Yazar "Celik, Mehmet" seçeneğine göre listele

Listeleniyor 1 - 7 / 7
  • Küçük Resim
    Öğe
    Demographic, clinical and laboratory characteristics of extrapulmonary tuberculosis: Eight-year results of a multicenter retrospective study in Turkey
    (Sage Publications Ltd, 2025) Celik, Mehmet; Gurbuz, Esra; Cicek, Yeliz; Buyuktuna, Seyit Ali; Gundag, Omur; Gulderen Kuscu, Evrim; Mermutluoglu, Cigdem
    Extrapulmonary tuberculosis (EPTB) is an important public health problem due to its diverse clinical presentations, diagnostic complexities, and significant impact on patient outcomes and public health. Our study aimed to understand the sociodemographic, clinical, and laboratory characteristics as well as diagnostic and treatment modalities of adult patients with EPTB. This is a multicentric retrospective study that covers patients with EPTB cases followed up from January 2015 to December 2022 among tuberculosis (TB) dispensaries and Infectious Diseases and Clinical Microbiology clinics of 15 hospitals located in various regions of Turkey. The study included 64.6% women with a mean age of 44 years and a mortality rate of 3.5% within 1 year of diagnosis. Initial constitutional symptoms were predominantly fatigue (57%) and anorexia (53.7%). The most commonly affected sites were the lymph nodes (49.1%) and pleura (9.7%). The lumbar region was particularly involved in cases with spinal TB. Diagnostic findings included acid-fast bacilli positivity in 27.5% of cases, tuberculosis polymerase chain reaction positivity in 41%, elevated adenosine deaminase levels in 91.2% (especially in pleural and peritoneal fluids), and mycobacterial culture positivity in 40.9%. Pathology slides showed granulomatous inflammation in 97.7%. Increased C-reactive protein (CRP) levels correlated with the number of organs affected. Anti-TB treatment-related hepatotoxicity was detected in 8.9% of patients. In this study, it is important to note that the lumbar region is predominantly affected with involvement in spinal region. CRP level was consistent with the number of organ involvements and was one of the most critical results of this study.
  • [ X ]
    Öğe
    Evaluation of Knowledge and Practices of Individuals Living with Livestock on Brucellosis: A Study from Eastern Anatolia Region, Turkey
    (University of Tabriz, 2023) Celik, Mehmet; Cicek, Yeliz; Atasoy, Pınar Yuruk; Botan, Emine Ulu; Alkan, Sevil
    Brucellosis is one of the most important zoonoses, which can be seen at higher risk, especially in livestock. This study aimed to evaluate the demographic characteristics and practices of people occupied in livestock on brucellosis. This cross-sectional survey was conducted between February 2023 and May 2023. The participants were asked questions about their socio-demographic information, level of knowledge about brucellosis, and basic practices during livestock. The mean age of the 204 participants included in the study was 41.53±15.66 years, and 64.7% (n=132) were male. Most participants were shepherds (45.1%). While all participants stated that they had heard of brucellosis and that the disease was transmitted from animals to humans, 12 (5.9%) stated that they had brucellosis before. No participants had received training on brucellosis. While all participants thought that brucellosis could be transmitted by consuming milk directly without boiling it, 98% thought that brucellosis could be transmitted from cheese made without boiling milk, and 96.6% from butter. The proportion of those who thought that the disease could be transmitted by touching abortion material or sick animals with bare hands was low (7.8% and 3.9%, respectively). The fact that the participants had some incorrect information and approaches about foodborne transmission, that they had not received any training on zoonotic infections, that they did not comply with the hygiene rules in contact with waste material, and that wrong practices in the case of new animal participation in the herd reveals that more information and action is needed for the eradication of brucellosis. © 2023, Published by University of Tabriz.
