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    Anticancer Uses of Medicinal Plants in Turkish Traditional Medicine
    (Kahramanmaras Sutcu Imam Univ Rektorlugu, 2019) Bozyel, Mustafa Eray; Merdamert Bozyel, Elif; Canli, Kerem; Altuner, Ergin Murat
    The use of plants as therapeutic agents have been known since the ancient times. In developing countries, traditional medicinal plants are critical for disease treatment. Various herbal drugs are obtained from these plants for therapeutic use. These herbal drugs are used in the treatment of many diseases from diabetes to cancer. Today, cancer is one of the most important life-threatening diseases for human. Some of the methods used in the treatment of cancer include herbal sources. The scientific world is not oblivious to many herbal drugs used for cancer in traditional treatment methods. Due to the limited effectiveness of drugs, an increasing number of studies have been conducted in the last decade to increase the success of cancer treatments. In recent years, the importance given to the herbal drugs used for medicinal purposes and the studies on the medicinal uses of plants have increased in our country. In this review, researches about the herbal drugs traditionally used against cancer by the local people were investigated. As a result of the study, 160 plant taxa and 17 multi-herbal formulas were reported for cancer treatment in Turkish traditional medicine.
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    Biochemical, Antioxidant Properties and Antimicrobial Activity of Steno-Endemic Origanum onites
    (Mdpi, 2023) Canli, Kerem; Bozyel, Mustafa Eray; Turu, Dilay; Benek, Atakan; Simsek, Ozcan; Altuner, Ergin Murat
    Origanum onites (Lamiaceae) is an Eastern Mediterranean plant that is widely used in Turkish traditional medicine. This study aimed to investigate the biochemical composition, antimicrobial activity, and antioxidant potential of O. onites. In this study, the biochemical composition of the O. onites ethanol extract (OOEt) was analyzed using GC-MS. The antimicrobial activity was investigated using a disk diffusion test and determining minimum inhibitory concentrations (MIC) against 30 microorganism strains, including 28 bacteria (some multidrug-resistant) and 2 fungi. Additionally, the antioxidant activity was evaluated using the DPPH method. The main component identified was carvacrol. OOEt demonstrated antimicrobial activity against a wide range of tested microorganism strains. OOEt displayed the highest activity against E. faecium (a Gram-positive bacterium) at 100 mu L with a 52 mm inhibition zone. Additionally, P. aeruginosa DSMZ 50071 and P. fluorescens P1, which are Gram-negative bacteria, were the most sensitive strains with a 24 mm inhibition zone in 100 mu L of OOEt. The data obtained from A. baumannii (a multidrug-resistant strain) is particularly striking, as higher activity was observed compared to all positive controls. All tested fungal strains showed more effective results than positive controls. The antioxidant activity of OOEt was found to be stronger than that of the positive control, ascorbic acid. This study determined that O. onites has significant antimicrobial and antioxidant potential.
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    CHEMICAL COMPOSITION AND IN VITRO ANTIMICROBIAL ACTIVITY OF MATTHIOLA TRICUSPIDATA ETHANOL EXTRACT
    (Parlar Scientific Publications (P S P), 2020) Canli, Kerem; Bozyel, Mustafa Eray; Benek, Atakan; Yetgin, Ali; Senturan, Merve; Altuner, Ergin Murat
    It is widely accepted by scientists that innovation of new antimicrobial agents has extreme importance for the sake of the future of human beings; therefore the researches about the antimicrobial potentials of plant extracts and their biochemical composition have great importance. This present study aims to investigate the antimicrobial activity of Matthiola tricuspidata ethanol extract against several Gram-positive and Gram-negative microorganisms and Candida albicans by disk diffusion method, and to identify its chemical composition by Gas Chromatography-Mass Spectrometry. As a result, it was observed that the extract showed activity for all microorganisms excluding Enterobacter aerogenes ATCC 13048, Escherichia coli ATCC 25922, E. coli, Klebsiella pneumoniae, Salmonella infantis, and Salmonella typhimurium SL1344 and some chemical compounds were detected, which may be responsible for the antimicrobial activity.
