccinated for COVID-19. Increasing parental age (OR 1.02 [1.01-1.05], p= 0.040), having a family member who has had COVID-19 (OR 1.47 [1.01-2.16], p= 0.043), and parents' trust in hospital COVID-19 measures (OR 2.04 [1.41-2.91], p= 0.001) have increased the desire to vaccinate their children against COVID-19. Conclusion: Considering that vaccination is the most important step in preventing infection, information provided to parents by reliable authorities can help increase vaccination acceptance rates.
