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Öğe Adropin Levels in Polycystic Ovary Syndrome Patients(Derman Medical Publ, 2017) Sen, Hacer; Erbag, Gokhan; Binnetoglu, Emine; Eroglu, Mustafa; Turkon, Hakan; Tekin, Sati Zeynep; Asik, MehmetAim: Polycystic ovary syndrome (PCOS) is one of the most commonly observed endocrinopathies in women of reproductive age. Women with PCOS are said to have increased classic risk factors for cardiovascular disease, hypertension, dyslipidemia, diabetes, and obesity, in addition to non-classic risk factors such as an increase in C-reactive protein (CRP), homocysteine, and tumor necrosis factor-a. Adropin is a protein thought to play a role in maintaining energy homeostasis and insulin response. The aim of our study is to investigate the relationship between levels of adropin and insulin resistance in PCOS patients with insulin resistance and an increased risk of diabetes. Material and Method: Fifty-seven female patients (30 patients with PCOS and 27 healthy control subjects) were enrolled in this study. All patient's body mass index and insulin resistance were calculated. The adropin levels were measured using commercial kits based on a competitive plasma EIA (enzyme immunoassay) method. Results: The adropin levels in the patient group were 10.79 ng/L, while the value was 13.02 ng/L in the control group, and the difference was statistically significant (p= 0.04). There was a significant negative correlation between the adropin levels and the insulin, aspartate aminotransferase (AST), triglyseride (TG), and homeostasis model assessment of insulin resistance (HOMA-IR) levels (p= 0.03, p= 0.03, p= 0.04, and p= 0.02, respectively). Discussion: In our study, the adropin level which is associated with insulin resistance, was found to be decreased in patients with PCOS. We think that it would be valuable to conduct new studies for the evaluation of adropin related clinical conditions leading to insulin resistance in patients with PCOS.Öğe An unusual gastric ulcer cause: celiac crisis(Springer Wien, 2014) Akbal, Erdem; Erbag, Gokhan; Binnetoglu, Emine; Gunes, Fahri; Bilen, Yildiz Garip[Anstract Not Available]Öğe Aromatase inhibitor treatment for breast cancer: short-term effect on bone health(Termedia Publishing House Ltd, 2015) Erbag, Gokhan; Uygun, Kazim; Binnetoglu, Emine; Korkmaz, Ayse Nurdan; Asik, Mehmet; Sen, Hacer; Gunes, FahriAim of this study was to examine the effects of aromatase inhibitors (AIs), which are used in every phase of breast cancer treatment, on the bone mineral density (BMD) of patients with early-stage breast cancer. Material and methods: Menopausal female patients who were diagnosed with stages 1-3 breast cancer and who were planned for anastrazole or letrozole as adjuvant therapy were examined. After the patients' BMD was measured, 45 patients without osteoporosis were included in the study. Six months after AI therapy started, the patients' BMD was measured again. Results: In this study, we tried to show that there was a statistical difference in the BMD of 45 patients before and 6 months after treatment. Among all measurements (femur and lumbar T-scores), the femur Z-score (p = 0.52) was the only score that was not statistically significant. Statistical significance (p < 0.01) was detected in comparative analysis of the other measurements. According to this analysis, a significant loss of BMD was seen even in the first six months after AI treatment was introduced. Conclusions: Female patients with breast cancer are at higher risk for bone loss and fractures than healthy women. In this study, we showed the negative effects on BMD of aromatase inhibitor therapy, one of the main contributions to osteoporosis in women with breast cancer. This study is the first to quantify the short-term effect of AI treatment on BMD in postmenopausal women with breast cancer.