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    Chemical composition, antioxidant, antimicrobial and anticancer activities of endemic Cephalaria tuteliana
    (Elsevier, 2024) Kiliccioglu, Ilker; Dulger, Gorkem; Senturk, Fatih; Bozyel, Mustafa Eray; Canli, Kerem; Dulger, Basaran
    Introduction: The genus Cephalaria, belonging to the Caprifoliaceae family, is a rich source of secondary metabolites, including mainly saponins which display a variety of biological activities, such as antimicrobial, antioxidant, and anticancerous effects. This study was carried out to observe the biochemical composition and to evaluate the biological activities of Cephalaria tuteliana Kus & Gokturk. Methods: The composition of endemic C. tuteliana was determined through gas chromatography-mass spectrometry (GC-MS) studies. Antimicrobial effect were determined by the disk diffusion and dilution methods for test bacteria and test fungi. The antioxidant potential of the ethanol extract was also investigated. Cell proliferation and apoptosis analysis were investigated by WST-1 and ELISA methods. The migration level of PC-3 prostate cancer cells after plant extract application was examined by wound healing assay. Also, molecular docking experiments were performed to investigate the anticancer activity of the major component found in the C.tuteliana extract. Results: GC-MS analysis showed that the predominant compounds were Phenol, 2,20-methylenebis [6-(1,1dimethyl ethyl)-4-methyl- (23.54 %), 9,12,15-octadecatrien-1-ol, (Z,Z,Z)-(6.06 %) and n-Hexadecanoic acid (3.03 %). The ethanolic extract of C. tuteliana displayed moderate antimicrobial activity against a spectrum of tested microorganisms. Also, it exhibited significant antiproliferative effects on PC-3 human prostate cancer cells while having no harmful effects on healthy control HUVEC cells. Furthermore, enhanced expressions of Caspase-3, 8, and 9 were observed in PC-3 cells after plant extract treatment. Also, cell migration level was notably reduced, especially at a dose of 400 mg/mL in PC-3 cells. The DPPH free radical scavenging activity of ethanolic extracts of C. tuteliana showed higher activity than ascorbic acid. Molecular docking experiments showed potential binding of the major aromatic compound in C.tuteliana extract to human androgen receptor 1E3G protein. Conclusion: These findings highlight the potential of C. tuteliana as a valuable natural resource and pave the way for further in vivo prostate cancer investigations. (c) 2024 SAAB. Published by Elsevier B.V. All rights reserved.
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    Ethnobotanical uses of medicinal plants for the treatment of herniated disc in Turkish traditional medicine
    (IGI Global, 2020) Bozyel, Mustafa Eray; Bozyel, Elif Merdamert; Canli, Kerem
    Humans have known the therapeutic properties and plant origin poisons of many plant species since ancientcient times. Ancient people who had no real and scientific knowledge on diseases and treatments tried to find solutions to these problems by the opportunities they had and the theories they could produce. Plants are the most important source of traditional folk medicine. People around the world have benefited from plants grown in their environment for this purpose. In these drugs, whole plant or various plant organs or secondary substances were used. Over the years, several therapies have emerged to treat herniated disc, ranging from conservative treatment to minimally invasive and percutaneous techniques to open surgical methods. This chapter examines the recent studies to form a compilation on ethnobotanical uses of medicinal plants for the treatment of herniated disc and their local names, parts, and usage forms in Turkish traditional medicine. © 2020 by IGI Global. All rights reserved.
