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    Circulating Salusin-beta Levels in Various Open-Angle Glaucoma Types
    (2021) Turgut, Burak; Mercan, Kadir; Ilhan, Nevin; Demır, Nesrin; Catak, Onur
    Purpose: To evaluate the levels of salusin-beta (?-Sal) in the serum in patients with open-angle glaucoma.\rMaterials and Methods: This pilot work was designed as an institutional controlled comparative clinical study. The serum ?-Sal levels of age\rand sex-matched 20 healthy volunteers as controls (Group 1), 15 patients with normal-tension glaucoma (NTG) (Group 2), 18 patients with\rpseudoexfoliative glaucoma (PXG) (Group 3) and 26 patients with primary open-angle glaucoma (POAG) (Group 4) were measured with the\renzyme-linked immunosorbent assay (ELISA) method.\rResults: There was no statistically signifi cant difference concerning age and gender among the groups (p>0. 05). The mean serum ?-Sal levels\rin Group 1, Group 2, Group 3 and Group 4 were 4977.02±3741.44 pg/mL; 1086.57±253.41 pg/mL; 1044.98±268.80 pg/mL and 868.32±181.78\rpg/mL, respectively. Although the mean ?-Sal levels in all glaucoma groups seem numerically lower than the control group, there was no\rstatistically signifi cant difference between the serum ?-Sal concentrations of the study groups (p>0.05).\rConclusion: These fi ndings suggest that serum salusin-? levels are not different among various open-angle glaucoma types. However,\rtheoretically, ?-Sal may contribute to the pathogenesis of glaucoma and may play a neuroprotective hormone in glaucoma. Further studies with\rlarge patient population are required to say whether ?-Sal plays a role in the pathogenesis of glaucomatous optic neuropathy.
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    The abnormal vitreomacular adhesion corresponding serous macula detachment area as a possible ocular risk factor in central serous chorioretinopathy
    (Gazi Eye Foundation, 2020) Turgut, Burak; Gungor Kobat, Sabiha; Catak, Onur
    Purpose: To investigate the frequency of abnormal vitreomacular adhesion (VMA) in central serous chorioretinopathy (CSCR) using spectral domain optical coherence tomography (SD-OCT). Materials and Methods: In this observational retrospective case-study, the OCT scans of 30 patients with acute CSCR (Group 1) and 15 patients with chronic CSCR (Group 2) cases which were diagnosed based on clinical, ophthalmological and OCT findings and which was followed in our hospital and 30 control subjects without retinopathy (Group 3) were retrospectively reviewed. The frequencies of VMA in the groups were evaluated. Results: 31 eyes of 30 patients had acute CSCR and 20 eyes of 15 patients had chronic CSCR. The control group included 30 normal eyes of 30 healthy control subjects. It was found that the frequency of VMA was 38,7% (12 eyes), 50% (10 eyes), 20% (6 eyes) in Group 1, Group 2 and Group 3, respectively. The difference among the frequency of VMAs in groups was statistically significant (p<0.05, p<0.05, p<0.05, respectively). Conclusion: This pilot study suggests that there is difference between the frequencies of VMA in the patients with CSCR and control group. © 2020 Gazi Eye Foundation. All rights reserved.