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Öğe A giant chorioangioma of the placenta with favorable outcome: a rare case presentation with literature review(2016) Beyazit, Fatma; Göret, Ceren Canbey; Pek, Eren; Gencer, MeryemChorioangioma, or hemangioma of the placenta, is the most frequent non-trophoblastic tumor of the placenta consisting of blood vessels and stroma. A great proportion of these tumors are small and well delineated within the placental parenchyma and have no or minimal adverse impact on the fetus. Unfortunately, large tumor size is linked to serious complications such as fetal anemia, hydrops and intrauterine death. This is probably because of arteriovenous shunts leading to progressive heart failure of the fetus. With the increasing rates of antenatal screenings with ultrasonography, prenatal diagnosis of these tumors is widely achieved. Here we report a case of giant placental chorioangioma diagnosed in the second trimester of pregnancy. The size of the tumor minimally increased during follow-up and at term, uncomplicated labor was achieved. Macroscopic and histologic examination confirmed the diagnosisÖğe A rare case of complete penoscrotal transposition with hypospadias in a newborn(Galenos Yayincilik, 2017) Beyazit, Fatma; Pek, Eren; Aylanc, Hakan[Anstract Not Available]Öğe Adalimumab mitigates ovarian ischemia-reperfusion injury in rats by regulating oxidative stress, apoptosis and resolution of inflammation(Wiley, 2019) Beyazit, Fatma; Buyuk, Basak; Turkon, Hakan; Elmas, Sait; Uzun, MetehanAim Ovarian torsion is a rare but an important reason of acute lower abdominal pain in women and associated with serious morbidity and mortality, if not treated promptly. The aim of this study was to evaluate the effects of an antitumor necrosis factor-alpha antibody on ovarian torsion in a rat model of ischemia-reperfusion (I/R) injury. Methods Forty female Wistar Albino rats were used in the present study. The rats were randomly divided into four groups: group I (sham), group II (I/R), group III (I/R + isotonic saline) and group IV (I/R + adalimumab). The I/R model was induced by torsion of both ovaries. Immunohistochemical staining for interleukin-1 beta (IL-1 beta), nuclear factor-kappa B (NF-kappa B), and inducible nitric oxide synthase was performed. Tissue and serum oxidative stress markers in conjunction with apoptotic index (AI) with the terminal deoxynucleotidyl transferase dUTP nick end labeling method were also calculated. Results Tissue total oxidant status, oxidative stress index and nitric oxide values were significantly decreased, and tissue total antioxidant status was found to be increased in group IV. Inflammation, vascular congestion and hemorrhagia were significantly lower in adalimumab-treated group. Serum oxidative stress markers and tissue malondialdehyde levels did not differ in study groups. The AI was significantly increased in groups 2 and 3. Adalimumab treatment significantly decreased the AI. Conclusion Adalimumab therapy in rats attenuated I/R induced ovarian injury, possibly suppressing inflammation, inhibiting oxidative stress, and altering apoptotic pathways.Öğe Alterations in sexual functions during and after pregnancy: Prejudice? Or Real?(Klinik Psikiyatri Dergisi, 2018) Beyazit, Fatma; Pek, Eren; Sahin, BasakSexual function in women is a complex and dynamic interaction of multiple variables including physical, emotinal, social, and physiological states. Moreover, sexual function is a key part of each human being's personality and a cornerstone in the overall couple relationship with an obvious affect on health related quality of life. A dysfunction in female sexual cycle can result in lack of desire for sexual contact, arousal and an inability to have an orgasm. Pregnancy is a period with many alterations in human physiology leading to challenges in sexual function. Endocrine, biologic, psychosomatic and social factors as well as anatomical alteations during pregnancy and the different mode of delivery may aggravate female sexual dysfunction. This literature review examines research articles that investigated female sexual function, sexual dysfunction, and sexual functioning in pregnancy in order to obtain how these parameters affect a woman's sexual related quality of life.