Öğe Decrease in TSH levels after lactose restriction in Hashimoto's thyroiditis patients with lactose intolerance(Springer, 2014) Asik, Mehmet; Gunes, Fahri; Binnetoglu, Emine; Eroglu, Mustafa; Bozkurt, Neslihan; Sen, Hacer; Akbal, ErdemWe aimed to evaluate the prevalence of lactose intolerance (LI) in patients with Hashimoto's thyroiditis (HT) and the effects of lactose restriction on thyroid function in these patients. Eighty-three HT patients taking l-thyroxine (LT4) were enrolled, and lactose tolerance tests were performed on all patients. Lactose intolerance was diagnosed in 75.9 % of the patients with HT. Thirty-eight patients with LI were started on a lactose-restricted diet for 8 weeks. Thirty-eight patients with LI (30 euthyroid and 8 with subclinical hypothyroidism), and 12 patients without LI were included in the final analysis. The level of TSH significantly decreased in the euthyroid and subclinical hypothyroid patients with LI [from 2.06 +/- A 1.02 to 1.51 +/- A 1.1 IU/mL and from 5.45 +/- A 0.74 to 2.25 +/- A 1.88 IU/mL, respectively (both P < 0.05)]. However, the level of TSH in patients without LI did not change significantly over the 8 weeks (P > 0.05). Lactose intolerance occurs at a high frequency in HT patients. Lactose restriction leads to decreased levels of TSH, and LI should be considered in hypothyroid patients who require increasing LT4 doses, have irregular TSH levels and are resistant to LT4 treatment.Öğe Dyspepsia, Irritable Bowel Syndrome, and Hematological Parameters in Recurrent Aphthous Stomatitis(Derman Medical Publ, 2017) Kilic, Sevilay; Cevizci, Sibel; Sen, Hacer; Isik, Selda; Gunes, Fahri; Binnetoglu, Emine; Hiz, Meliha MerveAim: The goal of this study was to investigate the relationship between gastrointestinal complaints (dyspepsia, irritable bowel syndrome) and hematological parameters among recurrent aphthous stomatitis (RAS) patients. Material and Method: Forty-four RAS patients with a diagnosis of recurrent oral ulcers in oral mucosa were included in this study. They answered a questionnaire concerning oral aphthous properties, dyspepsia problems, and irritable bowel syndrome. Routine hematological screening and hemoglobin, vitamin B12, folic acid, and TSH were analyzed retrospectively. Data analyses were performed using SPSS. Results: Constipation complaints by females were statistically more frequent than those of males (59.3% vs. 11.8%; p< 0.05). There was a positive, statistically moderate and significant correlation between the time passed without having an aphtha (r= 0.343; p= 0.026) and lymphocyte level (r= 0.383; p= 0.028). However, there was no association between the time passed without having an aphtha and age (r= 0.112; p= 0.473), aphtha recurrence frequency (r= 0.05; p= 0.738), vitamin B12 (r= 0.019; p= 0.929), and Hb levels (r= 0.047; p= 0.781). Discussion: It was determined that there was positive correlation between aphtha size and lymphocyte level. Further studies should be designed in light of the association of RAS and gastrointestinal system disease.Öğe Epicardial Adipose Tissue Thickness in Hemodialysis Patients(Wiley, 2014) Altun, Burak; Tasolar, Hakan; Eren, Necmi; Binnetoglu, Emine; Altun, Mehzat; Temiz, Ahmet; Gazi, EmineAim: Hemodialysis (HD) patients had higher cardiovascular mortality and it is related to atherosclerosis. Epicardial adipose tissue (EAT) thickness is a marker of atherosclerosis and independent predictor of coronary artery disease. The aim of our study was to evaluate the relationship between EAT and carotid intima-media thickness (CIMT) predictors of early atherosclerosis in HD patients. Methods: The study included 62 HD patients and 40 healthy controls. EAT thickness and CIMT were measured by echocardiography in all subjects. Results: Epicardial adipose tissue thickness and CIMT were higher (6.98 +/- 1.67 vs. 3.84 +/- 0.73 mm, P < 0.001, 0.94 +/- 0.17 vs. 0.63 +/- 0.11 mm, P < 0.001, respectively) in HD patients than in control subjects. EAT thickness were correlated with CIMT, HD duration, age, and calcium. In addition, HD duration, CIMT, and age were independent predictors of EAT thickness on HD patients in regression analysis. Conclusion: Epicardial adipose tissue thickness may be a useful indicator of early atherosclerosis in HD patients.