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    Preparation of collagen based composite materials with synthetic polymers for potential wound dressing applications
    (2014) Şahiner, Mehtap; Bütün, Sultan; Alpaslan, Duygu; Bitlisli, B. Oral
    Collagen is very important part of the fibrous proteins in the living organism. Animal tissues, especially tendons main structure contain collagen. In this investigation, natural collagen (coll) modified with different synthetic monomers such as 2-hydroxy ethylmethacrylate (HEMA) and acrylamide (AAm) was prepared as p(Coll-co-HEMA) and p(Coll-co-AAm) composites to enhance collagen natural characteristics. Biocompatibility of the prepared interpenetrating polymeric network (IPN) was tested with MTT Assay and found biocompatible. Model drugs, such as Trimetoprim (TMP) and Naproxene (NP) were used as antibacterial active agents for release studies from the synthesized composite hydrogel-collagen IPN matrices. The drug-loaded IPN films release studies were carried out in bio-mimetic media. It was found that collagen-synthetic polymer matrices can be readily prepared and used for drug delivery system in the release of active agents, providing great potential in wound dressing applications.