Öğe An Evaluation of Provoked Vulvodynia, Pelvic Floor Muscles and Sexual Functions in Female Patients with Fibromyalgia Syndrome(Galenos Yayincilik, 2017) Resorlu, Hatice; Beyazit, Fatma; Doner, Davut; Oymak, Sibel; Zateri, CoskunObjective: The aim of our study is to investigate the genital origin of pain, particularly provoked vulvodynia (PVD) in female patients with Fibromyalgia syndrome (FMS), to reveal the relationship between PVD and pelvic floor muscle functions and to evaluate patients' sexual functions. Materials and Methods: Twenty four female patients who were diagnosed with FMS and who had not yet been treated, sexually active and 24 control cases were included to study. Severity of dyspareunia and dysmenorrhea was evaluated with a visual analogue scale, PVD was assessed using the cotton swab exam of vulva and sexual functions were evaluated with using the Female Sexual Function Index (FSFI). Additionally, pelvic floor muscles were graded using Brink scoring. Results: The severity means of menstrual term pain and dyspareunia severity were significantly higher in the patients than the control group (p=0.003, p=0.006). Significant differences were observed between the patient and control group in terms of vulvar pain in cotton swab exam and total Brink scores (both p<0.001). FSFI score was lower in the patient group than in the control group (p=0.001). A powerful correlation in the negative direction was determined between the result of cotton swab exam and Brink score (p<0.001, r=-0.575). Conclusion: The result of our study showed that dysmenorrhea, dyspareunia and PVD were significantly high in the FMS patients than in the control group. Pelvic floor muscle functions were affected in the FMS patients, and PVD was closely associated with the pelvic floor muscle functions.Öğe An immunohistochemistry and histopathological study of ankaferd blood stopper in a rat model of cervical inflammation(Assoc Medica Brasileira, 2019) Beyazit, Fatma; Buyuk, BasakOBJECTIVE: Ankaferd Blood Stopper (ABS) is a medicinal plant extract used topically as a hemostatic, anti-inflammatory, and anti-oxidant agent. Its cytoprotective effect mainly depends on its pleiotropic properties by modulating inflammatory mediators such as IL-1 beta, IL-6, and TNF-alpha. This study aims to test the possible therapeutic effect of ABS in the treatment of erosive and inflammatory conditions occurring in the uterine cervix. METHODS: Twenty-four female Wistar Albino rats were used in the present study. Trichloracetic acid was applied intravaginally to establish an experimental rat model of cervicitis. The rats were randomly divided into three groups: group I (injury), group II (injury+isotoinc saline), and group III (injury+ABS). After 3 estrous cycles of ABS and isotonic saline treatment, the amount of inflammation, vascular congestion and erosion were evaluated in the cervical tissues by using a modified semi-quantitative scale of 0-3. Immunohistochemical staining with monoclonal antibodies against IL-1 beta was also performed. RESULTS: Compared with group I and II, the ABS group showed the least inflammatory cell infiltration, vascular congestion and cervical erosion, compared with the ABS group prominent IL-1 beta staining observed in group I and group II. CONCLUSION: Our data suggest that ABS is a highly effective alternative to induce normal cervical epithelium and can be used safely in the treatment of cervical inflammation with or without cervical erosion.Öğe Ankaferd hemostat (ABS) as a potential mucosal topical agent for the management of COVID-19 syndrome based on its PAR-1 inhibitory effect and oestrogen content(Churchill Livingstone, 2020) Beyazit, Fatma; Beyazit, Yavuz; Tanoglu, Alpaslan; Haznedaroglu, Ibrahim C.COVID-19 due to the SARS-CoV-2 infection is a multi-systemic immune syndrome affecting mainly the lungs, oropharyngeal region, and other vascular endothelial beds. There are tremendous ongoing efforts for the aim of developing drugs against the COVID-19 syndrome-associated inflammation. However, currently no specific medicine is present for the absolute pharmacological cure of COVID-19 mucositis. The re-purposing/re-positioning of already existing drugs is a very important strategy for the management of ongoing pandemy since the development of a new drug needs decades. Apart from altering