Öğe Evaluation of epicardial fat tissue thickness in patients with hyperthyroidism(Springer Wien, 2014) Binnetoglu, Emine; Asik, Mehmet; Altun, Burak; Sen, Hacer; Gazi, Emine; Erbag, Gokhan; Gunes, FahriThyroid hormones have several effects on the cardiovascular system, and recent studies have found that thyroid disorders affect coronary intima-media thickness (CIMT) in particular. Despite increased CIMT in patients with hyperthyroidism, the extent of the relationship between CIMT and epicardial fat thickness (EFT) in those patients is unknown. Furthermore, there is no report evaluating the relationship between EFT and overt hyperthyroidism (OH) in the literature. In this study, we aim to evaluate the effectiveness of EFT in predicting atherosclerosis as well as CIMT in patients with OH. A total of 30 newly diagnosed, untreated overt hyperthyroid patients and 44 control subjects were included in the study. EFT was measured using a commercially available echocardiography machine (VIVID 7; General Electric Medical Systems, Norway) with a 2.5-MHz probe. The echo-free space between the visceral and parietal pericardium on the anterior wall of the right ventricle was diagnosed as EFT. A linear-array imaging probe of the same echocardiography probe was used to evaluate the CIMT of the right common carotid artery. The hyperthyroid patients had a significantly greater EFT (mean: 4.31 +/- A 1.12 mm) than the healthy subjects (mean: 3.11 +/- A 0.84 mm; p < 0.001). CIMT was also significantly greater in the hyperthyroid patients (mean: 0.62 +/- A 0.17 mm) than in the healthy subjects (mean: 0.50 +/- A 0.11 mm; p < 0.01). In conclusion, the present study shows that mean EFT and CIMT were significantly higher in OH patients, irrespective of confounding factors such as hypertension.Öğe EVALUATION OF EPICARDIAL FAT TISSUE THICKNESS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM(Amer Assoc Clinical Endocrinologists, 2014) Asik, Mehmet; Sahin, Sinan; Temiz, Ahmet; Ozkaya, Mesut; Ozkul, Faruk; Sen, Hacer; Binnetoglu, EmineObjective: Primary hyperparathyroidism (pHPT) affects the cardiovascular system, and epicardial fat tissue (EFT) thickness is closely associated with cardiovascular diseases and atherosclerosis. Despite this, the association between EFT thickness and pHPT has not been studied in a clinical setting. This study aimed to assess EFT thickness in patients with pHPT. Methods: The study included 38 patients with pHPT and 40 healthy controls. EFT thickness, carotid intimamedia thickness (CIMT), serum levels of parathormone (PTH) and calcium, and blood chemistry profiles were determined in all subjects. Correlation and regression analyses were performed with EFT thickness and CIMT as dependent variables and age; systolic and diastolic blood pressure; body mass index (BMI); presence of diabetes mellitus; and free plasma glucose (FPG), PTH, and serum calcium (Ca) levels as independent variables. Results: Both the mean EFT thickness and the mean CIMT were significantly greater in the pHPT group than the control group (P<.001 for both). Correlation analysis showed that EFT thickness was significantly correlated with CIMT, age, systolic blood pressure, and PTH and serum Ca levels. Furthermore, the regression analysis revealed that EFT thickness retained its independent and positive association with FPG and serum Ca levels. Conclusions: The results of this study indicate that EFT thickness may be a useful marker of early atherosclerosis in patients with pHPT. Furthermore, the increase in EFT thickness appears to be due to hypercalcemia.