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    In vitro ANTIMICROBIAL ACTIVITY AND BIOCHEMICAL COMPOSITION OF Hibiscus syriacus FROM TURKEY
    (Parlar Scientific Publications (P S P), 2022) Canli, Kerem; Bozyel, Mustafa Eray; Benek, Atakan; Turu, Dilay; Yakan, Mustafa Ali; Altuner, Ergin Murat
    Hibiscus syriacus is an ornamental plant, and it also has uses in traditional medicine. This study aimed to investigate in vitro antimicrobial activity and the biochemical composition of Hibiscus syriacus. In this study, the biochemical composition of ethanol extracts of H. syriacus flowers (HSFEt) and H. syriacus leaves (HSLEt) was analyzed by GC-MS. The antimicrobial activity was investigated using a disk diffusion test against 39 bacteria (including 11 multidrug-resistant strains) and 2 fungi strains. 21 and 12 components were identified in HSFEt and HSLEt, respectively. The main component is 2,3-Dihydroxypropyl stearate in both extracts. HSFEt and HSLEt have antimicrobial activity against most of the tested microorganisms. It has been detected the highest activities against Staphylococcus aureus ATCC 25923 (ST11) with a 15 mm, Staphylococcus aureus (CI1) and Staphylococcus aureus MRSA+MDR (MDR9) with a 14 mm inhibition zones in HSFEt, and Staphylococcus aureus ATCC 25923 (STI1) with an 11 mm inhibition zone in HSLEt. All these results showed that a syriacus has antistaphylococcal potential.
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    In Vitro Antimicrobial Activity Screening of Ethanol Extract of Lavandula stoechas and Investigation of Its Biochemical Composition
    (Hindawi Ltd, 2019) Canli, Kerem; Yetgin, Ali; Benek, Atakan; Bozyel, Mustafa Eray; Altuner, Ergin Murat
    The aim of this study was to test antimicrobial activity of ethanol extract of Lavandula stoechas against 22 bacteria and 1 yeast. Also, biochemical composition of the extract was investigated. A wide range of Gram-positive, Gram-negative microorganisms, and multidrug resistant bacteria were selected to test the antimicrobial activity. As a result, the extract is observed to contain fenchone (bicyclo[2.2.1]heptan-2-one, 1,3,3-trimethyl-, (1R)-) and camphor (+)-2-bornanone) as major components and showed antimicrobial activity against all studied microorganisms except Escherichia coli ATCC 25922 and Klebsiella pneumoniae. The results of the study present that L. stoechas is active against MDR strains too.
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    Screening of in vitro antimicrobial activity of sedum hispanicum ethanol extract and determination of its biochemical composition
    (Parlar Scientific Publications, 2021) Canli, Kerem; Bozyel, Mustafa Eray; Benek, Atakan; Yetgin, Ali; Akatas, Ilgaz; Altuner, Ergin Murat
    Although medical sciences are progressing tremendously, the diseases caused by viruses, fungi, and bacteria are still an important issue for public health. For this reason, continuous research to determine new antimicrobial compounds is needed. This study investigated the in vitro antimicrobial activity and biochemical composition of Sedum hispanicum ethanol extract for the first time in the literature. The in vitro antimicrobial activity of ethanol extract obtained from Sedum hispanicum by disk diffusion method against seventeen bacteria strains and one fungi strain, and biochemical composition of the ethanol extract was determined by GC-MS. The extract showed antimicrobial activity against all bacteria strains at almost all doses (50, 100, and 200 mu L) at different rates, except Pseudomonas fluorescence and Candida albicans. Some compounds found in the extract are not matching with the libraries. As a reason for that, this medicinal plant is proposed to contain some unknown molecules, which should be identified. Our results indicate that research of compounds, particularly unknown ones in the ethanol extract and their antimicrobial activities should be examined further.
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    Turkish herbal medicine in the treatment of back pain
    (IGI Global, 2020) Bozyel, Mustafa Eray; Bozyel, Elif Merdamert; Canli, Kerem
    The number of plants used for treatments has been steadily increasing since ancient times. There were around 250 herbal drugs used during the Mesopotamian civilization. During the time of the Greeks, 60 medicinal plants were known. During the Arab-Persian civilization, this number increased to about 4,000. At the beginning of the 19th century, the number of known medicinal plants reached 13,000. These herbal drugs are used to treat many diseases, from diabetes to cancer. Back pain and related symptoms rank as the second most common affliction of humankind. One of the proposed methods to control and treat back pain symptoms is traditional folk medicine. This chapter examines the recent ethnobotanical studies to form a compilation on medicinal plants used as Turkish herbal medicine in the treatment of back pain and their local names, parts, and usage forms. © 2020 by IGI Global. All rights reserved.