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    A rare cause of spinal dysraphism: lipomeningomyelocele
    (Elsevier Science Inc, 2016) Resorlu, Hatice; Gokmen, Ferhat; Resorlu, Mustafa; Akbal, Ayla; Bozkurt, Emre
    [Anstract Not Available]
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    Cubital tunnel syndrome secondary to gouty tophi: A case report
    (Pakistan Medical Assoc, 2017) Resorlu, Hatice; Zateri, Coskun; Akbal, Ayla; Gokmen, Ferhat; Adam, Gurhan; Bilim, Serhad; Bozkurt, Emre
    Gout is a chronic rheumatic disease resulting from accumulation of monosodium urate crystals in tissues. The most important risk factor for the disease is hyperuricaemia. Precipitation of uric acid in the joint in the form of monosodium urate crystals is the main factor responsible for triggering attacks of arthritis. Tophi occur as a result of urate crystals that precipitate into joints and surrounding tissues. Tophi can erode the bone where they are located and cause compression in soft tissue due to a mass effect. The following case report describes a case of cubital tunnel syndrome developed in association with tophaceous compression and resolved with surgical decompression in a patient with chronic gouty arthritis.
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    Number of Metabolic Syndrome Risk Factors is Related to Carotid Intima-Media Thickness in Rheumatoid Arthritis Patients
    (Turkish League Against Rheumatism, 2015) Gokmen, Ferhat; Temiz, Ahmet; Akbal, Ayla; Sen, Hacer; Zateri, Coskun; Gokmen, Esra; Bozkurt, Emre
    Objectives: This study aims to investigate the relationship between carotid intima-media thickness (CIMT) and clinical and metabolic variables in rheumatoid arthritis (RA) patients. Patients and methods: The study included 76 RA patients (18 males, 58 females; mean age 50.1+/-9.8 years; range 21 to 69 years) and 42 control subjects (11 males, 31 females; mean age 49.2+/-9.7; range 28 to 66 years). Erythrocyte sedimentation rate, C-reactive protein, and disease activity score were used to assess disease activation. Rheumatoid factor, anti-cyclic citrullinated peptide antibodies, and metabolic syndrome components (fasting blood glucose, high density lipoprotein-cholesterol, triglyceride, blood pressure, and waist circumference) were measured. Results: Mean disease duration was 6.9+/-6.5 years. Patients with RA had higher CIMT than the controls (0.8+/-0.1 and 0.6+/-0.2, respectively; p< 0.001). Statistically significant positive correlations were observed between CIMT and age, erythrocyte sedimentation rate, C-reactive protein, and systolic and diastolic blood pressure. The CIMT in RA patients having metabolic syndrome risk components ranging from one to four were 0.76+/-0.16, 0.82+/-0.14, 0.86+/-0.13, and 0.92+/-0.13, respectively. CIMT was positively correlated with the number of metabolic syndrome risk components. Conclusion: Our study has shown elevated CIMT in RA. Presence of metabolic syndrome components in RA patients increases tendency to atherosclerosis and constitutes a severe risk for cardiovascular disease.
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    Romatoid artrit hastalarında high mobility group box-1 protein düzeyi ile hastalık aktivitesi ve ateroskleroz arasındaki ilişki
    (Çanakkale Onsekiz Mart Üniversitesi, 2015) Bozkurt, Emre; Gökmen, Ferhat
    Amaç: İki grup arasında serum HMGB1, IL-6 ve TNF-? düzeyleri ve karotis İMK ölçümlerini karşılaştırmayı amaçladık. Bu parametrelerin hastalık süresi, hastalık aktivite skoru 28 (DAS28), sağlık değerlendirme anketi (HAQ), hassas eklem sayısı, şiş eklem sayısı, ESR, CRP ve vücut kitle indeksi (VKİ) ile ilişkisini araştırdık. Yöntem: ACR/EULAR 2010 kriterlerine göre RA tanılı 40 hasta seçildi. Kontrol grubu, hasta grubu ile benzer özelliklere sahip 34 kişiden oluşturuldu. Hassas ve şiş eklem sayısı kaydedildi. VAS ağrı skoru değerlendirildi. HAQ skorları ve hasta global değerlendirmesi kaydedildi. DAS28 hesaplandı. Karotis İMK ölçümleri yüksek rezolüsyonlu B-mod ultrasonografi cihazı ile yapıldı. HMGB1, TNF-? ve IL-6 düzeyleri serumda ELISA yöntemi ile ölçüldü. Bulgular: Hasta grubunda serum HMGB1 ve IL-6 düzeyleri anlamlı olarak daha yüksek bulundu (p=0,04; p<0,001). Her iki grup arasında serum TNF-? düzeyleri arasında fark saptanmadı (p=0,063). Karotis İMK ölçümleri hasta grubunda anlamlı olarak daha yüksek saptandı (p=0,001). HGMB1 ile HAQ skoru, karotis İMK ve hassas eklem sayısı arasında orta derecede ilişki saptandı (p=0,017, r=0,391; p=0,017, r=0,374; p=0,011, r=0,398). HMGB1 ile DAS28 arasında anlamlı ilişki saptanmadı. Karotis İMK ile DAS28 ve RF arasında korelasyon saptandı (p=0,041, r=0,325; p=0,047, r=0,316). Sonuç: RA hastalarında HMGB1 düzeyini anlamlı olarak daha yüksek saptadık. Ayrıca RA hastalarında normal popülasyona göre ateroskleroz gelişiminin daha hızlı olduğu göz önünde bulundurulursa hasta grubunda karotis İMK'nin anlamlı olarak daha yüksek olması güncel veriler ile uyumludur. HMGB1'in hem RA patogenezinde hem de ateroskleroz gelişiminde öncül bir belirteç olabileceğini düşünmekteyiz. Ancak potansiyel bir belirteç diyebilmek için gelecek çalışmalara ihtiyaç vardır.
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    The relationship between C-reactive protein rs3091244 polymorphism and ankylosing spondylitis
    (Wiley-Blackwell, 2016) Akbal, Ayla; Resorlu, Hatice; Gokmen, Ferhat; Savas, Yilmaz; Zateri, Coskun; Sargin, Betul; Bozkurt, Emre
    AimsPrevious studies have shown that C-reactive protein (CRP) gene polymorphism can be related to inflammatory changes. The present study aimed to examine the association between CRP gene polymorphism and clinical and laboratory findings in ankylosing spondylitis (AS) patients. Materials and methodsA total of 80 patients, 40 with AS and 40 controls, were included in the study. Diagnosis of AS was made according to Assessment in AS International Working Group criteria. Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Metrology Index and Bath Ankylosing Spondylitis Radiology Index scores were evaluated. CRP gene C, A and T alleles were evaluated and were determined using the analysis of melting curves after real time polymerase chain reaction. The odds ratios were calculated for all alleles and haploids of the CRP gene. We investigated the relationship between the CRP polymorphism and clinical and laboratory findings. ResultsA, C, T allele frequencies in the control group were 15%, 57.5% and 27.5%. The allele frequencies in the AS group were 38%, 68.8% and 26.2%. While C and T allele frequencies were shown to be similar in the two groups, A allele frequency was higher in the AS group compared to the control group. The CC wild allele was 42.5% in the control group and 47.5% in the AS group (P = 1.0). Odds ratios for the C allele were 1.6, for the CC haploid 1.2 and for the CT haploid 3.7. Chest expansion and finger-to-ground distance was better in the CRP gene polymorphism group compared to the no polymorphism group. ConclusionThe presence of the CRP gene CC wild haploid and C allele in patients may indicate an increased risk for AS.