Öğe Evaluation of liver perfusion in diabetic patients using 99mTc-sestamibi(Springer Wien, 2015) Sen, Hacer; Tan, Yusuf Ziya; Binnetoglu, Emine; Asik, Mehmet; Gunes, Fahri; Erbag, Gokhan; Gazi, EmineObjective The liver is an important organ for various aspects of glucose metabolism, including glucose uptake, storage, and synthesis. It is a major organ in the metabolic process with perfusion provided by both the portal vein and hepatic artery. In diabetic patients organ perfusion is reduced and this is linked to atherosclerosis, and as a result complications occur. In this study, we aimed to evaluate liver perfusion by scintigraphic methods in diabetic patients. Design and patients We retrospectively investigated 1,100 myocardial perfusion scintigraphies taken between January 2011 and December 2012 at Canakkale Onsekiz Mart University Medical Faculty Nuclear Medicine Department. A total of 66 patients who were diagnosed with diabetes mellitus and had myocardial perfusion scintigraphies were included in the study. The control subjects included 127 patients without diabetes mellitus who were chosen at random. Patients with chronic liver disease were not included in the study. The values from liver regions of interest (liver-ROI) rates and heart regions of interest (heart-ROI) rates were compared between the patients and controls. Results Patients were grouped according to the presence of diabetes. In the diabetes mellitus group, the liver-ROI average was lower (p = 0.66) than in the controls. In the control group, the average liver-ROI/heart-ROI ratios were higher than the ratio in the diabetes mellitus group (p = 0.019). Multivariate variance analysis showed that the diabetes mellitus liver-ROI/heart-ROI ratio was independent of other risk factors (p = 0.003; F: 9.6). Powered by Editorial Manager. and ProduXion Manager. from Aries Systems Corporation. Conclusions This study shows that liver perfusion in diabetic patients is reduced compared with those without diabetes. Prospective studies with larger patient groups are required.Öğe EVALUATION OF THE RISK OF ATHEROSCLEROSIS IN PATIENTS WITH ADRENAL INCIDENTALOMA USING THE ULTRASOUND BIOMARKERS EFT AND CIMT(Carbone Editore, 2015) Sen, Hacer; Uysal, Fatma; Binnetoglu, Emine; Asik, Mehmet; Erbag, Gokhan; Gunes, Fahri; Eroglu, MustafaIntroduction: Adrenal incidentalomas (AIs) are masses frequently observed on radiological examination that have attracted attention due to their coincidence with metabolic disorders. Recently, the relationship between atherosclerosis and adrenal incidentalomas has been noted. Epicardial fat tissue (EFT) and carotid artery intima-media thickness (CIMT) measurements show the development of atherosclerosis (AS). The aim of this study is to evaluate the risk of cardiovascular disease in AI patients using EFT and CIMT readings. Materials and methods: Our study included 63 Al patients and 48 healthy controls. All patients were evaluated for blood pressure, Body Mass index(BMI), EFT, CIMT, and lipid parameters. Al patients were also investigated for hormonal secretion. The relationship between risk of atherosclerosis and EFT, CIMT was analyzed. Results: Control subjects (mean EFT, 3.92 +/- 1.14 mm) had lower EFT than patients with subclinical Cushing's syndrome (SCS) and non-functional adenoma (NFA) (mean EFT, 6.22 +/- 1.97 mm and 5.44 +/- 1.61 mm, respectively) (both P < 0.001). There was no difference in EFT between SCS and NFA patients. CIMT was significantly lower in control subjects (mean CIMT, 0.65 +/- 0.11 mm) than in NFA patients (mean CIMT, 0.75 +/- 0.18 mm) (P < 0.01). The EFT of SCS patients was not significantly different from the EFT of either NFA patients or controls. Conclusion: EFT thickness measurements may be helpful as an early atherosclerosis marker in AI patients.