angiotensin signaling pathways, novel drug candidates for re-purposing comprise medications shall target COVID-19 pathobiology, including pharmaceutical formulations that antagonize proteinase-activated receptors (PARs), mainly PAR-1. Activation of the PAR-1, mediators and hormones impact on the hemostasis, endothelial activation, alveolar epithelial cells and mucosal inflammatory responses which are the essentials of the COVID-19 pathophysiology. In this context, Ankaferd hemostat (Ankaferd Blood Stopper, ABS) which is an already approved hemostatic agent affecting via vital erythroid aggregation and fibrinogen gamma could be a potential topical remedy for the mucosal management of COVID-19. ABS is a clinically safe and effective topical hemostatic agent of plant origin capable of exerting pleiotropic effects on the endothelial cells, angiogenesis, cell proliferation and vascular dynamics. ABS had been approved as a topically applied hemostatic agent for the management of post-surgical/dental bleedings and healing of infected inflammatory mucosal wounds. The anti-inflammatory and proteinase-activated receptor axis properties of ABS with a considerable amount of oestrogenic hormone presence highlight this unique topical hemostatic drug regarding the clinical re-positioning for COVID-19-associated mucositis. Topical ABS as a biological response modifier may lessen SARS-CoV-2 associated microthrombosis, endothelial dysfunction, oropharyngeal inflammation and mucosal lung damage. Moreover, PAR-1 inhibition ability of ABS might be helpful for reducing the initial virus propagation and mocasal spread of COVID-19.Öğe Association between adiponectin and ADIPOQ (rs 1501299) gene polymorphism in gestational diabetes mellitus patients(Sciendo, 2023) Cakina, Suat; Ulu, Selin; Beyazit, Fatma; Ozen, Ebru; Postaci, Emine SevincIntroduction In this study, we seek to determine the association between the polymorphism of the ADIPOQ (rs1501299) gene and adiponectin levels in gestational diabetes mellitus (GDM) patients.Methods The study participants included 200 pregnant women, 100 healthy subjects as the control group, and 100 having GDM as the case group. The enzyme-linked immunosorbent assay (ELISA) was used to examine adiponectin levels. The polymerase chain reaction-restriction length polymorphism (PCR-RFLP) was also used for genotyping examination.Results Findings showed that GDM patients had significantly lower serum adiponectin levels (p=0.001). The T/T genotype ho-mozygotes prevalence for rs1501299 polymorphism was significantly lower in GDM patients. (p=0.047).Conclusion Low serum adiponectin levels are associated with GDM. The T allele of the rs1501299 (+276 G/T) polymorphism of the ADIPOQ gene protects against GDM.Öğe CTLA4+rs231775 gene polymorphism increases PCOS, regardless of the levels of interleukin-6 and tumor necrosis factor-? in the serum(Bayrakol Medical Publisher, 2023) Beyazit, Fatma; Cicekliyurt, Meliha Merve; Turkon, Hakan; Unsal, Mesut Abdulkerim; Pek, ErenAim: Polycystic ovarian syndrome (PCOS) is a long-standing inflammation-related disease with increased levels of circulating pro-inflammatory markers. By affecting inflammatory cytokine production, cytotoxic T lymphocyte-associated antigen (CTLA-4) polymorphism can alter the immune system and trigger distinct disease states. The aim of the study was to investigate if CTLA4 polymorphism is associated with PCOS, and if so, (2) whether this situation influences serum interleukin-6 (IL-6) and TNF-alpha in PCOS.Material and Methods: CTLA4+rs231775 gene polymorphism with IL-6 and TNF-a levels were determined in 92 PCOS women and 88 healthy controls. Study groups were further subdivided according to body mass index (BMI) and the degree of insulin resistance (IR), and comparisons were made within each study group.Results: The prevalence of the A allele of single nucleotide polymorphism (SNP) rs231775 was more frequent in PCOS women compared with healthy controls [OR: 1.99, 95% CI:1.273-3.107, p =0.0023]. The heterozygous genotype was also shown to be strongly associated with PCOS development [OR: 3.041, 95%CI:1.604-5.766, p=0.0005]. Although TNF-a levels of PCOS patients were detected to be elevated, no difference was found in the study groups with respect to serum IL-6 levels. In addition, no association was observed between CTLA4+rs231775 polymorphism and serum pro-inflammatory cytokine levels.Discussion: The present study demonstrates for the first time that CTLA4+rs231775 gene polymorphism increases susceptibility to PCOS 2 times more in the case of A allele carriage and 3 times more in heterozygous individuals, independent from the long-standing low-grade inflammatory disease state encountered in patients with PCOS.