  • [ X ]
    Öğe
    Investigation of hematologic findings related to brucellosis in Anatolian region
    (Saudi Med J, 2024) Celik, Mehmet; Arslan, Yusuf; Topcu, Ertugrul; Sahinoglu, Mustafa Serhat; Altindag, Deniz; Gurbuz, Esra; Atalay, Ebru
    Objectives: To investigate the prevalence of hematologic findings and the relationship between hemogram parameters and brucellosis stages in patients. Methods: This multi-center study included patients older than 16 years of age who were followed up with a diagnosis of brucellosis. Patients' results, including white blood cell, hemoglobin, neutrophil, lymphocyte, monocyte, mean platelet volume, platelet and eosinophil counts were analyzed at the initial diagnosis. Results: In this study 51.3% of the patients diagnosed with brucellosis were male. The age median was 45 years for female and 41 years for male. A total of 55.1% of the patients had acute brucellosis, 28.2% had subacute, 7.4% had chronic and 9% had relapse. The most common hematologic findings in brucellosis patients were anemia (25.9%), monocytosis (15.9%), eosinopenia (10.3%), and leukocytosis (7.1%). Pancytopenia occurred in 0.8% of patients and was more prominent in the acute phase. The acute brucellosis group had lower white blood cell, hemoglobin, neutrophil, eosinophil, and platelet counts and mean platelet volume, and higher monocyte counts compared to subacute and chronic subgroups. Conclusion: It was noteworthy that in addition to anemia and monocytosis, eosinopenia was third most prominent laboratory findings in the study. Pancytopenia and thrombocytopenia rates were low.
  • [ X ]
    Öğe
    Opinions of healthcare professionals on hand hygiene use and evaluation of hand hygiene compliance rates
    (2023) Celik, Mehmet; Ceylan, Mehmet Resat; Dedeoğlı, Gul Kılıc; Durna, Meryem; Atasoy, Pınar Yuruk; Alkan, Sevil
    Aim: The aim of this study was to determine the hand hygiene habits, beliefs, and practice levels of healthcare workers. Materials and Methods: A total of 238 healthcare workers were included in this crosssectional survey study. The first part of the questionnaire included sociodemographic data and questions about hand hygiene habits, while the second part included questions from the Hand Hygiene Belief Scale (HHBS) and Hand Hygiene Practice Inventory (HHPI). Results: The mean age of the participants was 33.16±8.54 years and 147 (61.8%) of them were male. The majority of the participants were nurses/health officers (n=92, 36.8%). The rate of those who had previously participated in in-service training was 58.4%. The mean HHBS score was 79.79 and the mean HHPI score was 60.08. The mean HHBS score was higher in women than in men (p=0.003). In terms of occupational groups, the mean HHBS score of physicians (p=0.024) and the mean HHPI score of nurses/health officers (p=0.006) were higher. It was determined that the mean HHPI score of the employees working in internal clinics was higher than those working in surgical clinics (p=0.044), while there was no significant difference in terms of the mean HHBS score. The mean HHPI was higher in participants who received in-service training on hand hygiene (p=0.004). Participants who spent <15 seconds on average while washing their hands had a lower mean HHPI than participants who spent a longer time washing their hands (p=0.003). Conclusion: In the study, it was found that the belief in hand hygiene was high and the practice was generally adopted. The fact that employees especially in surgical departments paid less attention to hand hygiene practice was an important problem. Increasing the frequency of in-service pieces of training to increase compliance with hand hygiene and eliminating the preventive factors will be extremely beneficial for reducing nosocomial infections.
  • [ X ]
    Öğe
    Possible drug-drug interactions among elderly patients receiving antiviral therapy for chronic hepatitis B
    (Medicinska Naklada, 2024) Celik, Mehmet; Arslan, Yusuf; Onder, Taylan; Alkan, Sevil; Sahin, Ahmet; Akgul, Fethiye
    Aim To identify possible drug-drug interactions in patients taking medications for other comorbidities while on antiviral therapy for chronic hepatitis B. Methods The study enrolled patients with chronic hepatitis B aged >= 60 years who were treated with antiviral therapy in five hospitals in Turkey between January 1 and March 1, 2023. The Lexicomp (R) Drug Interactions program was used to identify possible drug-drug interactions. Results The study included 213 patients (119 [55.9%] men). The mean age was 68.5 years. A potential drug- drug interaction was identified in 112 patients (52.6%). The most common type of interaction was type C (follow the treatment) (71.54%). The number of potential drug-drug interactions increased with an increase in the number of drugs used by the patients. A robust and affirmative correlation was observed between the number of medications used and the number of possible drug-drug interactions (r = 0.791, P < 0.001). Adverse interactions (interactions of types C and D, 3.7% of cases) were limited to patients receiving tenofovir disoproxil fumarate. Conclusion Nonsteroidal anti-inflammatory medications should be used cautiously in elderly patients with chronic hepatitis B treated with tenofovir disoproxil fumarate due to the increased risk of renal toxicity.