Öğe Gastrointestinal bleeding associated with dabigatran in a patient with panhypopituitarism(Springer Wien, 2014) Gunes, Fahri; Asik, Mehmet; Temiz, Ahmet; Binnetoglu, Emine; Sen, Hacer; Bilen, Ogun Irem; Akbal, Erdem[Anstract Not Available]Öğe Gaucher disease with pathological femoral neck fracture(2013) Binnetoglu, Emine; Komurcu, Erkam; Sen, Hacer; Kizildag, BetulFractures of the femoral neck are rare and usually result from serious and high-energy trauma in the skeleton in young adults. Gaucher's disease (GD) is a lysosomal storage disorder that has progressive course and is rarely seen. Research has shown that a pathological femoral neck fracture with GD mostly emerges in childhood. But in adults, there are no reports of pathological femoral neck fractures with GD. We present a unique case of GD with a pathological femoral neck fracture in a 54-year-old woman who did not undergo surgery because of haematological problems including thrombocytopaenia. Copyright 2013 BMJ Publishing Group. All rights reserved.Öğe Graves' Disease Associated with Alopecia Areata Developing after Hashimoto's Thyroiditis(Medical Assoc Nippon Medical Sch, 2013) Asik, Mehmet; Binnetoglu, Emine; Sen, Hacer; Tekeli, Zeliha; Uysal, Fatma; Ukinc, KubilayGraves' disease and Hashimoto's thyroiditis are the most common autoimmune thyroid diseases. Hypothyroidism can develop in patients with Graves' disease, either spontaneously or as a result of radioactive iodine therapy or surgery. However, it is rare for patients with Hashimoto's thyroiditis to subsequently develop Graves' disease. We report a case of alopecia areata associated with Graves' disease in a 41-year-old woman who had previously been diagnosed with Hashimoto's disease. Alopecia areata is an autoimmune disease associated with other autoimmune diseases such as thyroid disorders, anemia, and other skin disorders.Öğe Hyperimmunoglobulin D Syndrome: Case Report(Turkish League Against Rheumatism, 2015) Sen, Hacer; Silan, Fatma; Binnetoglu, Emine; Gunes, Fahri; Akurut, Cisem; Uludag, Ahmet; Ozdemir, OzturkHyperimmunoglobulin D syndrome is a rare autosomal recessive inherited disease characterized by fever attacks, which may be accompanied by chills, headache, abdominal pain, and cervical lymphadenopathy. Typical hyperimmunoglobulin D syndrome patients start to show symptoms in the first years of life. Diagnosis is based on the presence of symptoms with reduction in the enzyme activity of mevalonate kinase or by detecting the mutation in the mevalonate kinase gene that causes the disease. In this article, we present a 21-year-old female patient who started having fever attacks in early childhood and was diagnosed with familial Mediterranean fever; however, in spite of treatment, whose complaints did not resolve. The genetic analysis, which detected homozygote mevalonate kinase gene mutation and resulted in the hyperimmunoglobulin D syndrome diagnosis, is presented with an accompanying discussion of the literature.Öğe Is Neutrophil Lymphocyte Ratio an Indicator for Proteinuria in Chronic Kidney Disease?(John Wiley & Sons Inc, 2014) Binnetoglu, Emine; Sengul, Erkan; Halhalli, Gokcen; Dindar, Sevim; Sen, HacerBackground: Recent studies have shown that neutrophil lymphocyte ratio (NLR) is a strong indicator in determining inflammation in cardiac and non-cardiac diseases. We aimed to evaluate the relationship between proteinuria and NLR in chronic kidney disease (CKD) patients without diabetes mellitus (DM). Methods: Between 2011 and 2012 files of a total of 1000 CKD patients attending outpatient clinic were retrospectively scanned. Patients with DM, chronic disease, malignancy or stage 5 CKD were excluded. After these patients were excluded, a total of 69 patients with stage 3 and 4 CKD were evaluated. Results: The study comprised 27 patients with CKD without proteinuria (Group 1), 42 patients with CKD and proteinuria (Group 2) and 30 healthy volunteers (Group 3). NLR