Öğe Determining the factors influencing the intimate relationship between sexual satisfaction and dyadic adjustment in postmenopausal women(Termedia Publishing House Ltd, 2018) Beyazit, Fatma; Sahin, BasakIntroduction: Identifying and characterizing sexual dysfunction is crucial in order to improve the quality of the marital relationship in postmenopausal women. Regarding this, the present study aimed to determine the association of menopausal characteristics with sexual satisfaction and marital adjustment. Material and methods: This cross-sectional study was conducted on 89 postmenopausal women chosen using an improbable randomized sampling method. A questionnaire that collects demographic characteristics, the Dyadic Adjustment Scale (DAS) and The Golombok Rust Inventory of Sexual Satisfaction (GRISS) index were used to collect relevant data during the survey. Results: The mean age of postmenopausal women recruited to the present study was 54.6 +/- 6.7. The overall mean GRISS score and DAS score were 5.6 +/- 1.7 and 92.1 +/- 11.2 respectively. The mean GRISS scores were found to significantly increase as the ages of the women increased (p = 0.044). Mean DAS scores were lower in postmenopausal women that have menopause duration longer than 10 years (p = 0.035). Higher education level of the spouse is associated with lower GRISS scores (p = 0.024). No correlation was observed between marital adjustment and sexual satisfaction. Conclusions: Although sexual satisfaction and marital adjustment levels are decreased in the postmenopausal period, these two parameters do not seem to be related to each other. Multidimensional factors must be taken into account when evaluating sexual and marital satisfaction in postmenopausal women.Öğe Effect of Nausea and Vomiting on Anxiety and Depression Levels in Early Pregnancy(Ataturk Univ, 2018) Beyazit, Fatma; Sahin, BasakObjective: Nausea and vomiting of pregnancy (NVP) have been reported to be associated with distinct physiological responses to psychosocial stress. In this study, we aimed to evaluate the impact of nausea and vomiting on anxiety and depression during pregnancy. Materials and Methods: Eighty-three pregnant women with nausea and vomiting and 83 healthy pregnant women were included. All participants completed the demography- and pregnancy-related questionnaire, including Rhodes Index of Nausea and Vomiting, Beck Anxiety Inventory (BAI), and Edinburgh Postnatal Depression Scale (EPDS). Results: The median BAI and EPDS levels were 13 (min-max: 0-43) and 7 (min-max: 0-20) for the study group and 4 (min-max: 0-26) and 4 (min-max: 0-16) for control group, respectively. A univariate analysis revealed a statistically significant increase in terms of BAI levels (p<0.001) between the groups, but no significant difference was observed in terms of EPDS. In a logistic regression analysis, both anxiety (p=0.018) and depression (p=0.022) were found to be affected by NVP The BAI levels of the NVP group correlated with the severity of NVP. Conclusion: According to the results of the present study, women with severe NVP experienced a higher level of anxiety and depression which necessitates an extra awareness from healthcare professionals in order to be able to contribute effectively.