  • [ X ]
    Öğe
    Predictive Significance of Laboratory Tests in Bacteremic Brucellosis
    (Iranian Scientific Society Medical Entomology, 2024) Celik, Mehmet; Cicek, Yeliz; Atalay, Ebru; Altindag, Deniz; Akgul, Fethiye; Urkmez, Fatma Yekta; Gurbuez, Esra
    Background: Brucellosis is one of the most common zoonotic infections. Although culture is the gold standard diagnostic method, bacterial growth in blood cultures may not always occur due to various factors. We aimed to investigate demographic, clinical, and laboratory findings that may have predictive significance for bacteremia in brucellosis. Methods: Patients older than 18 years of age followed up with a diagnosis of brucellosis between 2012 and 2022 were included in this retrospective multicenter study. They were divided into two main subgroups according to their Brucella species reproductive status as bacteremic and non-bacteremic. Results: A total of 743 patients, 370 (49.80%) bacteremic and 373 (50.20%) non-bacteremic brucellosis patients, were enrolled. The mean age of the bacteremic group (36.74 years) was lower than the non-bacteremic group (43.18 yr). High fever, chills/cold, sweating, nausea, vomiting, and weight loss were more common in the bacteremic group. In the bacteremic group, white blood cell count, platelet count, hemoglobin level, mean platelet volume, eosinophil, and neutrophil counts were lower, and lymphocyte, erythrocyte sedimentation rate, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and ferritin levels were higher. According to the receiver operating characteristic (ROC) analysis, when the cut-off value of ferritin was considered 67, it was the parameter with the strongest predictive significance in Brucella bacteremia. Conclusion: High ferritin level, low eosinophil count, and increased erythrocyte sedimentation rate were determined as the most critical laboratory findings in predicting bacteremia in brucellosis.
  • [ X ]
    Öğe
    Testicular involvement of Brucellosis: a 10-year, multicentre study
    (J Infection Developing Countries, 2023) Celik, Mehmet; Akgul, Fethiye; Alkan, Sevil; Altindag, Deniz; Esmer, Fatih; Sahin, Ahmet; Ipek, Davut
    Introduction: The genito-urinary system is one of the most common areas of involvement in brucellosis. To present the epidemiological, clinical, and laboratory characteristics of patients with testicular involvement associated with brucellosis, together with the diagnostic and therapeutic approaches.Methodology: Patients followed up for brucellosis-related testicular involvement between January 2012 and November 2022 were included in the study. Brucellosis is defined as the production of Brucella spp. in cultures, or clinical symptoms together with the serum standard tube agglutination test titer of >= 1/160. Inflammation in scrotal Doppler ultrasonography was based on testicular involvement.Results: A retrospective evaluation was made of the data of 194 patients with brucellosis-related testicular involvement. The rate of determination of testicular involvement in brucellosis was 2.57%. The most affected patients were determined in the 16-30 years age range. On presentation, brucellosis was in the acute stage in 83.7% of patients. The most common symptoms on presentation were swelling and/or pain in the testes (86.6%). In the patients where a spermiogram could be performed, oligospermia was determined in 41.7%, and aspermia in 8.3%. When the testicular involvement of brucellosis was evaluated, epididymo-orchitis was present at the rate of 55.7%, epididymitis at 27.3%, and testis abscess at 5.1%.Conclusions: Although epididymo-orchitis was the most frequently determined form of involvement in this study, there was also seen to be a significant number of patients presenting with epididymitis. Male patients presented with the clinical status of brucellosis should be questioned about swelling and pain in the testes to avoid overlooking testicular involvement.