was highest in Group 2 and this was statistically significant compared with the control group (p = 0.012). The platelet lymphocyte ratio (PLR) in Group 2 was higher than the control group at a significant level (p = 0.004). There was a moderate positive correlation found between proteinuria and NLR (p = 0.013, r = 0.3). There was a positive correlation found between proteinuria and PLR (p = 0.002, r = 0.306). Conclusion: In conclusion, NLR, a parameter easily found in routine blood counts of CKD patients, is a marker with prognostic value for the presence and degree of proteinuria. (C) 2014 Wiley Periodicals, Inc.Öğe Isolated Adrenocorticotropic Hormone Deficiency (ACTH) Associated with Hashimoto's Disease(Galenos Yayincilik, 2014) Binnetoglu, Emine; Asik, Mehmet; Sen, Hacer; Gunes, Fahri; Kizildag, Betul; Akbal, Erdem; Tekeli, ZelihaIsolated adrenocorticotropic hormone (ACTH) deficiency (IAD) is a rare disease characterized by secondary adrenal insufficiency with low cortisol production and normal secretion of pituitary hormones other than ACTH. Association of IAD with Hashimoto's disease (HD) is rare. This suggests the possibility of common autoimmune process affecting both the pituitary and the thyroid glands. Here, we report two cases of IAD with HD.Öğe Less aggressive disease in patients with primary squamous cell carcinomas of the thyroid gland and coexisting lymphocytic thyroiditis(Termedia Publishing House Ltd, 2015) Asik, Mehmet; Binnetoglu, Emine; Sen, Hacer; Gunes, Fahri; Muratli, Asli; Kankaya, Duygu; Uysal, FatmaAim of the study: Primary squamous cell carcinoma (SCC) of the thyroid gland is extremely rare. Infrequently, primary SCC of the thyroid gland is accompanied by other thyroid diseases such as Hashimoto's thyroiditis (HT). Recently, studies have demonstrated that differentiated thyroid cancer with coexisting HT has a better prognosis. However, the prognosis of patients with primary SCC of the thyroid gland and coexistent HT has not been clearly identified. We compared the clinical characteristics and disease stages of patients with primary SCC with and without lymphocytic thyroiditis (LT). Material and methods: We reviewed reports of primary SCC of the thyroid gland published in the English literature. Results and conclusions: We identified 46 papers that included 17 cases of primary SCC of the thyroid gland with LT and 77 cases of primary SCC of the thyroid gland without LT. Lymph node metastasis and local invasion rates did not differ between these two groups. Distant metastases were absent in patients with LT, and were observed in 13 (16.9%) patients without LT. A greater proportion of patients without LT had advanced stage disease (stage IV A-B-C) than patients with LT (p < 0.05). Patients with primary SCC of the thyroid gland and coexisting LT had lower tumour-node-metastasis stage and frequency of distant metastasis than those without LT. Lymphocytic infiltration in patients with SCC appears to limit tumour growth and distant metastases.Öğe Number of metabolic syndrome risk parameters associated with TAFIa/ai antigen levels(Lippincott Williams & Wilkins, 2013) Gunes, Fahri; Akbal, Erdem; Asik, Mehmet; Sen, Hacer; Binnetoglu, Emine; Kizilgun, Murat; Ozbek, MustafaThrombin activatable fibrinolysis inhibitor (TAFI) is an important procoagulant factor. Patients with metabolic syndrome (MetS) also have an elevated procoagulant status. However, TAFI and its association with MetS are still not well known. We aimed to investigate TAFI in type 2 diabetes mellitus patients with MetS. We enrolled a total of 55 patients who had MetS (n=30) and 25 healthy controls. MetS was diagnosed using National Cholesterol Education Program Adult Treatment Panel III criteria. We measured activated and inactivated TAFI (TAFIa/ai) antigen in plasma samples using a commercially available ELISA kit (Imubind TAFIa/ai antigen ELISA; American