Öğe Effect of placenta previa on umbilical cord hematocrit value(Taylor & Francis Ltd, 2022) Halici-Ozturk, Filiz; Beyazit, Fatma; Yakut, Kadriye; Yucel Yetiskin, Fatma Didem; Ozturk, Merve; Sinaci, Selcan; Caglar, A. TurhanObjective Placenta previa is one of the causes of neonatal anemia. This condition is mainly explained by antenatal hemorrhage and incision of the anteriorly located placenta during cesarean section. However, the mechanism of neonatal anemia in placenta previa has not been extensively studied or well elucidated. This study investigates whether placenta previa is associated with lower hematocrit levels in newborns with no antenatal hemorrhage and placental incision. Key findings This prospective study investigated 47 patients with previa and 43 control patients who gave birth with a cesarean section at 34-38 weeks of gestation. Blood samples were obtained from the fetal end of the umbilical vein. The mean umbilical cord hematocrit value was 49.3% in the control patients and 46.7% in the patients with previa, and the difference was statistically significant (p = .029). No significant association was observed between hematocrit value and birth weight, gestational age, newborn gender, placenta position, or preoperative maternal hemoglobin level. Conclusion The study findings reveal that even if not complicated by antepartum or intrapartum hemorrhage, placenta previa may be associated with lower hematocrit values in newborns. Although in none of the cases, the umbilical cord hematocrit value was not as low as to be defined as anemia, this effect of previa on newborns should be considered because of the importance of iron status.Öğe Effects of vitamin B12, folate, uric acid, and serum biomarkers of inflammation on bone mineral density in postmenopausal women(Termedia Publishing House Ltd, 2018) Beyazit, Fatma; Pek, ErenIntroduction: Despite the accumulating evidence suggesting a possible relationship between femur and lumbar bone mineral density (BMD) and serum uric acid (UA), it is unclear whether alterations in UA levels reflect any underlying subclinical inflammatory conditions in postmenopausal osteoporosis. In addition, the mechanistic link between osteoporosis and dietary factors including vitamin B-1(2), and folate in postmenopausal women is still obscure. The aim of the present study is to investigate the association between serum vitamin folate, UA, and subclinical inflammatory markers and BMD measurements in postmenopausal women. Material and methods: One hundred and eighty-four postmenopausal women were recruited for the present study. Clinical data, as well as serum vitamin B-12, folate, UA, conventional inflammatory markers, and other related biochemical markers, were assessed for each subject. Bone mineral density measurements of proximal femur and lumbar spine were taken using dual-energy X-ray absorptiometry. Correlation analysis was performed between serum vitamin B-12, folate, UA and other biochemical and metabolic parameters. Results: Although no association was found between serum inflammatory markers, vitamin B-12 and folate levels with femur neck and lumbar spine BMD measurements, elevated UA levels were observed in subjects with normal BMD values. Higher BMD values were obtained in higher UA tertiles. UA (p < 0.001) and BMI (p = 0.003) were found to be correlated with femur neck BMD measurements. Conclusions: The femoral and lumbar BMD measurements were associated with serum UA levels. Higher serum UA levels were found to have a protective effect on postmenopausal osteoporosis irrespective of inflammation and dietary factors.Öğe Elevated circulating nitric oxide levels correlates with enhanced oxidative stress in patients with hyperemesis gravidarum(Taylor & Francis Inc, 2018) Beyazit, Fatma; Turkon, Hakan; Pek, Eren; Ozturk, Filiz Halici; Unsal, MesutSince the biochemical and molecular mechanisms responsible for ongoing oxidative stress in hyperemesis gravidarum (HEG) patients have not yet been fully elucidated, the aim of this study was to evaluate the possible role of nitric oxide (NO), malondialdehyde (MDA) and other oxidative stress markers in the disease pathophysiology. Moreover, the relation between oxidative stress markers and Helicobacter pylori (H. pylori) infection was also investigated. Women with pregnancies complicated by HEG (n=33) were compared with pregnant women without HEG (n=30) and with healthy non-pregnant women (n=31). Serum NO, MDA, total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and H. pylori infection status were determined for each subject. Serum NO levels and OSI index were found to be increased (p=.001 and .013, respectively) and TAS levels were decreased (p<.001) in HEG patients compared with both controls regardless of H. pylori infection status. Serum MDA and TOS levels were not different between the study groups. Helicobacter pylori infection rates were similar in each group. The reduced antioxidant