Diagnostica Inc., Stamford, Connecticut, USA). TAFIa/ai levels were then evaluated for links to MetS parameters. Mean TAFIa/ai levels were 156.6 +/- 66.9ng/dl in patients with MetS and 104.1 +/- 60.3ng/dl in the control group (P=0.005). None of the MetS parameters, including blood pressure, fasting plasma glucose, waist circumference, triglycerides or high-density lipoprotein cholesterol (HDL-C) levels were correlated with TAFIa/ai levels. However, TAFIa/ai level had a strong correlation with the number of metabolic risk components, which increased proportionally when MetS parameters were over three. When there were increased numbers of MetS risk components, we detected a rise in TAFIa/ai levels. TAFIa/ai levels could be an indicator of atherosclerotic tendency in patients with MetS. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.Öğe PLASMA LEVELS OF NESFATIN-1 IN PATIENTS WITH POLYCYSTIC OVARY SYDROME(Carbone Editore, 2014) Binnetoglu, Emine; Erbag, Gokhan; Gencer, Meryem; Turkon, Hakan; Asik, Mehmet; Gunes, Fahri; Sen, HacerIntroduction. Polycycstic ovary syndrome (PCOS) is an important disorder in women of reproductive age which is characterised with menstrual dysfunction, anovulation and hyperandrogenism. 5-10% of the female population affected by this syndrome. Nesfatin-1 is a new anorexigenic hormone which is expressed from several regions of hypothalamus and peripheral tissues. Nesfatin-1 is related with obesity, insulin resistance and appetite. We aimed to evaluated the nesfatin-1 levels in patients with PCOS. Material and methods: Sixty-five patients (37 patients with PCOS and 28 healthy control subjects) were enrolled in the study. We included newly diagnosed patients with PCOS in our study. Diagnosis of PCOS was based on the 2003 ESHREIASRM diagnostic criteria. Results: The patients with PCOS and controls were similar in terms of mean age body mass index (BMI), waist/hip (W/H) ratio and homeostasis model assessment-insulin resistance (HOMA-IR) index. Plasma Nesfatin-1 levels were similar between groups. There was no correlation between plasma Nesfatin-1 levels and other parameters. Conclusion: In conclusion nesfatin-1 may be play important role in glucose metabolism and insulin resistance. In this study due to the absence of insulin resistance in PCOS patients, levels of Nesfatin-1 were similar with control group. Nesfatin levels were associated with glucose metabolism, but further studies are needed in this regard.Öğe Platelet/lymphocyte ratio and risk of in-hospital mortality in patients with ST-elevated myocardial infarction(Int Scientific Information, Inc, 2014) Temiz, Ahmet; Gazi, Emine; Gungor, Omer; Barutcu, Ahmet; Altun, Burak; Bekler, Adem; Binnetoglu, EmineBackground: Platelet-to-lymphocyte ratio (PLR) is a new prognostic marker in coronary artery disease. We aimed to evaluate the relationship between PLR and in-hospital mortality in patients with ST-elevated acute myocardial infarction (AMI). Material/Methods: The present study included 636 patients with ST-elevated AMI. The study population was divided into tertiles based on their admission PLR. Patients having values in the third tertile was defined as the high PLR group (n=212) and those having values in the lower 2 tertiles were defined as the low PLR group (n=424). Results: Risk factors of coronary artery disease and treatments administered during the in-hospital period were similar between the groups. Male patient ratio was found to be lower in the high PLR group (73% vs. 82.8%, p=0.004). In-hospital mortality was increased in the high PLR group when compared to the low PLR group (12.7% vs. 5.9%, p=0.004). The PLR > 144 was found to be an independent predictor of in-hospital cardiovascular mortality (HR: 2.16, 95% CI: 1.16-4.0, p=0.014). Conclusions: This study showed that PLR is an independent predictor of cardiovascular mortality in patients with ST-elevated AMI.