activities, as well as the increased OSI and NO levels in HEG patients indicate possible oxidative stress conditions in HEG patients. Moreover, serum NO levels may be used as an adjunctive marker to distinguish HEG patients from other causes of emesis during pregnancy.Impact statementWhat is already known on this subject? Current evidence suggests that oxidative stress is a significant factor responsible for a number of complications during pregnancy.What do the results of this study add? Hyperemesis gravidarum is an oxidative stress condition, as reflected by increased nitric oxide (NO) and decreased total antioxidant status activity, regardless of H. Pylori infection.What are the implications for clinical practice and/or further research? Full disclosure of the association between circulating NO and hyperemesis gravidarum would shed light on underlying biological mechanisms and could help clinical management of similar pregnancy-associated morbidity states.Öğe Evaluation of Factors Affecting Sexual Activity and Sexuality-Related Quality of Life in Different Stages of Pregnancy(Istanbul Training & Research Hospital, 2019) Cavus, Evren; Beyazit, FatmaIntroduction: Pregnancy is a special period in which physiological and psychological changes are observed in the body. Sexuality-related problems exhibit significant changes during pregnancy. In this study, we aimed to determine the distribution of changes in sexual behavior during pregnancy according to the trimesters and to determine the effects of these dysfunctions on quality of life. Methods: This study was performed in order to investigate the sexual life of pregnant women during pregnancy and the factors that affect sexual function in women followed up in the outpatient of clinic Canakkale Onsekiz Mart University, Department of Obstetrics and Gynecology between June 2017 and July 2017. The study included 300 pregnant women. Demographic data form and two questionnaires were applied to pregnant women. One of the questionnaires was aimed to determine the sexual function of pregnant women [Female Sexual Function Index (FSFI)] and the other was aimed to determine the quality of sexual life in pregnancy [Sexual Quality of Life-Female (SQoL-F) questionnaire]. Results: SQoL-F scores were found to be higher in the second trimester than in the first trimester (p=0.005). There was a statistically significant difference between the trimesters in terms of total FSFI scores and the highest score was in the second trimester (p=0.048). Subscales of FSFI scores were also evaluated and lubrication score was higher in the second trimester compared to other trimesters ( p=0.009). Sexual success score in the second trimester was higher than in the first trimester (p=0.014). Conclusion: In this study, we observed a significant decrease in sexual functions during pregnancy and fluctuations in sexual function between trimesters that are comparable with literature data. It is very important for health professionals to provide guidance in solving current problems by providing appropriate counseling services to pregnant women who express that they have problems during sexual intercourse.Öğe Evaluation of Oxidative Stress in Women with Polycystic Ovarian Syndrome as Represented by Serum Ischemia Modified Albumin and Its Correlation with Testosterone and Insulin Resistance(Japan Soc Internal Medicine, 2016) Beyazit, Fatma; Yilmaz, Nafiye; Balci, Osman; Adam, Magdi; Yaman, Selen TaflanObjective Ischemia-mediated oxidative stress and inflammation have been reported to be important contributors to the pathogenesis of polycystic ovary syndrome (PCOS). Ischemia-modified albumin (IMA) is a novel marker generated under ischemic and oxidative conditions and may reflect disease activity in distinct disease states. Therefore, we investigated whether the serum IMA levels are affected in infertile PCOS patients. Methods Forty-six patients with infertile PCOS, 30 patients with unexplained infertility, and 31 age-and body mass index (BMI)-matched controls were included in this cross-sectional study. Biochemical parameters, serum IMA levels, and their correlations with serum testosterone and insulin resistance were determined for each subject. Results In patients with infertile PCOS, the serum IMA levels were significantly elevated (p=0.003) compared with unexplained infertility patients and controls. A correlation analysis suggested that the IMA levels only correlated with the serum free testosterone levels in PCOS patients (r=0.43, p=0.028). Conclusion Elevations in the serum IMA levels in infertile PCOS patients may suggest a possible additional role of oxidative stress mechanisms in disease pathophysiology. Moreover, correlation between serum IMA and testosterone levels may influence the quality of oocytes via alterations in the balance of critical follicular fluid factors in the follicular microenvironment.Öğe Evaluation of the hematologic system as a marker of subclinical inflammation in hyperemesis gravidarum: a case control study(Via Medica, 2017) Beyazit, Fatma; Ozturk, Filiz Halici; Pek, Eren; Unsal, Mesut AbdulkerimObjectives: Current evidence suggests that subclinical inflammation plays a significant role in the development of hyperemesis gravidarum (HEG). Simple hematological markers, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have been shown to reflect inflammatory burden and disease activity in several disorders. This study aimed to determine the diagnostic value of these hematological parameters for HEG. Material and methods: A total of 54 HEG patients and 58 age-and gestational-age-matched control subjects were studied. NLR, MPV, PLR, platelet distribution width (PDW), and red cell distribution width (RDW) values in all patients were calculated and recorded from complete blood cell counts. Results: For HEG patients, the median NLR was 3.2 (1.6-7.1), and the median PLR was 143.7 (78.1-334.6); for control subjects, the values were 2.1 (1.0-4.7) and 93.1 (47.3-194.7), respectively. Although both the NLR and PLR of HEG patients were found to be significantly higher than in the controls, no significant difference was found between the study groups in terms of MPV, RDW, or PDW. Correlation analysis revealed a significant correlation between NLR and CRP (r = 0.872, p < 0.001). Conclusions: Our results show that peripheral blood NLR and PLR values can reflect inflammatory burden in HEG patients and can be used as markers for HEG.Öğe Evaluation of thiol/disulfide homeostasis in patients with gestational diabetes mellitus(Taylor & Francis Ltd, 2020) Cakina, Suat; Aydin, Buket; Beyazit, FatmaThis study aimed to study the dynamic thiol/disulfide homeostasis in pregnant women with gestational diabetes mellitus (GDM). Forty-five pregnant women with GDM and 45 age-matched healthy pregnancies were included in this study. Thiol/disulfide homeostasis was measured using a commercial kit (Rel Assay Diagnostics). The patients with GDM had significantly higher disulfide concentrations than healthy pregnant patients (p = .001). Besides, the GDM group had significantly higher disulfide/total thiol, disuplhide/native thiol, and native thiol/total thiol ratio than healthy pregnant patients (p = .001, p = .001 and p = .001, respectively). The significantly higher concentrations of disulfide, disulfide/total thiol, disuplhide/native thiol, and native thiol/total thiol ratio in women with GDM could be considered as the increased oxidative stress.Öğe False-positive results of lupus anticoagulant tests should be kept in mind in pregnant patients receiving low molecular weight heparin(Galenos Publishing House, 2021) Beyazit, Fatma; Çetin, Ece Ünal; Beyazit, YavuzWe read the article by Dr Izhar et al. (1), entitled “Antiphospholipid antibodies in women presenting with preterm delivery because of preeclampsia or placental insufficiency”, in the last issue of your journal with great interest. The authors observed a high prevalence of anti-phospholipid antibodies (APLA) in women who have preterm delivery due to preeclampsia or placental insufficiency (PREPI), corroborating the results of previous reports. Their findings are of great interest and finally shed some more light on this interesting topic. Therefore, we would like to commend the authors for addressing this issue. However, several points caught our attention while reading this paper and we would like to highlight these to the reader.Öğe Hepatitis D infection should be taken in mind while evaluating neonatal outcomes related to maternal hepatitis B infection(Taylor & Francis Ltd, 2019) Beyazit, Fatma; Unsal, Mesut A.[Anstract Not Available]
